Putative endonuclease G

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

endonuclease G - putative

Species:

Leishmania infantum

UniProt:

A4HUH3_LEIIN

TriTrypDb:

LINF_100012900

Length:

507

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 9
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005743	mitochondrial inner membrane	5	1
GO:0016020	membrane	2	2
GO:0019866	organelle inner membrane	4	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4HUH3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HUH3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003824	catalytic activity	1	12
GO:0004518	nuclease activity	4	12
GO:0004519	endonuclease activity	5	12
GO:0005488	binding	1	12
GO:0016787	hydrolase activity	2	12
GO:0016788	hydrolase activity, acting on ester bonds	3	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12
GO:0000014	single-stranded DNA endodeoxyribonuclease activity	6	1
GO:0004520	DNA endonuclease activity	5	1
GO:0004521	RNA endonuclease activity	5	1
GO:0004536	DNA nuclease activity	4	1
GO:0004540	RNA nuclease activity	4	1
GO:0140097	catalytic activity, acting on DNA	3	1
GO:0140098	catalytic activity, acting on RNA	3	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	170	174	PF00656	0.490
CLV_C14_Caspase3-7	329	333	PF00656	0.420
CLV_NRD_NRD_1	128	130	PF00675	0.205
CLV_NRD_NRD_1	140	142	PF00675	0.205
CLV_NRD_NRD_1	147	149	PF00675	0.119
CLV_NRD_NRD_1	257	259	PF00675	0.234
CLV_PCSK_KEX2_1	128	130	PF00082	0.205
CLV_PCSK_KEX2_1	147	149	PF00082	0.119
CLV_PCSK_KEX2_1	33	35	PF00082	0.438
CLV_PCSK_PC1ET2_1	33	35	PF00082	0.457
CLV_PCSK_SKI1_1	370	374	PF00082	0.238
DOC_CKS1_1	82	87	PF01111	0.516
DOC_CYCLIN_yCln2_LP_2	74	80	PF00134	0.587
DOC_MAPK_gen_1	258	268	PF00069	0.479
DOC_MAPK_gen_1	33	39	PF00069	0.642
DOC_MAPK_gen_1	409	418	PF00069	0.436
DOC_MAPK_HePTP_8	256	268	PF00069	0.366
DOC_MAPK_MEF2A_6	259	268	PF00069	0.366
DOC_MAPK_MEF2A_6	339	348	PF00069	0.452
DOC_PP4_FxxP_1	387	390	PF00568	0.405
DOC_USP7_MATH_1	294	298	PF00917	0.512
DOC_USP7_MATH_1	327	331	PF00917	0.519
DOC_USP7_MATH_1	337	341	PF00917	0.512
DOC_USP7_MATH_1	363	367	PF00917	0.558
DOC_USP7_MATH_1	41	45	PF00917	0.678
DOC_USP7_MATH_1	438	442	PF00917	0.629
DOC_USP7_MATH_1	455	459	PF00917	0.436
DOC_USP7_MATH_1	51	55	PF00917	0.705
DOC_USP7_MATH_1	87	91	PF00917	0.644
DOC_WW_Pin1_4	148	153	PF00397	0.500
DOC_WW_Pin1_4	279	284	PF00397	0.532
DOC_WW_Pin1_4	357	362	PF00397	0.397
DOC_WW_Pin1_4	49	54	PF00397	0.686
DOC_WW_Pin1_4	81	86	PF00397	0.552
LIG_14-3-3_CanoR_1	380	385	PF00244	0.511
LIG_14-3-3_CanoR_1	43	53	PF00244	0.602
LIG_14-3-3_CanoR_1	463	467	PF00244	0.533
LIG_BIR_II_1	1	5	PF00653	0.401
LIG_BIR_III_2	437	441	PF00653	0.616
LIG_BRCT_BRCA1_1	365	369	PF00533	0.452
LIG_BRCT_BRCA1_1	440	444	PF00533	0.604
LIG_Clathr_ClatBox_1	312	316	PF01394	0.496
LIG_FHA_1	109	115	PF00498	0.492
LIG_FHA_1	255	261	PF00498	0.416
LIG_FHA_1	33	39	PF00498	0.653
LIG_FHA_1	347	353	PF00498	0.471
LIG_FHA_1	50	56	PF00498	0.693
LIG_Integrin_RGD_1	279	281	PF01839	0.213
LIG_Integrin_RGD_1	69	71	PF01839	0.400
LIG_LIR_Apic_2	401	406	PF02991	0.430
LIG_LIR_Gen_1	249	256	PF02991	0.416
LIG_LIR_Gen_1	465	474	PF02991	0.599
LIG_LIR_LC3C_4	35	39	PF02991	0.549
LIG_LIR_Nem_3	139	143	PF02991	0.452
LIG_LIR_Nem_3	22	27	PF02991	0.357
LIG_LIR_Nem_3	249	253	PF02991	0.405
LIG_LIR_Nem_3	366	372	PF02991	0.416
LIG_LIR_Nem_3	441	447	PF02991	0.541
LIG_LIR_Nem_3	465	469	PF02991	0.584
LIG_NRP_CendR_1	506	507	PF00754	0.348
LIG_SH2_CRK	140	144	PF00017	0.510
LIG_SH2_CRK	403	407	PF00017	0.416
LIG_SH2_CRK	447	451	PF00017	0.492
LIG_SH2_CRK	466	470	PF00017	0.515
LIG_SH2_STAP1	126	130	PF00017	0.426
LIG_SH2_STAP1	27	31	PF00017	0.698
LIG_SH2_STAT3	27	30	PF00017	0.628
LIG_SH2_STAT5	120	123	PF00017	0.486
LIG_SH2_STAT5	205	208	PF00017	0.439
LIG_SH2_STAT5	301	304	PF00017	0.489
LIG_SH3_3	146	152	PF00018	0.535
LIG_SH3_3	300	306	PF00018	0.412
LIG_SH3_3	321	327	PF00018	0.442
LIG_SH3_3	35	41	PF00018	0.599
LIG_SH3_3	359	365	PF00018	0.416
LIG_SH3_3	387	393	PF00018	0.405
LIG_SH3_3	75	81	PF00018	0.572
LIG_SUMO_SIM_par_1	360	366	PF11976	0.509
LIG_TYR_ITIM	138	143	PF00017	0.510
MOD_CK1_1	172	178	PF00069	0.563
MOD_CK1_1	204	210	PF00069	0.516
MOD_CK1_1	32	38	PF00069	0.657
MOD_CK1_1	44	50	PF00069	0.644
MOD_CK1_1	54	60	PF00069	0.728
MOD_CK1_1	64	70	PF00069	0.721
MOD_CK1_1	90	96	PF00069	0.519
MOD_CK2_1	107	113	PF00069	0.505
MOD_CK2_1	221	227	PF00069	0.408
MOD_Cter_Amidation	145	148	PF01082	0.220
MOD_DYRK1A_RPxSP_1	148	152	PF00069	0.452
MOD_GlcNHglycan	1	4	PF01048	0.579
MOD_GlcNHglycan	144	147	PF01048	0.308
MOD_GlcNHglycan	296	299	PF01048	0.310
MOD_GlcNHglycan	329	332	PF01048	0.272
MOD_GlcNHglycan	339	342	PF01048	0.233
MOD_GlcNHglycan	440	443	PF01048	0.330
MOD_GlcNHglycan	471	474	PF01048	0.396
MOD_GlcNHglycan	56	59	PF01048	0.412
MOD_GSK3_1	179	186	PF00069	0.484
MOD_GSK3_1	204	211	PF00069	0.449
MOD_GSK3_1	25	32	PF00069	0.571
MOD_GSK3_1	254	261	PF00069	0.472
MOD_GSK3_1	346	353	PF00069	0.509
MOD_GSK3_1	41	48	PF00069	0.619
MOD_GSK3_1	57	64	PF00069	0.633
MOD_N-GLC_1	183	188	PF02516	0.345
MOD_N-GLC_1	49	54	PF02516	0.473
MOD_NEK2_1	1	6	PF00069	0.385
MOD_NEK2_1	19	24	PF00069	0.228
MOD_NEK2_1	228	233	PF00069	0.414
MOD_NEK2_1	422	427	PF00069	0.521
MOD_NEK2_1	430	435	PF00069	0.505
MOD_NEK2_1	45	50	PF00069	0.639
MOD_NEK2_1	462	467	PF00069	0.581
MOD_NEK2_1	469	474	PF00069	0.614
MOD_PIKK_1	221	227	PF00454	0.472
MOD_PIKK_1	26	32	PF00454	0.652
MOD_PIKK_1	61	67	PF00454	0.652
MOD_PK_1	262	268	PF00069	0.452
MOD_PK_1	380	386	PF00069	0.469
MOD_PKA_1	147	153	PF00069	0.452
MOD_PKA_1	258	264	PF00069	0.472
MOD_PKA_2	147	153	PF00069	0.452
MOD_PKA_2	411	417	PF00069	0.440
MOD_PKA_2	438	444	PF00069	0.559
MOD_PKA_2	462	468	PF00069	0.584
MOD_Plk_1	190	196	PF00069	0.430
MOD_Plk_1	228	234	PF00069	0.440
MOD_Plk_1	241	247	PF00069	0.367
MOD_Plk_1	262	268	PF00069	0.509
MOD_Plk_1	422	428	PF00069	0.519
MOD_Plk_4	51	57	PF00069	0.577
MOD_ProDKin_1	148	154	PF00069	0.500
MOD_ProDKin_1	279	285	PF00069	0.532
MOD_ProDKin_1	357	363	PF00069	0.397
MOD_ProDKin_1	49	55	PF00069	0.688
MOD_ProDKin_1	81	87	PF00069	0.557
MOD_SUMO_for_1	289	292	PF00179	0.366
TRG_DiLeu_BaLyEn_6	6	11	PF01217	0.261
TRG_ENDOCYTIC_2	140	143	PF00928	0.510
TRG_ENDOCYTIC_2	447	450	PF00928	0.468
TRG_ENDOCYTIC_2	466	469	PF00928	0.511
TRG_ER_diArg_1	128	130	PF00400	0.445
TRG_ER_diArg_1	147	149	PF00400	0.319
TRG_ER_diArg_1	276	279	PF00400	0.521
TRG_NES_CRM1_1	254	270	PF08389	0.509
TRG_Pf-PMV_PEXEL_1	258	263	PF00026	0.252

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK94	Leptomonas seymouri	62%	100%
A0A0S4JFH6	Bodo saltans	38%	100%
A0A1X0NQR8	Trypanosomatidae	39%	100%
A0A3Q8I8T5	Leishmania donovani	100%	100%
A0A422NX36	Trypanosoma rangeli	40%	100%
A4H653	Leishmania braziliensis	81%	99%
C9ZVJ7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AN71	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q0IH72	Xenopus laevis	26%	100%
Q4QHF4	Leishmania major	94%	100%
Q502K1	Danio rerio	28%	100%
Q8C163	Mus musculus	26%	100%
Q9Y2C4	Homo sapiens	26%	100%
V5BJI6	Trypanosoma cruzi	39%	100%