LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

MIF4G domain-containing protein

Quick info Annotations Function or PPIs Localization Phosphorylation Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
MIF4G domain-containing protein
Gene product:
Eukaryotic translation initiation factor 4 gamma type 5 - putative
Species:
Leishmania infantum
UniProt:
A4HUL9_LEIIN
TriTrypDb:
LINF_100017900 *
Length:
731

Annotations

Annotations by Jardim et al.

Translation, Eukaryotic translation initiation factor 4 gamma type 5 Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0016281 eukaryotic translation initiation factor 4F complex 2 1
GO:0032991 protein-containing complex 1 1
GO:0110165 cellular anatomical entity 1 1

Phosphorylation

Promastigote: 433

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HUL9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HUL9

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 1
GO:0006412 translation 4 1
GO:0006518 peptide metabolic process 4 1
GO:0006725 cellular aromatic compound metabolic process 3 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0009058 biosynthetic process 2 1
GO:0009059 macromolecule biosynthetic process 4 1
GO:0009987 cellular process 1 1
GO:0019538 protein metabolic process 3 1
GO:0034641 cellular nitrogen compound metabolic process 3 1
GO:0034645 obsolete cellular macromolecule biosynthetic process 4 1
GO:0043043 peptide biosynthetic process 5 1
GO:0043170 macromolecule metabolic process 3 1
GO:0043603 amide metabolic process 3 1
GO:0043604 amide biosynthetic process 4 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0044249 cellular biosynthetic process 3 1
GO:0044260 obsolete cellular macromolecule metabolic process 3 1
GO:0044271 cellular nitrogen compound biosynthetic process 4 1
GO:0046483 heterocycle metabolic process 3 1
GO:0071704 organic substance metabolic process 2 1
GO:1901360 organic cyclic compound metabolic process 3 1
GO:1901564 organonitrogen compound metabolic process 3 1
GO:1901566 organonitrogen compound biosynthetic process 4 1
GO:1901576 organic substance biosynthetic process 3 1
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 12
GO:0003723 RNA binding 4 12
GO:0003743 translation initiation factor activity 4 12
GO:0005488 binding 1 12
GO:0008135 translation factor activity, RNA binding 3 12
GO:0045182 translation regulator activity 1 12
GO:0090079 translation regulator activity, nucleic acid binding 2 12
GO:0097159 organic cyclic compound binding 2 12
GO:1901363 heterocyclic compound binding 2 12
GO:0003729 mRNA binding 5 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 145 149 PF00656 0.515
CLV_NRD_NRD_1 112 114 PF00675 0.611
CLV_NRD_NRD_1 165 167 PF00675 0.454
CLV_NRD_NRD_1 328 330 PF00675 0.188
CLV_NRD_NRD_1 403 405 PF00675 0.591
CLV_NRD_NRD_1 706 708 PF00675 0.419
CLV_PCSK_KEX2_1 272 274 PF00082 0.297
CLV_PCSK_KEX2_1 328 330 PF00082 0.181
CLV_PCSK_KEX2_1 377 379 PF00082 0.194
CLV_PCSK_KEX2_1 403 405 PF00082 0.646
CLV_PCSK_PC1ET2_1 272 274 PF00082 0.234
CLV_PCSK_PC1ET2_1 377 379 PF00082 0.238
CLV_PCSK_SKI1_1 161 165 PF00082 0.556
CLV_PCSK_SKI1_1 189 193 PF00082 0.245
CLV_PCSK_SKI1_1 209 213 PF00082 0.263
CLV_PCSK_SKI1_1 273 277 PF00082 0.257
CLV_PCSK_SKI1_1 519 523 PF00082 0.382
CLV_PCSK_SKI1_1 604 608 PF00082 0.530
CLV_PCSK_SKI1_1 703 707 PF00082 0.400
CLV_PCSK_SKI1_1 708 712 PF00082 0.410
CLV_Separin_Metazoa 251 255 PF03568 0.482
CLV_Separin_Metazoa 704 708 PF03568 0.446
DEG_APCC_DBOX_1 505 513 PF00400 0.311
DEG_Nend_UBRbox_3 1 3 PF02207 0.610
DOC_CYCLIN_yCln2_LP_2 67 73 PF00134 0.561
DOC_MAPK_gen_1 186 196 PF00069 0.426
DOC_MAPK_gen_1 292 299 PF00069 0.381
DOC_MAPK_MEF2A_6 713 722 PF00069 0.445
DOC_PP1_RVXF_1 207 213 PF00149 0.447
DOC_PP1_RVXF_1 284 290 PF00149 0.407
DOC_PP1_RVXF_1 375 382 PF00149 0.422
DOC_PP2B_LxvP_1 67 70 PF13499 0.480
DOC_SPAK_OSR1_1 611 615 PF12202 0.276
DOC_USP7_MATH_1 118 122 PF00917 0.553
DOC_USP7_MATH_1 218 222 PF00917 0.395
DOC_WW_Pin1_4 275 280 PF00397 0.482
DOC_WW_Pin1_4 619 624 PF00397 0.346
DOC_WW_Pin1_4 666 671 PF00397 0.470
DOC_WW_Pin1_4 676 681 PF00397 0.343
LIG_14-3-3_CanoR_1 19 24 PF00244 0.579
LIG_14-3-3_CanoR_1 197 204 PF00244 0.380
LIG_14-3-3_CanoR_1 257 261 PF00244 0.489
LIG_14-3-3_CanoR_1 273 278 PF00244 0.309
LIG_14-3-3_CanoR_1 495 501 PF00244 0.343
LIG_14-3-3_CanoR_1 8 13 PF00244 0.619
LIG_Actin_WH2_2 691 709 PF00022 0.447
LIG_APCC_ABBAyCdc20_2 147 153 PF00400 0.565
LIG_BRCT_BRCA1_1 684 688 PF00533 0.272
LIG_CaM_IQ_9 284 300 PF13499 0.434
LIG_FHA_1 303 309 PF00498 0.381
LIG_FHA_1 434 440 PF00498 0.570
LIG_FHA_1 488 494 PF00498 0.282
LIG_FHA_1 569 575 PF00498 0.264
LIG_FHA_1 715 721 PF00498 0.384
LIG_FHA_2 198 204 PF00498 0.415
LIG_FHA_2 214 220 PF00498 0.489
LIG_FHA_2 364 370 PF00498 0.447
LIG_FHA_2 596 602 PF00498 0.556
LIG_FHA_2 637 643 PF00498 0.554
LIG_FHA_2 657 663 PF00498 0.197
LIG_HCF-1_HBM_1 101 104 PF13415 0.545
LIG_Integrin_isoDGR_2 428 430 PF01839 0.585
LIG_LIR_Gen_1 107 117 PF02991 0.542
LIG_LIR_Gen_1 220 231 PF02991 0.422
LIG_LIR_Gen_1 333 343 PF02991 0.384
LIG_LIR_Gen_1 453 461 PF02991 0.339
LIG_LIR_Gen_1 511 521 PF02991 0.324
LIG_LIR_Gen_1 541 552 PF02991 0.317
LIG_LIR_Gen_1 652 661 PF02991 0.351
LIG_LIR_Gen_1 685 695 PF02991 0.301
LIG_LIR_Nem_3 107 112 PF02991 0.440
LIG_LIR_Nem_3 220 226 PF02991 0.390
LIG_LIR_Nem_3 333 338 PF02991 0.384
LIG_LIR_Nem_3 453 457 PF02991 0.475
LIG_LIR_Nem_3 511 516 PF02991 0.305
LIG_LIR_Nem_3 541 547 PF02991 0.330
LIG_LIR_Nem_3 610 615 PF02991 0.316
LIG_LIR_Nem_3 652 657 PF02991 0.332
LIG_LIR_Nem_3 685 691 PF02991 0.280
LIG_LIR_Nem_3 700 705 PF02991 0.332
LIG_MLH1_MIPbox_1 684 688 PF16413 0.351
LIG_NRBOX 317 323 PF00104 0.390
LIG_NRBOX 614 620 PF00104 0.351
LIG_PCNA_PIPBox_1 380 389 PF02747 0.434
LIG_PCNA_yPIPBox_3 307 318 PF02747 0.527
LIG_PCNA_yPIPBox_3 377 387 PF02747 0.482
LIG_Pex14_1 492 496 PF04695 0.393
LIG_REV1ctd_RIR_1 209 217 PF16727 0.447
LIG_SH2_CRK 335 339 PF00017 0.482
LIG_SH2_CRK 621 625 PF00017 0.380
LIG_SH2_GRB2like 496 499 PF00017 0.353
LIG_SH2_GRB2like 653 656 PF00017 0.345
LIG_SH2_PTP2 227 230 PF00017 0.380
LIG_SH2_SRC 356 359 PF00017 0.434
LIG_SH2_STAP1 126 130 PF00017 0.523
LIG_SH2_STAP1 223 227 PF00017 0.482
LIG_SH2_STAP1 693 697 PF00017 0.438
LIG_SH2_STAT5 223 226 PF00017 0.434
LIG_SH2_STAT5 227 230 PF00017 0.381
LIG_SH2_STAT5 488 491 PF00017 0.271
LIG_SH2_STAT5 496 499 PF00017 0.277
LIG_SH2_STAT5 502 505 PF00017 0.323
LIG_SH2_STAT5 550 553 PF00017 0.259
LIG_SH2_STAT5 621 624 PF00017 0.378
LIG_SH2_STAT5 653 656 PF00017 0.292
LIG_SH2_STAT5 723 726 PF00017 0.332
LIG_SH3_3 22 28 PF00018 0.610
LIG_SH3_3 343 349 PF00018 0.482
LIG_SH3_3 432 438 PF00018 0.525
LIG_SH3_3 446 452 PF00018 0.427
LIG_SH3_3 53 59 PF00018 0.618
LIG_SH3_3 69 75 PF00018 0.663
LIG_SH3_3 93 99 PF00018 0.589
LIG_SUMO_SIM_anti_2 471 479 PF11976 0.331
LIG_SUMO_SIM_anti_2 483 488 PF11976 0.365
LIG_SUMO_SIM_anti_2 639 646 PF11976 0.381
LIG_SUMO_SIM_par_1 471 479 PF11976 0.487
LIG_SUMO_SIM_par_1 716 721 PF11976 0.442
LIG_TRAF2_1 200 203 PF00917 0.482
LIG_TRAF2_1 443 446 PF00917 0.576
LIG_TRAF2_1 538 541 PF00917 0.457
LIG_TRAF2_1 77 80 PF00917 0.682
LIG_TRAF2_1 81 84 PF00917 0.672
LIG_TRAF2_2 600 605 PF00917 0.571
LIG_TYR_ITSM 331 338 PF00017 0.482
LIG_UBA3_1 512 519 PF00899 0.350
LIG_UBA3_1 543 549 PF00899 0.376
LIG_WRC_WIRS_1 687 692 PF05994 0.290
MOD_CK1_1 157 163 PF00069 0.518
MOD_CK1_1 221 227 PF00069 0.495
MOD_CK1_1 433 439 PF00069 0.630
MOD_CK1_1 475 481 PF00069 0.387
MOD_CK1_1 568 574 PF00069 0.277
MOD_CK2_1 179 185 PF00069 0.498
MOD_CK2_1 196 202 PF00069 0.392
MOD_CK2_1 213 219 PF00069 0.490
MOD_CK2_1 234 240 PF00069 0.499
MOD_CK2_1 260 266 PF00069 0.481
MOD_CK2_1 363 369 PF00069 0.487
MOD_CK2_1 466 472 PF00069 0.365
MOD_CK2_1 535 541 PF00069 0.445
MOD_CK2_1 94 100 PF00069 0.610
MOD_GlcNHglycan 10 13 PF01048 0.569
MOD_GlcNHglycan 262 265 PF01048 0.286
MOD_GlcNHglycan 289 292 PF01048 0.285
MOD_GlcNHglycan 409 412 PF01048 0.696
MOD_GlcNHglycan 420 423 PF01048 0.714
MOD_GlcNHglycan 537 540 PF01048 0.454
MOD_GlcNHglycan 684 687 PF01048 0.285
MOD_GlcNHglycan 82 88 PF01048 0.644
MOD_GSK3_1 157 164 PF00069 0.507
MOD_GSK3_1 256 263 PF00069 0.447
MOD_GSK3_1 472 479 PF00069 0.386
MOD_GSK3_1 496 503 PF00069 0.385
MOD_GSK3_1 666 673 PF00069 0.436
MOD_GSK3_1 682 689 PF00069 0.187
MOD_N-GLC_1 142 147 PF02516 0.592
MOD_N-GLC_1 154 159 PF02516 0.591
MOD_N-GLC_1 212 217 PF02516 0.204
MOD_N-GLC_1 418 423 PF02516 0.655
MOD_NEK2_1 212 217 PF00069 0.419
MOD_NEK2_1 234 239 PF00069 0.439
MOD_NEK2_1 260 265 PF00069 0.482
MOD_NEK2_1 302 307 PF00069 0.403
MOD_NEK2_1 370 375 PF00069 0.395
MOD_NEK2_1 386 391 PF00069 0.404
MOD_NEK2_1 464 469 PF00069 0.351
MOD_NEK2_1 512 517 PF00069 0.383
MOD_NEK2_1 682 687 PF00069 0.340
MOD_NEK2_1 697 702 PF00069 0.314
MOD_NEK2_2 218 223 PF00069 0.392
MOD_PIKK_1 62 68 PF00454 0.683
MOD_PIKK_1 697 703 PF00454 0.438
MOD_PKA_2 196 202 PF00069 0.380
MOD_PKA_2 256 262 PF00069 0.489
MOD_PKA_2 363 369 PF00069 0.520
MOD_PKA_2 402 408 PF00069 0.640
MOD_PKA_2 7 13 PF00069 0.619
MOD_Plk_1 142 148 PF00069 0.593
MOD_Plk_1 154 160 PF00069 0.595
MOD_Plk_1 218 224 PF00069 0.403
MOD_Plk_1 333 339 PF00069 0.530
MOD_Plk_1 504 510 PF00069 0.445
MOD_Plk_1 649 655 PF00069 0.414
MOD_Plk_1 94 100 PF00069 0.640
MOD_Plk_2-3 142 148 PF00069 0.593
MOD_Plk_4 256 262 PF00069 0.468
MOD_Plk_4 27 33 PF00069 0.598
MOD_Plk_4 317 323 PF00069 0.482
MOD_Plk_4 333 339 PF00069 0.530
MOD_Plk_4 420 426 PF00069 0.559
MOD_Plk_4 472 478 PF00069 0.425
MOD_Plk_4 512 518 PF00069 0.454
MOD_Plk_4 553 559 PF00069 0.396
MOD_Plk_4 560 566 PF00069 0.406
MOD_Plk_4 636 642 PF00069 0.534
MOD_Plk_4 649 655 PF00069 0.282
MOD_Plk_4 714 720 PF00069 0.396
MOD_ProDKin_1 275 281 PF00069 0.482
MOD_ProDKin_1 619 625 PF00069 0.364
MOD_ProDKin_1 666 672 PF00069 0.459
MOD_ProDKin_1 676 682 PF00069 0.340
MOD_SUMO_for_1 187 190 PF00179 0.380
MOD_SUMO_for_1 77 80 PF00179 0.614
MOD_SUMO_rev_2 160 168 PF00179 0.452
MOD_SUMO_rev_2 593 600 PF00179 0.481
MOD_SUMO_rev_2 601 608 PF00179 0.450
TRG_DiLeu_BaEn_3 242 248 PF01217 0.434
TRG_ENDOCYTIC_2 223 226 PF00928 0.482
TRG_ENDOCYTIC_2 227 230 PF00928 0.381
TRG_ENDOCYTIC_2 335 338 PF00928 0.390
TRG_ENDOCYTIC_2 454 457 PF00928 0.470
TRG_ENDOCYTIC_2 702 705 PF00928 0.413
TRG_ER_diArg_1 506 509 PF00400 0.320
TRG_NES_CRM1_1 185 198 PF08389 0.422

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PEC9 Leptomonas seymouri 71% 96%
A0A0S4J374 Bodo saltans 29% 84%
A0A1X0NQC6 Trypanosomatidae 46% 97%
A0A3R7KDY4 Trypanosoma rangeli 40% 99%
A0A3S7WRD0 Leishmania donovani 100% 93%
A4H696 Leishmania braziliensis 91% 100%
C9ZVP6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 42% 98%
E9ANB8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 97% 100%
Q4QHA6 Leishmania major 97% 100%
V5BTU8 Trypanosoma cruzi 40% 99%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS