LeishMANIAdb
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Membrane-associated protein

Quick info Annotations Function or PPIs Localization Phosphorylation Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Membrane-associated protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4HUH4_LEIIN
TriTrypDb:
LINF_100013000
Length:
756

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 9, no: 3
NetGPI no yes: 0, no: 12
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0016020 membrane 2 11
GO:0031974 membrane-enclosed lumen 2 1
GO:0031981 nuclear lumen 5 1
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 1
GO:0043233 organelle lumen 3 1
GO:0070013 intracellular organelle lumen 4 1
GO:0097014 ciliary plasm 5 1
GO:0099568 cytoplasmic region 3 1
GO:0110165 cellular anatomical entity 1 11

Phosphorylation

Amastigote: 741, 746, 750

Expansion

Sequence features

A4HUH4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HUH4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 292 296 PF00656 0.293
CLV_C14_Caspase3-7 614 618 PF00656 0.467
CLV_NRD_NRD_1 6 8 PF00675 0.723
CLV_NRD_NRD_1 688 690 PF00675 0.745
CLV_NRD_NRD_1 722 724 PF00675 0.442
CLV_PCSK_KEX2_1 6 8 PF00082 0.736
CLV_PCSK_KEX2_1 720 722 PF00082 0.434
CLV_PCSK_PC1ET2_1 720 722 PF00082 0.434
CLV_PCSK_SKI1_1 306 310 PF00082 0.507
CLV_PCSK_SKI1_1 487 491 PF00082 0.530
CLV_PCSK_SKI1_1 723 727 PF00082 0.537
DEG_APCC_DBOX_1 720 728 PF00400 0.639
DEG_SCF_FBW7_1 437 444 PF00400 0.267
DEG_SPOP_SBC_1 229 233 PF00917 0.418
DEG_SPOP_SBC_1 26 30 PF00917 0.503
DEG_SPOP_SBC_1 282 286 PF00917 0.437
DOC_ANK_TNKS_1 433 440 PF00023 0.263
DOC_CKS1_1 236 241 PF01111 0.430
DOC_CKS1_1 438 443 PF01111 0.418
DOC_CYCLIN_yCln2_LP_2 490 496 PF00134 0.350
DOC_CYCLIN_yCln2_LP_2 516 522 PF00134 0.319
DOC_PP2B_LxvP_1 516 519 PF13499 0.286
DOC_PP2B_LxvP_1 638 641 PF13499 0.369
DOC_PP4_FxxP_1 236 239 PF00568 0.375
DOC_PP4_FxxP_1 461 464 PF00568 0.383
DOC_USP7_MATH_1 130 134 PF00917 0.448
DOC_USP7_MATH_1 220 224 PF00917 0.461
DOC_USP7_MATH_1 229 233 PF00917 0.381
DOC_USP7_MATH_1 283 287 PF00917 0.391
DOC_USP7_MATH_1 301 305 PF00917 0.220
DOC_USP7_MATH_1 441 445 PF00917 0.436
DOC_USP7_MATH_1 55 59 PF00917 0.346
DOC_USP7_MATH_1 700 704 PF00917 0.464
DOC_WW_Pin1_4 235 240 PF00397 0.426
DOC_WW_Pin1_4 320 325 PF00397 0.474
DOC_WW_Pin1_4 364 369 PF00397 0.424
DOC_WW_Pin1_4 405 410 PF00397 0.449
DOC_WW_Pin1_4 437 442 PF00397 0.397
DOC_WW_Pin1_4 534 539 PF00397 0.429
DOC_WW_Pin1_4 556 561 PF00397 0.442
DOC_WW_Pin1_4 602 607 PF00397 0.487
LIG_14-3-3_CanoR_1 129 137 PF00244 0.468
LIG_14-3-3_CanoR_1 275 280 PF00244 0.450
LIG_14-3-3_CanoR_1 427 433 PF00244 0.444
LIG_14-3-3_CanoR_1 6 16 PF00244 0.541
LIG_14-3-3_CanoR_1 722 728 PF00244 0.752
LIG_14-3-3_CanoR_1 93 98 PF00244 0.357
LIG_BRCT_BRCA1_1 211 215 PF00533 0.335
LIG_BRCT_BRCA1_1 221 225 PF00533 0.300
LIG_BRCT_BRCA1_1 232 236 PF00533 0.251
LIG_BRCT_BRCA1_1 248 252 PF00533 0.418
LIG_BRCT_BRCA1_1 322 326 PF00533 0.335
LIG_BRCT_BRCA1_1 424 428 PF00533 0.345
LIG_BRCT_BRCA1_1 528 532 PF00533 0.508
LIG_BRCT_BRCA1_1 85 89 PF00533 0.362
LIG_deltaCOP1_diTrp_1 242 252 PF00928 0.306
LIG_deltaCOP1_diTrp_1 412 420 PF00928 0.366
LIG_EH_1 61 65 PF12763 0.341
LIG_FHA_1 136 142 PF00498 0.454
LIG_FHA_1 238 244 PF00498 0.392
LIG_FHA_1 275 281 PF00498 0.424
LIG_FHA_1 283 289 PF00498 0.356
LIG_FHA_1 335 341 PF00498 0.374
LIG_FHA_1 406 412 PF00498 0.362
LIG_FHA_1 454 460 PF00498 0.416
LIG_FHA_1 546 552 PF00498 0.384
LIG_FHA_1 634 640 PF00498 0.411
LIG_FHA_1 649 655 PF00498 0.384
LIG_FHA_1 675 681 PF00498 0.407
LIG_FHA_1 691 697 PF00498 0.258
LIG_FHA_1 70 76 PF00498 0.468
LIG_FHA_1 77 83 PF00498 0.422
LIG_FHA_2 171 177 PF00498 0.300
LIG_FHA_2 258 264 PF00498 0.314
LIG_FHA_2 290 296 PF00498 0.323
LIG_FHA_2 357 363 PF00498 0.469
LIG_LIR_Apic_2 233 239 PF02991 0.368
LIG_LIR_Gen_1 168 174 PF02991 0.333
LIG_LIR_Gen_1 212 221 PF02991 0.438
LIG_LIR_Gen_1 297 308 PF02991 0.460
LIG_LIR_Gen_1 413 424 PF02991 0.288
LIG_LIR_Gen_1 561 572 PF02991 0.389
LIG_LIR_Gen_1 671 680 PF02991 0.364
LIG_LIR_Nem_3 120 126 PF02991 0.433
LIG_LIR_Nem_3 168 172 PF02991 0.305
LIG_LIR_Nem_3 212 218 PF02991 0.358
LIG_LIR_Nem_3 222 228 PF02991 0.293
LIG_LIR_Nem_3 242 248 PF02991 0.348
LIG_LIR_Nem_3 297 303 PF02991 0.453
LIG_LIR_Nem_3 323 329 PF02991 0.398
LIG_LIR_Nem_3 367 372 PF02991 0.449
LIG_LIR_Nem_3 413 419 PF02991 0.320
LIG_LIR_Nem_3 561 567 PF02991 0.349
LIG_LIR_Nem_3 671 676 PF02991 0.324
LIG_LIR_Nem_3 86 91 PF02991 0.333
LIG_LIR_Nem_3 95 100 PF02991 0.344
LIG_LYPXL_yS_3 492 495 PF13949 0.408
LIG_MLH1_MIPbox_1 528 532 PF16413 0.405
LIG_MLH1_MIPbox_1 85 89 PF16413 0.338
LIG_NRBOX 512 518 PF00104 0.398
LIG_Pex14_1 416 420 PF04695 0.292
LIG_Pex14_2 369 373 PF04695 0.344
LIG_PTB_Apo_2 423 430 PF02174 0.346
LIG_PTB_Apo_2 540 547 PF02174 0.353
LIG_SH2_CRK 300 304 PF00017 0.369
LIG_SH2_CRK 564 568 PF00017 0.351
LIG_SH2_CRK 591 595 PF00017 0.357
LIG_SH2_GRB2like 452 455 PF00017 0.361
LIG_SH2_GRB2like 645 648 PF00017 0.373
LIG_SH2_NCK_1 300 304 PF00017 0.357
LIG_SH2_NCK_1 34 38 PF00017 0.363
LIG_SH2_NCK_1 389 393 PF00017 0.361
LIG_SH2_NCK_1 564 568 PF00017 0.351
LIG_SH2_NCK_1 591 595 PF00017 0.339
LIG_SH2_PTP2 401 404 PF00017 0.412
LIG_SH2_SRC 34 37 PF00017 0.372
LIG_SH2_STAP1 496 500 PF00017 0.352
LIG_SH2_STAP1 564 568 PF00017 0.351
LIG_SH2_STAP1 94 98 PF00017 0.328
LIG_SH2_STAT3 142 145 PF00017 0.379
LIG_SH2_STAT3 159 162 PF00017 0.411
LIG_SH2_STAT5 143 146 PF00017 0.284
LIG_SH2_STAT5 159 162 PF00017 0.294
LIG_SH2_STAT5 180 183 PF00017 0.281
LIG_SH2_STAT5 289 292 PF00017 0.360
LIG_SH2_STAT5 372 375 PF00017 0.417
LIG_SH2_STAT5 401 404 PF00017 0.381
LIG_SH2_STAT5 494 497 PF00017 0.396
LIG_SH2_STAT5 558 561 PF00017 0.357
LIG_SH2_STAT5 591 594 PF00017 0.330
LIG_SH2_STAT5 608 611 PF00017 0.595
LIG_SH2_STAT5 679 682 PF00017 0.397
LIG_SH2_STAT5 87 90 PF00017 0.385
LIG_SH2_STAT5 97 100 PF00017 0.395
LIG_SH3_3 638 644 PF00018 0.474
LIG_SH3_3 649 655 PF00018 0.262
LIG_SH3_3 724 730 PF00018 0.642
LIG_Sin3_3 14 21 PF02671 0.551
LIG_SUMO_SIM_anti_2 698 703 PF11976 0.299
LIG_SUMO_SIM_par_1 380 385 PF11976 0.355
LIG_TRAF2_1 593 596 PF00917 0.418
LIG_TYR_ITIM 298 303 PF00017 0.369
LIG_TYR_ITIM 490 495 PF00017 0.411
LIG_TYR_ITIM 589 594 PF00017 0.349
LIG_WRC_WIRS_1 88 93 PF05994 0.272
MOD_CDK_SPK_2 405 410 PF00069 0.284
MOD_CK1_1 202 208 PF00069 0.447
MOD_CK1_1 269 275 PF00069 0.376
MOD_CK1_1 294 300 PF00069 0.391
MOD_CK1_1 320 326 PF00069 0.416
MOD_CK1_1 356 362 PF00069 0.399
MOD_CK1_1 430 436 PF00069 0.387
MOD_CK1_1 611 617 PF00069 0.513
MOD_CK2_1 301 307 PF00069 0.445
MOD_GlcNHglycan 110 113 PF01048 0.584
MOD_GlcNHglycan 201 204 PF01048 0.561
MOD_GlcNHglycan 232 235 PF01048 0.589
MOD_GlcNHglycan 248 251 PF01048 0.561
MOD_GlcNHglycan 285 288 PF01048 0.589
MOD_GlcNHglycan 303 306 PF01048 0.418
MOD_GlcNHglycan 528 531 PF01048 0.694
MOD_GlcNHglycan 610 613 PF01048 0.705
MOD_GlcNHglycan 702 705 PF01048 0.454
MOD_GlcNHglycan 9 12 PF01048 0.750
MOD_GSK3_1 205 212 PF00069 0.333
MOD_GSK3_1 253 260 PF00069 0.382
MOD_GSK3_1 261 268 PF00069 0.324
MOD_GSK3_1 283 290 PF00069 0.350
MOD_GSK3_1 341 348 PF00069 0.323
MOD_GSK3_1 356 363 PF00069 0.402
MOD_GSK3_1 411 418 PF00069 0.334
MOD_GSK3_1 437 444 PF00069 0.401
MOD_GSK3_1 533 540 PF00069 0.424
MOD_GSK3_1 602 609 PF00069 0.464
MOD_GSK3_1 611 618 PF00069 0.474
MOD_GSK3_1 681 688 PF00069 0.429
MOD_GSK3_1 743 750 PF00069 0.755
MOD_GSK3_1 83 90 PF00069 0.335
MOD_N-GLC_1 130 135 PF02516 0.631
MOD_N-GLC_1 246 251 PF02516 0.568
MOD_N-GLC_1 356 361 PF02516 0.611
MOD_N-GLC_1 375 380 PF02516 0.503
MOD_N-GLC_1 404 409 PF02516 0.578
MOD_N-GLC_1 453 458 PF02516 0.566
MOD_N-GLC_1 470 475 PF02516 0.484
MOD_N-GLC_1 501 506 PF02516 0.618
MOD_N-GLC_1 509 514 PF02516 0.538
MOD_N-GLC_1 526 531 PF02516 0.596
MOD_N-GLC_1 533 538 PF02516 0.530
MOD_N-GLC_1 546 551 PF02516 0.449
MOD_N-GLC_1 633 638 PF02516 0.556
MOD_N-GLC_1 648 653 PF02516 0.542
MOD_N-GLC_1 660 665 PF02516 0.541
MOD_N-GLC_1 674 679 PF02516 0.527
MOD_N-GLC_1 681 686 PF02516 0.613
MOD_NEK2_1 136 141 PF00069 0.360
MOD_NEK2_1 181 186 PF00069 0.248
MOD_NEK2_1 228 233 PF00069 0.312
MOD_NEK2_1 246 251 PF00069 0.406
MOD_NEK2_1 261 266 PF00069 0.321
MOD_NEK2_1 281 286 PF00069 0.324
MOD_NEK2_1 374 379 PF00069 0.442
MOD_NEK2_1 428 433 PF00069 0.384
MOD_NEK2_1 442 447 PF00069 0.276
MOD_NEK2_1 526 531 PF00069 0.448
MOD_NEK2_1 532 537 PF00069 0.410
MOD_NEK2_1 546 551 PF00069 0.268
MOD_NEK2_1 662 667 PF00069 0.362
MOD_NEK2_2 124 129 PF00069 0.386
MOD_NEK2_2 648 653 PF00069 0.248
MOD_PIKK_1 158 164 PF00454 0.436
MOD_PIKK_1 181 187 PF00454 0.246
MOD_PIKK_1 202 208 PF00454 0.334
MOD_PK_1 275 281 PF00069 0.300
MOD_PKA_1 6 12 PF00069 0.532
MOD_PKA_2 117 123 PF00069 0.390
MOD_PKA_2 269 275 PF00069 0.431
MOD_PKA_2 6 12 PF00069 0.580
MOD_PKA_2 92 98 PF00069 0.315
MOD_PKB_1 721 729 PF00069 0.750
MOD_Plk_1 170 176 PF00069 0.351
MOD_Plk_1 294 300 PF00069 0.317
MOD_Plk_1 356 362 PF00069 0.401
MOD_Plk_1 374 380 PF00069 0.365
MOD_Plk_1 411 417 PF00069 0.360
MOD_Plk_1 501 507 PF00069 0.435
MOD_Plk_1 509 515 PF00069 0.347
MOD_Plk_1 546 552 PF00069 0.386
MOD_Plk_1 648 654 PF00069 0.324
MOD_Plk_1 660 666 PF00069 0.405
MOD_Plk_1 75 81 PF00069 0.431
MOD_Plk_2-3 412 418 PF00069 0.407
MOD_Plk_2-3 743 749 PF00069 0.725
MOD_Plk_4 137 143 PF00069 0.354
MOD_Plk_4 153 159 PF00069 0.290
MOD_Plk_4 257 263 PF00069 0.352
MOD_Plk_4 275 281 PF00069 0.449
MOD_Plk_4 345 351 PF00069 0.342
MOD_Plk_4 375 381 PF00069 0.380
MOD_Plk_4 415 421 PF00069 0.345
MOD_Plk_4 509 515 PF00069 0.461
MOD_Plk_4 546 552 PF00069 0.366
MOD_Plk_4 723 729 PF00069 0.751
MOD_Plk_4 76 82 PF00069 0.345
MOD_Plk_4 83 89 PF00069 0.349
MOD_Plk_4 93 99 PF00069 0.258
MOD_ProDKin_1 235 241 PF00069 0.428
MOD_ProDKin_1 320 326 PF00069 0.467
MOD_ProDKin_1 364 370 PF00069 0.421
MOD_ProDKin_1 405 411 PF00069 0.443
MOD_ProDKin_1 437 443 PF00069 0.402
MOD_ProDKin_1 534 540 PF00069 0.428
MOD_ProDKin_1 556 562 PF00069 0.439
MOD_ProDKin_1 602 608 PF00069 0.495
MOD_SUMO_rev_2 304 310 PF00179 0.455
TRG_DiLeu_BaEn_1 214 219 PF01217 0.330
TRG_DiLeu_BaEn_1 76 81 PF01217 0.394
TRG_DiLeu_BaLyEn_6 378 383 PF01217 0.308
TRG_ENDOCYTIC_2 300 303 PF00928 0.469
TRG_ENDOCYTIC_2 389 392 PF00928 0.409
TRG_ENDOCYTIC_2 401 404 PF00928 0.403
TRG_ENDOCYTIC_2 492 495 PF00928 0.360
TRG_ENDOCYTIC_2 564 567 PF00928 0.434
TRG_ENDOCYTIC_2 591 594 PF00928 0.450
TRG_ENDOCYTIC_2 97 100 PF00928 0.341
TRG_ER_diArg_1 5 7 PF00400 0.555
TRG_ER_diArg_1 721 723 PF00400 0.639
TRG_NLS_MonoCore_2 719 724 PF00514 0.628

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HWL9 Leptomonas seymouri 39% 100%
A0A1X0NRS2 Trypanosomatidae 30% 100%
A0A3Q8I8Q8 Leishmania donovani 100% 100%
A0A422NWY1 Trypanosoma rangeli 29% 100%
A4H654 Leishmania braziliensis 73% 100%
C9ZQ00 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 24% 92%
C9ZVJ3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 100%
C9ZVJ8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 100%
E9AN72 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 100%
Q4QHF3 Leishmania major 91% 100%
V5B409 Trypanosoma cruzi 27% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS