Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HUI9_LEIIN

TriTrypDb:

LINF_100014400

Length:

660

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HUI9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HUI9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	168	172	PF00656	0.441
CLV_NRD_NRD_1	184	186	PF00675	0.543
CLV_NRD_NRD_1	342	344	PF00675	0.644
CLV_NRD_NRD_1	387	389	PF00675	0.573
CLV_NRD_NRD_1	41	43	PF00675	0.384
CLV_NRD_NRD_1	424	426	PF00675	0.641
CLV_NRD_NRD_1	555	557	PF00675	0.580
CLV_NRD_NRD_1	599	601	PF00675	0.587
CLV_PCSK_FUR_1	555	559	PF00082	0.559
CLV_PCSK_KEX2_1	184	186	PF00082	0.543
CLV_PCSK_KEX2_1	341	343	PF00082	0.650
CLV_PCSK_KEX2_1	351	353	PF00082	0.742
CLV_PCSK_KEX2_1	387	389	PF00082	0.573
CLV_PCSK_KEX2_1	41	43	PF00082	0.388
CLV_PCSK_KEX2_1	424	426	PF00082	0.641
CLV_PCSK_KEX2_1	48	50	PF00082	0.498
CLV_PCSK_KEX2_1	555	557	PF00082	0.551
CLV_PCSK_KEX2_1	599	601	PF00082	0.587
CLV_PCSK_PC1ET2_1	341	343	PF00082	0.598
CLV_PCSK_PC1ET2_1	351	353	PF00082	0.725
CLV_PCSK_PC1ET2_1	48	50	PF00082	0.509
CLV_PCSK_PC1ET2_1	557	559	PF00082	0.569
CLV_PCSK_SKI1_1	184	188	PF00082	0.466
CLV_PCSK_SKI1_1	412	416	PF00082	0.492
CLV_PCSK_SKI1_1	449	453	PF00082	0.475
CLV_PCSK_SKI1_1	82	86	PF00082	0.409
DEG_APCC_DBOX_1	627	635	PF00400	0.496
DEG_APCC_DBOX_1	63	71	PF00400	0.424
DEG_Kelch_actinfilin_1	437	441	PF01344	0.423
DEG_SPOP_SBC_1	54	58	PF00917	0.523
DOC_CYCLIN_RxL_1	311	321	PF00134	0.350
DOC_CYCLIN_RxL_1	406	419	PF00134	0.493
DOC_MAPK_DCC_7	190	199	PF00069	0.486
DOC_MAPK_HePTP_8	187	199	PF00069	0.466
DOC_MAPK_MEF2A_6	125	132	PF00069	0.430
DOC_MAPK_MEF2A_6	190	199	PF00069	0.585
DOC_MAPK_MEF2A_6	261	269	PF00069	0.477
DOC_MAPK_MEF2A_6	361	370	PF00069	0.498
DOC_MAPK_MEF2A_6	64	72	PF00069	0.406
DOC_PP1_RVXF_1	26	33	PF00149	0.414
DOC_PP1_RVXF_1	312	319	PF00149	0.447
DOC_PP1_RVXF_1	47	54	PF00149	0.491
DOC_PP1_RVXF_1	73	80	PF00149	0.336
DOC_PP2B_LxvP_1	11	14	PF13499	0.398
DOC_USP7_MATH_1	102	106	PF00917	0.499
DOC_USP7_MATH_1	143	147	PF00917	0.695
DOC_USP7_MATH_1	297	301	PF00917	0.692
DOC_USP7_MATH_1	44	48	PF00917	0.452
DOC_USP7_MATH_1	54	58	PF00917	0.499
DOC_USP7_MATH_1	63	67	PF00917	0.436
DOC_USP7_MATH_1	97	101	PF00917	0.560
DOC_WW_Pin1_4	14	19	PF00397	0.480
DOC_WW_Pin1_4	151	156	PF00397	0.731
DOC_WW_Pin1_4	163	168	PF00397	0.465
DOC_WW_Pin1_4	190	195	PF00397	0.559
DOC_WW_Pin1_4	202	207	PF00397	0.622
DOC_WW_Pin1_4	220	225	PF00397	0.557
DOC_WW_Pin1_4	414	419	PF00397	0.532
DOC_WW_Pin1_4	42	47	PF00397	0.421
DOC_WW_Pin1_4	494	499	PF00397	0.646
LIG_14-3-3_CanoR_1	125	131	PF00244	0.475
LIG_14-3-3_CanoR_1	147	152	PF00244	0.670
LIG_14-3-3_CanoR_1	198	206	PF00244	0.539
LIG_14-3-3_CanoR_1	261	269	PF00244	0.477
LIG_14-3-3_CanoR_1	312	317	PF00244	0.408
LIG_14-3-3_CanoR_1	387	396	PF00244	0.545
LIG_14-3-3_CanoR_1	605	611	PF00244	0.396
LIG_14-3-3_CanoR_1	64	68	PF00244	0.449
LIG_APCC_ABBA_1	632	637	PF00400	0.481
LIG_BIR_II_1	1	5	PF00653	0.375
LIG_BRCT_BRCA1_1	314	318	PF00533	0.447
LIG_BRCT_BRCA1_1	427	431	PF00533	0.562
LIG_DLG_GKlike_1	312	319	PF00625	0.447
LIG_FHA_1	1	7	PF00498	0.371
LIG_FHA_1	127	133	PF00498	0.450
LIG_FHA_1	173	179	PF00498	0.436
LIG_FHA_1	296	302	PF00498	0.592
LIG_FHA_1	332	338	PF00498	0.504
LIG_FHA_1	440	446	PF00498	0.457
LIG_FHA_1	450	456	PF00498	0.440
LIG_FHA_1	521	527	PF00498	0.458
LIG_FHA_1	578	584	PF00498	0.532
LIG_FHA_1	612	618	PF00498	0.429
LIG_FHA_2	232	238	PF00498	0.470
LIG_FHA_2	242	248	PF00498	0.488
LIG_FHA_2	445	451	PF00498	0.401
LIG_Integrin_RGD_1	190	192	PF01839	0.493
LIG_LIR_Gen_1	519	529	PF02991	0.433
LIG_LIR_Nem_3	391	396	PF02991	0.413
LIG_LIR_Nem_3	450	454	PF02991	0.412
LIG_LIR_Nem_3	519	525	PF02991	0.436
LIG_LIR_Nem_3	544	549	PF02991	0.409
LIG_Pex14_2	120	124	PF04695	0.460
LIG_Pex14_2	318	322	PF04695	0.440
LIG_SH2_CRK	522	526	PF00017	0.439
LIG_SH2_SRC	396	399	PF00017	0.364
LIG_SH2_STAP1	289	293	PF00017	0.537
LIG_SH2_STAP1	522	526	PF00017	0.423
LIG_SH2_STAP1	538	542	PF00017	0.302
LIG_SH2_STAT3	650	653	PF00017	0.464
LIG_SH2_STAT5	454	457	PF00017	0.432
LIG_SH2_STAT5	522	525	PF00017	0.408
LIG_SH2_STAT5	78	81	PF00017	0.444
LIG_SH3_3	149	155	PF00018	0.617
LIG_SH3_3	15	21	PF00018	0.620
LIG_SH3_3	203	209	PF00018	0.630
LIG_SH3_3	365	371	PF00018	0.488
LIG_SH3_3	502	508	PF00018	0.561
LIG_SH3_3	57	63	PF00018	0.590
LIG_SH3_3	67	73	PF00018	0.364
LIG_SUMO_SIM_anti_2	497	503	PF11976	0.578
LIG_SUMO_SIM_anti_2	612	620	PF11976	0.494
LIG_SUMO_SIM_par_1	128	134	PF11976	0.449
LIG_SUMO_SIM_par_1	437	442	PF11976	0.421
LIG_SUMO_SIM_par_1	579	586	PF11976	0.544
LIG_TRAF2_1	2	5	PF00917	0.401
LIG_TYR_ITIM	520	525	PF00017	0.438
LIG_UBA3_1	516	524	PF00899	0.436
LIG_UBA3_1	631	638	PF00899	0.510
LIG_WW_3	21	25	PF00397	0.444
MOD_CDC14_SPxK_1	45	48	PF00782	0.456
MOD_CDK_SPxK_1	42	48	PF00069	0.431
MOD_CDK_SPxxK_3	17	24	PF00069	0.450
MOD_CDK_SPxxK_3	42	49	PF00069	0.438
MOD_CK1_1	139	145	PF00069	0.613
MOD_CK1_1	17	23	PF00069	0.477
MOD_CK1_1	202	208	PF00069	0.753
MOD_CK1_1	300	306	PF00069	0.680
MOD_CK1_1	577	583	PF00069	0.545
MOD_CK2_1	102	108	PF00069	0.624
MOD_CK2_1	139	145	PF00069	0.668
MOD_CK2_1	151	157	PF00069	0.583
MOD_CK2_1	231	237	PF00069	0.466
MOD_CK2_1	260	266	PF00069	0.564
MOD_CK2_1	414	420	PF00069	0.509
MOD_CK2_1	444	450	PF00069	0.443
MOD_Cter_Amidation	182	185	PF01082	0.424
MOD_GlcNHglycan	138	141	PF01048	0.620
MOD_GlcNHglycan	210	213	PF01048	0.714
MOD_GlcNHglycan	262	265	PF01048	0.621
MOD_GlcNHglycan	285	288	PF01048	0.660
MOD_GlcNHglycan	289	292	PF01048	0.656
MOD_GlcNHglycan	352	355	PF01048	0.623
MOD_GlcNHglycan	527	530	PF01048	0.471
MOD_GlcNHglycan	576	579	PF01048	0.711
MOD_GlcNHglycan	607	610	PF01048	0.574
MOD_GlcNHglycan	656	659	PF01048	0.547
MOD_GlcNHglycan	86	89	PF01048	0.635
MOD_GlcNHglycan	97	100	PF01048	0.499
MOD_GSK3_1	13	20	PF00069	0.474
MOD_GSK3_1	139	146	PF00069	0.713
MOD_GSK3_1	147	154	PF00069	0.766
MOD_GSK3_1	278	285	PF00069	0.577
MOD_GSK3_1	300	307	PF00069	0.688
MOD_GSK3_1	346	353	PF00069	0.579
MOD_GSK3_1	40	47	PF00069	0.457
MOD_GSK3_1	439	446	PF00069	0.587
MOD_GSK3_1	516	523	PF00069	0.439
MOD_GSK3_1	52	59	PF00069	0.572
MOD_GSK3_1	537	544	PF00069	0.478
MOD_GSK3_1	577	584	PF00069	0.546
MOD_GSK3_1	600	607	PF00069	0.426
MOD_GSK3_1	84	91	PF00069	0.583
MOD_GSK3_1	97	104	PF00069	0.574
MOD_LATS_1	423	429	PF00433	0.571
MOD_N-GLC_1	574	579	PF02516	0.551
MOD_NEK2_1	101	106	PF00069	0.641
MOD_NEK2_1	110	115	PF00069	0.496
MOD_NEK2_1	278	283	PF00069	0.462
MOD_NEK2_1	35	40	PF00069	0.364
MOD_NEK2_1	376	381	PF00069	0.415
MOD_NEK2_1	389	394	PF00069	0.468
MOD_NEK2_1	444	449	PF00069	0.429
MOD_NEK2_1	516	521	PF00069	0.429
MOD_NEK2_1	53	58	PF00069	0.637
MOD_NEK2_1	84	89	PF00069	0.559
MOD_NEK2_2	427	432	PF00069	0.509
MOD_PIKK_1	110	116	PF00454	0.461
MOD_PIKK_1	439	445	PF00454	0.456
MOD_PKA_2	260	266	PF00069	0.592
MOD_PKA_2	40	46	PF00069	0.485
MOD_PKA_2	604	610	PF00069	0.396
MOD_PKA_2	63	69	PF00069	0.481
MOD_Plk_1	278	284	PF00069	0.630
MOD_Plk_1	304	310	PF00069	0.696
MOD_Plk_1	563	569	PF00069	0.574
MOD_Plk_4	297	303	PF00069	0.709
MOD_Plk_4	35	41	PF00069	0.454
MOD_Plk_4	563	569	PF00069	0.574
MOD_Plk_4	63	69	PF00069	0.444
MOD_ProDKin_1	14	20	PF00069	0.482
MOD_ProDKin_1	151	157	PF00069	0.728
MOD_ProDKin_1	163	169	PF00069	0.456
MOD_ProDKin_1	190	196	PF00069	0.571
MOD_ProDKin_1	202	208	PF00069	0.610
MOD_ProDKin_1	220	226	PF00069	0.553
MOD_ProDKin_1	414	420	PF00069	0.540
MOD_ProDKin_1	42	48	PF00069	0.431
MOD_ProDKin_1	494	500	PF00069	0.639
TRG_DiLeu_BaEn_1	613	618	PF01217	0.427
TRG_DiLeu_BaEn_4	220	226	PF01217	0.461
TRG_DiLeu_BaLyEn_6	182	187	PF01217	0.447
TRG_ENDOCYTIC_2	522	525	PF00928	0.444
TRG_ER_diArg_1	184	186	PF00400	0.462
TRG_ER_diArg_1	386	388	PF00400	0.571
TRG_ER_diArg_1	40	42	PF00400	0.374
TRG_ER_diArg_1	424	426	PF00400	0.625
TRG_ER_diArg_1	554	556	PF00400	0.543
TRG_ER_diArg_1	598	600	PF00400	0.395
TRG_Pf-PMV_PEXEL_1	407	411	PF00026	0.417
TRG_Pf-PMV_PEXEL_1	547	551	PF00026	0.531

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZQ1	Leptomonas seymouri	36%	96%
A0A0N1PDV8	Leptomonas seymouri	29%	100%
A0A3S5H6G6	Leishmania donovani	99%	100%
A0A3S7WR70	Leishmania donovani	30%	100%
A4H664	Leishmania braziliensis	31%	100%
A4H665	Leishmania braziliensis	69%	100%
A4HUI8	Leishmania infantum	30%	100%
E9AN86	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9AN87	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4QHD7	Leishmania major	88%	100%