LeishMANIAdb
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Putative amino acid transporter

Quick info Annotations Function or PPIs Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative amino acid transporter
Gene product:
amino acid permease 24 - putative
Species:
Leishmania infantum
UniProt:
A4HUI4_LEIIN
TriTrypDb:
LINF_100013850
Length:
488

Annotations

LeishMANIAdb annotations

Related to animal and plant proton-coupled amino acid transporters. The family has modestly expanded in kinetoplastid parazites.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 19
NetGPI no yes: 0, no: 19
Cellular components
Term Name Level Count
GO:0016020 membrane 2 19
GO:0110165 cellular anatomical entity 1 19
GO:0005774 vacuolar membrane 5 2
GO:0031090 organelle membrane 3 2
GO:0098588 bounding membrane of organelle 4 2

Phosphorylation

Promastigote: 45

Expansion

Sequence features

A4HUI4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HUI4

Function

Biological processes
Term Name Level Count
GO:0003333 amino acid transmembrane transport 5 2
GO:0006810 transport 3 2
GO:0006865 amino acid transport 5 2
GO:0009987 cellular process 1 2
GO:0015849 organic acid transport 5 2
GO:0051179 localization 1 2
GO:0051234 establishment of localization 2 2
GO:0055085 transmembrane transport 2 2
GO:0071702 organic substance transport 4 2
GO:0071705 nitrogen compound transport 4 2
GO:1903825 organic acid transmembrane transport 3 2
GO:1905039 carboxylic acid transmembrane transport 4 2
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 2
GO:0005342 organic acid transmembrane transporter activity 3 2
GO:0015171 amino acid transmembrane transporter activity 5 2
GO:0015179 L-amino acid transmembrane transporter activity 6 2
GO:0022857 transmembrane transporter activity 2 2
GO:0046943 carboxylic acid transmembrane transporter activity 4 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 437 441 PF00656 0.623
CLV_C14_Caspase3-7 7 11 PF00656 0.729
CLV_PCSK_KEX2_1 296 298 PF00082 0.353
CLV_PCSK_KEX2_1 462 464 PF00082 0.386
CLV_PCSK_PC1ET2_1 296 298 PF00082 0.353
CLV_PCSK_PC1ET2_1 462 464 PF00082 0.380
CLV_PCSK_SKI1_1 301 305 PF00082 0.307
CLV_PCSK_SKI1_1 347 351 PF00082 0.321
CLV_PCSK_SKI1_1 450 454 PF00082 0.337
CLV_PCSK_SKI1_1 88 92 PF00082 0.247
DEG_APCC_KENBOX_2 80 84 PF00400 0.607
DOC_MAPK_FxFP_2 356 359 PF00069 0.348
DOC_MAPK_gen_1 196 205 PF00069 0.306
DOC_MAPK_gen_1 374 383 PF00069 0.476
DOC_MAPK_gen_1 462 472 PF00069 0.501
DOC_MAPK_HePTP_8 373 385 PF00069 0.515
DOC_MAPK_MEF2A_6 133 142 PF00069 0.367
DOC_MAPK_MEF2A_6 196 205 PF00069 0.322
DOC_MAPK_MEF2A_6 347 356 PF00069 0.347
DOC_MAPK_MEF2A_6 376 385 PF00069 0.468
DOC_MAPK_MEF2A_6 386 393 PF00069 0.271
DOC_MAPK_MEF2A_6 463 472 PF00069 0.490
DOC_MAPK_NFAT4_5 386 394 PF00069 0.348
DOC_PP1_RVXF_1 345 351 PF00149 0.347
DOC_PP4_FxxP_1 103 106 PF00568 0.307
DOC_PP4_FxxP_1 356 359 PF00568 0.348
DOC_USP7_MATH_1 224 228 PF00917 0.321
DOC_USP7_MATH_1 230 234 PF00917 0.421
DOC_USP7_MATH_1 338 342 PF00917 0.250
DOC_USP7_MATH_1 414 418 PF00917 0.378
LIG_14-3-3_CanoR_1 3 13 PF00244 0.780
LIG_14-3-3_CanoR_1 443 447 PF00244 0.530
LIG_BIR_II_1 1 5 PF00653 0.755
LIG_BRCT_BRCA1_1 203 207 PF00533 0.435
LIG_EH1_1 113 121 PF00400 0.320
LIG_EH1_1 348 356 PF00400 0.181
LIG_FHA_1 130 136 PF00498 0.403
LIG_FHA_1 224 230 PF00498 0.306
LIG_FHA_1 302 308 PF00498 0.483
LIG_FHA_1 318 324 PF00498 0.264
LIG_FHA_1 328 334 PF00498 0.241
LIG_FHA_1 355 361 PF00498 0.354
LIG_FHA_1 400 406 PF00498 0.326
LIG_FHA_1 479 485 PF00498 0.339
LIG_FHA_2 15 21 PF00498 0.697
LIG_FHA_2 186 192 PF00498 0.338
LIG_FHA_2 25 31 PF00498 0.736
LIG_FHA_2 5 11 PF00498 0.767
LIG_GBD_Chelix_1 115 123 PF00786 0.393
LIG_GBD_Chelix_1 311 319 PF00786 0.437
LIG_LIR_Apic_2 100 106 PF02991 0.326
LIG_LIR_Gen_1 148 157 PF02991 0.509
LIG_LIR_Gen_1 198 208 PF02991 0.321
LIG_LIR_Gen_1 233 244 PF02991 0.378
LIG_LIR_Gen_1 30 38 PF02991 0.725
LIG_LIR_Gen_1 60 68 PF02991 0.747
LIG_LIR_Gen_1 89 98 PF02991 0.364
LIG_LIR_Nem_3 148 153 PF02991 0.468
LIG_LIR_Nem_3 198 203 PF02991 0.329
LIG_LIR_Nem_3 233 239 PF02991 0.361
LIG_LIR_Nem_3 30 35 PF02991 0.758
LIG_LIR_Nem_3 320 325 PF02991 0.368
LIG_LIR_Nem_3 379 383 PF02991 0.492
LIG_LIR_Nem_3 460 464 PF02991 0.527
LIG_LIR_Nem_3 89 94 PF02991 0.364
LIG_PALB2_WD40_1 265 273 PF16756 0.315
LIG_PDZ_Class_3 483 488 PF00595 0.413
LIG_Pex14_1 313 317 PF04695 0.371
LIG_Pex14_1 449 453 PF04695 0.581
LIG_Pex14_2 207 211 PF04695 0.374
LIG_PTB_Apo_2 350 357 PF02174 0.383
LIG_SH2_CRK 150 154 PF00017 0.489
LIG_SH2_CRK 181 185 PF00017 0.391
LIG_SH2_CRK 236 240 PF00017 0.414
LIG_SH2_NCK_1 482 486 PF00017 0.400
LIG_SH2_PTP2 467 470 PF00017 0.445
LIG_SH2_STAP1 181 185 PF00017 0.387
LIG_SH2_STAT3 358 361 PF00017 0.314
LIG_SH2_STAT5 114 117 PF00017 0.339
LIG_SH2_STAT5 156 159 PF00017 0.490
LIG_SH2_STAT5 181 184 PF00017 0.245
LIG_SH2_STAT5 200 203 PF00017 0.339
LIG_SH2_STAT5 314 317 PF00017 0.313
LIG_SH2_STAT5 322 325 PF00017 0.332
LIG_SH2_STAT5 467 470 PF00017 0.301
LIG_SH2_STAT5 61 64 PF00017 0.754
LIG_SH3_3 433 439 PF00018 0.529
LIG_SH3_3 451 457 PF00018 0.610
LIG_SUMO_SIM_anti_2 217 224 PF11976 0.487
LIG_SUMO_SIM_anti_2 281 287 PF11976 0.371
LIG_SUMO_SIM_par_1 221 227 PF11976 0.496
LIG_SUMO_SIM_par_1 303 308 PF11976 0.408
LIG_TYR_ITIM 179 184 PF00017 0.354
LIG_TYR_ITIM 234 239 PF00017 0.414
LIG_TYR_ITSM 146 153 PF00017 0.532
LIG_UBA3_1 427 433 PF00899 0.258
LIG_Vh1_VBS_1 337 355 PF01044 0.158
LIG_WRC_WIRS_1 105 110 PF05994 0.354
MOD_CK1_1 145 151 PF00069 0.506
MOD_CK1_1 328 334 PF00069 0.327
MOD_CK1_1 341 347 PF00069 0.287
MOD_CK1_1 6 12 PF00069 0.743
MOD_CK2_1 14 20 PF00069 0.685
MOD_CK2_1 185 191 PF00069 0.338
MOD_CK2_1 24 30 PF00069 0.734
MOD_CK2_1 31 37 PF00069 0.729
MOD_CK2_1 480 486 PF00069 0.457
MOD_CK2_1 6 12 PF00069 0.740
MOD_GlcNHglycan 363 366 PF01048 0.365
MOD_GlcNHglycan 402 405 PF01048 0.510
MOD_GlcNHglycan 88 91 PF01048 0.296
MOD_GSK3_1 142 149 PF00069 0.548
MOD_GSK3_1 214 221 PF00069 0.353
MOD_GSK3_1 224 231 PF00069 0.324
MOD_GSK3_1 301 308 PF00069 0.499
MOD_GSK3_1 325 332 PF00069 0.320
MOD_GSK3_1 337 344 PF00069 0.257
MOD_GSK3_1 400 407 PF00069 0.469
MOD_GSK3_1 480 487 PF00069 0.440
MOD_N-GLC_1 142 147 PF02516 0.356
MOD_N-GLC_1 218 223 PF02516 0.278
MOD_N-GLC_2 85 87 PF02516 0.158
MOD_NEK2_1 179 184 PF00069 0.343
MOD_NEK2_1 185 190 PF00069 0.278
MOD_NEK2_1 195 200 PF00069 0.270
MOD_NEK2_1 201 206 PF00069 0.314
MOD_NEK2_1 223 228 PF00069 0.397
MOD_NEK2_1 242 247 PF00069 0.350
MOD_NEK2_1 305 310 PF00069 0.393
MOD_NEK2_1 317 322 PF00069 0.295
MOD_NEK2_1 329 334 PF00069 0.213
MOD_NEK2_1 337 342 PF00069 0.265
MOD_NEK2_1 354 359 PF00069 0.348
MOD_NEK2_2 230 235 PF00069 0.442
MOD_NEK2_2 342 347 PF00069 0.306
MOD_NEK2_2 457 462 PF00069 0.619
MOD_OFUCOSY 210 215 PF10250 0.378
MOD_PIKK_1 14 20 PF00454 0.701
MOD_PIKK_1 148 154 PF00454 0.514
MOD_PIKK_1 179 185 PF00454 0.351
MOD_PIKK_1 247 253 PF00454 0.335
MOD_PIKK_1 291 297 PF00454 0.522
MOD_PKA_2 24 30 PF00069 0.712
MOD_PKA_2 442 448 PF00069 0.527
MOD_Plk_1 129 135 PF00069 0.348
MOD_Plk_1 145 151 PF00069 0.484
MOD_Plk_1 218 224 PF00069 0.478
MOD_Plk_1 369 375 PF00069 0.525
MOD_Plk_1 68 74 PF00069 0.640
MOD_Plk_4 104 110 PF00069 0.317
MOD_Plk_4 114 120 PF00069 0.303
MOD_Plk_4 185 191 PF00069 0.236
MOD_Plk_4 201 207 PF00069 0.320
MOD_Plk_4 218 224 PF00069 0.398
MOD_Plk_4 230 236 PF00069 0.375
MOD_Plk_4 24 30 PF00069 0.726
MOD_Plk_4 242 248 PF00069 0.277
MOD_Plk_4 301 307 PF00069 0.482
MOD_Plk_4 329 335 PF00069 0.257
MOD_Plk_4 404 410 PF00069 0.279
MOD_Plk_4 423 429 PF00069 0.192
MOD_Plk_4 68 74 PF00069 0.677
MOD_SUMO_rev_2 50 58 PF00179 0.791
TRG_DiLeu_BaLyEn_6 130 135 PF01217 0.373
TRG_DiLeu_BaLyEn_6 383 388 PF01217 0.414
TRG_ENDOCYTIC_2 150 153 PF00928 0.453
TRG_ENDOCYTIC_2 181 184 PF00928 0.339
TRG_ENDOCYTIC_2 200 203 PF00928 0.315
TRG_ENDOCYTIC_2 236 239 PF00928 0.404
TRG_ENDOCYTIC_2 314 317 PF00928 0.316
TRG_ENDOCYTIC_2 467 470 PF00928 0.306
TRG_ENDOCYTIC_2 61 64 PF00928 0.754
TRG_NLS_Bipartite_1 450 466 PF00514 0.606
TRG_Pf-PMV_PEXEL_1 133 137 PF00026 0.437

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P6H0 Leptomonas seymouri 70% 100%
A0A0N0P8T9 Leptomonas seymouri 21% 98%
A0A0N1PCP5 Leptomonas seymouri 69% 100%
A0A1X0NHS6 Trypanosomatidae 46% 100%
A0A1X0NRL3 Trypanosomatidae 24% 100%
A0A1X0NYI3 Trypanosomatidae 22% 98%
A0A1X0NZK6 Trypanosomatidae 48% 100%
A0A1X0P7Z8 Trypanosomatidae 30% 78%
A0A381MBS1 Leishmania infantum 99% 100%
A0A3Q8IB21 Leishmania donovani 99% 100%
A0A3Q8IFZ0 Leishmania donovani 23% 95%
A0A3S5H6G5 Leishmania donovani 98% 100%
A0A3S5H6T4 Leishmania donovani 23% 96%
A0A3S7WQ39 Leishmania donovani 22% 100%
A0A422MW74 Trypanosoma rangeli 21% 95%
A0A422MZQ8 Trypanosoma rangeli 34% 82%
A4H565 Leishmania braziliensis 21% 100%
A4H662 Leishmania braziliensis 78% 100%
A4HKQ7 Leishmania braziliensis 23% 100%
A4HNZ6 Leishmania braziliensis 29% 100%
A4HTE2 Leishmania infantum 22% 100%
C9ZW15 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 47% 100%
D0A2X2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 85%
E9AN82 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 100%
E9AYW8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 22% 100%
F4ILY9 Arabidopsis thaliana 24% 100%
P36062 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 21% 71%
Q10074 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 23% 74%
Q495M3 Homo sapiens 20% 100%
Q495N2 Homo sapiens 23% 100%
Q4KL91 Xenopus laevis 21% 93%
Q4Q6M8 Leishmania major 24% 95%
Q4QHE2 Leishmania major 94% 100%
Q4QHE4 Leishmania major 94% 100%
Q4QIH0 Leishmania major 24% 100%
Q4V8B1 Rattus norvegicus 24% 100%
Q6YBV0 Homo sapiens 22% 97%
Q7Z2H8 Homo sapiens 22% 100%
Q811P0 Mus musculus 23% 100%
Q8CH36 Mus musculus 22% 98%
Q8K415 Rattus norvegicus 22% 100%
Q8K4D3 Mus musculus 23% 100%
Q924A5 Rattus norvegicus 22% 100%
Q9SF09 Arabidopsis thaliana 21% 100%
Q9SVG0 Arabidopsis thaliana 25% 100%
Q9VT04 Drosophila melanogaster 21% 100%
Q9W056 Drosophila melanogaster 25% 100%
V5BHF0 Trypanosoma cruzi 43% 100%
V5BJY7 Trypanosoma cruzi 34% 82%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS