LeishMANIAdb
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RNA-binding protein-like protein

Quick info Annotations Function or PPIs Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
RNA-binding protein-like protein
Gene product:
RNA-binding protein-like protein
Species:
Leishmania infantum
UniProt:
A4HUL4_LEIIN
TriTrypDb:
LINF_100017400
Length:
382

Annotations

Annotations by Jardim et al.

Nucleic acid binding, RNA-binding -like

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Cellular components
Term Name Level Count
GO:0005730 nucleolus 5 1
GO:0043226 organelle 2 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Phosphorylation

Promastigote: 141

Expansion

Sequence features

A4HUL4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HUL4

Function

Biological processes
Term Name Level Count
GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 10 1
GO:0000470 maturation of LSU-rRNA 9 1
GO:0006139 nucleobase-containing compound metabolic process 3 1
GO:0006364 rRNA processing 8 1
GO:0006396 RNA processing 6 1
GO:0006725 cellular aromatic compound metabolic process 3 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0009987 cellular process 1 1
GO:0016070 RNA metabolic process 5 1
GO:0016072 rRNA metabolic process 7 1
GO:0034470 ncRNA processing 7 1
GO:0034641 cellular nitrogen compound metabolic process 3 1
GO:0034660 ncRNA metabolic process 6 1
GO:0043170 macromolecule metabolic process 3 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0046483 heterocycle metabolic process 3 1
GO:0071704 organic substance metabolic process 2 1
GO:0090304 nucleic acid metabolic process 4 1
GO:1901360 organic cyclic compound metabolic process 3 1
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 8
GO:0003723 RNA binding 4 8
GO:0005488 binding 1 8
GO:0097159 organic cyclic compound binding 2 8
GO:1901363 heterocyclic compound binding 2 8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 127 131 PF00656 0.690
CLV_C14_Caspase3-7 298 302 PF00656 0.430
CLV_NRD_NRD_1 18 20 PF00675 0.670
CLV_NRD_NRD_1 253 255 PF00675 0.591
CLV_NRD_NRD_1 264 266 PF00675 0.419
CLV_NRD_NRD_1 284 286 PF00675 0.600
CLV_NRD_NRD_1 374 376 PF00675 0.707
CLV_NRD_NRD_1 59 61 PF00675 0.783
CLV_PCSK_FUR_1 206 210 PF00082 0.317
CLV_PCSK_KEX2_1 18 20 PF00082 0.758
CLV_PCSK_KEX2_1 208 210 PF00082 0.317
CLV_PCSK_KEX2_1 252 254 PF00082 0.625
CLV_PCSK_KEX2_1 263 265 PF00082 0.387
CLV_PCSK_KEX2_1 284 286 PF00082 0.672
CLV_PCSK_KEX2_1 333 335 PF00082 0.642
CLV_PCSK_KEX2_1 370 372 PF00082 0.697
CLV_PCSK_KEX2_1 374 376 PF00082 0.789
CLV_PCSK_KEX2_1 59 61 PF00082 0.720
CLV_PCSK_KEX2_1 85 87 PF00082 0.694
CLV_PCSK_KEX2_1 93 95 PF00082 0.736
CLV_PCSK_PC1ET2_1 18 20 PF00082 0.758
CLV_PCSK_PC1ET2_1 208 210 PF00082 0.356
CLV_PCSK_PC1ET2_1 333 335 PF00082 0.642
CLV_PCSK_PC1ET2_1 370 372 PF00082 0.697
CLV_PCSK_PC1ET2_1 85 87 PF00082 0.694
CLV_PCSK_PC1ET2_1 93 95 PF00082 0.736
CLV_PCSK_SKI1_1 247 251 PF00082 0.525
CLV_PCSK_SKI1_1 264 268 PF00082 0.277
CLV_PCSK_SKI1_1 370 374 PF00082 0.676
CLV_PCSK_SKI1_1 79 83 PF00082 0.730
DEG_SPOP_SBC_1 70 74 PF00917 0.726
DOC_CYCLIN_RxL_1 17 28 PF00134 0.633
DOC_MAPK_gen_1 18 24 PF00069 0.652
DOC_MAPK_gen_1 212 221 PF00069 0.556
DOC_MAPK_gen_1 284 293 PF00069 0.565
DOC_MAPK_MEF2A_6 223 231 PF00069 0.556
DOC_MAPK_MEF2A_6 284 293 PF00069 0.565
DOC_PP1_RVXF_1 173 179 PF00149 0.376
DOC_PP1_RVXF_1 18 25 PF00149 0.646
DOC_PP4_FxxP_1 178 181 PF00568 0.514
DOC_PP4_FxxP_1 183 186 PF00568 0.522
DOC_USP7_MATH_1 103 107 PF00917 0.709
DOC_USP7_MATH_1 124 128 PF00917 0.710
DOC_USP7_MATH_1 154 158 PF00917 0.808
DOC_USP7_UBL2_3 352 356 PF12436 0.644
DOC_USP7_UBL2_3 366 370 PF12436 0.702
DOC_USP7_UBL2_3 4 8 PF12436 0.776
DOC_USP7_UBL2_3 46 50 PF12436 0.782
DOC_WW_Pin1_4 365 370 PF00397 0.639
LIG_14-3-3_CanoR_1 175 179 PF00244 0.411
LIG_14-3-3_CanoR_1 19 25 PF00244 0.710
LIG_14-3-3_CanoR_1 206 216 PF00244 0.496
LIG_14-3-3_CanoR_1 247 252 PF00244 0.562
LIG_14-3-3_CanoR_1 336 345 PF00244 0.698
LIG_FHA_1 355 361 PF00498 0.731
LIG_FHA_1 36 42 PF00498 0.600
LIG_FHA_2 296 302 PF00498 0.509
LIG_FHA_2 93 99 PF00498 0.587
LIG_LIR_Apic_2 177 181 PF02991 0.522
LIG_LIR_Apic_2 182 186 PF02991 0.512
LIG_LIR_Nem_3 169 174 PF02991 0.496
LIG_Pex14_2 191 195 PF04695 0.517
LIG_Pex14_2 313 317 PF04695 0.526
LIG_SH2_CRK 171 175 PF00017 0.523
LIG_SH2_CRK 189 193 PF00017 0.556
LIG_SH2_SRC 305 308 PF00017 0.497
LIG_SH2_STAT3 271 274 PF00017 0.426
LIG_SH2_STAT5 218 221 PF00017 0.506
LIG_SH2_STAT5 305 308 PF00017 0.609
LIG_SH3_3 38 44 PF00018 0.677
LIG_SH3_3 96 102 PF00018 0.773
LIG_SUMO_SIM_par_1 227 233 PF11976 0.556
LIG_TRAF2_1 106 109 PF00917 0.783
LIG_TRAF2_1 95 98 PF00917 0.721
MOD_CDC14_SPxK_1 368 371 PF00782 0.688
MOD_CDK_SPK_2 365 370 PF00069 0.723
MOD_CDK_SPxK_1 365 371 PF00069 0.734
MOD_CK1_1 156 162 PF00069 0.707
MOD_CK1_1 164 170 PF00069 0.621
MOD_CK1_1 207 213 PF00069 0.517
MOD_CK1_1 337 343 PF00069 0.693
MOD_CK2_1 103 109 PF00069 0.725
MOD_CK2_1 138 144 PF00069 0.690
MOD_CK2_1 20 26 PF00069 0.540
MOD_CK2_1 92 98 PF00069 0.585
MOD_Cter_Amidation 16 19 PF01082 0.692
MOD_GlcNHglycan 11 14 PF01048 0.623
MOD_GlcNHglycan 156 159 PF01048 0.696
MOD_GlcNHglycan 224 227 PF01048 0.337
MOD_GlcNHglycan 362 365 PF01048 0.619
MOD_GlcNHglycan 73 76 PF01048 0.765
MOD_GlcNHglycan 86 89 PF01048 0.585
MOD_GSK3_1 152 159 PF00069 0.710
MOD_GSK3_1 20 27 PF00069 0.545
MOD_GSK3_1 317 324 PF00069 0.572
MOD_GSK3_1 337 344 PF00069 0.781
MOD_GSK3_1 355 362 PF00069 0.697
MOD_GSK3_1 65 72 PF00069 0.701
MOD_GSK3_1 9 16 PF00069 0.675
MOD_N-GLC_1 109 114 PF02516 0.834
MOD_N-GLC_1 130 135 PF02516 0.554
MOD_N-GLC_1 164 169 PF02516 0.637
MOD_N-GLC_1 341 346 PF02516 0.604
MOD_N-GLC_1 70 75 PF02516 0.606
MOD_NEK2_1 195 200 PF00069 0.556
MOD_NEK2_1 24 29 PF00069 0.537
MOD_NEK2_1 317 322 PF00069 0.588
MOD_NEK2_1 84 89 PF00069 0.696
MOD_NEK2_2 25 30 PF00069 0.641
MOD_NEK2_2 3 8 PF00069 0.640
MOD_PIKK_1 270 276 PF00454 0.424
MOD_PIKK_1 317 323 PF00454 0.608
MOD_PKA_1 20 26 PF00069 0.625
MOD_PKA_1 332 338 PF00069 0.700
MOD_PKA_1 370 376 PF00069 0.693
MOD_PKA_1 66 72 PF00069 0.735
MOD_PKA_2 161 167 PF00069 0.661
MOD_PKA_2 174 180 PF00069 0.329
MOD_PKA_2 370 376 PF00069 0.693
MOD_PKB_1 245 253 PF00069 0.555
MOD_Plk_1 25 31 PF00069 0.514
MOD_Plk_1 341 347 PF00069 0.766
MOD_Plk_2-3 109 115 PF00069 0.683
MOD_Plk_4 174 180 PF00069 0.430
MOD_Plk_4 195 201 PF00069 0.607
MOD_ProDKin_1 365 371 PF00069 0.644
MOD_SUMO_rev_2 307 315 PF00179 0.434
TRG_ENDOCYTIC_2 171 174 PF00928 0.467
TRG_ENDOCYTIC_2 189 192 PF00928 0.517
TRG_ENDOCYTIC_2 218 221 PF00928 0.506
TRG_ER_diArg_1 244 247 PF00400 0.525
TRG_ER_diArg_1 251 254 PF00400 0.555
TRG_ER_diArg_1 263 265 PF00400 0.374
TRG_ER_diArg_1 283 285 PF00400 0.681
TRG_ER_diArg_1 58 60 PF00400 0.710
TRG_NLS_Bipartite_1 8 23 PF00514 0.699
TRG_NLS_MonoCore_2 17 22 PF00514 0.671
TRG_NLS_MonoCore_2 330 335 PF00514 0.675
TRG_NLS_MonoExtC_3 331 336 PF00514 0.688
TRG_NLS_MonoExtN_4 18 23 PF00514 0.657
TRG_NLS_MonoExtN_4 331 337 PF00514 0.691

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1P9B0 Leptomonas seymouri 60% 92%
A0A3Q8I7S8 Leishmania donovani 99% 100%
A0A3R7KMG8 Trypanosoma rangeli 49% 91%
A4H691 Leishmania braziliensis 73% 100%
E9ANB3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
Q4QHB1 Leishmania major 90% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS