Histone H3

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Histone H3

Gene product:

histone H3 - putative

Species:

Leishmania infantum

UniProt:

A4HUL0_LEIIN

TriTrypDb:

LINF_100017000

Length:

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 50

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000786	nucleosome	3	12
GO:0032991	protein-containing complex	1	12
GO:0032993	protein-DNA complex	2	12
GO:0044815	DNA packaging complex	2	12
GO:0005634	nucleus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4HUL0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HUL0

PDB structure(s): 6kxv_A , 6kxv_E

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003677	DNA binding	4	12
GO:0005198	structural molecule activity	1	12
GO:0005488	binding	1	12
GO:0005515	protein binding	2	12
GO:0030527	structural constituent of chromatin	2	12
GO:0046982	protein heterodimerization activity	4	12
GO:0046983	protein dimerization activity	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	34	36	PF00675	0.284
CLV_NRD_NRD_1	46	48	PF00675	0.284
CLV_PCSK_FUR_1	9	13	PF00082	0.284
CLV_PCSK_KEX2_1	11	13	PF00082	0.284
CLV_PCSK_KEX2_1	34	36	PF00082	0.284
CLV_PCSK_PC1ET2_1	11	13	PF00082	0.284
CLV_PCSK_SKI1_1	12	16	PF00082	0.284
CLV_PCSK_SKI1_1	82	86	PF00082	0.400
DOC_MAPK_gen_1	47	57	PF00069	0.600
DOC_USP7_UBL2_3	17	21	PF12436	0.484
DOC_WW_Pin1_4	68	73	PF00397	0.370
LIG_BIR_II_1	1	5	PF00653	0.484
LIG_FHA_1	38	44	PF00498	0.487
LIG_FHA_1	51	57	PF00498	0.368
LIG_MYND_1	74	78	PF01753	0.366
LIG_SH3_3	66	72	PF00018	0.370
LIG_SH3_3	80	86	PF00018	0.398
LIG_WW_2	74	77	PF00397	0.362
MOD_CK1_1	16	22	PF00069	0.470
MOD_CK1_1	24	30	PF00069	0.586
MOD_GlcNHglycan	23	26	PF01048	0.393
MOD_GSK3_1	12	19	PF00069	0.484
MOD_NEK2_1	49	54	PF00069	0.545
MOD_PKB_1	35	43	PF00069	0.487
MOD_Plk_4	51	57	PF00069	0.515
MOD_ProDKin_1	68	74	PF00069	0.370
TRG_ER_diArg_1	34	36	PF00400	0.487
TRG_NLS_MonoExtC_3	16	21	PF00514	0.484

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IC67	Leishmania donovani	100%	66%
A0A422MY58	Trypanosoma rangeli	76%	74%
A4H675	Leishmania braziliensis	86%	66%
A4HUJ9	Leishmania infantum	100%	66%
A4HWV9	Leishmania infantum	96%	66%
E9AN97	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	66%
E9AQL5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	66%
G9CU80	Leishmania donovani	96%	66%
P40285	Leishmania infantum	81%	67%
P81195	Stylonychia lemnae	59%	75%
P81198	Stylonychia lemnae	57%	77%
P81199	Stylonychia lemnae	56%	75%
Q27489	Caenorhabditis elegans	48%	68%
Q4QEV9	Leishmania major	97%	66%
Q4QHB5	Leishmania major	97%	66%