Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HUL1_LEIIN

TriTrypDb:

LINF_100016900

Length:

616

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HUL1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HUL1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	148	152	PF00656	0.537
CLV_C14_Caspase3-7	387	391	PF00656	0.301
CLV_NRD_NRD_1	114	116	PF00675	0.485
CLV_NRD_NRD_1	487	489	PF00675	0.640
CLV_NRD_NRD_1	494	496	PF00675	0.362
CLV_NRD_NRD_1	564	566	PF00675	0.555
CLV_PCSK_KEX2_1	114	116	PF00082	0.752
CLV_PCSK_KEX2_1	428	430	PF00082	0.521
CLV_PCSK_KEX2_1	48	50	PF00082	0.464
CLV_PCSK_KEX2_1	494	496	PF00082	0.402
CLV_PCSK_PC1ET2_1	428	430	PF00082	0.521
CLV_PCSK_PC1ET2_1	48	50	PF00082	0.464
CLV_PCSK_SKI1_1	177	181	PF00082	0.359
CLV_PCSK_SKI1_1	372	376	PF00082	0.390
CLV_PCSK_SKI1_1	386	390	PF00082	0.288
CLV_PCSK_SKI1_1	448	452	PF00082	0.340
CLV_PCSK_SKI1_1	606	610	PF00082	0.441
DEG_Nend_UBRbox_3	1	3	PF02207	0.508
DEG_SIAH_1	574	582	PF03145	0.485
DEG_SPOP_SBC_1	356	360	PF00917	0.464
DOC_MAPK_DCC_7	569	578	PF00069	0.483
DOC_MAPK_gen_1	494	500	PF00069	0.334
DOC_MAPK_MEF2A_6	196	203	PF00069	0.328
DOC_PP1_RVXF_1	198	204	PF00149	0.323
DOC_PP1_RVXF_1	446	453	PF00149	0.339
DOC_PP1_RVXF_1	604	610	PF00149	0.428
DOC_USP7_MATH_1	117	121	PF00917	0.538
DOC_USP7_MATH_1	239	243	PF00917	0.541
DOC_USP7_MATH_1	258	262	PF00917	0.475
DOC_USP7_MATH_1	27	31	PF00917	0.357
DOC_USP7_MATH_1	274	278	PF00917	0.485
DOC_USP7_MATH_1	356	360	PF00917	0.471
DOC_USP7_MATH_1	384	388	PF00917	0.286
DOC_USP7_MATH_1	433	437	PF00917	0.531
DOC_USP7_MATH_1	479	483	PF00917	0.416
DOC_USP7_MATH_1	53	57	PF00917	0.504
DOC_USP7_MATH_1	585	589	PF00917	0.498
DOC_USP7_MATH_1	6	10	PF00917	0.524
DOC_USP7_MATH_1	610	614	PF00917	0.449
DOC_WW_Pin1_4	140	145	PF00397	0.625
DOC_WW_Pin1_4	185	190	PF00397	0.461
DOC_WW_Pin1_4	260	265	PF00397	0.530
DOC_WW_Pin1_4	297	302	PF00397	0.417
DOC_WW_Pin1_4	550	555	PF00397	0.536
DOC_WW_Pin1_4	569	574	PF00397	0.472
DOC_WW_Pin1_4	577	582	PF00397	0.504
LIG_14-3-3_CanoR_1	246	252	PF00244	0.537
LIG_14-3-3_CanoR_1	448	453	PF00244	0.342
LIG_14-3-3_CanoR_1	522	531	PF00244	0.511
LIG_APCC_ABBA_1	199	204	PF00400	0.310
LIG_eIF4E_1	373	379	PF01652	0.378
LIG_FHA_1	155	161	PF00498	0.427
LIG_FHA_1	319	325	PF00498	0.321
LIG_FHA_1	478	484	PF00498	0.441
LIG_FHA_1	491	497	PF00498	0.344
LIG_FHA_1	502	508	PF00498	0.323
LIG_FHA_1	531	537	PF00498	0.718
LIG_FHA_2	146	152	PF00498	0.543
LIG_FHA_2	164	170	PF00498	0.310
LIG_FHA_2	212	218	PF00498	0.379
LIG_FHA_2	261	267	PF00498	0.530
LIG_FHA_2	463	469	PF00498	0.438
LIG_GBD_Chelix_1	446	454	PF00786	0.344
LIG_HCF-1_HBM_1	16	19	PF13415	0.433
LIG_LIR_Gen_1	16	27	PF02991	0.398
LIG_LIR_Gen_1	451	460	PF02991	0.375
LIG_LIR_Nem_3	16	22	PF02991	0.421
LIG_LIR_Nem_3	220	224	PF02991	0.568
LIG_LIR_Nem_3	390	396	PF02991	0.311
LIG_LIR_Nem_3	453	459	PF02991	0.378
LIG_Pex14_2	333	337	PF04695	0.302
LIG_Pex14_2	452	456	PF04695	0.348
LIG_SH2_SRC	19	22	PF00017	0.401
LIG_SH2_STAT5	373	376	PF00017	0.387
LIG_SH2_STAT5	464	467	PF00017	0.440
LIG_SH3_3	268	274	PF00018	0.547
LIG_SH3_3	321	327	PF00018	0.326
LIG_SH3_3	335	341	PF00018	0.475
LIG_SH3_3	567	573	PF00018	0.596
LIG_SH3_3	575	581	PF00018	0.534
LIG_SH3_3	604	610	PF00018	0.428
LIG_SUMO_SIM_anti_2	250	255	PF11976	0.517
LIG_SUMO_SIM_par_1	120	127	PF11976	0.460
LIG_SUMO_SIM_par_1	574	580	PF11976	0.487
LIG_TYR_ITIM	374	379	PF00017	0.369
LIG_WRC_WIRS_1	385	390	PF05994	0.299
LIG_WRC_WIRS_1	449	454	PF05994	0.331
LIG_WRC_WIRS_1	561	566	PF05994	0.534
MOD_CDK_SPxxK_3	140	147	PF00069	0.544
MOD_CK1_1	233	239	PF00069	0.508
MOD_CK1_1	297	303	PF00069	0.410
MOD_CK1_1	358	364	PF00069	0.494
MOD_CK1_1	511	517	PF00069	0.498
MOD_CK1_1	525	531	PF00069	0.505
MOD_CK2_1	163	169	PF00069	0.405
MOD_CK2_1	211	217	PF00069	0.375
MOD_CK2_1	260	266	PF00069	0.538
MOD_CK2_1	374	380	PF00069	0.361
MOD_CK2_1	462	468	PF00069	0.432
MOD_DYRK1A_RPxSP_1	569	573	PF00069	0.514
MOD_GlcNHglycan	119	122	PF01048	0.485
MOD_GlcNHglycan	126	129	PF01048	0.507
MOD_GlcNHglycan	234	238	PF01048	0.514
MOD_GlcNHglycan	241	244	PF01048	0.508
MOD_GlcNHglycan	255	259	PF01048	0.519
MOD_GlcNHglycan	260	263	PF01048	0.480
MOD_GlcNHglycan	289	292	PF01048	0.518
MOD_GlcNHglycan	296	299	PF01048	0.389
MOD_GlcNHglycan	362	365	PF01048	0.499
MOD_GlcNHglycan	417	420	PF01048	0.526
MOD_GlcNHglycan	435	438	PF01048	0.475
MOD_GlcNHglycan	508	511	PF01048	0.422
MOD_GlcNHglycan	515	518	PF01048	0.508
MOD_GlcNHglycan	554	557	PF01048	0.521
MOD_GlcNHglycan	8	11	PF01048	0.515
MOD_GSK3_1	254	261	PF00069	0.569
MOD_GSK3_1	352	359	PF00069	0.479
MOD_GSK3_1	473	480	PF00069	0.520
MOD_GSK3_1	502	509	PF00069	0.358
MOD_GSK3_1	511	518	PF00069	0.494
MOD_GSK3_1	521	528	PF00069	0.509
MOD_GSK3_1	548	555	PF00069	0.544
MOD_NEK2_1	163	168	PF00069	0.335
MOD_NEK2_1	180	185	PF00069	0.408
MOD_NEK2_1	318	323	PF00069	0.309
MOD_NEK2_1	331	336	PF00069	0.290
MOD_NEK2_1	349	354	PF00069	0.465
MOD_NEK2_1	396	401	PF00069	0.371
MOD_NEK2_1	455	460	PF00069	0.481
MOD_NEK2_1	473	478	PF00069	0.723
MOD_NEK2_1	501	506	PF00069	0.615
MOD_NEK2_1	508	513	PF00069	0.596
MOD_NEK2_1	523	528	PF00069	0.490
MOD_NEK2_2	585	590	PF00069	0.479
MOD_PIKK_1	27	33	PF00454	0.369
MOD_PKA_2	401	407	PF00069	0.486
MOD_PKA_2	521	527	PF00069	0.618
MOD_PKA_2	53	59	PF00069	0.529
MOD_Plk_1	396	402	PF00069	0.422
MOD_Plk_1	473	479	PF00069	0.519
MOD_Plk_1	537	543	PF00069	0.505
MOD_Plk_4	249	255	PF00069	0.516
MOD_Plk_4	309	315	PF00069	0.343
MOD_Plk_4	363	369	PF00069	0.482
MOD_Plk_4	374	380	PF00069	0.357
MOD_Plk_4	384	390	PF00069	0.283
MOD_Plk_4	455	461	PF00069	0.453
MOD_ProDKin_1	140	146	PF00069	0.622
MOD_ProDKin_1	185	191	PF00069	0.458
MOD_ProDKin_1	260	266	PF00069	0.533
MOD_ProDKin_1	297	303	PF00069	0.418
MOD_ProDKin_1	550	556	PF00069	0.536
MOD_ProDKin_1	569	575	PF00069	0.474
MOD_ProDKin_1	577	583	PF00069	0.502
MOD_SUMO_rev_2	56	60	PF00179	0.531
TRG_DiLeu_BaLyEn_6	445	450	PF01217	0.355
TRG_ENDOCYTIC_2	19	22	PF00928	0.394
TRG_ENDOCYTIC_2	376	379	PF00928	0.353
TRG_ER_diArg_1	113	115	PF00400	0.490
TRG_ER_diArg_1	174	177	PF00400	0.597
TRG_ER_diArg_1	494	496	PF00400	0.376
TRG_Pf-PMV_PEXEL_1	39	43	PF00026	0.323

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSV0	Leptomonas seymouri	35%	100%
A0A3S7WRB9	Leishmania donovani	99%	100%
E9ANA8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4QHB6	Leishmania major	88%	100%