Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HUM0_LEIIN

TriTrypDb:

LINF_100018000

Length:

652

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 1, no: 2
NetGPI	no	yes: 0, no: 3

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HUM0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HUM0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	180	184	PF00656	0.473
CLV_C14_Caspase3-7	328	332	PF00656	0.731
CLV_C14_Caspase3-7	563	567	PF00656	0.723
CLV_C14_Caspase3-7	576	580	PF00656	0.544
CLV_NRD_NRD_1	134	136	PF00675	0.502
CLV_NRD_NRD_1	191	193	PF00675	0.499
CLV_NRD_NRD_1	21	23	PF00675	0.485
CLV_NRD_NRD_1	212	214	PF00675	0.594
CLV_NRD_NRD_1	442	444	PF00675	0.575
CLV_NRD_NRD_1	648	650	PF00675	0.735
CLV_PCSK_FUR_1	324	328	PF00082	0.735
CLV_PCSK_KEX2_1	134	136	PF00082	0.502
CLV_PCSK_KEX2_1	191	193	PF00082	0.499
CLV_PCSK_KEX2_1	21	23	PF00082	0.485
CLV_PCSK_KEX2_1	211	213	PF00082	0.592
CLV_PCSK_KEX2_1	326	328	PF00082	0.744
CLV_PCSK_KEX2_1	442	444	PF00082	0.575
CLV_PCSK_PC1ET2_1	326	328	PF00082	0.744
CLV_PCSK_SKI1_1	192	196	PF00082	0.435
DEG_APCC_DBOX_1	313	321	PF00400	0.730
DEG_SPOP_SBC_1	230	234	PF00917	0.705
DEG_SPOP_SBC_1	374	378	PF00917	0.734
DEG_SPOP_SBC_1	78	82	PF00917	0.480
DOC_CKS1_1	194	199	PF01111	0.546
DOC_CKS1_1	386	391	PF01111	0.720
DOC_CKS1_1	462	467	PF01111	0.519
DOC_CKS1_1	514	519	PF01111	0.643
DOC_CKS1_1	58	63	PF01111	0.476
DOC_MAPK_gen_1	115	124	PF00069	0.424
DOC_MAPK_gen_1	179	188	PF00069	0.519
DOC_MAPK_gen_1	21	27	PF00069	0.498
DOC_MAPK_gen_1	633	642	PF00069	0.735
DOC_MAPK_MEF2A_6	117	126	PF00069	0.417
DOC_PP4_FxxP_1	58	61	PF00568	0.474
DOC_PP4_FxxP_1	84	87	PF00568	0.475
DOC_USP7_MATH_1	140	144	PF00917	0.554
DOC_USP7_MATH_1	173	177	PF00917	0.513
DOC_USP7_MATH_1	313	317	PF00917	0.724
DOC_USP7_MATH_1	374	378	PF00917	0.727
DOC_USP7_MATH_1	390	394	PF00917	0.457
DOC_USP7_MATH_1	546	550	PF00917	0.712
DOC_USP7_MATH_1	578	582	PF00917	0.762
DOC_USP7_MATH_1	78	82	PF00917	0.480
DOC_WW_Pin1_4	107	112	PF00397	0.457
DOC_WW_Pin1_4	193	198	PF00397	0.490
DOC_WW_Pin1_4	297	302	PF00397	0.753
DOC_WW_Pin1_4	360	365	PF00397	0.724
DOC_WW_Pin1_4	380	385	PF00397	0.674
DOC_WW_Pin1_4	461	466	PF00397	0.512
DOC_WW_Pin1_4	504	509	PF00397	0.658
DOC_WW_Pin1_4	510	515	PF00397	0.601
DOC_WW_Pin1_4	57	62	PF00397	0.473
DOC_WW_Pin1_4	596	601	PF00397	0.752
DOC_WW_Pin1_4	65	70	PF00397	0.632
LIG_14-3-3_CanoR_1	314	323	PF00244	0.730
LIG_14-3-3_CanoR_1	493	497	PF00244	0.660
LIG_14-3-3_CanoR_1	50	55	PF00244	0.529
LIG_14-3-3_CanoR_1	536	540	PF00244	0.619
LIG_14-3-3_CanoR_1	635	642	PF00244	0.735
LIG_14-3-3_CanoR_1	76	84	PF00244	0.511
LIG_14-3-3_CanoR_1	97	106	PF00244	0.470
LIG_14-3-3_CterR_2	649	652	PF00244	0.738
LIG_BIR_III_4	577	581	PF00653	0.730
LIG_BRCT_BRCA1_1	233	237	PF00533	0.719
LIG_BRCT_BRCA1_1	392	396	PF00533	0.671
LIG_BRCT_BRCA1_1	80	84	PF00533	0.482
LIG_EVH1_1	66	70	PF00568	0.487
LIG_FHA_1	160	166	PF00498	0.434
LIG_FHA_1	361	367	PF00498	0.756
LIG_FHA_1	412	418	PF00498	0.452
LIG_FHA_2	149	155	PF00498	0.658
LIG_FHA_2	221	227	PF00498	0.656
LIG_FHA_2	326	332	PF00498	0.734
LIG_FHA_2	36	42	PF00498	0.477
LIG_FHA_2	574	580	PF00498	0.726
LIG_LIR_Apic_2	81	87	PF02991	0.478
LIG_LIR_Gen_1	116	126	PF02991	0.417
LIG_LIR_Gen_1	158	168	PF02991	0.513
LIG_LIR_Gen_1	519	527	PF02991	0.505
LIG_LIR_Gen_1	552	562	PF02991	0.719
LIG_LIR_Nem_3	116	121	PF02991	0.474
LIG_LIR_Nem_3	158	164	PF02991	0.527
LIG_LIR_Nem_3	519	523	PF02991	0.572
LIG_LIR_Nem_3	538	543	PF02991	0.625
LIG_LIR_Nem_3	552	557	PF02991	0.661
LIG_NRBOX	316	322	PF00104	0.732
LIG_NRBOX	415	421	PF00104	0.478
LIG_NRBOX	611	617	PF00104	0.599
LIG_Pex14_1	449	453	PF04695	0.389
LIG_Pex14_2	4	8	PF04695	0.438
LIG_SH2_CRK	540	544	PF00017	0.631
LIG_SH2_STAT5	463	466	PF00017	0.517
LIG_SH2_STAT5	540	543	PF00017	0.573
LIG_SH3_2	600	605	PF14604	0.737
LIG_SH3_3	103	109	PF00018	0.461
LIG_SH3_3	162	168	PF00018	0.490
LIG_SH3_3	191	197	PF00018	0.554
LIG_SH3_3	295	301	PF00018	0.799
LIG_SH3_3	432	438	PF00018	0.535
LIG_SH3_3	459	465	PF00018	0.449
LIG_SH3_3	511	517	PF00018	0.658
LIG_SH3_3	540	546	PF00018	0.693
LIG_SH3_3	58	64	PF00018	0.530
LIG_SH3_3	597	603	PF00018	0.746
LIG_SUMO_SIM_anti_2	12	18	PF11976	0.445
LIG_SUMO_SIM_anti_2	414	420	PF11976	0.416
LIG_SUMO_SIM_par_1	38	43	PF11976	0.475
LIG_TRFH_1	193	197	PF08558	0.552
LIG_UBA3_1	320	326	PF00899	0.735
MOD_CDC14_SPxK_1	300	303	PF00782	0.752
MOD_CDK_SPK_2	380	385	PF00069	0.739
MOD_CDK_SPxK_1	297	303	PF00069	0.754
MOD_CDK_SPxK_1	385	391	PF00069	0.723
MOD_CK1_1	149	155	PF00069	0.733
MOD_CK1_1	220	226	PF00069	0.652
MOD_CK1_1	293	299	PF00069	0.691
MOD_CK1_1	335	341	PF00069	0.791
MOD_CK1_1	376	382	PF00069	0.739
MOD_CK1_1	507	513	PF00069	0.707
MOD_CK1_1	538	544	PF00069	0.626
MOD_CK1_1	549	555	PF00069	0.662
MOD_CK1_1	625	631	PF00069	0.728
MOD_CK1_1	77	83	PF00069	0.479
MOD_CK2_1	149	155	PF00069	0.534
MOD_CK2_1	220	226	PF00069	0.652
MOD_CK2_1	35	41	PF00069	0.477
MOD_Cter_Amidation	324	327	PF01082	0.736
MOD_DYRK1A_RPxSP_1	297	301	PF00069	0.755
MOD_GlcNHglycan	142	145	PF01048	0.590
MOD_GlcNHglycan	272	275	PF01048	0.690
MOD_GlcNHglycan	292	295	PF01048	0.481
MOD_GlcNHglycan	317	320	PF01048	0.683
MOD_GlcNHglycan	349	352	PF01048	0.746
MOD_GlcNHglycan	378	381	PF01048	0.732
MOD_GlcNHglycan	449	452	PF01048	0.513
MOD_GlcNHglycan	548	551	PF01048	0.749
MOD_GlcNHglycan	596	599	PF01048	0.752
MOD_GlcNHglycan	76	79	PF01048	0.522
MOD_GSK3_1	135	142	PF00069	0.517
MOD_GSK3_1	144	151	PF00069	0.497
MOD_GSK3_1	244	251	PF00069	0.673
MOD_GSK3_1	266	273	PF00069	0.637
MOD_GSK3_1	293	300	PF00069	0.690
MOD_GSK3_1	31	38	PF00069	0.519
MOD_GSK3_1	315	322	PF00069	0.678
MOD_GSK3_1	327	334	PF00069	0.647
MOD_GSK3_1	337	344	PF00069	0.793
MOD_GSK3_1	347	354	PF00069	0.465
MOD_GSK3_1	374	381	PF00069	0.730
MOD_GSK3_1	546	553	PF00069	0.694
MOD_GSK3_1	65	72	PF00069	0.490
MOD_GSK3_1	74	81	PF00069	0.449
MOD_GSK3_1	92	99	PF00069	0.509
MOD_LATS_1	137	143	PF00433	0.524
MOD_N-GLC_1	35	40	PF02516	0.478
MOD_NEK2_1	100	105	PF00069	0.520
MOD_NEK2_1	219	224	PF00069	0.648
MOD_NEK2_1	276	281	PF00069	0.623
MOD_NEK2_1	375	380	PF00069	0.682
MOD_NEK2_1	40	45	PF00069	0.470
MOD_NEK2_1	9	14	PF00069	0.443
MOD_NEK2_2	319	324	PF00069	0.735
MOD_PIKK_1	149	155	PF00454	0.492
MOD_PIKK_1	231	237	PF00454	0.714
MOD_PIKK_1	248	254	PF00454	0.715
MOD_PIKK_1	260	266	PF00454	0.611
MOD_PKA_2	140	146	PF00069	0.634
MOD_PKA_2	313	319	PF00069	0.662
MOD_PKA_2	492	498	PF00069	0.656
MOD_PKA_2	535	541	PF00069	0.675
MOD_PKA_2	636	642	PF00069	0.733
MOD_PKA_2	85	91	PF00069	0.471
MOD_PKA_2	96	102	PF00069	0.433
MOD_PKB_1	242	250	PF00069	0.691
MOD_PKB_1	633	641	PF00069	0.735
MOD_Plk_4	100	106	PF00069	0.470
MOD_Plk_4	173	179	PF00069	0.520
MOD_Plk_4	276	282	PF00069	0.667
MOD_Plk_4	35	41	PF00069	0.477
MOD_Plk_4	405	411	PF00069	0.536
MOD_Plk_4	578	584	PF00069	0.728
MOD_Plk_4	79	85	PF00069	0.479
MOD_ProDKin_1	107	113	PF00069	0.456
MOD_ProDKin_1	193	199	PF00069	0.484
MOD_ProDKin_1	297	303	PF00069	0.754
MOD_ProDKin_1	360	366	PF00069	0.724
MOD_ProDKin_1	380	386	PF00069	0.675
MOD_ProDKin_1	461	467	PF00069	0.517
MOD_ProDKin_1	504	510	PF00069	0.660
MOD_ProDKin_1	513	519	PF00069	0.563
MOD_ProDKin_1	57	63	PF00069	0.474
MOD_ProDKin_1	596	602	PF00069	0.751
MOD_ProDKin_1	65	71	PF00069	0.636
MOD_SUMO_rev_2	645	651	PF00179	0.732
TRG_DiLeu_BaEn_1	611	616	PF01217	0.599
TRG_ENDOCYTIC_2	118	121	PF00928	0.423
TRG_ENDOCYTIC_2	207	210	PF00928	0.410
TRG_ENDOCYTIC_2	540	543	PF00928	0.631
TRG_ER_diArg_1	133	135	PF00400	0.501
TRG_ER_diArg_1	191	193	PF00400	0.499
TRG_ER_diArg_1	210	213	PF00400	0.576
TRG_ER_diArg_1	242	245	PF00400	0.730
TRG_ER_diArg_1	442	444	PF00400	0.575
TRG_ER_diArg_1	631	634	PF00400	0.773
TRG_Pf-PMV_PEXEL_1	179	183	PF00026	0.537

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKM0	Leptomonas seymouri	30%	100%
A0A3S5H6H1	Leishmania donovani	99%	100%