LeishMANIAdb
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Flagellar glycoprotein-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Flagellar glycoprotein-like protein
Gene product:
flagellar glycoprotein-like protein
Species:
Leishmania infantum
UniProt:
A4HUH5_LEIIN
TriTrypDb:
LINF_100013100
Length:
593

Annotations

Annotations by Jardim et al.

Flagella, Flagellar glyco-like

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) yes yes: 3
Silverman et al. no yes: 0
Pissara et al. yes yes: 12
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 8, no: 1
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0005929 cilium 4 6
GO:0031514 motile cilium 5 6
GO:0042995 cell projection 2 6
GO:0043226 organelle 2 6
GO:0043227 membrane-bounded organelle 3 6
GO:0110165 cellular anatomical entity 1 7
GO:0120025 plasma membrane bounded cell projection 3 6
GO:0016020 membrane 2 5
GO:0020016 ciliary pocket 2 1

Expansion

Sequence features

A4HUH5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HUH5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 455 459 PF00656 0.341
CLV_C14_Caspase3-7 70 74 PF00656 0.442
CLV_NRD_NRD_1 10 12 PF00675 0.815
CLV_NRD_NRD_1 123 125 PF00675 0.700
CLV_NRD_NRD_1 15 17 PF00675 0.781
CLV_PCSK_KEX2_1 10 12 PF00082 0.782
CLV_PCSK_KEX2_1 125 127 PF00082 0.586
CLV_PCSK_KEX2_1 15 17 PF00082 0.740
CLV_PCSK_KEX2_1 506 508 PF00082 0.663
CLV_PCSK_PC1ET2_1 125 127 PF00082 0.586
CLV_PCSK_PC1ET2_1 506 508 PF00082 0.663
CLV_PCSK_PC7_1 11 17 PF00082 0.677
CLV_PCSK_SKI1_1 499 503 PF00082 0.622
CLV_PCSK_SKI1_1 509 513 PF00082 0.536
CLV_PCSK_SKI1_1 535 539 PF00082 0.662
DEG_APCC_DBOX_1 508 516 PF00400 0.356
DOC_CKS1_1 187 192 PF01111 0.433
DOC_CKS1_1 273 278 PF01111 0.484
DOC_CYCLIN_yCln2_LP_2 37 43 PF00134 0.699
DOC_PP2B_LxvP_1 215 218 PF13499 0.439
DOC_PP4_FxxP_1 446 449 PF00568 0.404
DOC_PP4_FxxP_1 485 488 PF00568 0.441
DOC_USP7_MATH_1 299 303 PF00917 0.375
DOC_USP7_MATH_1 309 313 PF00917 0.341
DOC_USP7_MATH_1 365 369 PF00917 0.587
DOC_USP7_MATH_1 43 47 PF00917 0.709
DOC_USP7_MATH_1 558 562 PF00917 0.344
DOC_USP7_MATH_2 365 371 PF00917 0.554
DOC_USP7_UBL2_3 502 506 PF12436 0.385
DOC_WW_Pin1_4 130 135 PF00397 0.378
DOC_WW_Pin1_4 18 23 PF00397 0.659
DOC_WW_Pin1_4 186 191 PF00397 0.400
DOC_WW_Pin1_4 219 224 PF00397 0.478
DOC_WW_Pin1_4 272 277 PF00397 0.468
DOC_WW_Pin1_4 313 318 PF00397 0.456
DOC_WW_Pin1_4 358 363 PF00397 0.414
DOC_WW_Pin1_4 500 505 PF00397 0.376
DOC_WW_Pin1_4 576 581 PF00397 0.519
LIG_14-3-3_CanoR_1 147 152 PF00244 0.438
LIG_14-3-3_CanoR_1 342 350 PF00244 0.410
LIG_APCC_ABBA_1 336 341 PF00400 0.365
LIG_APCC_ABBAyCdc20_2 335 341 PF00400 0.349
LIG_BIR_II_1 1 5 PF00653 0.686
LIG_BRCT_BRCA1_1 246 250 PF00533 0.385
LIG_BRCT_BRCA1_1 580 584 PF00533 0.664
LIG_eIF4E_1 495 501 PF01652 0.323
LIG_FHA_1 172 178 PF00498 0.456
LIG_FHA_1 290 296 PF00498 0.366
LIG_FHA_1 327 333 PF00498 0.478
LIG_FHA_1 351 357 PF00498 0.382
LIG_FHA_1 452 458 PF00498 0.499
LIG_FHA_1 477 483 PF00498 0.353
LIG_FHA_1 583 589 PF00498 0.761
LIG_FHA_2 453 459 PF00498 0.371
LIG_GBD_Chelix_1 160 168 PF00786 0.577
LIG_Integrin_RGD_1 126 128 PF01839 0.633
LIG_LIR_Apic_2 231 237 PF02991 0.428
LIG_LIR_Apic_2 262 266 PF02991 0.475
LIG_LIR_Apic_2 445 449 PF02991 0.458
LIG_LIR_Gen_1 209 218 PF02991 0.446
LIG_LIR_Gen_1 352 363 PF02991 0.450
LIG_LIR_Gen_1 423 433 PF02991 0.411
LIG_LIR_Gen_1 55 66 PF02991 0.437
LIG_LIR_Gen_1 581 592 PF02991 0.691
LIG_LIR_Nem_3 135 141 PF02991 0.486
LIG_LIR_Nem_3 209 214 PF02991 0.446
LIG_LIR_Nem_3 280 284 PF02991 0.470
LIG_LIR_Nem_3 344 350 PF02991 0.369
LIG_LIR_Nem_3 352 358 PF02991 0.368
LIG_LIR_Nem_3 55 61 PF02991 0.417
LIG_LIR_Nem_3 581 587 PF02991 0.679
LIG_MYND_1 317 321 PF01753 0.433
LIG_NRBOX 32 38 PF00104 0.575
LIG_Pex14_2 442 446 PF04695 0.340
LIG_PTB_Apo_2 152 159 PF02174 0.428
LIG_PTB_Apo_2 205 212 PF02174 0.361
LIG_PTB_Phospho_1 205 211 PF10480 0.357
LIG_REV1ctd_RIR_1 337 346 PF16727 0.436
LIG_SH2_CRK 211 215 PF00017 0.418
LIG_SH2_CRK 58 62 PF00017 0.430
LIG_SH2_CRK 81 85 PF00017 0.471
LIG_SH2_PTP2 263 266 PF00017 0.443
LIG_SH2_SRC 216 219 PF00017 0.377
LIG_SH2_STAT5 115 118 PF00017 0.412
LIG_SH2_STAT5 159 162 PF00017 0.339
LIG_SH2_STAT5 216 219 PF00017 0.454
LIG_SH2_STAT5 234 237 PF00017 0.425
LIG_SH2_STAT5 259 262 PF00017 0.416
LIG_SH2_STAT5 263 266 PF00017 0.472
LIG_SH2_STAT5 296 299 PF00017 0.416
LIG_SH2_STAT5 348 351 PF00017 0.380
LIG_SH2_STAT5 495 498 PF00017 0.418
LIG_SH3_3 270 276 PF00018 0.448
LIG_SH3_3 359 365 PF00018 0.505
LIG_SH3_3 444 450 PF00018 0.377
LIG_SH3_3 498 504 PF00018 0.336
LIG_SH3_3 537 543 PF00018 0.454
LIG_SH3_3 585 591 PF00018 0.752
LIG_SUMO_SIM_anti_2 479 484 PF11976 0.424
LIG_SUMO_SIM_par_1 323 330 PF11976 0.421
LIG_SUMO_SIM_par_1 573 579 PF11976 0.475
LIG_TYR_ITSM 207 214 PF00017 0.364
LIG_TYR_ITSM 53 60 PF00017 0.399
MOD_CDC14_SPxK_1 503 506 PF00782 0.401
MOD_CDK_SPxK_1 500 506 PF00069 0.404
MOD_CDK_SPxxK_3 500 507 PF00069 0.349
MOD_CK1_1 196 202 PF00069 0.459
MOD_CK1_1 219 225 PF00069 0.458
MOD_CK1_1 244 250 PF00069 0.378
MOD_CK1_1 267 273 PF00069 0.395
MOD_CK1_1 312 318 PF00069 0.432
MOD_CK1_1 368 374 PF00069 0.620
MOD_CK1_1 375 381 PF00069 0.557
MOD_CK1_1 382 388 PF00069 0.502
MOD_CK1_1 389 395 PF00069 0.443
MOD_CK1_1 46 52 PF00069 0.414
MOD_CK1_1 514 520 PF00069 0.492
MOD_CK2_1 390 396 PF00069 0.620
MOD_GlcNHglycan 102 105 PF01048 0.622
MOD_GlcNHglycan 198 201 PF01048 0.724
MOD_GlcNHglycan 312 315 PF01048 0.616
MOD_GlcNHglycan 358 361 PF01048 0.657
MOD_GlcNHglycan 370 373 PF01048 0.677
MOD_GlcNHglycan 386 389 PF01048 0.711
MOD_GlcNHglycan 399 402 PF01048 0.685
MOD_GlcNHglycan 517 520 PF01048 0.667
MOD_GlcNHglycan 548 551 PF01048 0.749
MOD_GlcNHglycan 63 66 PF01048 0.683
MOD_GlcNHglycan 75 78 PF01048 0.563
MOD_GSK3_1 143 150 PF00069 0.482
MOD_GSK3_1 168 175 PF00069 0.459
MOD_GSK3_1 189 196 PF00069 0.460
MOD_GSK3_1 200 207 PF00069 0.470
MOD_GSK3_1 267 274 PF00069 0.465
MOD_GSK3_1 285 292 PF00069 0.319
MOD_GSK3_1 295 302 PF00069 0.394
MOD_GSK3_1 309 316 PF00069 0.330
MOD_GSK3_1 366 373 PF00069 0.575
MOD_GSK3_1 374 381 PF00069 0.607
MOD_GSK3_1 382 389 PF00069 0.518
MOD_GSK3_1 416 423 PF00069 0.408
MOD_GSK3_1 448 455 PF00069 0.483
MOD_GSK3_1 468 475 PF00069 0.396
MOD_GSK3_1 511 518 PF00069 0.428
MOD_GSK3_1 529 536 PF00069 0.418
MOD_GSK3_1 578 585 PF00069 0.658
MOD_GSK3_1 69 76 PF00069 0.425
MOD_N-GLC_1 171 176 PF02516 0.659
MOD_N-GLC_1 227 232 PF02516 0.670
MOD_N-GLC_1 252 257 PF02516 0.602
MOD_N-GLC_1 299 304 PF02516 0.674
MOD_N-GLC_1 416 421 PF02516 0.664
MOD_N-GLC_1 451 456 PF02516 0.636
MOD_N-GLC_1 461 466 PF02516 0.562
MOD_N-GLC_1 468 473 PF02516 0.545
MOD_N-GLC_1 515 520 PF02516 0.635
MOD_N-GLC_1 528 533 PF02516 0.644
MOD_NEK2_1 100 105 PF00069 0.453
MOD_NEK2_1 160 165 PF00069 0.340
MOD_NEK2_1 168 173 PF00069 0.338
MOD_NEK2_1 193 198 PF00069 0.455
MOD_NEK2_1 295 300 PF00069 0.460
MOD_NEK2_1 307 312 PF00069 0.348
MOD_NEK2_1 327 332 PF00069 0.257
MOD_NEK2_1 350 355 PF00069 0.428
MOD_NEK2_1 356 361 PF00069 0.291
MOD_NEK2_1 511 516 PF00069 0.373
MOD_NEK2_2 200 205 PF00069 0.321
MOD_PIKK_1 289 295 PF00454 0.326
MOD_PIKK_1 350 356 PF00454 0.380
MOD_PIKK_1 420 426 PF00454 0.390
MOD_PIKK_1 493 499 PF00454 0.461
MOD_PKA_2 168 174 PF00069 0.341
MOD_PKA_2 341 347 PF00069 0.430
MOD_Plk_1 252 258 PF00069 0.383
MOD_Plk_1 327 333 PF00069 0.330
MOD_Plk_1 416 422 PF00069 0.459
MOD_Plk_1 451 457 PF00069 0.418
MOD_Plk_1 461 467 PF00069 0.359
MOD_Plk_4 177 183 PF00069 0.402
MOD_Plk_4 193 199 PF00069 0.332
MOD_Plk_4 200 206 PF00069 0.420
MOD_Plk_4 210 216 PF00069 0.370
MOD_Plk_4 315 321 PF00069 0.504
MOD_Plk_4 327 333 PF00069 0.356
MOD_Plk_4 343 349 PF00069 0.288
MOD_Plk_4 452 458 PF00069 0.522
MOD_Plk_4 52 58 PF00069 0.452
MOD_Plk_4 559 565 PF00069 0.430
MOD_ProDKin_1 130 136 PF00069 0.371
MOD_ProDKin_1 18 24 PF00069 0.654
MOD_ProDKin_1 186 192 PF00069 0.399
MOD_ProDKin_1 219 225 PF00069 0.475
MOD_ProDKin_1 272 278 PF00069 0.470
MOD_ProDKin_1 313 319 PF00069 0.453
MOD_ProDKin_1 358 364 PF00069 0.424
MOD_ProDKin_1 500 506 PF00069 0.380
MOD_ProDKin_1 576 582 PF00069 0.521
TRG_DiLeu_BaLyEn_6 105 110 PF01217 0.441
TRG_ENDOCYTIC_2 211 214 PF00928 0.401
TRG_ENDOCYTIC_2 426 429 PF00928 0.405
TRG_ENDOCYTIC_2 57 60 PF00928 0.388
TRG_ENDOCYTIC_2 81 84 PF00928 0.477
TRG_ER_diArg_1 10 12 PF00400 0.664
TRG_ER_diArg_1 14 16 PF00400 0.660
TRG_NLS_MonoExtN_4 504 510 PF00514 0.328

Homologs

Protein Taxonomy Sequence identity Coverage
A0A1X0NRY9 Trypanosomatidae 31% 100%
A0A3S7WR66 Leishmania donovani 98% 98%
A0A422NWX8 Trypanosoma rangeli 31% 100%
A4H655 Leishmania braziliensis 71% 99%
C9ZVK0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 100%
E9AN73 Leishmania mexicana (strain MHOM/GT/2001/U1103) 83% 100%
Q4QHF2 Leishmania major 85% 97%
V5BP43 Trypanosoma cruzi 29% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS