Transmembrane protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HUK4_LEIIN

TriTrypDb:

LINF_100015900

Length:

199

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

A4HUK4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HUK4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	14	16	PF00675	0.315
CLV_NRD_NRD_1	75	77	PF00675	0.358
CLV_PCSK_SKI1_1	15	19	PF00082	0.276
DOC_CYCLIN_yCln2_LP_2	102	108	PF00134	0.324
DOC_MAPK_gen_1	15	22	PF00069	0.467
DOC_MAPK_gen_1	76	87	PF00069	0.437
DOC_MAPK_MEF2A_6	15	24	PF00069	0.450
DOC_PP2B_LxvP_1	102	105	PF13499	0.303
DOC_USP7_MATH_1	112	116	PF00917	0.353
DOC_USP7_MATH_1	2	6	PF00917	0.542
DOC_USP7_UBL2_3	45	49	PF12436	0.424
LIG_14-3-3_CanoR_1	15	21	PF00244	0.473
LIG_BIR_II_1	1	5	PF00653	0.565
LIG_BIR_III_3	1	5	PF00653	0.557
LIG_BRCT_BRCA1_1	114	118	PF00533	0.438
LIG_eIF4E_1	83	89	PF01652	0.400
LIG_FHA_1	175	181	PF00498	0.456
LIG_FHA_1	90	96	PF00498	0.471
LIG_FHA_2	185	191	PF00498	0.546
LIG_LIR_Gen_1	161	170	PF02991	0.406
LIG_LIR_Gen_1	190	197	PF02991	0.574
LIG_LIR_Gen_1	50	60	PF02991	0.288
LIG_LIR_Gen_1	86	95	PF02991	0.357
LIG_LIR_Nem_3	119	125	PF02991	0.419
LIG_LIR_Nem_3	50	55	PF02991	0.331
LIG_LIR_Nem_3	86	90	PF02991	0.357
LIG_Pex14_2	13	17	PF04695	0.517
LIG_Pex14_2	158	162	PF04695	0.358
LIG_Rb_pABgroove_1	167	175	PF01858	0.271
LIG_SH2_CRK	122	126	PF00017	0.359
LIG_SH2_CRK	79	83	PF00017	0.451
LIG_SH2_SRC	168	171	PF00017	0.404
LIG_SH2_SRC	33	36	PF00017	0.404
LIG_SH2_STAP1	83	87	PF00017	0.404
LIG_SH2_STAT5	122	125	PF00017	0.358
LIG_SH2_STAT5	168	171	PF00017	0.397
LIG_SH2_STAT5	33	36	PF00017	0.291
LIG_SH2_STAT5	68	71	PF00017	0.281
LIG_SUMO_SIM_anti_2	61	67	PF11976	0.328
LIG_SUMO_SIM_par_1	168	174	PF11976	0.289
LIG_TYR_ITIM	66	71	PF00017	0.291
LIG_UBA3_1	10	16	PF00899	0.553
LIG_Vh1_VBS_1	74	92	PF01044	0.475
LIG_WRC_WIRS_1	10	15	PF05994	0.601
MOD_CK1_1	127	133	PF00069	0.355
MOD_CK1_1	61	67	PF00069	0.284
MOD_CK2_1	184	190	PF00069	0.540
MOD_GlcNHglycan	49	52	PF01048	0.478
MOD_GSK3_1	112	119	PF00069	0.497
MOD_GSK3_1	120	127	PF00069	0.290
MOD_GSK3_1	39	46	PF00069	0.466
MOD_N-GLC_1	120	125	PF02516	0.523
MOD_N-GLC_1	137	142	PF02516	0.519
MOD_NEK2_1	116	121	PF00069	0.471
MOD_NEK2_1	158	163	PF00069	0.378
MOD_NEK2_1	47	52	PF00069	0.417
MOD_NEK2_1	88	93	PF00069	0.279
MOD_NEK2_2	112	117	PF00069	0.298
MOD_PIKK_1	39	45	PF00454	0.496
MOD_Plk_1	137	143	PF00069	0.350
MOD_Plk_4	127	133	PF00069	0.342
MOD_Plk_4	158	164	PF00069	0.404
MOD_Plk_4	174	180	PF00069	0.357
MOD_Plk_4	61	67	PF00069	0.263
MOD_Plk_4	89	95	PF00069	0.381
MOD_Plk_4	9	15	PF00069	0.528
TRG_DiLeu_BaLyEn_6	77	82	PF01217	0.517
TRG_ENDOCYTIC_2	122	125	PF00928	0.443
TRG_ENDOCYTIC_2	68	71	PF00928	0.271
TRG_ENDOCYTIC_2	79	82	PF00928	0.436

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIX0	Leptomonas seymouri	75%	100%
A0A0S4IQ04	Bodo saltans	49%	95%
A0A1X0NQA5	Trypanosomatidae	56%	99%
A0A3S7WRA7	Leishmania donovani	100%	100%
A0A422NCQ9	Trypanosoma rangeli	56%	99%
A4H680	Leishmania braziliensis	85%	100%
C9ZVM9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9ANA2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4QHC2	Leishmania major	97%	100%