LeishMANIAdb
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Nuclear transport factor 2

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Nuclear transport factor 2
Gene product:
nuclear transport factor 2 - putative
Species:
Leishmania infantum
UniProt:
A4HUJ7_LEIIN
TriTrypDb:
LINF_100015200
Length:
124

Annotations

Annotations by Jardim et al.

Transporters, nuclear transport factor 2

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 4
Forrest at al. (procyclic) yes yes: 4
Silverman et al. no yes: 0
Pissara et al. yes yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 12
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
TermNameLevelCount
GO:0005654 nucleoplasm 2 1
GO:0005737 cytoplasm 2 1
GO:0032991 protein-containing complex 1 1
GO:0044613 nuclear pore central transport channel 3 1
GO:0110165 cellular anatomical entity 1 1
GO:0140513 nuclear protein-containing complex 2 1
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Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HUJ7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HUJ7

Function

Biological processes
TermNameLevelCount
GO:0006810 transport 3 10
GO:0006913 nucleocytoplasmic transport 5 10
GO:0009987 cellular process 1 10
GO:0046907 intracellular transport 3 10
GO:0051169 nuclear transport 4 10
GO:0051179 localization 1 10
GO:0051234 establishment of localization 2 10
GO:0051641 cellular localization 2 10
GO:0051649 establishment of localization in cell 3 10
Previous1Next
Could not find GO molecular_function term for this entry.

Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
DEG_APCC_DBOX_1 21 29 PF00400 0.278
DOC_USP7_MATH_1 71 75 PF00917 0.374
LIG_14-3-3_CanoR_1 30 35 PF00244 0.294
LIG_AP2alpha_1 96 100 PF02296 0.278
LIG_BIR_II_1 1 5 PF00653 0.360
LIG_BRCT_BRCA1_1 92 96 PF00533 0.395
LIG_eIF4E_1 29 35 PF01652 0.278
LIG_LIR_Gen_1 2 11 PF02991 0.321
LIG_LIR_Gen_1 93 103 PF02991 0.390
LIG_LIR_Nem_3 2 6 PF02991 0.336
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1IL30 Leptomonas seymouri 82% 100%
A0A1X0NS09 Trypanosomatidae 68% 100%
A0A3R7JTH9 Trypanosoma rangeli 65% 100%
A0A3S5H6G7 Leishmania donovani 100% 100%
A4H673 Leishmania braziliensis 86% 100%
C9ZVM2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 64% 100%
E9AN95 Leishmania mexicana (strain MHOM/GT/2001/U1103) 97% 100%
O42242 Xenopus laevis 33% 98%
P33331 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 33% 99%
P61970 Homo sapiens 35% 98%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS