Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DnaJ domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4HUL6_LEIIN

TriTrypDb:

LINF_100017600

Length:

275

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HUL6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HUL6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	228	230	PF00675	0.525
CLV_NRD_NRD_1	234	236	PF00675	0.451
CLV_NRD_NRD_1	251	253	PF00675	0.416
CLV_NRD_NRD_1	56	58	PF00675	0.395
CLV_PCSK_KEX2_1	228	230	PF00082	0.523
CLV_PCSK_KEX2_1	233	235	PF00082	0.461
CLV_PCSK_KEX2_1	251	253	PF00082	0.389
CLV_PCSK_KEX2_1	53	55	PF00082	0.256
CLV_PCSK_KEX2_1	58	60	PF00082	0.292
CLV_PCSK_PC1ET2_1	53	55	PF00082	0.283
CLV_PCSK_PC1ET2_1	58	60	PF00082	0.317
CLV_PCSK_PC7_1	229	235	PF00082	0.557
CLV_PCSK_PC7_1	54	60	PF00082	0.216
CLV_PCSK_SKI1_1	150	154	PF00082	0.646
CLV_PCSK_SKI1_1	228	232	PF00082	0.435
CLV_PCSK_SKI1_1	77	81	PF00082	0.410
CLV_PCSK_SKI1_1	94	98	PF00082	0.410
DEG_APCC_KENBOX_2	195	199	PF00400	0.472
DOC_CYCLIN_RxL_1	91	98	PF00134	0.306
DOC_MAPK_gen_1	171	179	PF00069	0.399
DOC_MAPK_gen_1	53	63	PF00069	0.278
DOC_MIT_MIM_1	55	63	PF04212	0.391
DOC_PP1_RVXF_1	40	47	PF00149	0.397
DOC_PP4_FxxP_1	140	143	PF00568	0.512
DOC_PP4_FxxP_1	152	155	PF00568	0.584
DOC_PP4_FxxP_1	46	49	PF00568	0.279
DOC_USP7_MATH_1	111	115	PF00917	0.774
DOC_USP7_MATH_1	116	120	PF00917	0.707
DOC_USP7_MATH_1	143	147	PF00917	0.626
DOC_USP7_MATH_1	175	179	PF00917	0.536
LIG_14-3-3_CanoR_1	150	155	PF00244	0.607
LIG_14-3-3_CanoR_1	158	165	PF00244	0.580
LIG_14-3-3_CanoR_1	228	237	PF00244	0.488
LIG_deltaCOP1_diTrp_1	130	140	PF00928	0.615
LIG_FHA_2	19	25	PF00498	0.509
LIG_IRF3_LxIS_1	31	38	PF10401	0.355
LIG_LIR_Apic_2	137	143	PF02991	0.533
LIG_LIR_Gen_1	130	140	PF02991	0.560
LIG_LIR_Gen_1	178	186	PF02991	0.446
LIG_LIR_Gen_1	216	226	PF02991	0.562
LIG_LIR_Gen_1	87	97	PF02991	0.410
LIG_LIR_Nem_3	130	136	PF02991	0.615
LIG_LIR_Nem_3	178	182	PF02991	0.383
LIG_LIR_Nem_3	216	221	PF02991	0.472
LIG_LIR_Nem_3	267	273	PF02991	0.463
LIG_LIR_Nem_3	87	93	PF02991	0.311
LIG_MAD2	42	50	PF02301	0.282
LIG_NRBOX	92	98	PF00104	0.357
LIG_Pex14_2	152	156	PF04695	0.582
LIG_SH2_CRK	90	94	PF00017	0.279
LIG_SH2_PTP2	270	273	PF00017	0.442
LIG_SH2_STAP1	185	189	PF00017	0.455
LIG_SH2_STAT5	217	220	PF00017	0.503
LIG_SH2_STAT5	270	273	PF00017	0.398
LIG_SH2_STAT5	90	93	PF00017	0.355
LIG_TYR_ITIM	268	273	PF00017	0.447
MOD_CK1_1	114	120	PF00069	0.643
MOD_CK1_1	145	151	PF00069	0.622
MOD_CK1_1	163	169	PF00069	0.508
MOD_CK2_1	163	169	PF00069	0.556
MOD_Cter_Amidation	249	252	PF01082	0.417
MOD_GlcNHglycan	114	117	PF01048	0.654
MOD_GlcNHglycan	118	121	PF01048	0.658
MOD_GlcNHglycan	122	125	PF01048	0.637
MOD_GlcNHglycan	18	21	PF01048	0.542
MOD_GlcNHglycan	224	227	PF01048	0.481
MOD_GSK3_1	112	119	PF00069	0.604
MOD_GSK3_1	156	163	PF00069	0.625
MOD_GSK3_1	207	214	PF00069	0.475
MOD_GSK3_1	236	243	PF00069	0.595
MOD_GSK3_1	84	91	PF00069	0.415
MOD_N-GLC_1	175	180	PF02516	0.494
MOD_NEK2_1	16	21	PF00069	0.645
MOD_NEK2_2	264	269	PF00069	0.487
MOD_PKA_1	228	234	PF00069	0.650
MOD_PKA_2	111	117	PF00069	0.742
MOD_PKA_2	157	163	PF00069	0.629
MOD_PKA_2	192	198	PF00069	0.554
MOD_PKA_2	228	234	PF00069	0.650
MOD_Plk_1	175	181	PF00069	0.403
MOD_Plk_4	160	166	PF00069	0.545
MOD_SUMO_rev_2	163	172	PF00179	0.476
TRG_ENDOCYTIC_2	270	273	PF00928	0.398
TRG_ENDOCYTIC_2	90	93	PF00928	0.279
TRG_ER_diArg_1	227	229	PF00400	0.512
TRG_ER_diArg_1	233	235	PF00400	0.496
TRG_ER_diArg_1	251	254	PF00400	0.436
TRG_ER_diArg_1	56	59	PF00400	0.399
TRG_NLS_MonoExtN_4	54	61	PF00514	0.239
TRG_Pf-PMV_PEXEL_1	187	192	PF00026	0.512
TRG_Pf-PMV_PEXEL_1	42	47	PF00026	0.410
TRG_Pf-PMV_PEXEL_1	94	98	PF00026	0.360

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HRV7	Leptomonas seymouri	58%	100%
A0A0S4JQU3	Bodo saltans	31%	100%
A0A1X0NRW0	Trypanosomatidae	34%	100%
A0A3Q8IB40	Leishmania donovani	98%	100%
A0A3R7ND09	Trypanosoma rangeli	36%	100%
A4H693	Leishmania braziliensis	75%	100%
C9ZVP3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9ANB5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QHA9	Leishmania major	89%	100%