Putative carrier protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

carrier protein - putative

Species:

Leishmania infantum

UniProt:

A4HUL3_LEIIN

TriTrypDb:

LINF_100017300

Length:

395

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 25
NetGPI	no	yes: 0, no: 25

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	26
GO:0110165	cellular anatomical entity	1	26

Expansion

Sequence features

A4HUL3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HUL3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	286	290	PF00656	0.452
CLV_NRD_NRD_1	114	116	PF00675	0.267
CLV_NRD_NRD_1	214	216	PF00675	0.192
CLV_NRD_NRD_1	351	353	PF00675	0.284
CLV_PCSK_KEX2_1	214	216	PF00082	0.192
CLV_PCSK_KEX2_1	350	352	PF00082	0.248
CLV_PCSK_PC7_1	346	352	PF00082	0.309
CLV_PCSK_SKI1_1	102	106	PF00082	0.257
CLV_PCSK_SKI1_1	142	146	PF00082	0.288
CLV_PCSK_SKI1_1	206	210	PF00082	0.226
CLV_PCSK_SKI1_1	232	236	PF00082	0.214
CLV_PCSK_SKI1_1	260	264	PF00082	0.470
DEG_APCC_DBOX_1	141	149	PF00400	0.572
DEG_Nend_Nbox_1	1	3	PF02207	0.684
DEG_SCF_FBW7_1	333	340	PF00400	0.474
DOC_CKS1_1	334	339	PF01111	0.443
DOC_CYCLIN_yCln2_LP_2	105	111	PF00134	0.504
DOC_CYCLIN_yCln2_LP_2	322	328	PF00134	0.264
DOC_MAPK_HePTP_8	348	365	PF00069	0.347
DOC_MAPK_MEF2A_6	194	202	PF00069	0.432
DOC_USP7_MATH_1	20	24	PF00917	0.763
DOC_USP7_MATH_1	210	214	PF00917	0.495
DOC_USP7_MATH_1	287	291	PF00917	0.371
DOC_USP7_MATH_1	375	379	PF00917	0.268
DOC_WW_Pin1_4	208	213	PF00397	0.509
DOC_WW_Pin1_4	333	338	PF00397	0.443
DOC_WW_Pin1_4	54	59	PF00397	0.744
LIG_14-3-3_CanoR_1	115	125	PF00244	0.502
LIG_14-3-3_CanoR_1	214	220	PF00244	0.443
LIG_14-3-3_CanoR_1	229	235	PF00244	0.507
LIG_14-3-3_CanoR_1	258	263	PF00244	0.348
LIG_Actin_WH2_2	218	234	PF00022	0.526
LIG_BRCT_BRCA1_1	131	135	PF00533	0.493
LIG_CtBP_PxDLS_1	108	112	PF00389	0.482
LIG_deltaCOP1_diTrp_1	289	297	PF00928	0.460
LIG_FHA_1	125	131	PF00498	0.508
LIG_FHA_1	238	244	PF00498	0.310
LIG_FHA_1	317	323	PF00498	0.257
LIG_FHA_1	343	349	PF00498	0.474
LIG_FHA_1	61	67	PF00498	0.660
LIG_FHA_1	74	80	PF00498	0.571
LIG_FHA_2	375	381	PF00498	0.263
LIG_IBAR_NPY_1	324	326	PF08397	0.293
LIG_LIR_Apic_2	289	295	PF02991	0.461
LIG_LIR_Gen_1	159	166	PF02991	0.460
LIG_LIR_Gen_1	378	386	PF02991	0.232
LIG_LIR_Gen_1	82	91	PF02991	0.495
LIG_LIR_LC3C_4	240	244	PF02991	0.435
LIG_LIR_Nem_3	126	131	PF02991	0.536
LIG_LIR_Nem_3	138	144	PF02991	0.562
LIG_LIR_Nem_3	159	165	PF02991	0.476
LIG_LIR_Nem_3	218	222	PF02991	0.453
LIG_LIR_Nem_3	233	238	PF02991	0.300
LIG_LIR_Nem_3	378	384	PF02991	0.211
LIG_LIR_Nem_3	82	86	PF02991	0.502
LIG_LYPXL_SIV_4	325	333	PF13949	0.327
LIG_Pex14_1	252	256	PF04695	0.258
LIG_SH2_CRK	256	260	PF00017	0.341
LIG_SH2_CRK	358	362	PF00017	0.337
LIG_SH2_SRC	15	18	PF00017	0.630
LIG_SH2_SRC	379	382	PF00017	0.222
LIG_SH2_STAP1	381	385	PF00017	0.232
LIG_SH2_STAT5	162	165	PF00017	0.461
LIG_SH2_STAT5	187	190	PF00017	0.386
LIG_SH2_STAT5	326	329	PF00017	0.450
LIG_SH3_3	11	17	PF00018	0.724
LIG_SH3_3	193	199	PF00018	0.501
LIG_SH3_3	23	29	PF00018	0.782
LIG_TYR_ITIM	160	165	PF00017	0.516
LIG_WRC_WIRS_1	259	264	PF05994	0.331
MOD_CDC14_SPxK_1	211	214	PF00782	0.392
MOD_CDK_SPxK_1	208	214	PF00069	0.392
MOD_CDK_SPxxK_3	208	215	PF00069	0.402
MOD_CK1_1	218	224	PF00069	0.489
MOD_CK1_1	275	281	PF00069	0.404
MOD_CK1_1	312	318	PF00069	0.215
MOD_CK1_1	49	55	PF00069	0.764
MOD_CK2_1	3	9	PF00069	0.733
MOD_CK2_1	374	380	PF00069	0.295
MOD_GlcNHglycan	118	121	PF01048	0.375
MOD_GlcNHglycan	16	20	PF01048	0.495
MOD_GlcNHglycan	184	187	PF01048	0.231
MOD_GlcNHglycan	265	269	PF01048	0.571
MOD_GlcNHglycan	289	292	PF01048	0.607
MOD_GlcNHglycan	315	318	PF01048	0.262
MOD_GlcNHglycan	358	361	PF01048	0.326
MOD_GlcNHglycan	49	52	PF01048	0.566
MOD_GSK3_1	206	213	PF00069	0.478
MOD_GSK3_1	293	300	PF00069	0.328
MOD_GSK3_1	309	316	PF00069	0.172
MOD_GSK3_1	32	39	PF00069	0.728
MOD_GSK3_1	333	340	PF00069	0.471
MOD_GSK3_1	49	56	PF00069	0.722
MOD_GSK3_1	75	82	PF00069	0.581
MOD_N-GLC_1	79	84	PF02516	0.327
MOD_N-GLC_2	366	368	PF02516	0.410
MOD_NEK2_1	192	197	PF00069	0.554
MOD_NEK2_1	2	7	PF00069	0.697
MOD_NEK2_1	238	243	PF00069	0.325
MOD_NEK2_1	263	268	PF00069	0.311
MOD_NEK2_1	361	366	PF00069	0.280
MOD_NEK2_1	374	379	PF00069	0.212
MOD_NEK2_2	22	27	PF00069	0.616
MOD_NEK2_2	230	235	PF00069	0.422
MOD_PIKK_1	278	284	PF00454	0.357
MOD_PKA_1	115	121	PF00069	0.510
MOD_PKA_2	272	278	PF00069	0.463
MOD_Plk_1	3	9	PF00069	0.705
MOD_Plk_1	79	85	PF00069	0.519
MOD_Plk_4	198	204	PF00069	0.406
MOD_Plk_4	238	244	PF00069	0.321
MOD_Plk_4	258	264	PF00069	0.149
MOD_Plk_4	3	9	PF00069	0.716
MOD_Plk_4	337	343	PF00069	0.492
MOD_ProDKin_1	208	214	PF00069	0.509
MOD_ProDKin_1	333	339	PF00069	0.443
MOD_ProDKin_1	54	60	PF00069	0.739
TRG_DiLeu_BaEn_4	67	73	PF01217	0.728
TRG_ENDOCYTIC_2	162	165	PF00928	0.474
TRG_ENDOCYTIC_2	205	208	PF00928	0.524
TRG_ENDOCYTIC_2	256	259	PF00928	0.246
TRG_ENDOCYTIC_2	326	329	PF00928	0.457
TRG_ENDOCYTIC_2	358	361	PF00928	0.293
TRG_ENDOCYTIC_2	381	384	PF00928	0.232
TRG_ENDOCYTIC_2	83	86	PF00928	0.498
TRG_ER_diArg_1	214	216	PF00400	0.392
TRG_ER_diArg_1	350	352	PF00400	0.370
TRG_Pf-PMV_PEXEL_1	142	146	PF00026	0.302

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4V4	Leptomonas seymouri	25%	100%
A0A0N1I8S5	Leptomonas seymouri	29%	100%
A0A0N1IBB8	Leptomonas seymouri	23%	82%
A0A0N1IHK9	Leptomonas seymouri	65%	100%
A0A0S4JF45	Bodo saltans	30%	96%
A0A0S4JH99	Bodo saltans	44%	78%
A0A0S4JIT1	Bodo saltans	32%	100%
A0A1X0NN16	Trypanosomatidae	30%	100%
A0A1X0NQB5	Trypanosomatidae	54%	100%
A0A1X0P6Z0	Trypanosomatidae	26%	99%
A0A3Q8IC78	Leishmania donovani	100%	100%
A0A3Q8IS12	Leishmania donovani	29%	100%
A0A3R7L1P3	Trypanosoma rangeli	28%	100%
A0A3S7WUZ5	Leishmania donovani	24%	88%
A0A422NGL1	Trypanosoma rangeli	53%	100%
A0A422P0Q3	Trypanosoma rangeli	29%	100%
A4H690	Leishmania braziliensis	80%	100%
A4H9K7	Leishmania braziliensis	26%	100%
A4HQI4	Leishmania braziliensis	30%	100%
A4HXX3	Leishmania infantum	24%	88%
C9ZVP0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
C9ZZS9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	99%
E9AHZ3	Leishmania infantum	29%	100%
E9ANB2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
E9ARN7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9AU97	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
Q0CT66	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	25%	100%
Q1DRJ3	Coccidioides immitis (strain RS)	26%	100%
Q1LZB3	Bos taurus	23%	100%
Q4Q094	Leishmania major	29%	100%
Q4QDU2	Leishmania major	26%	100%
Q4QHB2	Leishmania major	90%	99%
Q54VX4	Dictyostelium discoideum	23%	100%
Q9BSK2	Homo sapiens	22%	100%
V5BTU3	Trypanosoma cruzi	52%	100%
V5DDT9	Trypanosoma cruzi	29%	100%
V5DN72	Trypanosoma cruzi	29%	100%