Myotubularin phosphatase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HUI8_LEIIN

TriTrypDb:

LINF_100014300

Length:

641

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HUI8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HUI8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	205	209	PF00656	0.516
CLV_C14_Caspase3-7	260	264	PF00656	0.637
CLV_NRD_NRD_1	361	363	PF00675	0.520
CLV_NRD_NRD_1	393	395	PF00675	0.496
CLV_NRD_NRD_1	412	414	PF00675	0.446
CLV_NRD_NRD_1	546	548	PF00675	0.323
CLV_NRD_NRD_1	9	11	PF00675	0.412
CLV_PCSK_KEX2_1	361	363	PF00082	0.512
CLV_PCSK_KEX2_1	393	395	PF00082	0.496
CLV_PCSK_KEX2_1	412	414	PF00082	0.446
CLV_PCSK_KEX2_1	546	548	PF00082	0.318
CLV_PCSK_KEX2_1	9	11	PF00082	0.422
CLV_PCSK_SKI1_1	198	202	PF00082	0.386
CLV_PCSK_SKI1_1	418	422	PF00082	0.432
CLV_PCSK_SKI1_1	465	469	PF00082	0.410
CLV_PCSK_SKI1_1	532	536	PF00082	0.338
CLV_PCSK_SKI1_1	546	550	PF00082	0.296
DEG_COP1_1	321	331	PF00400	0.567
DEG_SPOP_SBC_1	174	178	PF00917	0.503
DOC_CDC14_PxL_1	515	523	PF14671	0.373
DOC_CKS1_1	396	401	PF01111	0.392
DOC_CYCLIN_yClb3_PxF_3	16	24	PF00134	0.390
DOC_MAPK_DCC_7	493	502	PF00069	0.538
DOC_MAPK_gen_1	217	226	PF00069	0.469
DOC_MAPK_gen_1	602	611	PF00069	0.340
DOC_MAPK_MEF2A_6	493	502	PF00069	0.538
DOC_MAPK_MEF2A_6	532	539	PF00069	0.399
DOC_MAPK_MEF2A_6	589	597	PF00069	0.326
DOC_MAPK_NFAT4_5	532	540	PF00069	0.397
DOC_PP2B_LxvP_1	421	424	PF13499	0.460
DOC_PP2B_LxvP_1	521	524	PF13499	0.396
DOC_PP4_FxxP_1	420	423	PF00568	0.398
DOC_PP4_MxPP_1	172	175	PF00568	0.543
DOC_USP7_MATH_1	102	106	PF00917	0.510
DOC_USP7_MATH_1	209	213	PF00917	0.516
DOC_USP7_MATH_1	327	331	PF00917	0.687
DOC_USP7_MATH_1	467	471	PF00917	0.589
DOC_USP7_MATH_1	507	511	PF00917	0.531
DOC_USP7_MATH_1	555	559	PF00917	0.403
DOC_USP7_MATH_1	566	570	PF00917	0.422
DOC_USP7_MATH_1	63	67	PF00917	0.545
DOC_USP7_MATH_1	91	95	PF00917	0.581
DOC_WW_Pin1_4	1	6	PF00397	0.547
DOC_WW_Pin1_4	165	170	PF00397	0.686
DOC_WW_Pin1_4	246	251	PF00397	0.696
DOC_WW_Pin1_4	253	258	PF00397	0.576
DOC_WW_Pin1_4	330	335	PF00397	0.578
DOC_WW_Pin1_4	395	400	PF00397	0.380
DOC_WW_Pin1_4	81	86	PF00397	0.443
LIG_14-3-3_CanoR_1	198	203	PF00244	0.506
LIG_14-3-3_CanoR_1	393	399	PF00244	0.516
LIG_14-3-3_CanoR_1	41	46	PF00244	0.411
LIG_14-3-3_CanoR_1	412	416	PF00244	0.387
LIG_14-3-3_CanoR_1	469	473	PF00244	0.456
LIG_14-3-3_CanoR_1	564	574	PF00244	0.414
LIG_14-3-3_CanoR_1	604	611	PF00244	0.330
LIG_Actin_WH2_2	345	363	PF00022	0.421
LIG_Actin_WH2_2	454	471	PF00022	0.340
LIG_APCC_ABBA_1	18	23	PF00400	0.388
LIG_APCC_ABBA_1	572	577	PF00400	0.368
LIG_BIR_II_1	1	5	PF00653	0.467
LIG_BIR_III_4	620	624	PF00653	0.373
LIG_BRCT_BRCA1_1	341	345	PF00533	0.429
LIG_BRCT_BRCA1_1	43	47	PF00533	0.449
LIG_BRCT_BRCA1_1	541	545	PF00533	0.379
LIG_BRCT_BRCA1_1	83	87	PF00533	0.443
LIG_eIF4E_2	401	407	PF01652	0.409
LIG_FHA_1	15	21	PF00498	0.358
LIG_FHA_1	175	181	PF00498	0.524
LIG_FHA_1	186	192	PF00498	0.495
LIG_FHA_1	2	8	PF00498	0.502
LIG_FHA_1	446	452	PF00498	0.380
LIG_FHA_1	592	598	PF00498	0.368
LIG_FHA_2	203	209	PF00498	0.487
LIG_FHA_2	412	418	PF00498	0.377
LIG_FHA_2	99	105	PF00498	0.565
LIG_Integrin_RGD_1	227	229	PF01839	0.525
LIG_LIR_Apic_2	398	404	PF02991	0.401
LIG_LIR_Apic_2	417	423	PF02991	0.345
LIG_LIR_Gen_1	256	265	PF02991	0.384
LIG_LIR_Gen_1	383	392	PF02991	0.364
LIG_LIR_Gen_1	44	55	PF02991	0.420
LIG_LIR_Gen_1	455	464	PF02991	0.363
LIG_LIR_LC3C_4	514	517	PF02991	0.322
LIG_LIR_Nem_3	256	261	PF02991	0.420
LIG_LIR_Nem_3	383	389	PF02991	0.387
LIG_LIR_Nem_3	44	50	PF02991	0.422
LIG_LIR_Nem_3	455	461	PF02991	0.369
LIG_LIR_Nem_3	81	86	PF02991	0.393
LIG_MLH1_MIPbox_1	83	87	PF16413	0.443
LIG_PTAP_UEV_1	540	545	PF05743	0.331
LIG_RPA_C_Fungi	383	395	PF08784	0.353
LIG_SH2_CRK	45	49	PF00017	0.371
LIG_SH2_NCK_1	606	610	PF00017	0.363
LIG_SH2_SRC	575	578	PF00017	0.371
LIG_SH2_STAP1	45	49	PF00017	0.338
LIG_SH2_STAT3	120	123	PF00017	0.401
LIG_SH2_STAT3	233	236	PF00017	0.595
LIG_SH2_STAT5	120	123	PF00017	0.416
LIG_SH2_STAT5	233	236	PF00017	0.535
LIG_SH2_STAT5	258	261	PF00017	0.487
LIG_SH2_STAT5	460	463	PF00017	0.384
LIG_SH2_STAT5	606	609	PF00017	0.364
LIG_SH2_STAT5	86	89	PF00017	0.376
LIG_SH3_1	10	16	PF00018	0.373
LIG_SH3_1	538	544	PF00018	0.393
LIG_SH3_2	541	546	PF14604	0.307
LIG_SH3_3	10	16	PF00018	0.415
LIG_SH3_3	247	253	PF00018	0.732
LIG_SH3_3	367	373	PF00018	0.513
LIG_SH3_3	45	51	PF00018	0.428
LIG_SH3_3	513	519	PF00018	0.484
LIG_SH3_3	538	544	PF00018	0.393
LIG_SH3_3	69	75	PF00018	0.443
LIG_SUMO_SIM_anti_2	514	519	PF11976	0.424
LIG_SUMO_SIM_anti_2	594	600	PF11976	0.438
LIG_SUMO_SIM_par_1	131	136	PF11976	0.396
LIG_SUMO_SIM_par_1	588	594	PF11976	0.341
MOD_CK1_1	146	152	PF00069	0.729
MOD_CK1_1	168	174	PF00069	0.679
MOD_CK1_1	249	255	PF00069	0.666
MOD_CK1_1	330	336	PF00069	0.670
MOD_CK1_1	374	380	PF00069	0.401
MOD_CK1_1	511	517	PF00069	0.456
MOD_CK1_1	565	571	PF00069	0.512
MOD_CK2_1	374	380	PF00069	0.434
MOD_CK2_1	450	456	PF00069	0.360
MOD_CK2_1	555	561	PF00069	0.417
MOD_CK2_1	98	104	PF00069	0.581
MOD_GlcNHglycan	104	107	PF01048	0.565
MOD_GlcNHglycan	110	114	PF01048	0.417
MOD_GlcNHglycan	148	151	PF01048	0.637
MOD_GlcNHglycan	246	249	PF01048	0.792
MOD_GlcNHglycan	329	332	PF01048	0.610
MOD_GlcNHglycan	367	370	PF01048	0.531
MOD_GlcNHglycan	439	442	PF01048	0.498
MOD_GlcNHglycan	452	455	PF01048	0.261
MOD_GlcNHglycan	465	468	PF01048	0.404
MOD_GlcNHglycan	470	473	PF01048	0.566
MOD_GlcNHglycan	505	508	PF01048	0.531
MOD_GlcNHglycan	532	535	PF01048	0.449
MOD_GlcNHglycan	541	544	PF01048	0.421
MOD_GlcNHglycan	557	560	PF01048	0.482
MOD_GlcNHglycan	564	567	PF01048	0.428
MOD_GlcNHglycan	88	91	PF01048	0.569
MOD_GSK3_1	131	138	PF00069	0.480
MOD_GSK3_1	164	171	PF00069	0.691
MOD_GSK3_1	174	181	PF00069	0.485
MOD_GSK3_1	198	205	PF00069	0.491
MOD_GSK3_1	209	216	PF00069	0.599
MOD_GSK3_1	249	256	PF00069	0.727
MOD_GSK3_1	332	339	PF00069	0.670
MOD_GSK3_1	445	452	PF00069	0.452
MOD_GSK3_1	463	470	PF00069	0.350
MOD_GSK3_1	503	510	PF00069	0.606
MOD_GSK3_1	555	562	PF00069	0.463
MOD_GSK3_1	81	88	PF00069	0.428
MOD_GSK3_1	98	105	PF00069	0.495
MOD_LATS_1	160	166	PF00433	0.670
MOD_N-GLC_1	609	614	PF02516	0.397
MOD_NEK2_1	109	114	PF00069	0.504
MOD_NEK2_1	131	136	PF00069	0.412
MOD_NEK2_1	270	275	PF00069	0.460
MOD_NEK2_1	43	48	PF00069	0.340
MOD_NEK2_1	468	473	PF00069	0.589
MOD_NEK2_1	530	535	PF00069	0.369
MOD_NEK2_2	559	564	PF00069	0.407
MOD_PIKK_1	111	117	PF00454	0.418
MOD_PIKK_1	154	160	PF00454	0.663
MOD_PIKK_1	209	215	PF00454	0.708
MOD_PIKK_1	445	451	PF00454	0.373
MOD_PKA_2	138	144	PF00069	0.589
MOD_PKA_2	411	417	PF00069	0.461
MOD_PKA_2	468	474	PF00069	0.448
MOD_PKB_1	602	610	PF00069	0.343
MOD_Plk_1	609	615	PF00069	0.425
MOD_Plk_2-3	285	291	PF00069	0.480
MOD_Plk_4	116	122	PF00069	0.395
MOD_Plk_4	348	354	PF00069	0.509
MOD_Plk_4	397	403	PF00069	0.438
MOD_Plk_4	43	49	PF00069	0.399
MOD_Plk_4	511	517	PF00069	0.423
MOD_Plk_4	64	70	PF00069	0.369
MOD_Plk_4	73	79	PF00069	0.403
MOD_ProDKin_1	1	7	PF00069	0.532
MOD_ProDKin_1	165	171	PF00069	0.685
MOD_ProDKin_1	246	252	PF00069	0.695
MOD_ProDKin_1	253	259	PF00069	0.575
MOD_ProDKin_1	330	336	PF00069	0.572
MOD_ProDKin_1	395	401	PF00069	0.387
MOD_ProDKin_1	81	87	PF00069	0.435
TRG_AP2beta_CARGO_1	383	393	PF09066	0.334
TRG_ENDOCYTIC_2	258	261	PF00928	0.502
TRG_ENDOCYTIC_2	45	48	PF00928	0.372
TRG_ENDOCYTIC_2	606	609	PF00928	0.364
TRG_ER_diArg_1	235	238	PF00400	0.498
TRG_ER_diArg_1	275	278	PF00400	0.470
TRG_ER_diArg_1	360	362	PF00400	0.457
TRG_ER_diArg_1	392	394	PF00400	0.492
TRG_ER_diArg_1	545	547	PF00400	0.317
TRG_ER_diArg_1	601	604	PF00400	0.392
TRG_ER_diArg_1	8	10	PF00400	0.420
TRG_Pf-PMV_PEXEL_1	344	348	PF00026	0.425
TRG_Pf-PMV_PEXEL_1	547	551	PF00026	0.396

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZQ1	Leptomonas seymouri	28%	93%
A0A0N1PDV8	Leptomonas seymouri	46%	100%
A0A3S5H6G6	Leishmania donovani	30%	100%
A0A3S7WR70	Leishmania donovani	99%	100%
A4H664	Leishmania braziliensis	67%	97%
A4HUI9	Leishmania infantum	30%	97%
E9AN86	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	98%
E9AN87	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
Q4QHD7	Leishmania major	31%	100%
Q4QHD8	Leishmania major	89%	99%