Leishmanolysin

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Leishmanolysin

Gene product:

GP63 - leishmanolysin

Species:

Leishmania infantum

UniProt:

A4HUF9_LEIIN

TriTrypDb:

LINF_100011200

Length:

641

Annotations

LeishMANIAdb annotations

Publication identifier(s): 31356625
GPI-anchored cell surface protease. Broad-spectrum ectoenzyme involved in pathogenesis. Heavily expanded family in all parazitic species.. Localization: Cell surface (experimental)

LeishMANIAdb interaction annotations

by homology
Contact email: albert.descoteaux@iaf.inrs.ca
Publication title: The host cell secretory pathway mediates the export of Leishmania virulence factors out of the parasitophorous vacuole
Publication 1st author(s): Amandine Isnard
Publication Identifier(s): 25826301
Host organism: -1
Interaction detection method(s): protease assay
Interaction type: physical association
Identification method participant A: monoclonal antibody western blot
Identification method participant B: monoclonal antibody western blot
ID(s) interactor A: P05627
ID(s) interactor B: P08148
Taxid interactor A: Mus musculus
Taxid interactor B: Leishmania major
Biological role(s) interactor A: enzyme
Biological role(s) interactor B: enzyme target
Experimental role(s) interactor A: neutral component

Annotations by Jardim et al.

Plasma membrane, GP63, leishmanolysin GP63-3

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 51

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 41, no: 8
NetGPI	no	yes: 0, no: 49

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	50
GO:0110165	cellular anatomical entity	1	50
GO:0005737	cytoplasm	2	4
GO:0018995	host cellular component	2	4
GO:0033643	host cell part	3	4
GO:0033646	host intracellular part	4	4
GO:0033647	host intracellular organelle	5	4
GO:0033648	host intracellular membrane-bounded organelle	6	4
GO:0042025	host cell nucleus	7	4

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4HUF9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HUF9

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	50
GO:0006807	nitrogen compound metabolic process	2	50
GO:0007155	cell adhesion	2	50
GO:0008152	metabolic process	1	50
GO:0009987	cellular process	1	50
GO:0019538	protein metabolic process	3	50
GO:0043170	macromolecule metabolic process	3	50
GO:0044238	primary metabolic process	2	50
GO:0071704	organic substance metabolic process	2	50
GO:1901564	organonitrogen compound metabolic process	3	50
GO:0009966	regulation of signal transduction	4	4
GO:0010646	regulation of cell communication	4	4
GO:0010749	regulation of nitric oxide mediated signal transduction	6	4
GO:0023051	regulation of signaling	3	4
GO:0035821	modulation of process of another organism	2	4
GO:0044003	modulation by symbiont of host process	3	4
GO:0044068	modulation by symbiont of host cellular process	4	4
GO:0044081	modulation by symbiont of host nitric oxide-mediated signal transduction	5	4
GO:0044403	biological process involved in symbiotic interaction	2	4
GO:0044419	biological process involved in interspecies interaction between organisms	1	4
GO:0044501	modulation of signal transduction in another organism	3	4
GO:0048583	regulation of response to stimulus	3	4
GO:0050789	regulation of biological process	2	4
GO:0050794	regulation of cellular process	3	4
GO:0051701	biological process involved in interaction with host	3	4
GO:0052027	modulation by symbiont of host signal transduction pathway	4	4
GO:0065007	biological regulation	1	4
GO:0075130	modulation by symbiont of host protein kinase-mediated signal transduction	5	4
GO:1902531	regulation of intracellular signal transduction	5	4

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	50
GO:0004175	endopeptidase activity	4	50
GO:0004222	metalloendopeptidase activity	5	50
GO:0005488	binding	1	50
GO:0008233	peptidase activity	3	50
GO:0008237	metallopeptidase activity	4	50
GO:0016787	hydrolase activity	2	50
GO:0043167	ion binding	2	50
GO:0043169	cation binding	3	50
GO:0046872	metal ion binding	4	50
GO:0140096	catalytic activity, acting on a protein	2	50
GO:0008047	enzyme activator activity	3	4
GO:0008160	protein tyrosine phosphatase activator activity	6	4
GO:0019208	phosphatase regulator activity	3	4
GO:0019211	phosphatase activator activity	4	4
GO:0019888	protein phosphatase regulator activity	4	4
GO:0030234	enzyme regulator activity	2	4
GO:0072542	protein phosphatase activator activity	5	4
GO:0098772	molecular function regulator activity	1	4
GO:0140677	molecular function activator activity	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	582	586	PF00656	0.297
CLV_NRD_NRD_1	89	91	PF00675	0.384
CLV_PCSK_KEX2_1	149	151	PF00082	0.522
CLV_PCSK_KEX2_1	89	91	PF00082	0.384
CLV_PCSK_PC1ET2_1	149	151	PF00082	0.510
CLV_PCSK_SKI1_1	150	154	PF00082	0.499
CLV_PCSK_SKI1_1	257	261	PF00082	0.502
CLV_PCSK_SKI1_1	335	339	PF00082	0.438
CLV_PCSK_SKI1_1	393	397	PF00082	0.415
CLV_PCSK_SKI1_1	568	572	PF00082	0.386
DEG_APCC_DBOX_1	537	545	PF00400	0.271
DEG_SPOP_SBC_1	3	7	PF00917	0.588
DOC_CKS1_1	427	432	PF01111	0.162
DOC_CYCLIN_yCln2_LP_2	115	121	PF00134	0.230
DOC_CYCLIN_yCln2_LP_2	341	347	PF00134	0.244
DOC_MAPK_gen_1	287	295	PF00069	0.282
DOC_PP2B_LxvP_1	341	344	PF13499	0.326
DOC_PP4_FxxP_1	191	194	PF00568	0.347
DOC_USP7_MATH_1	574	578	PF00917	0.252
DOC_WW_Pin1_4	426	431	PF00397	0.168
DOC_WW_Pin1_4	444	449	PF00397	0.162
DOC_WW_Pin1_4	531	536	PF00397	0.351
LIG_14-3-3_CanoR_1	10	15	PF00244	0.576
LIG_14-3-3_CanoR_1	107	115	PF00244	0.332
LIG_14-3-3_CanoR_1	425	430	PF00244	0.207
LIG_14-3-3_CanoR_1	518	523	PF00244	0.333
LIG_14-3-3_CanoR_1	56	62	PF00244	0.322
LIG_14-3-3_CanoR_1	63	68	PF00244	0.253
LIG_APCC_ABBA_1	162	167	PF00400	0.351
LIG_APCC_ABBA_1	356	361	PF00400	0.324
LIG_APCC_ABBA_1	478	483	PF00400	0.351
LIG_BIR_II_1	1	5	PF00653	0.645
LIG_BRCT_BRCA1_1	269	273	PF00533	0.274
LIG_BRCT_BRCA1_1	427	431	PF00533	0.136
LIG_BRCT_BRCA1_1	544	548	PF00533	0.351
LIG_FHA_1	110	116	PF00498	0.270
LIG_FHA_1	164	170	PF00498	0.269
LIG_FHA_1	179	185	PF00498	0.231
LIG_FHA_1	203	209	PF00498	0.253
LIG_FHA_1	224	230	PF00498	0.244
LIG_FHA_1	254	260	PF00498	0.297
LIG_FHA_1	273	279	PF00498	0.148
LIG_FHA_1	353	359	PF00498	0.341
LIG_FHA_1	412	418	PF00498	0.323
LIG_FHA_1	419	425	PF00498	0.259
LIG_FHA_1	517	523	PF00498	0.332
LIG_FHA_1	532	538	PF00498	0.179
LIG_FHA_2	138	144	PF00498	0.274
LIG_LIR_Apic_2	190	194	PF02991	0.332
LIG_LIR_Gen_1	249	259	PF02991	0.299
LIG_LIR_Gen_1	272	280	PF02991	0.205
LIG_LIR_Gen_1	313	321	PF02991	0.345
LIG_LIR_Gen_1	432	443	PF02991	0.230
LIG_LIR_Gen_1	476	485	PF02991	0.220
LIG_LIR_Nem_3	205	210	PF02991	0.324
LIG_LIR_Nem_3	249	254	PF02991	0.299
LIG_LIR_Nem_3	272	277	PF02991	0.206
LIG_LIR_Nem_3	313	319	PF02991	0.308
LIG_LIR_Nem_3	428	434	PF02991	0.234
LIG_LIR_Nem_3	447	452	PF02991	0.236
LIG_LIR_Nem_3	476	481	PF02991	0.229
LIG_Pex14_1	398	402	PF04695	0.339
LIG_Pex14_1	632	636	PF04695	0.483
LIG_Pex14_2	269	273	PF04695	0.288
LIG_Pex14_2	431	435	PF04695	0.160
LIG_Pex14_2	474	478	PF04695	0.153
LIG_PTB_Apo_2	201	208	PF02174	0.335
LIG_SH2_CRK	251	255	PF00017	0.295
LIG_SH2_CRK	351	355	PF00017	0.351
LIG_SH2_CRK	427	431	PF00017	0.180
LIG_SH2_CRK	504	508	PF00017	0.312
LIG_SH2_GRB2like	530	533	PF00017	0.234
LIG_SH2_NCK_1	427	431	PF00017	0.133
LIG_SH2_PTP2	559	562	PF00017	0.347
LIG_SH2_PTP2	78	81	PF00017	0.238
LIG_SH2_SRC	156	159	PF00017	0.192
LIG_SH2_SRC	316	319	PF00017	0.236
LIG_SH2_SRC	559	562	PF00017	0.347
LIG_SH2_STAP1	251	255	PF00017	0.303
LIG_SH2_STAP1	520	524	PF00017	0.351
LIG_SH2_STAT3	520	523	PF00017	0.335
LIG_SH2_STAT5	156	159	PF00017	0.218
LIG_SH2_STAT5	210	213	PF00017	0.328
LIG_SH2_STAT5	316	319	PF00017	0.311
LIG_SH2_STAT5	437	440	PF00017	0.333
LIG_SH2_STAT5	452	455	PF00017	0.164
LIG_SH2_STAT5	530	533	PF00017	0.282
LIG_SH2_STAT5	553	556	PF00017	0.347
LIG_SH2_STAT5	559	562	PF00017	0.280
LIG_SH2_STAT5	78	81	PF00017	0.320
LIG_SH3_3	71	77	PF00018	0.234
LIG_SH3_5	448	452	PF00018	0.162
LIG_SUMO_SIM_anti_2	275	281	PF11976	0.174
LIG_SUMO_SIM_par_1	275	281	PF11976	0.140
LIG_SUMO_SIM_par_1	623	628	PF11976	0.186
LIG_TRAF2_1	215	218	PF00917	0.219
LIG_TRAF2_1	547	550	PF00917	0.198
LIG_TYR_ITIM	314	319	PF00017	0.334
LIG_TYR_ITIM	76	81	PF00017	0.283
LIG_UBA3_1	283	289	PF00899	0.146
LIG_Vh1_VBS_1	602	620	PF01044	0.147
MOD_CDK_SPxxK_3	531	538	PF00069	0.360
MOD_CK1_1	2	8	PF00069	0.615
MOD_CK1_1	213	219	PF00069	0.427
MOD_CK1_1	327	333	PF00069	0.370
MOD_CK1_1	352	358	PF00069	0.235
MOD_CK1_1	460	466	PF00069	0.244
MOD_CK1_1	542	548	PF00069	0.310
MOD_CK1_1	577	583	PF00069	0.379
MOD_CK1_1	93	99	PF00069	0.292
MOD_CK2_1	367	373	PF00069	0.441
MOD_CK2_1	543	549	PF00069	0.258
MOD_GlcNHglycan	269	272	PF01048	0.190
MOD_GlcNHglycan	326	329	PF01048	0.365
MOD_GlcNHglycan	351	354	PF01048	0.309
MOD_GlcNHglycan	475	478	PF01048	0.144
MOD_GlcNHglycan	545	548	PF01048	0.161
MOD_GlcNHglycan	581	584	PF01048	0.380
MOD_GlcNHglycan	71	74	PF01048	0.403
MOD_GlcNHglycan	92	95	PF01048	0.261
MOD_GSK3_1	109	116	PF00069	0.271
MOD_GSK3_1	196	203	PF00069	0.430
MOD_GSK3_1	253	260	PF00069	0.328
MOD_GSK3_1	291	298	PF00069	0.144
MOD_GSK3_1	425	432	PF00069	0.226
MOD_GSK3_1	512	519	PF00069	0.286
MOD_GSK3_1	539	546	PF00069	0.302
MOD_GSK3_1	574	581	PF00069	0.346
MOD_N-GLC_1	178	183	PF02516	0.131
MOD_N-GLC_1	291	296	PF02516	0.254
MOD_N-GLC_1	393	398	PF02516	0.355
MOD_N-GLC_1	439	444	PF02516	0.179
MOD_N-GLC_1	495	500	PF02516	0.168
MOD_N-GLC_1	531	536	PF02516	0.281
MOD_NEK2_1	267	272	PF00069	0.370
MOD_NEK2_1	278	283	PF00069	0.273
MOD_NEK2_1	291	296	PF00069	0.151
MOD_NEK2_1	418	423	PF00069	0.151
MOD_NEK2_1	612	617	PF00069	0.168
MOD_NEK2_1	625	630	PF00069	0.318
MOD_PIKK_1	278	284	PF00454	0.133
MOD_PK_1	10	16	PF00069	0.566
MOD_PK_1	518	524	PF00069	0.318
MOD_PKA_2	524	530	PF00069	0.256
MOD_PKA_2	57	63	PF00069	0.278
MOD_Plk_1	291	297	PF00069	0.160
MOD_Plk_1	406	412	PF00069	0.272
MOD_Plk_1	439	445	PF00069	0.193
MOD_Plk_1	466	472	PF00069	0.163
MOD_Plk_1	539	545	PF00069	0.291
MOD_Plk_2-3	143	149	PF00069	0.342
MOD_Plk_4	269	275	PF00069	0.276
MOD_Plk_4	291	297	PF00069	0.228
MOD_Plk_4	612	618	PF00069	0.152
MOD_Plk_4	93	99	PF00069	0.240
MOD_ProDKin_1	426	432	PF00069	0.185
MOD_ProDKin_1	444	450	PF00069	0.176
MOD_ProDKin_1	531	537	PF00069	0.441
MOD_SUMO_for_1	337	340	PF00179	0.283
MOD_SUMO_rev_2	185	194	PF00179	0.296
TRG_ENDOCYTIC_2	251	254	PF00928	0.379
TRG_ENDOCYTIC_2	316	319	PF00928	0.384
TRG_ENDOCYTIC_2	351	354	PF00928	0.441
TRG_ENDOCYTIC_2	446	449	PF00928	0.274
TRG_ENDOCYTIC_2	452	455	PF00928	0.322
TRG_ENDOCYTIC_2	504	507	PF00928	0.416
TRG_ENDOCYTIC_2	559	562	PF00928	0.435
TRG_ENDOCYTIC_2	78	81	PF00928	0.283
TRG_ER_diArg_1	89	91	PF00400	0.208
TRG_NES_CRM1_1	276	290	PF08389	0.184
TRG_Pf-PMV_PEXEL_1	47	51	PF00026	0.254

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL11	Leptomonas seymouri	35%	98%
A0A0S4IN60	Bodo saltans	29%	71%
A0A0S4IYM3	Bodo saltans	30%	88%
A0A1X0NDG7	Trypanosomatidae	28%	98%
A0A1X0NDJ3	Trypanosomatidae	26%	89%
A0A1X0NDK2	Trypanosomatidae	33%	100%
A0A1X0NDK7	Trypanosomatidae	28%	90%
A0A1X0NDK9	Trypanosomatidae	31%	100%
A0A1X0NDM7	Trypanosomatidae	28%	100%
A0A1X0NDU8	Trypanosomatidae	28%	96%
A0A1X0NE71	Trypanosomatidae	28%	100%
A0A1X0NEE9	Trypanosomatidae	27%	69%
A0A1X0NER9	Trypanosomatidae	32%	100%
A0A1X0NET7	Trypanosomatidae	35%	100%
A0A1X0NEX7	Trypanosomatidae	31%	98%
A0A1X0NEZ6	Trypanosomatidae	28%	98%
A0A1X0NF32	Trypanosomatidae	30%	100%
A0A1X0NF41	Trypanosomatidae	29%	100%
A0A1X0NFJ0	Trypanosomatidae	29%	100%
A0A1X0NFK3	Trypanosomatidae	29%	96%
A0A1X0NFL1	Trypanosomatidae	29%	68%
A0A1X0NFS0	Trypanosomatidae	31%	74%
A0A1X0NFT1	Trypanosomatidae	30%	70%
A0A1X0NFU4	Trypanosomatidae	30%	78%
A0A1X0NFZ9	Trypanosomatidae	31%	100%
A0A1X0NG20	Trypanosomatidae	30%	100%
A0A1X0NGP3	Trypanosomatidae	30%	75%
A0A1X0NGY3	Trypanosomatidae	29%	83%
A0A1X0NGZ3	Trypanosomatidae	31%	100%
A0A1X0NH86	Trypanosomatidae	29%	73%
A0A1X0NHQ6	Trypanosomatidae	29%	100%
A0A1X0NI38	Trypanosomatidae	27%	73%
A0A1X0NI74	Trypanosomatidae	28%	86%
A0A1X0NII4	Trypanosomatidae	28%	76%
A0A1X0NIZ3	Trypanosomatidae	32%	100%
A0A1X0NJS3	Trypanosomatidae	29%	98%
A0A1X0NJU4	Trypanosomatidae	28%	74%
A0A1X0NK29	Trypanosomatidae	27%	69%
A0A1X0NK66	Trypanosomatidae	29%	97%
A0A1X0NKJ8	Trypanosomatidae	27%	86%
A0A1X0NKW9	Trypanosomatidae	30%	100%
A0A1X0NME2	Trypanosomatidae	31%	100%
A0A1X0NMK3	Trypanosomatidae	27%	100%
A0A1X0NMK7	Trypanosomatidae	36%	100%
A0A1X0NMV0	Trypanosomatidae	30%	87%
A0A1X0NN43	Trypanosomatidae	30%	89%
A0A1X0NNK8	Trypanosomatidae	30%	97%
A0A1X0NP64	Trypanosomatidae	28%	72%
A0A1X0NPW0	Trypanosomatidae	29%	100%
A0A1X0NQM4	Trypanosomatidae	33%	100%
A0A1X0NQN3	Trypanosomatidae	35%	100%
A0A1X0NQU4	Trypanosomatidae	35%	99%
A0A1X0NQW6	Trypanosomatidae	31%	100%
A0A1X0NRF3	Trypanosomatidae	33%	95%
A0A1X0NRY8	Trypanosomatidae	36%	100%
A0A1X0NU16	Trypanosomatidae	34%	100%
A0A1X0NUR2	Trypanosomatidae	33%	87%
A0A1X0NV28	Trypanosomatidae	34%	100%
A0A1X0NVC3	Trypanosomatidae	30%	94%
A0A1X0NVE0	Trypanosomatidae	29%	82%
A0A1X0NW07	Trypanosomatidae	26%	100%
A0A1X0NX94	Trypanosomatidae	28%	99%
A0A1X0NX98	Trypanosomatidae	29%	80%
A0A1X0NXB6	Trypanosomatidae	29%	91%
A0A1X0NXH6	Trypanosomatidae	31%	88%
A0A1X0NXQ4	Trypanosomatidae	27%	95%
A0A1X0NXR7	Trypanosomatidae	32%	85%
A0A1X0NYE3	Trypanosomatidae	29%	100%
A0A1X0NYE7	Trypanosomatidae	30%	100%
A0A1X0NYN2	Trypanosomatidae	34%	100%
A0A1X0NYN4	Trypanosomatidae	27%	90%
A0A1X0NYS5	Trypanosomatidae	33%	100%
A0A1X0NYZ2	Trypanosomatidae	38%	100%
A0A1X0NZ46	Trypanosomatidae	27%	100%
A0A1X0NZ63	Trypanosomatidae	29%	100%
A0A1X0NZN6	Trypanosomatidae	29%	98%
A0A1X0P055	Trypanosomatidae	32%	100%
A0A1X0P154	Trypanosomatidae	27%	100%
A0A1X0P331	Trypanosomatidae	32%	100%
A0A1X0P3K0	Trypanosomatidae	26%	88%
A0A1X0P3S2	Trypanosomatidae	26%	100%
A0A1X0P4L8	Trypanosomatidae	31%	100%
A0A1X0P4Y5	Trypanosomatidae	26%	100%
A0A1X0P544	Trypanosomatidae	28%	100%
A0A1X0P5J0	Trypanosomatidae	33%	93%
A0A1X0P7K5	Trypanosomatidae	28%	72%
A0A1X0P7R3	Trypanosomatidae	33%	100%
A0A1X0P8B4	Trypanosomatidae	31%	100%
A0A1X0P9Z4	Trypanosomatidae	28%	100%
A0A1X0PB04	Trypanosomatidae	31%	100%
A0A3Q8I8N3	Leishmania donovani	83%	100%
A0A3Q8I8P8	Leishmania donovani	85%	100%
A0A3Q8I8S6	Leishmania donovani	97%	100%
A0A3Q8I8S9	Leishmania donovani	85%	100%
A0A3Q8IAZ8	Leishmania donovani	83%	100%
A0A3Q8IC35	Leishmania donovani	84%	100%
A0A3Q8IC44	Leishmania donovani	80%	100%
A0A3Q8IH61	Leishmania donovani	83%	100%
A0A3Q8IIN4	Leishmania donovani	37%	100%
A0A3R7JT49	Trypanosoma rangeli	35%	76%
A0A3R7JTB6	Trypanosoma rangeli	31%	91%
A0A3R7JV87	Trypanosoma rangeli	33%	100%
A0A3R7K7T9	Trypanosoma rangeli	33%	100%
A0A3R7K9S1	Trypanosoma rangeli	33%	100%
A0A3R7KB14	Trypanosoma rangeli	34%	73%
A0A3R7KLR6	Trypanosoma rangeli	30%	100%
A0A3R7KMY2	Trypanosoma rangeli	33%	96%
A0A3R7LFC4	Trypanosoma rangeli	33%	95%
A0A3R7LFZ4	Trypanosoma rangeli	34%	100%
A0A3R7LWG1	Trypanosoma rangeli	32%	100%
A0A3R7LX11	Trypanosoma rangeli	34%	100%
A0A3R7M1R8	Trypanosoma rangeli	34%	100%
A0A3R7M574	Trypanosoma rangeli	34%	100%
A0A3R7M7N6	Trypanosoma rangeli	35%	93%
A0A3R7MTS2	Trypanosoma rangeli	35%	100%
A0A3R7MW36	Trypanosoma rangeli	34%	100%
A0A3R7MXF4	Trypanosoma rangeli	35%	100%
A0A3R7N1W7	Trypanosoma rangeli	34%	100%
A0A3R7N289	Trypanosoma rangeli	33%	88%
A0A3R7NTI8	Trypanosoma rangeli	34%	100%
A0A3R7R2J4	Trypanosoma rangeli	34%	99%
A0A3R7R5R1	Trypanosoma rangeli	33%	100%
A0A3R7R818	Trypanosoma rangeli	32%	100%
A0A3S5H6G0	Leishmania donovani	85%	100%
A0A3S5IQY2	Trypanosoma rangeli	36%	100%
A0A3S7WR43	Leishmania donovani	83%	100%
A0A3S7WR46	Leishmania donovani	85%	100%
A0A3S7WR60	Leishmania donovani	86%	100%
A0A3S7X192	Leishmania donovani	36%	100%
A0A422MRQ6	Trypanosoma rangeli	35%	86%
A0A422MU95	Trypanosoma rangeli	35%	100%
A0A422MVF5	Trypanosoma rangeli	33%	100%
A0A422MVS3	Trypanosoma rangeli	32%	100%
A0A422MW99	Trypanosoma rangeli	30%	86%
A0A422MZ47	Trypanosoma rangeli	34%	100%
A0A422MZG4	Trypanosoma rangeli	35%	100%
A0A422N361	Trypanosoma rangeli	32%	100%
A0A422N7Q6	Trypanosoma rangeli	34%	99%
A0A422NDS2	Trypanosoma rangeli	31%	100%
A0A422NDT3	Trypanosoma rangeli	30%	100%
A0A422NP82	Trypanosoma rangeli	36%	100%
A4H626	Leishmania braziliensis	60%	100%
A4H627	Leishmania braziliensis	59%	100%
A4H630	Leishmania braziliensis	65%	100%
A4H631	Leishmania braziliensis	61%	100%
A4H632	Leishmania braziliensis	65%	100%
A4H633	Leishmania braziliensis	62%	100%
A4H634	Leishmania braziliensis	66%	99%
A4H635	Leishmania braziliensis	67%	100%
A4H636	Leishmania braziliensis	62%	100%
A4H637	Leishmania braziliensis	67%	100%
A4H638	Leishmania braziliensis	70%	100%
A4H639	Leishmania braziliensis	68%	97%
A4H640	Leishmania braziliensis	66%	100%
A4H6D3	Leishmania braziliensis	62%	100%
A4H6D5	Leishmania braziliensis	61%	100%
A4H6D7	Leishmania braziliensis	59%	100%
A4H6D8	Leishmania braziliensis	59%	100%
A4H6D9	Leishmania braziliensis	58%	100%
A4H6E0	Leishmania braziliensis	60%	100%
A4H6E1	Leishmania braziliensis	60%	100%
A4H6E2	Leishmania braziliensis	62%	100%
A4H6E3	Leishmania braziliensis	62%	100%
A4H6E5	Leishmania braziliensis	73%	100%
A4HJI2	Leishmania braziliensis	36%	100%
A4HUF6	Leishmania infantum	83%	100%
A4HUF8	Leishmania infantum	85%	100%
A4HUG0	Leishmania infantum	85%	84%
A4I6X5	Leishmania infantum	37%	100%
C9ZUT5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
D0A1R8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
D0A7S8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	95%
D0A855	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AHH5	Leishmania infantum	36%	100%
E9AN53	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
E9AN54	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
E9AN55	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
E9AN56	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
E9AN57	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
E9AZL8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E9B1Z9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
O62446	Caenorhabditis elegans	25%	97%
P08148	Leishmania major	81%	100%
P15706	Leishmania chagasi	85%	100%
P23223	Leishmania donovani	82%	100%
P43150	Leishmania mexicana	80%	99%
Q00689	Leishmania guyanensis	67%	100%
Q06031	Crithidia fasciculata	52%	98%
Q27673	Leishmania amazonensis	75%	100%
Q29AK2	Drosophila pseudoobscura pseudoobscura	23%	94%
Q4Q662	Leishmania major	36%	100%
Q4Q8L3	Leishmania major	38%	100%
Q4QHG9	Leishmania major	81%	100%
Q4QHH0	Leishmania major	85%	100%
Q4QHH1	Leishmania major	81%	100%
Q4QHH2	Leishmania major	81%	100%
Q61YG1	Caenorhabditis briggsae	24%	97%
Q6LA77	Leishmania infantum	85%	100%
Q8MNZ1	Leishmania tropica	87%	98%
Q9VH19	Drosophila melanogaster	23%	94%
V5A359	Trypanosoma cruzi	36%	100%
V5A488	Trypanosoma cruzi	33%	79%
V5AII7	Trypanosoma cruzi	37%	100%
V5APQ4	Trypanosoma cruzi	33%	81%
V5AX72	Trypanosoma cruzi	34%	87%
V5B5M0	Trypanosoma cruzi	33%	87%
V5B9W5	Trypanosoma cruzi	28%	95%
V5BAN1	Trypanosoma cruzi	34%	82%
V5BLT3	Trypanosoma cruzi	31%	100%
V5CI97	Trypanosoma cruzi	32%	100%
V5D358	Trypanosoma cruzi	35%	76%