Putative folate/biopterin transporter

Quick info Annotations Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pteridine transporter (truncated) - putative

Species:

Leishmania infantum

UniProt:

A4HUF5_LEIIN

TriTrypDb:

LINF_100009500

Length:

658

Annotations

Annotations by Jardim et al.

Transporters, folate/biopterin transporter FT5

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	yes	yes: 9
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 52

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 70
NetGPI	no	yes: 0, no: 70

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	71
GO:0110165	cellular anatomical entity	1	71
GO:0005737	cytoplasm	2	6
GO:0005886	plasma membrane	3	1

Phosphorylation

Promastigote: 638, 639, 640
Promastigote/Amastigote: 240, 276

Expansion

Sequence features

A4HUF5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HUF5

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0015877	biopterin transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0015224	biopterin transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	207	209	PF00675	0.328
CLV_NRD_NRD_1	225	227	PF00675	0.364
CLV_NRD_NRD_1	654	656	PF00675	0.597
CLV_PCSK_KEX2_1	488	490	PF00082	0.548
CLV_PCSK_KEX2_1	656	658	PF00082	0.576
CLV_PCSK_KEX2_1	87	89	PF00082	0.323
CLV_PCSK_PC1ET2_1	488	490	PF00082	0.548
CLV_PCSK_PC1ET2_1	656	658	PF00082	0.404
CLV_PCSK_PC1ET2_1	87	89	PF00082	0.323
CLV_PCSK_SKI1_1	229	233	PF00082	0.291
CLV_PCSK_SKI1_1	289	293	PF00082	0.372
CLV_PCSK_SKI1_1	613	617	PF00082	0.274
CLV_PCSK_SKI1_1	70	74	PF00082	0.380
DEG_APCC_DBOX_1	228	236	PF00400	0.451
DEG_COP1_1	276	284	PF00400	0.416
DEG_Nend_UBRbox_1	1	4	PF02207	0.525
DOC_CDC14_PxL_1	574	582	PF14671	0.357
DOC_CYCLIN_yCln2_LP_2	591	597	PF00134	0.404
DOC_MAPK_gen_1	226	234	PF00069	0.573
DOC_MAPK_gen_1	244	253	PF00069	0.611
DOC_MAPK_gen_1	488	496	PF00069	0.349
DOC_MAPK_gen_1	87	93	PF00069	0.532
DOC_MAPK_MEF2A_6	17	24	PF00069	0.567
DOC_MAPK_MEF2A_6	181	188	PF00069	0.355
DOC_MAPK_MEF2A_6	226	234	PF00069	0.430
DOC_MAPK_MEF2A_6	488	496	PF00069	0.383
DOC_PP1_RVXF_1	464	470	PF00149	0.545
DOC_PP2B_LxvP_1	409	412	PF13499	0.400
DOC_PP2B_LxvP_1	591	594	PF13499	0.390
DOC_PP2B_LxvP_1	597	600	PF13499	0.356
DOC_USP7_MATH_1	153	157	PF00917	0.348
DOC_USP7_MATH_1	237	241	PF00917	0.538
DOC_USP7_MATH_1	414	418	PF00917	0.351
DOC_USP7_MATH_1	530	534	PF00917	0.512
DOC_USP7_MATH_1	614	618	PF00917	0.437
DOC_WW_Pin1_4	566	571	PF00397	0.375
LIG_14-3-3_CanoR_1	466	470	PF00244	0.517
LIG_APCC_ABBA_1	4	9	PF00400	0.666
LIG_APCC_ABBAyCdc20_2	266	272	PF00400	0.413
LIG_CSL_BTD_1	517	520	PF09270	0.424
LIG_EVH1_2	570	574	PF00568	0.386
LIG_FHA_1	351	357	PF00498	0.382
LIG_FHA_1	366	372	PF00498	0.285
LIG_FHA_1	404	410	PF00498	0.448
LIG_FHA_1	466	472	PF00498	0.518
LIG_FHA_1	594	600	PF00498	0.442
LIG_FHA_1	636	642	PF00498	0.830
LIG_FHA_1	646	652	PF00498	0.588
LIG_FHA_1	71	77	PF00498	0.596
LIG_LIR_Apic_2	385	391	PF02991	0.444
LIG_LIR_Gen_1	137	148	PF02991	0.555
LIG_LIR_Gen_1	156	167	PF02991	0.530
LIG_LIR_Gen_1	406	415	PF02991	0.391
LIG_LIR_Gen_1	435	444	PF02991	0.356
LIG_LIR_Gen_1	454	460	PF02991	0.420
LIG_LIR_Gen_1	480	487	PF02991	0.360
LIG_LIR_Gen_1	535	544	PF02991	0.542
LIG_LIR_Gen_1	78	85	PF02991	0.546
LIG_LIR_LC3C_4	298	303	PF02991	0.418
LIG_LIR_Nem_3	137	143	PF02991	0.562
LIG_LIR_Nem_3	156	162	PF02991	0.318
LIG_LIR_Nem_3	196	202	PF02991	0.370
LIG_LIR_Nem_3	313	319	PF02991	0.584
LIG_LIR_Nem_3	406	411	PF02991	0.416
LIG_LIR_Nem_3	433	437	PF02991	0.326
LIG_LIR_Nem_3	454	459	PF02991	0.368
LIG_LIR_Nem_3	480	485	PF02991	0.362
LIG_LIR_Nem_3	78	83	PF02991	0.521
LIG_LIR_Nem_3	86	92	PF02991	0.521
LIG_MYND_3	281	285	PF01753	0.410
LIG_Pex14_1	157	161	PF04695	0.400
LIG_Pex14_2	200	204	PF04695	0.312
LIG_Pex14_2	432	436	PF04695	0.337
LIG_Pex14_2	456	460	PF04695	0.398
LIG_SH2_CRK	105	109	PF00017	0.353
LIG_SH2_CRK	140	144	PF00017	0.541
LIG_SH2_CRK	348	352	PF00017	0.372
LIG_SH2_CRK	437	441	PF00017	0.329
LIG_SH2_CRK	56	60	PF00017	0.538
LIG_SH2_CRK	90	94	PF00017	0.401
LIG_SH2_NCK_1	437	441	PF00017	0.327
LIG_SH2_PTP2	493	496	PF00017	0.426
LIG_SH2_STAP1	140	144	PF00017	0.516
LIG_SH2_STAP1	348	352	PF00017	0.420
LIG_SH2_STAP1	538	542	PF00017	0.365
LIG_SH2_STAP1	85	89	PF00017	0.527
LIG_SH2_STAT3	39	42	PF00017	0.442
LIG_SH2_STAT5	26	29	PF00017	0.550
LIG_SH2_STAT5	316	319	PF00017	0.607
LIG_SH2_STAT5	402	405	PF00017	0.381
LIG_SH2_STAT5	408	411	PF00017	0.373
LIG_SH2_STAT5	419	422	PF00017	0.313
LIG_SH2_STAT5	434	437	PF00017	0.289
LIG_SH2_STAT5	458	461	PF00017	0.477
LIG_SH2_STAT5	493	496	PF00017	0.328
LIG_SH2_STAT5	502	505	PF00017	0.320
LIG_SH2_STAT5	85	88	PF00017	0.528
LIG_SH3_3	106	112	PF00018	0.326
LIG_SH3_3	318	324	PF00018	0.624
LIG_SH3_3	424	430	PF00018	0.311
LIG_SUMO_SIM_anti_2	248	255	PF11976	0.416
LIG_SUMO_SIM_par_1	520	526	PF11976	0.355
LIG_TRAF2_1	276	279	PF00917	0.416
LIG_TRAF2_1	291	294	PF00917	0.591
LIG_TRFH_1	105	109	PF08558	0.388
LIG_TYR_ITIM	103	108	PF00017	0.407
LIG_TYR_ITIM	220	225	PF00017	0.222
LIG_TYR_ITSM	433	440	PF00017	0.430
LIG_UBA3_1	328	336	PF00899	0.412
LIG_Vh1_VBS_1	357	375	PF01044	0.474
LIG_Vh1_VBS_1	436	454	PF01044	0.413
LIG_WRC_WIRS_1	415	420	PF05994	0.361
MOD_CK1_1	461	467	PF00069	0.378
MOD_CK1_1	565	571	PF00069	0.324
MOD_CK1_1	617	623	PF00069	0.549
MOD_CK2_1	273	279	PF00069	0.313
MOD_CK2_1	636	642	PF00069	0.793
MOD_GlcNHglycan	113	116	PF01048	0.383
MOD_GlcNHglycan	188	191	PF01048	0.398
MOD_GlcNHglycan	244	247	PF01048	0.362
MOD_GlcNHglycan	258	261	PF01048	0.287
MOD_GlcNHglycan	616	619	PF01048	0.450
MOD_GSK3_1	346	353	PF00069	0.401
MOD_GSK3_1	432	439	PF00069	0.405
MOD_GSK3_1	461	468	PF00069	0.390
MOD_GSK3_1	547	554	PF00069	0.400
MOD_GSK3_1	562	569	PF00069	0.371
MOD_GSK3_1	61	68	PF00069	0.423
MOD_N-GLC_1	572	577	PF02516	0.230
MOD_N-GLC_1	636	641	PF02516	0.766
MOD_NEK2_1	123	128	PF00069	0.371
MOD_NEK2_1	346	351	PF00069	0.398
MOD_NEK2_1	352	357	PF00069	0.379
MOD_NEK2_1	365	370	PF00069	0.324
MOD_NEK2_1	403	408	PF00069	0.496
MOD_NEK2_1	432	437	PF00069	0.389
MOD_NEK2_1	44	49	PF00069	0.319
MOD_NEK2_1	469	474	PF00069	0.393
MOD_NEK2_1	547	552	PF00069	0.381
MOD_NEK2_1	65	70	PF00069	0.402
MOD_NEK2_1	83	88	PF00069	0.309
MOD_NEK2_1	91	96	PF00069	0.364
MOD_NEK2_2	414	419	PF00069	0.363
MOD_OFUCOSY	354	361	PF10250	0.424
MOD_PKA_2	465	471	PF00069	0.376
MOD_PKA_2	530	536	PF00069	0.361
MOD_Plk_1	636	642	PF00069	0.507
MOD_Plk_4	153	159	PF00069	0.371
MOD_Plk_4	346	352	PF00069	0.382
MOD_Plk_4	360	366	PF00069	0.337
MOD_Plk_4	383	389	PF00069	0.420
MOD_Plk_4	403	409	PF00069	0.379
MOD_Plk_4	414	420	PF00069	0.365
MOD_Plk_4	432	438	PF00069	0.490
MOD_Plk_4	470	476	PF00069	0.345
MOD_Plk_4	477	483	PF00069	0.353
MOD_Plk_4	532	538	PF00069	0.408
MOD_Plk_4	593	599	PF00069	0.407
MOD_ProDKin_1	566	572	PF00069	0.444
MOD_SUMO_rev_2	606	615	PF00179	0.434
MOD_SUMO_rev_2	650	658	PF00179	0.479
TRG_DiLeu_BaEn_4	306	312	PF01217	0.228
TRG_DiLeu_BaLyEn_6	586	591	PF01217	0.347
TRG_ENDOCYTIC_2	105	108	PF00928	0.367
TRG_ENDOCYTIC_2	140	143	PF00928	0.371
TRG_ENDOCYTIC_2	222	225	PF00928	0.474
TRG_ENDOCYTIC_2	348	351	PF00928	0.373
TRG_ENDOCYTIC_2	402	405	PF00928	0.385
TRG_ENDOCYTIC_2	408	411	PF00928	0.386
TRG_ENDOCYTIC_2	437	440	PF00928	0.382
TRG_ENDOCYTIC_2	493	496	PF00928	0.507
TRG_ENDOCYTIC_2	538	541	PF00928	0.366
TRG_ENDOCYTIC_2	56	59	PF00928	0.351
TRG_ENDOCYTIC_2	90	93	PF00928	0.379
TRG_NES_CRM1_1	410	424	PF08389	0.327

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2U2	Leptomonas seymouri	51%	93%
A0A0N1HY49	Leptomonas seymouri	54%	98%
A0A0N1HZ06	Leptomonas seymouri	40%	100%
A0A0N1IHL1	Leptomonas seymouri	43%	92%
A0A0N1PAY4	Leptomonas seymouri	52%	75%
A0A0N1PB77	Leptomonas seymouri	39%	100%
A0A0N1PBZ2	Leptomonas seymouri	61%	98%
A0A0N1PCC1	Leptomonas seymouri	46%	99%
A0A381MBI0	Leishmania infantum	48%	100%
A0A3Q8I8X7	Leishmania donovani	49%	100%
A0A3Q8IAZ0	Leishmania donovani	59%	94%
A0A3Q8IH50	Leishmania donovani	99%	91%
A0A3Q8IVN0	Leishmania donovani	40%	100%
A0A3R7M4J1	Trypanosoma rangeli	45%	100%
A0A3S5H5P4	Leishmania donovani	50%	97%
A0A3S5H5V2	Leishmania donovani	45%	100%
A0A3S5H6F6	Leishmania donovani	58%	94%
A0A3S5H763	Leishmania donovani	62%	98%
A0A3S7WR10	Leishmania donovani	49%	88%
A0A3S7WR14	Leishmania donovani	60%	96%
A0A3S7WR15	Leishmania donovani	58%	77%
A0A3S7WR24	Leishmania donovani	59%	93%
A4H4T8	Leishmania braziliensis	44%	100%
A4H5Y4	Leishmania braziliensis	49%	100%
A4H617	Leishmania braziliensis	57%	100%
A4H618	Leishmania braziliensis	57%	100%
A4H619	Leishmania braziliensis	57%	100%
A4H620	Leishmania braziliensis	82%	100%
A4H6C3	Leishmania braziliensis	49%	100%
A4HNH7	Leishmania braziliensis	37%	100%
A4HSS2	Leishmania infantum	49%	100%
A4HUE4	Leishmania infantum	49%	100%
A4HUE5	Leishmania infantum	58%	100%
A4HUE6	Leishmania infantum	60%	100%
A4HUE7	Leishmania infantum	58%	100%
A4HUE8	Leishmania infantum	58%	100%
A4HUF4	Leishmania infantum	58%	100%
A4HYA9	Leishmania infantum	63%	98%
A4IC33	Leishmania infantum	39%	100%
C9ZIK0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
C9ZIK3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
C9ZVE8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
C9ZVE9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
C9ZVF1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
D0A423	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E8NHQ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	59%	100%
E9AG72	Leishmania infantum	45%	100%
E9AI40	Leishmania braziliensis	60%	100%
E9AJY4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	98%
E9AKQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	100%
E9AL06	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E9AN44	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	100%
E9AN45	Leishmania mexicana (strain MHOM/GT/2001/U1103)	58%	99%
E9AN46	Leishmania mexicana (strain MHOM/GT/2001/U1103)	59%	100%
E9AN47	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
E9ANE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	100%
E9AS42	Leishmania mexicana (strain MHOM/GT/2001/U1103)	62%	100%
E9B741	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	99%
Q4QDC4	Leishmania major	60%	100%
Q4QH81	Leishmania major	48%	100%
Q4QHH7	Leishmania major	93%	100%
Q4QHH8	Leishmania major	57%	100%
Q4QHH9	Leishmania major	56%	100%
Q4QHI0	Leishmania major	59%	100%
Q4QHI1	Leishmania major	59%	97%
Q4QHI2	Leishmania major	57%	100%
Q4QIU9	Leishmania major	44%	100%
Q4QJ48	Leishmania major	48%	100%
Q7KIP2	Leishmania major	39%	99%