A_deaminase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HUJ6_LEIIN

TriTrypDb:

LINF_100015100

Length:

732

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HUJ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HUJ6

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006152	purine nucleoside catabolic process	6	1
GO:0006154	adenosine catabolic process	8	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009058	biosynthetic process	2	1
GO:0009116	nucleoside metabolic process	4	1
GO:0009119	ribonucleoside metabolic process	5	1
GO:0009163	nucleoside biosynthetic process	5	1
GO:0009164	nucleoside catabolic process	5	1
GO:0009987	cellular process	1	1
GO:0018130	heterocycle biosynthetic process	4	1
GO:0019438	aromatic compound biosynthetic process	4	1
GO:0019439	aromatic compound catabolic process	4	1
GO:0034404	nucleobase-containing small molecule biosynthetic process	4	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034654	nucleobase-containing compound biosynthetic process	4	1
GO:0034655	nucleobase-containing compound catabolic process	4	1
GO:0034656	nucleobase-containing small molecule catabolic process	4	1
GO:0042278	purine nucleoside metabolic process	5	1
GO:0042451	purine nucleoside biosynthetic process	6	1
GO:0042454	ribonucleoside catabolic process	6	1
GO:0042455	ribonucleoside biosynthetic process	6	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044270	cellular nitrogen compound catabolic process	4	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0044281	small molecule metabolic process	2	1
GO:0044282	small molecule catabolic process	3	1
GO:0044283	small molecule biosynthetic process	3	1
GO:0046085	adenosine metabolic process	7	1
GO:0046102	inosine metabolic process	7	1
GO:0046103	inosine biosynthetic process	8	1
GO:0046128	purine ribonucleoside metabolic process	6	1
GO:0046129	purine ribonucleoside biosynthetic process	7	1
GO:0046130	purine ribonucleoside catabolic process	7	1
GO:0046483	heterocycle metabolic process	3	1
GO:0046700	heterocycle catabolic process	4	1
GO:0055086	nucleobase-containing small molecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0072521	purine-containing compound metabolic process	4	1
GO:0072522	purine-containing compound biosynthetic process	5	1
GO:0072523	purine-containing compound catabolic process	5	1
GO:1901135	carbohydrate derivative metabolic process	3	1
GO:1901136	carbohydrate derivative catabolic process	4	1
GO:1901137	carbohydrate derivative biosynthetic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901361	organic cyclic compound catabolic process	4	1
GO:1901362	organic cyclic compound biosynthetic process	4	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901566	organonitrogen compound biosynthetic process	4	1
GO:1901575	organic substance catabolic process	3	1
GO:1901576	organic substance biosynthetic process	3	1
GO:1901657	glycosyl compound metabolic process	4	1
GO:1901658	glycosyl compound catabolic process	5	1
GO:1901659	glycosyl compound biosynthetic process	5	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0016787	hydrolase activity	2	11
GO:0019239	deaminase activity	3	11
GO:0004000	adenosine deaminase activity	4	1
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	3	1
GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	167	171	PF00656	0.521
CLV_C14_Caspase3-7	410	414	PF00656	0.526
CLV_C14_Caspase3-7	554	558	PF00656	0.527
CLV_C14_Caspase3-7	609	613	PF00656	0.596
CLV_NRD_NRD_1	173	175	PF00675	0.477
CLV_NRD_NRD_1	177	179	PF00675	0.497
CLV_NRD_NRD_1	275	277	PF00675	0.508
CLV_NRD_NRD_1	342	344	PF00675	0.568
CLV_NRD_NRD_1	372	374	PF00675	0.429
CLV_NRD_NRD_1	405	407	PF00675	0.488
CLV_NRD_NRD_1	505	507	PF00675	0.636
CLV_NRD_NRD_1	536	538	PF00675	0.430
CLV_NRD_NRD_1	95	97	PF00675	0.586
CLV_PCSK_FUR_1	503	507	PF00082	0.495
CLV_PCSK_KEX2_1	173	175	PF00082	0.477
CLV_PCSK_KEX2_1	177	179	PF00082	0.497
CLV_PCSK_KEX2_1	274	276	PF00082	0.487
CLV_PCSK_KEX2_1	342	344	PF00082	0.568
CLV_PCSK_KEX2_1	372	374	PF00082	0.453
CLV_PCSK_KEX2_1	405	407	PF00082	0.458
CLV_PCSK_KEX2_1	503	505	PF00082	0.586
CLV_PCSK_KEX2_1	536	538	PF00082	0.432
CLV_PCSK_KEX2_1	94	96	PF00082	0.628
CLV_PCSK_PC1ET2_1	94	96	PF00082	0.626
CLV_PCSK_PC7_1	169	175	PF00082	0.473
CLV_PCSK_SKI1_1	135	139	PF00082	0.358
CLV_PCSK_SKI1_1	276	280	PF00082	0.430
CLV_PCSK_SKI1_1	284	288	PF00082	0.393
CLV_PCSK_SKI1_1	293	297	PF00082	0.290
CLV_PCSK_SKI1_1	300	304	PF00082	0.390
CLV_PCSK_SKI1_1	513	517	PF00082	0.398
CLV_PCSK_SKI1_1	574	578	PF00082	0.353
CLV_PCSK_SKI1_1	583	587	PF00082	0.345
DEG_APCC_DBOX_1	275	283	PF00400	0.477
DEG_APCC_DBOX_1	631	639	PF00400	0.339
DEG_Nend_UBRbox_2	1	3	PF02207	0.634
DEG_SCF_FBW7_1	100	107	PF00400	0.506
DEG_SCF_FBW7_1	417	424	PF00400	0.319
DEG_SCF_FBW7_1	706	713	PF00400	0.458
DEG_SPOP_SBC_1	361	365	PF00917	0.507
DOC_CDC14_PxL_1	33	41	PF14671	0.378
DOC_CYCLIN_RxL_1	289	297	PF00134	0.398
DOC_CYCLIN_RxL_1	580	589	PF00134	0.387
DOC_CYCLIN_yCln2_LP_2	641	647	PF00134	0.431
DOC_MAPK_DCC_7	6	14	PF00069	0.434
DOC_MAPK_gen_1	94	102	PF00069	0.481
DOC_MAPK_HePTP_8	286	298	PF00069	0.322
DOC_MAPK_MEF2A_6	289	298	PF00069	0.318
DOC_MAPK_MEF2A_6	418	425	PF00069	0.424
DOC_PP1_RVXF_1	36	42	PF00149	0.344
DOC_PP2B_LxvP_1	262	265	PF13499	0.412
DOC_PP2B_LxvP_1	441	444	PF13499	0.443
DOC_PP2B_LxvP_1	641	644	PF13499	0.335
DOC_PP2B_PxIxI_1	420	426	PF00149	0.313
DOC_PP4_FxxP_1	452	455	PF00568	0.487
DOC_PP4_FxxP_1	562	565	PF00568	0.330
DOC_PP4_FxxP_1	639	642	PF00568	0.294
DOC_USP7_MATH_1	104	108	PF00917	0.697
DOC_USP7_MATH_1	217	221	PF00917	0.404
DOC_USP7_MATH_1	265	269	PF00917	0.485
DOC_USP7_MATH_1	359	363	PF00917	0.614
DOC_USP7_MATH_1	553	557	PF00917	0.603
DOC_USP7_MATH_1	659	663	PF00917	0.669
DOC_USP7_MATH_1	710	714	PF00917	0.515
DOC_WW_Pin1_4	100	105	PF00397	0.663
DOC_WW_Pin1_4	115	120	PF00397	0.489
DOC_WW_Pin1_4	349	354	PF00397	0.613
DOC_WW_Pin1_4	357	362	PF00397	0.561
DOC_WW_Pin1_4	417	422	PF00397	0.429
DOC_WW_Pin1_4	614	619	PF00397	0.499
DOC_WW_Pin1_4	695	700	PF00397	0.479
DOC_WW_Pin1_4	706	711	PF00397	0.375
LIG_14-3-3_CanoR_1	165	169	PF00244	0.346
LIG_14-3-3_CanoR_1	173	177	PF00244	0.400
LIG_14-3-3_CanoR_1	284	292	PF00244	0.452
LIG_14-3-3_CanoR_1	293	299	PF00244	0.374
LIG_14-3-3_CanoR_1	3	13	PF00244	0.450
LIG_14-3-3_CanoR_1	300	308	PF00244	0.390
LIG_14-3-3_CanoR_1	632	636	PF00244	0.298
LIG_14-3-3_CanoR_1	690	696	PF00244	0.368
LIG_Actin_WH2_2	157	175	PF00022	0.355
LIG_deltaCOP1_diTrp_1	445	452	PF00928	0.375
LIG_deltaCOP1_diTrp_1	681	688	PF00928	0.484
LIG_deltaCOP1_diTrp_1	719	727	PF00928	0.338
LIG_FHA_1	209	215	PF00498	0.353
LIG_FHA_1	375	381	PF00498	0.337
LIG_FHA_1	418	424	PF00498	0.488
LIG_FHA_1	520	526	PF00498	0.540
LIG_FHA_1	559	565	PF00498	0.443
LIG_FHA_1	618	624	PF00498	0.425
LIG_FHA_1	701	707	PF00498	0.616
LIG_FHA_2	101	107	PF00498	0.668
LIG_FHA_2	116	122	PF00498	0.510
LIG_FHA_2	126	132	PF00498	0.328
LIG_FHA_2	151	157	PF00498	0.334
LIG_FHA_2	191	197	PF00498	0.386
LIG_FHA_2	379	385	PF00498	0.309
LIG_FHA_2	5	11	PF00498	0.508
LIG_FHA_2	607	613	PF00498	0.671
LIG_GBD_Chelix_1	160	168	PF00786	0.457
LIG_LIR_Apic_2	560	565	PF02991	0.467
LIG_LIR_Gen_1	128	137	PF02991	0.341
LIG_LIR_Gen_1	687	696	PF02991	0.482
LIG_LIR_Gen_1	719	727	PF02991	0.462
LIG_LIR_Nem_3	128	133	PF02991	0.361
LIG_LIR_Nem_3	255	261	PF02991	0.370
LIG_LIR_Nem_3	280	286	PF02991	0.384
LIG_LIR_Nem_3	445	450	PF02991	0.326
LIG_LIR_Nem_3	514	519	PF02991	0.460
LIG_LIR_Nem_3	684	688	PF02991	0.479
LIG_LIR_Nem_3	719	723	PF02991	0.412
LIG_LIR_Nem_3	724	730	PF02991	0.399
LIG_NRBOX	488	494	PF00104	0.494
LIG_NRBOX	56	62	PF00104	0.416
LIG_Pex14_1	250	254	PF04695	0.329
LIG_Pex14_2	626	630	PF04695	0.392
LIG_PTB_Apo_2	136	143	PF02174	0.298
LIG_PTB_Apo_2	563	570	PF02174	0.312
LIG_SH2_CRK	258	262	PF00017	0.396
LIG_SH2_NCK_1	254	258	PF00017	0.456
LIG_SH2_NCK_1	656	660	PF00017	0.588
LIG_SH2_STAP1	254	258	PF00017	0.456
LIG_SH2_STAT5	125	128	PF00017	0.348
LIG_SH2_STAT5	190	193	PF00017	0.326
LIG_SH2_STAT5	277	280	PF00017	0.420
LIG_SH3_3	350	356	PF00018	0.621
LIG_SH3_3	541	547	PF00018	0.556
LIG_SUMO_SIM_anti_2	156	163	PF11976	0.399
LIG_SUMO_SIM_par_1	10	16	PF11976	0.487
LIG_SUMO_SIM_par_1	205	211	PF11976	0.459
LIG_SUMO_SIM_par_1	98	103	PF11976	0.503
LIG_TRAF2_1	154	157	PF00917	0.339
LIG_TRAF2_1	181	184	PF00917	0.606
MOD_CDK_SPxxK_3	115	122	PF00069	0.474
MOD_CK1_1	327	333	PF00069	0.455
MOD_CK1_1	352	358	PF00069	0.679
MOD_CK1_1	362	368	PF00069	0.494
MOD_CK1_1	568	574	PF00069	0.321
MOD_CK1_1	657	663	PF00069	0.634
MOD_CK1_1	713	719	PF00069	0.445
MOD_CK2_1	115	121	PF00069	0.570
MOD_CK2_1	150	156	PF00069	0.307
MOD_CK2_1	190	196	PF00069	0.391
MOD_CK2_1	4	10	PF00069	0.549
MOD_CK2_1	495	501	PF00069	0.590
MOD_CK2_1	695	701	PF00069	0.559
MOD_CK2_1	713	719	PF00069	0.260
MOD_CMANNOS	682	685	PF00535	0.484
MOD_GlcNHglycan	106	109	PF01048	0.613
MOD_GlcNHglycan	153	156	PF01048	0.308
MOD_GlcNHglycan	202	205	PF01048	0.477
MOD_GlcNHglycan	219	222	PF01048	0.530
MOD_GlcNHglycan	357	360	PF01048	0.802
MOD_GlcNHglycan	384	388	PF01048	0.326
MOD_GlcNHglycan	413	417	PF01048	0.554
MOD_GlcNHglycan	457	461	PF01048	0.474
MOD_GlcNHglycan	49	52	PF01048	0.437
MOD_GlcNHglycan	513	516	PF01048	0.515
MOD_GlcNHglycan	546	550	PF01048	0.716
MOD_GlcNHglycan	609	612	PF01048	0.607
MOD_GlcNHglycan	706	709	PF01048	0.489
MOD_GlcNHglycan	74	77	PF01048	0.712
MOD_GSK3_1	100	107	PF00069	0.694
MOD_GSK3_1	190	197	PF00069	0.364
MOD_GSK3_1	213	220	PF00069	0.460
MOD_GSK3_1	348	355	PF00069	0.692
MOD_GSK3_1	357	364	PF00069	0.648
MOD_GSK3_1	374	381	PF00069	0.239
MOD_GSK3_1	417	424	PF00069	0.392
MOD_GSK3_1	45	52	PF00069	0.366
MOD_GSK3_1	471	478	PF00069	0.368
MOD_GSK3_1	495	502	PF00069	0.501
MOD_GSK3_1	507	514	PF00069	0.655
MOD_GSK3_1	553	560	PF00069	0.579
MOD_GSK3_1	691	698	PF00069	0.449
MOD_GSK3_1	700	707	PF00069	0.583
MOD_N-GLC_1	284	289	PF02516	0.523
MOD_N-GLC_1	347	352	PF02516	0.725
MOD_N-GLC_1	45	50	PF02516	0.309
MOD_N-GLC_1	539	544	PF02516	0.503
MOD_N-GLC_1	565	570	PF02516	0.308
MOD_NEK2_1	140	145	PF00069	0.320
MOD_NEK2_1	150	155	PF00069	0.278
MOD_NEK2_1	172	177	PF00069	0.475
MOD_NEK2_1	294	299	PF00069	0.344
MOD_NEK2_1	374	379	PF00069	0.399
MOD_NEK2_1	383	388	PF00069	0.367
MOD_NEK2_1	4	9	PF00069	0.539
MOD_NEK2_1	45	50	PF00069	0.316
MOD_NEK2_1	470	475	PF00069	0.350
MOD_NEK2_1	495	500	PF00069	0.530
MOD_NEK2_1	577	582	PF00069	0.365
MOD_NEK2_1	586	591	PF00069	0.360
MOD_NEK2_2	125	130	PF00069	0.365
MOD_NEK2_2	421	426	PF00069	0.498
MOD_NEK2_2	565	570	PF00069	0.336
MOD_PIKK_1	229	235	PF00454	0.466
MOD_PIKK_1	314	320	PF00454	0.481
MOD_PIKK_1	586	592	PF00454	0.466
MOD_PIKK_1	88	94	PF00454	0.573
MOD_PKA_1	342	348	PF00069	0.577
MOD_PKA_2	164	170	PF00069	0.392
MOD_PKA_2	172	178	PF00069	0.442
MOD_PKA_2	311	317	PF00069	0.484
MOD_PKA_2	342	348	PF00069	0.717
MOD_PKA_2	374	380	PF00069	0.341
MOD_PKA_2	5	11	PF00069	0.432
MOD_PKA_2	599	605	PF00069	0.548
MOD_PKA_2	631	637	PF00069	0.297
MOD_PKA_2	713	719	PF00069	0.540
MOD_Plk_1	266	272	PF00069	0.593
MOD_Plk_1	456	462	PF00069	0.397
MOD_Plk_1	539	545	PF00069	0.511
MOD_Plk_1	565	571	PF00069	0.338
MOD_Plk_4	190	196	PF00069	0.327
MOD_Plk_4	257	263	PF00069	0.414
MOD_Plk_4	28	34	PF00069	0.389
MOD_Plk_4	49	55	PF00069	0.424
MOD_Plk_4	558	564	PF00069	0.503
MOD_Plk_4	684	690	PF00069	0.526
MOD_ProDKin_1	100	106	PF00069	0.663
MOD_ProDKin_1	115	121	PF00069	0.484
MOD_ProDKin_1	349	355	PF00069	0.615
MOD_ProDKin_1	357	363	PF00069	0.555
MOD_ProDKin_1	417	423	PF00069	0.427
MOD_ProDKin_1	614	620	PF00069	0.486
MOD_ProDKin_1	695	701	PF00069	0.494
MOD_ProDKin_1	706	712	PF00069	0.361
TRG_DiLeu_BaLyEn_6	290	295	PF01217	0.350
TRG_DiLeu_BaLyEn_6	56	61	PF01217	0.399
TRG_ENDOCYTIC_2	134	137	PF00928	0.329
TRG_ENDOCYTIC_2	254	257	PF00928	0.362
TRG_ENDOCYTIC_2	258	261	PF00928	0.356
TRG_ENDOCYTIC_2	394	397	PF00928	0.491
TRG_ER_diArg_1	172	174	PF00400	0.468
TRG_ER_diArg_1	176	178	PF00400	0.457
TRG_ER_diArg_1	274	276	PF00400	0.428
TRG_ER_diArg_1	372	375	PF00400	0.446
TRG_ER_diArg_1	503	506	PF00400	0.512
TRG_ER_diArg_1	535	537	PF00400	0.434
TRG_Pf-PMV_PEXEL_1	284	288	PF00026	0.428
TRG_Pf-PMV_PEXEL_1	372	376	PF00026	0.467

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6F9	Leptomonas seymouri	49%	98%
A0A1X0NRU3	Trypanosomatidae	32%	100%
A0A3S5IS54	Trypanosoma rangeli	36%	100%
A0A3S7WR98	Leishmania donovani	99%	100%
A4H672	Leishmania braziliensis	74%	99%
C9ZVM1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AN94	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	98%
Q4QHD0	Leishmania major	92%	99%
V5BTS5	Trypanosoma cruzi	36%	100%