Nuclear transport factor 2

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nuclear transport factor 2 - putative

Species:

Leishmania infantum

UniProt:

A4HUJ7_LEIIN

TriTrypDb:

LINF_100015200

Length:

124

Annotations

Annotations by Jardim et al.

Transporters, nuclear transport factor 2

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 4
Forrest at al. (procyclic)	yes	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 12

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

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Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0032991	protein-containing complex	1	1
GO:0044613	nuclear pore central transport channel	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0140513	nuclear protein-containing complex	2	1

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Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4HUJ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HUJ7

Function

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Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	10
GO:0006913	nucleocytoplasmic transport	5	10
GO:0009987	cellular process	1	10
GO:0046907	intracellular transport	3	10
GO:0051169	nuclear transport	4	10
GO:0051179	localization	1	10
GO:0051234	establishment of localization	2	10
GO:0051641	cellular localization	2	10
GO:0051649	establishment of localization in cell	3	10

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Could not find GO molecular_function term for this entry.

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
DEG_APCC_DBOX_1	21	29	PF00400	0.278
DOC_USP7_MATH_1	71	75	PF00917	0.374
LIG_14-3-3_CanoR_1	30	35	PF00244	0.294
LIG_AP2alpha_1	96	100	PF02296	0.278
LIG_BIR_II_1	1	5	PF00653	0.360
LIG_BRCT_BRCA1_1	92	96	PF00533	0.395
LIG_eIF4E_1	29	35	PF01652	0.278
LIG_LIR_Gen_1	2	11	PF02991	0.321
LIG_LIR_Gen_1	93	103	PF02991	0.390
LIG_LIR_Nem_3	2	6	PF02991	0.336

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL30	Leptomonas seymouri	82%	100%
A0A1X0NS09	Trypanosomatidae	68%	100%
A0A3R7JTH9	Trypanosoma rangeli	65%	100%
A0A3S5H6G7	Leishmania donovani	100%	100%
A4H673	Leishmania braziliensis	86%	100%
C9ZVM2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	100%
E9AN95	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
O42242	Xenopus laevis	33%	98%
P33331	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	33%	99%
P61970	Homo sapiens	35%	98%

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