LeishMANIAdb
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Putative folate/biopterin transporter

Quick info Annotations Function or PPIs Localization Phosphorylation Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative folate/biopterin transporter
Gene product:
pteridine transporter (truncated) - putative
Species:
Leishmania infantum
UniProt:
A4HUF4_LEIIN
TriTrypDb:
LINF_100009400
Length:
698

Annotations

Annotations by Jardim et al.

Transporters, folate/biopterin transporter

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 9
Silverman et al. no yes: 0
Pissara et al. yes yes: 52
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 6
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 6
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 70
NetGPI no yes: 0, no: 70
Cellular components
Term Name Level Count
GO:0016020 membrane 2 71
GO:0110165 cellular anatomical entity 1 71
GO:0005737 cytoplasm 2 6
GO:0005886 plasma membrane 3 1

Phosphorylation

Promastigote: 307

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HUF4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HUF4

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 1
GO:0015877 biopterin transport 5 1
GO:0051179 localization 1 1
GO:0051234 establishment of localization 2 1
GO:0071702 organic substance transport 4 1
GO:0071705 nitrogen compound transport 4 1
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 1
GO:0015224 biopterin transmembrane transporter activity 3 1
GO:0022857 transmembrane transporter activity 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 667 671 PF00656 0.737
CLV_MEL_PAP_1 438 444 PF00089 0.219
CLV_NRD_NRD_1 271 273 PF00675 0.309
CLV_NRD_NRD_1 48 50 PF00675 0.384
CLV_PCSK_KEX2_1 133 135 PF00082 0.269
CLV_PCSK_KEX2_1 299 301 PF00082 0.345
CLV_PCSK_KEX2_1 48 50 PF00082 0.417
CLV_PCSK_KEX2_1 519 521 PF00082 0.494
CLV_PCSK_KEX2_1 9 11 PF00082 0.383
CLV_PCSK_PC1ET2_1 133 135 PF00082 0.269
CLV_PCSK_PC1ET2_1 299 301 PF00082 0.345
CLV_PCSK_PC1ET2_1 519 521 PF00082 0.494
CLV_PCSK_PC1ET2_1 9 11 PF00082 0.383
CLV_PCSK_SKI1_1 116 120 PF00082 0.326
CLV_PCSK_SKI1_1 316 320 PF00082 0.344
DEG_APCC_DBOX_1 276 284 PF00400 0.394
DOC_CDC14_PxL_1 609 617 PF14671 0.304
DOC_CKS1_1 621 626 PF01111 0.405
DOC_CYCLIN_yCln2_LP_2 549 552 PF00134 0.372
DOC_CYCLIN_yCln2_LP_2 626 632 PF00134 0.352
DOC_MAPK_gen_1 133 139 PF00069 0.479
DOC_MAPK_gen_1 257 267 PF00069 0.521
DOC_MAPK_gen_1 272 280 PF00069 0.511
DOC_MAPK_gen_1 519 527 PF00069 0.295
DOC_MAPK_gen_1 637 646 PF00069 0.558
DOC_MAPK_MEF2A_6 227 234 PF00069 0.301
DOC_MAPK_MEF2A_6 519 527 PF00069 0.329
DOC_PP1_RVXF_1 495 501 PF00149 0.492
DOC_PP2B_LxvP_1 549 552 PF13499 0.313
DOC_PP2B_LxvP_1 626 629 PF13499 0.339
DOC_PP2B_PxIxI_1 227 233 PF00149 0.256
DOC_USP7_MATH_1 196 200 PF00917 0.452
DOC_USP7_MATH_1 302 306 PF00917 0.558
DOC_USP7_MATH_1 561 565 PF00917 0.458
DOC_USP7_MATH_1 663 667 PF00917 0.602
DOC_WW_Pin1_4 298 303 PF00397 0.549
DOC_WW_Pin1_4 620 625 PF00397 0.388
LIG_14-3-3_CanoR_1 104 111 PF00244 0.464
LIG_14-3-3_CanoR_1 257 267 PF00244 0.556
LIG_14-3-3_CanoR_1 304 311 PF00244 0.546
LIG_14-3-3_CanoR_1 497 501 PF00244 0.463
LIG_Actin_WH2_2 50 65 PF00022 0.590
LIG_APCC_ABBA_1 50 55 PF00400 0.604
LIG_APCC_ABBAyCdc20_2 49 55 PF00400 0.473
LIG_BIR_II_1 1 5 PF00653 0.717
LIG_BIR_III_4 13 17 PF00653 0.688
LIG_Clathr_ClatBox_1 265 269 PF01394 0.416
LIG_EH1_1 499 507 PF00400 0.315
LIG_eIF4E_1 609 615 PF01652 0.199
LIG_FHA_1 117 123 PF00498 0.541
LIG_FHA_1 208 214 PF00498 0.312
LIG_FHA_1 365 371 PF00498 0.561
LIG_FHA_1 382 388 PF00498 0.331
LIG_FHA_1 397 403 PF00498 0.231
LIG_FHA_1 481 487 PF00498 0.369
LIG_FHA_1 497 503 PF00498 0.464
LIG_FHA_1 621 627 PF00498 0.391
LIG_FHA_2 269 275 PF00498 0.563
LIG_FHA_2 598 604 PF00498 0.196
LIG_GBD_Chelix_1 478 486 PF00786 0.201
LIG_GBD_Chelix_1 501 509 PF00786 0.446
LIG_GBD_Chelix_1 539 547 PF00786 0.474
LIG_HP1_1 552 556 PF01393 0.374
LIG_LIR_Apic_2 29 35 PF02991 0.577
LIG_LIR_Apic_2 348 354 PF02991 0.502
LIG_LIR_Apic_2 417 422 PF02991 0.389
LIG_LIR_Apic_2 453 457 PF02991 0.304
LIG_LIR_Apic_2 592 596 PF02991 0.275
LIG_LIR_Gen_1 124 131 PF02991 0.493
LIG_LIR_Gen_1 202 209 PF02991 0.474
LIG_LIR_Gen_1 466 475 PF02991 0.303
LIG_LIR_Gen_1 485 492 PF02991 0.368
LIG_LIR_Gen_1 566 576 PF02991 0.489
LIG_LIR_Gen_1 87 95 PF02991 0.511
LIG_LIR_Nem_3 124 129 PF02991 0.467
LIG_LIR_Nem_3 132 138 PF02991 0.467
LIG_LIR_Nem_3 202 208 PF02991 0.266
LIG_LIR_Nem_3 242 248 PF02991 0.319
LIG_LIR_Nem_3 371 377 PF02991 0.471
LIG_LIR_Nem_3 417 421 PF02991 0.359
LIG_LIR_Nem_3 464 468 PF02991 0.273
LIG_LIR_Nem_3 485 490 PF02991 0.316
LIG_Pex14_2 169 173 PF04695 0.340
LIG_Pex14_2 463 467 PF04695 0.283
LIG_Pex14_2 487 491 PF04695 0.346
LIG_PTB_Apo_2 459 466 PF02174 0.344
LIG_PTB_Apo_2 485 492 PF02174 0.412
LIG_PTB_Phospho_1 459 465 PF10480 0.375
LIG_SH2_CRK 102 106 PF00017 0.485
LIG_SH2_CRK 136 140 PF00017 0.349
LIG_SH2_CRK 151 155 PF00017 0.301
LIG_SH2_CRK 186 190 PF00017 0.487
LIG_SH2_CRK 351 355 PF00017 0.588
LIG_SH2_CRK 379 383 PF00017 0.320
LIG_SH2_CRK 454 458 PF00017 0.300
LIG_SH2_CRK 468 472 PF00017 0.276
LIG_SH2_CRK 537 541 PF00017 0.334
LIG_SH2_CRK 593 597 PF00017 0.298
LIG_SH2_CRK 609 613 PF00017 0.329
LIG_SH2_GRB2like 450 453 PF00017 0.329
LIG_SH2_GRB2like 609 612 PF00017 0.323
LIG_SH2_NCK_1 334 338 PF00017 0.405
LIG_SH2_NCK_1 468 472 PF00017 0.273
LIG_SH2_NCK_1 537 541 PF00017 0.238
LIG_SH2_PTP2 32 35 PF00017 0.574
LIG_SH2_PTP2 524 527 PF00017 0.370
LIG_SH2_SRC 32 35 PF00017 0.580
LIG_SH2_SRC 334 337 PF00017 0.408
LIG_SH2_SRC 338 341 PF00017 0.396
LIG_SH2_STAP1 131 135 PF00017 0.473
LIG_SH2_STAP1 186 190 PF00017 0.463
LIG_SH2_STAP1 334 338 PF00017 0.402
LIG_SH2_STAP1 379 383 PF00017 0.368
LIG_SH2_STAP1 569 573 PF00017 0.314
LIG_SH2_STAP1 88 92 PF00017 0.509
LIG_SH2_STAT5 131 134 PF00017 0.474
LIG_SH2_STAT5 246 249 PF00017 0.412
LIG_SH2_STAT5 32 35 PF00017 0.571
LIG_SH2_STAT5 433 436 PF00017 0.329
LIG_SH2_STAT5 450 453 PF00017 0.260
LIG_SH2_STAT5 465 468 PF00017 0.235
LIG_SH2_STAT5 524 527 PF00017 0.275
LIG_SH2_STAT5 533 536 PF00017 0.266
LIG_SH2_STAT5 537 540 PF00017 0.311
LIG_SH3_1 351 357 PF00018 0.556
LIG_SH3_3 351 357 PF00018 0.567
LIG_SH3_3 439 445 PF00018 0.334
LIG_SUMO_SIM_anti_2 631 636 PF11976 0.437
LIG_SUMO_SIM_par_1 480 485 PF11976 0.205
LIG_SUMO_SIM_par_1 551 557 PF11976 0.303
LIG_TRFH_1 151 155 PF08558 0.336
LIG_TYR_ITIM 149 154 PF00017 0.356
LIG_TYR_ITSM 464 471 PF00017 0.378
LIG_UBA3_1 149 157 PF00899 0.328
LIG_UBA3_1 265 273 PF00899 0.491
LIG_UBA3_1 486 493 PF00899 0.389
LIG_UBA3_1 632 637 PF00899 0.204
LIG_Vh1_VBS_1 377 395 PF01044 0.382
LIG_Vh1_VBS_1 467 485 PF01044 0.361
MOD_CDC14_SPxK_1 301 304 PF00782 0.202
MOD_CDK_SPxK_1 298 304 PF00069 0.202
MOD_CK1_1 106 112 PF00069 0.337
MOD_CK1_1 199 205 PF00069 0.321
MOD_CK1_1 666 672 PF00069 0.581
MOD_CK2_1 268 274 PF00069 0.412
MOD_Cter_Amidation 297 300 PF01082 0.442
MOD_GlcNHglycan 158 162 PF01048 0.334
MOD_GlcNHglycan 234 237 PF01048 0.346
MOD_GlcNHglycan 442 445 PF01048 0.407
MOD_GSK3_1 103 110 PF00069 0.381
MOD_GSK3_1 209 216 PF00069 0.294
MOD_GSK3_1 228 235 PF00069 0.415
MOD_GSK3_1 298 305 PF00069 0.343
MOD_GSK3_1 364 371 PF00069 0.452
MOD_GSK3_1 377 384 PF00069 0.349
MOD_GSK3_1 436 443 PF00069 0.218
MOD_GSK3_1 463 470 PF00069 0.354
MOD_GSK3_1 496 503 PF00069 0.339
MOD_GSK3_1 574 581 PF00069 0.350
MOD_N-GLC_1 284 289 PF02516 0.165
MOD_N-GLC_1 461 466 PF02516 0.330
MOD_N-GLC_2 620 622 PF02516 0.458
MOD_NEK2_1 111 116 PF00069 0.350
MOD_NEK2_1 129 134 PF00069 0.257
MOD_NEK2_1 137 142 PF00069 0.312
MOD_NEK2_1 169 174 PF00069 0.319
MOD_NEK2_1 209 214 PF00069 0.300
MOD_NEK2_1 268 273 PF00069 0.408
MOD_NEK2_1 377 382 PF00069 0.347
MOD_NEK2_1 396 401 PF00069 0.272
MOD_NEK2_1 463 468 PF00069 0.337
MOD_NEK2_1 500 505 PF00069 0.341
MOD_NEK2_1 578 583 PF00069 0.330
MOD_NEK2_1 68 73 PF00069 0.426
MOD_NEK2_2 228 233 PF00069 0.440
MOD_PIKK_1 179 185 PF00454 0.301
MOD_PIKK_1 597 603 PF00454 0.478
MOD_PK_1 104 110 PF00069 0.425
MOD_PK_1 436 442 PF00069 0.362
MOD_PKA_2 103 109 PF00069 0.351
MOD_PKA_2 440 446 PF00069 0.432
MOD_PKA_2 496 502 PF00069 0.324
MOD_PKA_2 561 567 PF00069 0.309
MOD_Plk_1 461 467 PF00069 0.347
MOD_Plk_4 196 202 PF00069 0.321
MOD_Plk_4 209 215 PF00069 0.311
MOD_Plk_4 36 42 PF00069 0.469
MOD_Plk_4 377 383 PF00069 0.330
MOD_Plk_4 414 420 PF00069 0.369
MOD_Plk_4 463 469 PF00069 0.436
MOD_Plk_4 474 480 PF00069 0.300
MOD_Plk_4 482 488 PF00069 0.178
MOD_Plk_4 496 502 PF00069 0.320
MOD_Plk_4 535 541 PF00069 0.321
MOD_Plk_4 563 569 PF00069 0.356
MOD_Plk_4 628 634 PF00069 0.356
MOD_ProDKin_1 298 304 PF00069 0.431
MOD_ProDKin_1 620 626 PF00069 0.388
MOD_SUMO_for_1 8 11 PF00179 0.475
MOD_SUMO_rev_2 642 651 PF00179 0.382
TRG_DiLeu_BaEn_2 261 267 PF01217 0.284
TRG_DiLeu_BaLyEn_6 610 615 PF01217 0.355
TRG_DiLeu_BaLyEn_6 621 626 PF01217 0.295
TRG_ENDOCYTIC_2 102 105 PF00928 0.300
TRG_ENDOCYTIC_2 136 139 PF00928 0.327
TRG_ENDOCYTIC_2 151 154 PF00928 0.315
TRG_ENDOCYTIC_2 186 189 PF00928 0.319
TRG_ENDOCYTIC_2 379 382 PF00928 0.321
TRG_ENDOCYTIC_2 468 471 PF00928 0.331
TRG_ENDOCYTIC_2 524 527 PF00928 0.452
TRG_ENDOCYTIC_2 537 540 PF00928 0.353
TRG_ENDOCYTIC_2 569 572 PF00928 0.315
TRG_ENDOCYTIC_2 609 612 PF00928 0.398
TRG_ENDOCYTIC_2 88 91 PF00928 0.327
TRG_ER_diArg_1 47 49 PF00400 0.537
TRG_Pf-PMV_PEXEL_1 257 262 PF00026 0.465

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P2U2 Leptomonas seymouri 47% 99%
A0A0N1HY49 Leptomonas seymouri 45% 100%
A0A0N1HZ06 Leptomonas seymouri 35% 100%
A0A0N1IHL1 Leptomonas seymouri 37% 98%
A0A0N1PAY4 Leptomonas seymouri 46% 79%
A0A0N1PB77 Leptomonas seymouri 34% 100%
A0A0N1PBZ2 Leptomonas seymouri 67% 100%
A0A0N1PCC1 Leptomonas seymouri 41% 100%
A0A381MBI0 Leishmania infantum 42% 100%
A0A3Q8I8X7 Leishmania donovani 41% 100%
A0A3Q8IAZ0 Leishmania donovani 92% 100%
A0A3Q8IH50 Leishmania donovani 59% 97%
A0A3Q8IVN0 Leishmania donovani 36% 100%
A0A3R7M4J1 Trypanosoma rangeli 40% 100%
A0A3S5H5P4 Leishmania donovani 43% 100%
A0A3S5H5V2 Leishmania donovani 41% 100%
A0A3S5H6F6 Leishmania donovani 98% 100%
A0A3S5H763 Leishmania donovani 51% 100%
A0A3S7WR10 Leishmania donovani 42% 94%
A0A3S7WR14 Leishmania donovani 80% 100%
A0A3S7WR15 Leishmania donovani 71% 82%
A0A3S7WR24 Leishmania donovani 97% 99%
A4H4T8 Leishmania braziliensis 43% 100%
A4H5Y4 Leishmania braziliensis 43% 100%
A4H617 Leishmania braziliensis 80% 100%
A4H618 Leishmania braziliensis 80% 100%
A4H619 Leishmania braziliensis 80% 100%
A4H620 Leishmania braziliensis 57% 100%
A4H6C3 Leishmania braziliensis 44% 100%
A4HNH7 Leishmania braziliensis 36% 98%
A4HSS2 Leishmania infantum 43% 100%
A4HUE4 Leishmania infantum 42% 100%
A4HUE5 Leishmania infantum 75% 100%
A4HUE6 Leishmania infantum 82% 100%
A4HUE7 Leishmania infantum 92% 100%
A4HUE8 Leishmania infantum 97% 100%
A4HUF5 Leishmania infantum 58% 100%
A4HYA9 Leishmania infantum 51% 100%
A4IC33 Leishmania infantum 36% 100%
C9ZIK0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 37% 100%
C9ZIK3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 37% 100%
C9ZVE8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 39% 100%
C9ZVE9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 40% 100%
C9ZVF1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 40% 100%
D0A423 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 39% 100%
E8NHQ5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
E9AG72 Leishmania infantum 41% 100%
E9AI40 Leishmania braziliensis 76% 100%
E9AJY4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 44% 100%
E9AKQ9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 43% 100%
E9AL06 Leishmania mexicana (strain MHOM/GT/2001/U1103) 43% 100%
E9AN44 Leishmania mexicana (strain MHOM/GT/2001/U1103) 42% 100%
E9AN45 Leishmania mexicana (strain MHOM/GT/2001/U1103) 74% 99%
E9AN46 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
E9AN47 Leishmania mexicana (strain MHOM/GT/2001/U1103) 58% 100%
E9ANE5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 44% 100%
E9AS42 Leishmania mexicana (strain MHOM/GT/2001/U1103) 51% 100%
E9B741 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 98%
Q4QDC4 Leishmania major 51% 100%
Q4QH81 Leishmania major 43% 100%
Q4QHH7 Leishmania major 59% 100%
Q4QHH8 Leishmania major 91% 100%
Q4QHH9 Leishmania major 91% 100%
Q4QHI0 Leishmania major 89% 99%
Q4QHI1 Leishmania major 84% 100%
Q4QHI2 Leishmania major 79% 100%
Q4QIU9 Leishmania major 43% 100%
Q4QJ48 Leishmania major 43% 100%
Q7KIP2 Leishmania major 36% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS