Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HUG5_LEIIN

TriTrypDb:

LINF_100012100

Length:

1155

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HUG5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HUG5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1043	1047	PF00656	0.559
CLV_C14_Caspase3-7	742	746	PF00656	0.668
CLV_NRD_NRD_1	109	111	PF00675	0.597
CLV_NRD_NRD_1	245	247	PF00675	0.536
CLV_NRD_NRD_1	258	260	PF00675	0.580
CLV_NRD_NRD_1	380	382	PF00675	0.511
CLV_NRD_NRD_1	399	401	PF00675	0.514
CLV_NRD_NRD_1	470	472	PF00675	0.580
CLV_NRD_NRD_1	633	635	PF00675	0.576
CLV_NRD_NRD_1	657	659	PF00675	0.564
CLV_NRD_NRD_1	724	726	PF00675	0.477
CLV_NRD_NRD_1	732	734	PF00675	0.455
CLV_PCSK_KEX2_1	109	111	PF00082	0.597
CLV_PCSK_KEX2_1	245	247	PF00082	0.480
CLV_PCSK_KEX2_1	258	260	PF00082	0.536
CLV_PCSK_KEX2_1	321	323	PF00082	0.487
CLV_PCSK_KEX2_1	398	400	PF00082	0.536
CLV_PCSK_KEX2_1	470	472	PF00082	0.580
CLV_PCSK_KEX2_1	578	580	PF00082	0.720
CLV_PCSK_KEX2_1	633	635	PF00082	0.577
CLV_PCSK_KEX2_1	657	659	PF00082	0.564
CLV_PCSK_KEX2_1	724	726	PF00082	0.477
CLV_PCSK_KEX2_1	732	734	PF00082	0.455
CLV_PCSK_PC1ET2_1	321	323	PF00082	0.487
CLV_PCSK_PC1ET2_1	578	580	PF00082	0.699
CLV_PCSK_PC7_1	574	580	PF00082	0.686
CLV_PCSK_PC7_1	629	635	PF00082	0.555
CLV_PCSK_SKI1_1	237	241	PF00082	0.425
CLV_PCSK_SKI1_1	305	309	PF00082	0.649
CLV_PCSK_SKI1_1	382	386	PF00082	0.410
CLV_PCSK_SKI1_1	501	505	PF00082	0.492
CLV_PCSK_SKI1_1	623	627	PF00082	0.500
CLV_PCSK_SKI1_1	72	76	PF00082	0.728
CLV_PCSK_SKI1_1	782	786	PF00082	0.588
CLV_PCSK_SKI1_1	794	798	PF00082	0.441
CLV_PCSK_SKI1_1	810	814	PF00082	0.386
CLV_PCSK_SKI1_1	908	912	PF00082	0.643
CLV_Separin_Metazoa	106	110	PF03568	0.610
CLV_Separin_Metazoa	27	31	PF03568	0.574
CLV_Separin_Metazoa	50	54	PF03568	0.556
DEG_APCC_DBOX_1	236	244	PF00400	0.524
DEG_APCC_DBOX_1	692	700	PF00400	0.530
DEG_APCC_KENBOX_2	1017	1021	PF00400	0.647
DEG_APCC_KENBOX_2	222	226	PF00400	0.440
DEG_Nend_UBRbox_3	1	3	PF02207	0.697
DEG_SCF_FBW7_1	8	15	PF00400	0.577
DEG_SPOP_SBC_1	1012	1016	PF00917	0.651
DEG_SPOP_SBC_1	1023	1027	PF00917	0.624
DOC_CKS1_1	1092	1097	PF01111	0.757
DOC_CKS1_1	871	876	PF01111	0.628
DOC_CYCLIN_RxL_1	234	244	PF00134	0.526
DOC_CYCLIN_RxL_1	486	498	PF00134	0.539
DOC_MAPK_gen_1	417	424	PF00069	0.628
DOC_MAPK_RevD_3	384	400	PF00069	0.417
DOC_PP2B_LxvP_1	1033	1036	PF13499	0.561
DOC_PP2B_LxvP_1	991	994	PF13499	0.713
DOC_PP4_FxxP_1	545	548	PF00568	0.582
DOC_USP7_MATH_1	102	106	PF00917	0.524
DOC_USP7_MATH_1	1023	1027	PF00917	0.634
DOC_USP7_MATH_1	1036	1040	PF00917	0.591
DOC_USP7_MATH_1	1042	1046	PF00917	0.526
DOC_USP7_MATH_1	1064	1068	PF00917	0.663
DOC_USP7_MATH_1	1108	1112	PF00917	0.741
DOC_USP7_MATH_1	1117	1121	PF00917	0.755
DOC_USP7_MATH_1	18	22	PF00917	0.675
DOC_USP7_MATH_1	285	289	PF00917	0.489
DOC_USP7_MATH_1	300	304	PF00917	0.614
DOC_USP7_MATH_1	452	456	PF00917	0.493
DOC_USP7_MATH_1	585	589	PF00917	0.819
DOC_USP7_MATH_1	656	660	PF00917	0.551
DOC_USP7_MATH_1	753	757	PF00917	0.646
DOC_USP7_MATH_1	875	879	PF00917	0.715
DOC_USP7_MATH_1	95	99	PF00917	0.636
DOC_USP7_MATH_1	961	965	PF00917	0.696
DOC_WW_Pin1_4	1026	1031	PF00397	0.718
DOC_WW_Pin1_4	1091	1096	PF00397	0.742
DOC_WW_Pin1_4	1131	1136	PF00397	0.765
DOC_WW_Pin1_4	12	17	PF00397	0.619
DOC_WW_Pin1_4	158	163	PF00397	0.655
DOC_WW_Pin1_4	4	9	PF00397	0.641
DOC_WW_Pin1_4	521	526	PF00397	0.730
DOC_WW_Pin1_4	595	600	PF00397	0.670
DOC_WW_Pin1_4	870	875	PF00397	0.618
DOC_WW_Pin1_4	879	884	PF00397	0.712
DOC_WW_Pin1_4	949	954	PF00397	0.679
DOC_WW_Pin1_4	989	994	PF00397	0.651
LIG_14-3-3_CanoR_1	1010	1017	PF00244	0.556
LIG_14-3-3_CanoR_1	199	203	PF00244	0.414
LIG_14-3-3_CanoR_1	227	233	PF00244	0.552
LIG_14-3-3_CanoR_1	268	273	PF00244	0.446
LIG_14-3-3_CanoR_1	356	362	PF00244	0.468
LIG_14-3-3_CanoR_1	369	375	PF00244	0.406
LIG_14-3-3_CanoR_1	38	47	PF00244	0.602
LIG_14-3-3_CanoR_1	419	425	PF00244	0.575
LIG_14-3-3_CanoR_1	617	626	PF00244	0.565
LIG_14-3-3_CanoR_1	657	661	PF00244	0.512
LIG_14-3-3_CanoR_1	670	675	PF00244	0.537
LIG_14-3-3_CanoR_1	683	692	PF00244	0.446
LIG_14-3-3_CanoR_1	693	697	PF00244	0.487
LIG_14-3-3_CanoR_1	761	769	PF00244	0.521
LIG_14-3-3_CanoR_1	782	791	PF00244	0.436
LIG_14-3-3_CanoR_1	827	835	PF00244	0.530
LIG_14-3-3_CanoR_1	850	855	PF00244	0.517
LIG_Actin_WH2_2	354	371	PF00022	0.447
LIG_APCC_ABBA_1	493	498	PF00400	0.538
LIG_APCC_ABBA_1	597	602	PF00400	0.600
LIG_BIR_III_2	984	988	PF00653	0.638
LIG_EVH1_1	1132	1136	PF00568	0.636
LIG_FHA_1	174	180	PF00498	0.511
LIG_FHA_1	260	266	PF00498	0.509
LIG_FHA_1	46	52	PF00498	0.522
LIG_FHA_1	669	675	PF00498	0.508
LIG_FHA_1	684	690	PF00498	0.295
LIG_FHA_1	761	767	PF00498	0.524
LIG_FHA_1	787	793	PF00498	0.419
LIG_FHA_1	884	890	PF00498	0.662
LIG_FHA_1	901	907	PF00498	0.628
LIG_FHA_1	997	1003	PF00498	0.689
LIG_FHA_2	1014	1020	PF00498	0.560
LIG_FHA_2	1041	1047	PF00498	0.809
LIG_FHA_2	219	225	PF00498	0.569
LIG_FHA_2	441	447	PF00498	0.533
LIG_FHA_2	640	646	PF00498	0.518
LIG_FHA_2	692	698	PF00498	0.530
LIG_FHA_2	740	746	PF00498	0.589
LIG_LIR_Apic_2	542	548	PF02991	0.724
LIG_LIR_Gen_1	602	612	PF02991	0.448
LIG_LIR_Nem_3	602	607	PF02991	0.581
LIG_OCRL_FandH_1	603	615	PF00620	0.508
LIG_PDZ_Class_3	1150	1155	PF00595	0.649
LIG_Pex14_1	839	843	PF04695	0.544
LIG_PTAP_UEV_1	1078	1083	PF05743	0.634
LIG_SH2_STAP1	685	689	PF00017	0.481
LIG_SH2_STAT5	685	688	PF00017	0.531
LIG_SH2_STAT5	772	775	PF00017	0.435
LIG_SH2_STAT5	791	794	PF00017	0.427
LIG_SH3_3	1035	1041	PF00018	0.694
LIG_SH3_3	1076	1082	PF00018	0.779
LIG_SH3_3	1089	1095	PF00018	0.706
LIG_SH3_3	1130	1136	PF00018	0.659
LIG_SH3_3	159	165	PF00018	0.655
LIG_SH3_3	456	462	PF00018	0.514
LIG_SH3_3	868	874	PF00018	0.516
LIG_SH3_3	91	97	PF00018	0.614
LIG_SH3_3	944	950	PF00018	0.727
LIG_SH3_3	968	974	PF00018	0.799
LIG_SUMO_SIM_anti_2	507	515	PF11976	0.503
LIG_SUMO_SIM_par_1	507	515	PF11976	0.576
LIG_TRAF2_1	1067	1070	PF00917	0.774
LIG_TRAF2_1	1124	1127	PF00917	0.644
LIG_TRAF2_1	24	27	PF00917	0.566
LIG_TRAF2_1	464	467	PF00917	0.568
LIG_TRAF2_1	651	654	PF00917	0.565
LIG_UBA3_1	215	223	PF00899	0.547
LIG_WRC_WIRS_1	195	200	PF05994	0.478
MOD_CDK_SPxK_1	595	601	PF00069	0.613
MOD_CK1_1	1013	1019	PF00069	0.728
MOD_CK1_1	1026	1032	PF00069	0.586
MOD_CK1_1	1074	1080	PF00069	0.821
MOD_CK1_1	1134	1140	PF00069	0.708
MOD_CK1_1	157	163	PF00069	0.559
MOD_CK1_1	331	337	PF00069	0.613
MOD_CK1_1	430	436	PF00069	0.566
MOD_CK1_1	539	545	PF00069	0.558
MOD_CK1_1	592	598	PF00069	0.651
MOD_CK1_1	603	609	PF00069	0.551
MOD_CK1_1	641	647	PF00069	0.586
MOD_CK1_1	687	693	PF00069	0.498
MOD_CK1_1	7	13	PF00069	0.751
MOD_CK1_1	739	745	PF00069	0.661
MOD_CK1_1	879	885	PF00069	0.707
MOD_CK1_1	952	958	PF00069	0.741
MOD_CK1_1	976	982	PF00069	0.813
MOD_CK1_1	98	104	PF00069	0.445
MOD_CK2_1	1013	1019	PF00069	0.566
MOD_CK2_1	1064	1070	PF00069	0.764
MOD_CK2_1	1135	1141	PF00069	0.834
MOD_CK2_1	197	203	PF00069	0.567
MOD_CK2_1	218	224	PF00069	0.566
MOD_CK2_1	430	436	PF00069	0.586
MOD_CK2_1	440	446	PF00069	0.555
MOD_CK2_1	639	645	PF00069	0.515
MOD_CK2_1	691	697	PF00069	0.534
MOD_Cter_Amidation	576	579	PF01082	0.692
MOD_GlcNHglycan	100	103	PF01048	0.418
MOD_GlcNHglycan	1033	1036	PF01048	0.682
MOD_GlcNHglycan	1038	1041	PF01048	0.656
MOD_GlcNHglycan	1072	1076	PF01048	0.790
MOD_GlcNHglycan	1079	1082	PF01048	0.750
MOD_GlcNHglycan	1137	1140	PF01048	0.788
MOD_GlcNHglycan	21	24	PF01048	0.494
MOD_GlcNHglycan	274	279	PF01048	0.585
MOD_GlcNHglycan	4	7	PF01048	0.714
MOD_GlcNHglycan	454	457	PF01048	0.590
MOD_GlcNHglycan	538	541	PF01048	0.628
MOD_GlcNHglycan	587	590	PF01048	0.752
MOD_GlcNHglycan	686	689	PF01048	0.495
MOD_GlcNHglycan	755	758	PF01048	0.694
MOD_GlcNHglycan	814	818	PF01048	0.529
MOD_GlcNHglycan	828	831	PF01048	0.391
MOD_GlcNHglycan	878	881	PF01048	0.678
MOD_GlcNHglycan	894	898	PF01048	0.693
MOD_GlcNHglycan	947	950	PF01048	0.704
MOD_GSK3_1	1008	1015	PF00069	0.606
MOD_GSK3_1	1022	1029	PF00069	0.551
MOD_GSK3_1	1036	1043	PF00069	0.585
MOD_GSK3_1	1087	1094	PF00069	0.677
MOD_GSK3_1	1113	1120	PF00069	0.771
MOD_GSK3_1	1131	1138	PF00069	0.523
MOD_GSK3_1	14	21	PF00069	0.695
MOD_GSK3_1	154	161	PF00069	0.547
MOD_GSK3_1	187	194	PF00069	0.515
MOD_GSK3_1	305	312	PF00069	0.655
MOD_GSK3_1	327	334	PF00069	0.635
MOD_GSK3_1	4	11	PF00069	0.726
MOD_GSK3_1	420	427	PF00069	0.594
MOD_GSK3_1	536	543	PF00069	0.649
MOD_GSK3_1	585	592	PF00069	0.759
MOD_GSK3_1	665	672	PF00069	0.546
MOD_GSK3_1	683	690	PF00069	0.469
MOD_GSK3_1	741	748	PF00069	0.699
MOD_GSK3_1	778	785	PF00069	0.497
MOD_GSK3_1	875	882	PF00069	0.615
MOD_GSK3_1	945	952	PF00069	0.658
MOD_GSK3_1	973	980	PF00069	0.778
MOD_GSK3_1	98	105	PF00069	0.476
MOD_GSK3_1	992	999	PF00069	0.770
MOD_N-GLC_1	228	233	PF02516	0.456
MOD_N-GLC_1	585	590	PF02516	0.627
MOD_N-GLC_1	883	888	PF02516	0.617
MOD_NEK2_1	1	6	PF00069	0.696
MOD_NEK2_1	154	159	PF00069	0.609
MOD_NEK2_1	368	373	PF00069	0.474
MOD_NEK2_1	420	425	PF00069	0.495
MOD_NEK2_1	618	623	PF00069	0.547
MOD_NEK2_1	639	644	PF00069	0.554
MOD_NEK2_1	691	696	PF00069	0.505
MOD_NEK2_1	813	818	PF00069	0.494
MOD_NEK2_1	900	905	PF00069	0.587
MOD_NEK2_2	218	223	PF00069	0.434
MOD_NEK2_2	300	305	PF00069	0.380
MOD_NEK2_2	440	445	PF00069	0.536
MOD_PIKK_1	1065	1071	PF00454	0.663
MOD_PIKK_1	1117	1123	PF00454	0.716
MOD_PIKK_1	305	311	PF00454	0.525
MOD_PIKK_1	368	374	PF00454	0.445
MOD_PIKK_1	45	51	PF00454	0.523
MOD_PIKK_1	611	617	PF00454	0.491
MOD_PIKK_1	67	73	PF00454	0.500
MOD_PIKK_1	782	788	PF00454	0.489
MOD_PK_1	850	856	PF00069	0.555
MOD_PKA_1	578	584	PF00069	0.645
MOD_PKA_2	173	179	PF00069	0.438
MOD_PKA_2	198	204	PF00069	0.416
MOD_PKA_2	368	374	PF00069	0.438
MOD_PKA_2	45	51	PF00069	0.579
MOD_PKA_2	512	518	PF00069	0.689
MOD_PKA_2	578	584	PF00069	0.711
MOD_PKA_2	600	606	PF00069	0.520
MOD_PKA_2	656	662	PF00069	0.535
MOD_PKA_2	669	675	PF00069	0.539
MOD_PKA_2	692	698	PF00069	0.501
MOD_PKA_2	760	766	PF00069	0.599
MOD_PKA_2	826	832	PF00069	0.447
MOD_PKA_2	95	101	PF00069	0.536
MOD_PKB_1	266	274	PF00069	0.417
MOD_Plk_1	154	160	PF00069	0.615
MOD_Plk_1	228	234	PF00069	0.456
MOD_Plk_1	253	259	PF00069	0.597
MOD_Plk_1	30	36	PF00069	0.515
MOD_Plk_1	593	599	PF00069	0.677
MOD_Plk_1	786	792	PF00069	0.489
MOD_Plk_1	893	899	PF00069	0.671
MOD_Plk_2-3	1148	1154	PF00069	0.566
MOD_Plk_4	454	460	PF00069	0.511
MOD_Plk_4	600	606	PF00069	0.534
MOD_Plk_4	687	693	PF00069	0.490
MOD_Plk_4	787	793	PF00069	0.544
MOD_Plk_4	850	856	PF00069	0.490
MOD_Plk_4	857	863	PF00069	0.502
MOD_Plk_4	95	101	PF00069	0.665
MOD_Plk_4	992	998	PF00069	0.634
MOD_ProDKin_1	1026	1032	PF00069	0.721
MOD_ProDKin_1	1091	1097	PF00069	0.740
MOD_ProDKin_1	1131	1137	PF00069	0.706
MOD_ProDKin_1	12	18	PF00069	0.613
MOD_ProDKin_1	158	164	PF00069	0.654
MOD_ProDKin_1	4	10	PF00069	0.643
MOD_ProDKin_1	521	527	PF00069	0.732
MOD_ProDKin_1	595	601	PF00069	0.667
MOD_ProDKin_1	870	876	PF00069	0.626
MOD_ProDKin_1	879	885	PF00069	0.714
MOD_ProDKin_1	949	955	PF00069	0.680
MOD_ProDKin_1	989	995	PF00069	0.652
MOD_SUMO_for_1	272	275	PF00179	0.362
MOD_SUMO_for_1	475	478	PF00179	0.432
MOD_SUMO_rev_2	1141	1151	PF00179	0.660
MOD_SUMO_rev_2	255	265	PF00179	0.515
MOD_SUMO_rev_2	397	406	PF00179	0.501
MOD_SUMO_rev_2	836	841	PF00179	0.450
TRG_DiLeu_BaEn_1	143	148	PF01217	0.553
TRG_DiLeu_BaEn_1	175	180	PF01217	0.508
TRG_DiLeu_BaEn_1	416	421	PF01217	0.561
TRG_DiLeu_BaEn_1	505	510	PF01217	0.543
TRG_DiLeu_BaEn_1	929	934	PF01217	0.464
TRG_DiLeu_BaEn_4	260	266	PF01217	0.479
TRG_DiLeu_BaEn_4	313	319	PF01217	0.542
TRG_DiLeu_BaEn_4	401	407	PF01217	0.456
TRG_DiLeu_BaLyEn_6	614	619	PF01217	0.519
TRG_DiLeu_LyEn_5	416	421	PF01217	0.561
TRG_ENDOCYTIC_2	843	846	PF00928	0.579
TRG_ER_diArg_1	108	110	PF00400	0.599
TRG_ER_diArg_1	257	259	PF00400	0.609
TRG_ER_diArg_1	398	400	PF00400	0.536
TRG_ER_diArg_1	469	471	PF00400	0.585
TRG_ER_diArg_1	633	635	PF00400	0.587
TRG_ER_diArg_1	731	733	PF00400	0.590
TRG_NES_CRM1_1	923	937	PF08389	0.466
TRG_NLS_MonoExtC_3	320	326	PF00514	0.491
TRG_Pf-PMV_PEXEL_1	171	175	PF00026	0.556
TRG_Pf-PMV_PEXEL_1	237	241	PF00026	0.529
TRG_Pf-PMV_PEXEL_1	251	255	PF00026	0.533
TRG_Pf-PMV_PEXEL_1	263	267	PF00026	0.404
TRG_Pf-PMV_PEXEL_1	305	309	PF00026	0.656
TRG_Pf-PMV_PEXEL_1	352	357	PF00026	0.450
TRG_Pf-PMV_PEXEL_1	442	446	PF00026	0.519
TRG_Pf-PMV_PEXEL_1	501	505	PF00026	0.511
TRG_Pf-PMV_PEXEL_1	623	627	PF00026	0.497
TRG_Pf-PMV_PEXEL_1	72	76	PF00026	0.655
TRG_Pf-PMV_PEXEL_1	822	826	PF00026	0.482
TRG_Pf-PMV_PEXEL_1	865	869	PF00026	0.555

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5I9	Leptomonas seymouri	61%	100%
A0A1X0NQ72	Trypanosomatidae	28%	100%
A0A3R7KN13	Trypanosoma rangeli	30%	100%
A0A3S7WR55	Leishmania donovani	100%	100%
A4H645	Leishmania braziliensis	81%	100%
E9AN63	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QHG2	Leishmania major	92%	99%
V5BB18	Trypanosoma cruzi	29%	100%