LeishMANIAdb
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Putative endonuclease G

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative endonuclease G
Gene product:
endonuclease G - putative
Species:
Leishmania infantum
UniProt:
A4HUH3_LEIIN
TriTrypDb:
LINF_100012900
Length:
507

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 2, no: 9
NetGPI no yes: 0, no: 11
Cellular components
TermNameLevelCount
GO:0005634 nucleus 5 1
GO:0005743 mitochondrial inner membrane 5 1
GO:0016020 membrane 2 2
GO:0019866 organelle inner membrane 4 1
GO:0031090 organelle membrane 3 1
GO:0031966 mitochondrial membrane 4 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
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Expansion

Sequence features

A4HUH3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HUH3

Function

Could not find GO biological_process term for this entry.
Molecular functions
TermNameLevelCount
GO:0000014 single-stranded DNA endodeoxyribonuclease activity 6 1
GO:0003676 nucleic acid binding 3 12
GO:0003824 catalytic activity 1 12
GO:0004518 nuclease activity 4 12
GO:0004519 endonuclease activity 5 12
GO:0004520 DNA endonuclease activity 5 1
GO:0004521 RNA endonuclease activity 5 1
GO:0004536 DNA nuclease activity 4 1
GO:0004540 RNA nuclease activity 4 1
GO:0005488 binding 1 12
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 170 174 PF00656 0.490
CLV_C14_Caspase3-7 329 333 PF00656 0.420
CLV_NRD_NRD_1 128 130 PF00675 0.205
CLV_NRD_NRD_1 140 142 PF00675 0.205
CLV_NRD_NRD_1 147 149 PF00675 0.119
CLV_NRD_NRD_1 257 259 PF00675 0.234
CLV_PCSK_KEX2_1 128 130 PF00082 0.205
CLV_PCSK_KEX2_1 147 149 PF00082 0.119
CLV_PCSK_KEX2_1 33 35 PF00082 0.438
CLV_PCSK_PC1ET2_1 33 35 PF00082 0.457
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1IK94 Leptomonas seymouri 62% 100%
A0A0S4JFH6 Bodo saltans 38% 100%
A0A1X0NQR8 Trypanosomatidae 39% 100%
A0A3Q8I8T5 Leishmania donovani 100% 100%
A0A422NX36 Trypanosoma rangeli 40% 100%
A4H653 Leishmania braziliensis 81% 99%
C9ZVJ7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 38% 100%
E9AN71 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
Q0IH72 Xenopus laevis 26% 100%
Q4QHF4 Leishmania major 94% 100%
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Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS