Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania infantum

UniProt:

A4HUF0_LEIIN

TriTrypDb:

LINF_100009700

Length:

635

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HUF0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HUF0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	401	405	PF00656	0.695
CLV_C14_Caspase3-7	59	63	PF00656	0.617
CLV_NRD_NRD_1	119	121	PF00675	0.661
CLV_NRD_NRD_1	2	4	PF00675	0.643
CLV_NRD_NRD_1	345	347	PF00675	0.636
CLV_NRD_NRD_1	377	379	PF00675	0.654
CLV_NRD_NRD_1	427	429	PF00675	0.475
CLV_NRD_NRD_1	540	542	PF00675	0.711
CLV_PCSK_KEX2_1	119	121	PF00082	0.661
CLV_PCSK_KEX2_1	2	4	PF00082	0.643
CLV_PCSK_KEX2_1	345	347	PF00082	0.633
CLV_PCSK_KEX2_1	377	379	PF00082	0.654
CLV_PCSK_KEX2_1	427	429	PF00082	0.475
CLV_PCSK_KEX2_1	540	542	PF00082	0.749
CLV_PCSK_KEX2_1	547	549	PF00082	0.694
CLV_PCSK_PC1ET2_1	547	549	PF00082	0.736
CLV_PCSK_SKI1_1	541	545	PF00082	0.676
DEG_Nend_UBRbox_1	1	4	PF02207	0.643
DEG_SCF_FBW7_1	328	333	PF00400	0.701
DEG_SPOP_SBC_1	108	112	PF00917	0.706
DEG_SPOP_SBC_1	151	155	PF00917	0.622
DEG_SPOP_SBC_1	470	474	PF00917	0.597
DOC_CKS1_1	4	9	PF01111	0.636
DOC_CKS1_1	85	90	PF01111	0.541
DOC_CYCLIN_RxL_1	87	97	PF00134	0.726
DOC_CYCLIN_yCln2_LP_2	509	512	PF00134	0.552
DOC_MAPK_DCC_7	26	34	PF00069	0.656
DOC_MAPK_DCC_7	501	509	PF00069	0.545
DOC_MAPK_DCC_7	528	538	PF00069	0.597
DOC_MAPK_FxFP_2	66	69	PF00069	0.695
DOC_MAPK_gen_1	22	32	PF00069	0.650
DOC_MAPK_gen_1	374	384	PF00069	0.764
DOC_MAPK_gen_1	427	433	PF00069	0.452
DOC_MAPK_gen_1	443	451	PF00069	0.393
DOC_MAPK_gen_1	452	460	PF00069	0.439
DOC_MAPK_MEF2A_6	26	34	PF00069	0.656
DOC_MAPK_MEF2A_6	377	386	PF00069	0.652
DOC_PP2B_LxvP_1	509	512	PF13499	0.552
DOC_PP4_FxxP_1	66	69	PF00568	0.695
DOC_USP7_MATH_1	151	155	PF00917	0.797
DOC_USP7_MATH_1	179	183	PF00917	0.668
DOC_USP7_MATH_1	24	28	PF00917	0.559
DOC_USP7_MATH_1	261	265	PF00917	0.710
DOC_USP7_MATH_1	315	319	PF00917	0.642
DOC_USP7_MATH_1	330	334	PF00917	0.704
DOC_USP7_MATH_1	398	402	PF00917	0.789
DOC_USP7_MATH_1	462	466	PF00917	0.538
DOC_USP7_MATH_1	486	490	PF00917	0.379
DOC_USP7_MATH_1	527	531	PF00917	0.593
DOC_USP7_MATH_1	569	573	PF00917	0.560
DOC_USP7_MATH_1	605	609	PF00917	0.537
DOC_WW_Pin1_4	181	186	PF00397	0.684
DOC_WW_Pin1_4	215	220	PF00397	0.804
DOC_WW_Pin1_4	282	287	PF00397	0.804
DOC_WW_Pin1_4	292	297	PF00397	0.651
DOC_WW_Pin1_4	3	8	PF00397	0.810
DOC_WW_Pin1_4	320	325	PF00397	0.836
DOC_WW_Pin1_4	326	331	PF00397	0.546
DOC_WW_Pin1_4	338	343	PF00397	0.673
DOC_WW_Pin1_4	34	39	PF00397	0.829
DOC_WW_Pin1_4	358	363	PF00397	0.469
DOC_WW_Pin1_4	47	52	PF00397	0.615
DOC_WW_Pin1_4	502	507	PF00397	0.699
DOC_WW_Pin1_4	521	526	PF00397	0.524
DOC_WW_Pin1_4	531	536	PF00397	0.643
DOC_WW_Pin1_4	563	568	PF00397	0.642
DOC_WW_Pin1_4	627	632	PF00397	0.629
DOC_WW_Pin1_4	76	81	PF00397	0.848
DOC_WW_Pin1_4	84	89	PF00397	0.686
LIG_14-3-3_CanoR_1	120	126	PF00244	0.640
LIG_14-3-3_CanoR_1	145	150	PF00244	0.743
LIG_14-3-3_CanoR_1	224	234	PF00244	0.598
LIG_14-3-3_CanoR_1	345	350	PF00244	0.666
LIG_14-3-3_CanoR_1	412	417	PF00244	0.595
LIG_14-3-3_CanoR_1	427	432	PF00244	0.430
LIG_14-3-3_CanoR_1	513	520	PF00244	0.603
LIG_14-3-3_CanoR_1	528	533	PF00244	0.704
LIG_14-3-3_CanoR_1	623	631	PF00244	0.623
LIG_Actin_WH2_2	406	424	PF00022	0.644
LIG_Actin_WH2_2	431	447	PF00022	0.639
LIG_BIR_III_2	74	78	PF00653	0.677
LIG_BIR_III_4	303	307	PF00653	0.702
LIG_BRCT_BRCA1_1	489	493	PF00533	0.546
LIG_CSL_BTD_1	293	296	PF09270	0.636
LIG_eIF4E_1	453	459	PF01652	0.453
LIG_FHA_1	109	115	PF00498	0.807
LIG_FHA_1	121	127	PF00498	0.583
LIG_FHA_1	133	139	PF00498	0.531
LIG_FHA_1	268	274	PF00498	0.581
LIG_FHA_1	314	320	PF00498	0.670
LIG_FHA_1	418	424	PF00498	0.507
LIG_FHA_1	454	460	PF00498	0.632
LIG_FHA_1	462	468	PF00498	0.608
LIG_FHA_2	218	224	PF00498	0.631
LIG_FHA_2	308	314	PF00498	0.696
LIG_FHA_2	560	566	PF00498	0.613
LIG_LIR_Apic_2	64	69	PF02991	0.688
LIG_LIR_Gen_1	490	499	PF02991	0.571
LIG_LIR_Nem_3	312	317	PF02991	0.707
LIG_LIR_Nem_3	490	496	PF02991	0.540
LIG_MYND_1	586	590	PF01753	0.596
LIG_MYND_1	84	88	PF01753	0.545
LIG_PCNA_yPIPBox_3	140	150	PF02747	0.627
LIG_SH2_NCK_1	245	249	PF00017	0.647
LIG_SH2_STAT5	441	444	PF00017	0.498
LIG_SH2_STAT5	619	622	PF00017	0.549
LIG_SH3_2	85	90	PF14604	0.541
LIG_SH3_3	1	7	PF00018	0.639
LIG_SH3_3	154	160	PF00018	0.801
LIG_SH3_3	190	196	PF00018	0.687
LIG_SH3_3	200	206	PF00018	0.567
LIG_SH3_3	290	296	PF00018	0.707
LIG_SH3_3	32	38	PF00018	0.832
LIG_SH3_3	331	337	PF00018	0.758
LIG_SH3_3	553	559	PF00018	0.719
LIG_SH3_3	584	590	PF00018	0.601
LIG_SH3_3	599	605	PF00018	0.516
LIG_SH3_3	611	617	PF00018	0.702
LIG_SH3_3	74	80	PF00018	0.726
LIG_SH3_3	82	88	PF00018	0.628
LIG_SUMO_SIM_anti_2	429	435	PF11976	0.428
LIG_SUMO_SIM_anti_2	505	511	PF11976	0.548
LIG_SUMO_SIM_par_1	30	37	PF11976	0.656
LIG_SUMO_SIM_par_1	379	385	PF11976	0.693
LIG_TRAF2_1	385	388	PF00917	0.738
LIG_TYR_ITIM	439	444	PF00017	0.456
LIG_WW_3	184	188	PF00397	0.717
LIG_WW_3	285	289	PF00397	0.685
LIG_WW_3	510	514	PF00397	0.549
MOD_CDC14_SPxK_1	534	537	PF00782	0.632
MOD_CDK_SPK_2	320	325	PF00069	0.836
MOD_CDK_SPK_2	340	345	PF00069	0.676
MOD_CDK_SPK_2	523	528	PF00069	0.646
MOD_CDK_SPxK_1	181	187	PF00069	0.717
MOD_CDK_SPxK_1	282	288	PF00069	0.687
MOD_CDK_SPxK_1	340	346	PF00069	0.678
MOD_CDK_SPxK_1	531	537	PF00069	0.629
MOD_CDK_SPxK_1	84	90	PF00069	0.543
MOD_CDK_SPxxK_3	338	345	PF00069	0.796
MOD_CDK_SPxxK_3	521	528	PF00069	0.702
MOD_CK1_1	225	231	PF00069	0.690
MOD_CK1_1	275	281	PF00069	0.640
MOD_CK1_1	417	423	PF00069	0.650
MOD_CK1_1	465	471	PF00069	0.608
MOD_CK1_1	473	479	PF00069	0.472
MOD_CK1_1	49	55	PF00069	0.831
MOD_CK1_1	521	527	PF00069	0.586
MOD_CK1_1	531	537	PF00069	0.551
MOD_CK1_1	57	63	PF00069	0.660
MOD_CK1_1	79	85	PF00069	0.741
MOD_CK2_1	217	223	PF00069	0.632
MOD_CK2_1	243	249	PF00069	0.757
MOD_CK2_1	382	388	PF00069	0.753
MOD_CK2_1	465	471	PF00069	0.599
MOD_CK2_1	559	565	PF00069	0.612
MOD_CK2_1	591	597	PF00069	0.545
MOD_DYRK1A_RPxSP_1	3	7	PF00069	0.812
MOD_DYRK1A_RPxSP_1	523	527	PF00069	0.643
MOD_GlcNHglycan	175	178	PF01048	0.717
MOD_GlcNHglycan	199	202	PF01048	0.713
MOD_GlcNHglycan	210	213	PF01048	0.681
MOD_GlcNHglycan	227	230	PF01048	0.534
MOD_GlcNHglycan	245	248	PF01048	0.581
MOD_GlcNHglycan	259	262	PF01048	0.586
MOD_GlcNHglycan	26	29	PF01048	0.672
MOD_GlcNHglycan	263	266	PF01048	0.523
MOD_GlcNHglycan	279	282	PF01048	0.502
MOD_GlcNHglycan	296	299	PF01048	0.681
MOD_GlcNHglycan	364	367	PF01048	0.761
MOD_GlcNHglycan	393	396	PF01048	0.699
MOD_GlcNHglycan	416	419	PF01048	0.669
MOD_GlcNHglycan	466	470	PF01048	0.652
MOD_GlcNHglycan	473	476	PF01048	0.565
MOD_GlcNHglycan	514	517	PF01048	0.727
MOD_GlcNHglycan	520	523	PF01048	0.673
MOD_GlcNHglycan	530	533	PF01048	0.558
MOD_GlcNHglycan	571	574	PF01048	0.738
MOD_GlcNHglycan	96	99	PF01048	0.553
MOD_GSK3_1	109	116	PF00069	0.746
MOD_GSK3_1	204	211	PF00069	0.768
MOD_GSK3_1	257	264	PF00069	0.732
MOD_GSK3_1	273	280	PF00069	0.530
MOD_GSK3_1	282	289	PF00069	0.621
MOD_GSK3_1	294	301	PF00069	0.630
MOD_GSK3_1	309	316	PF00069	0.804
MOD_GSK3_1	320	327	PF00069	0.720
MOD_GSK3_1	358	365	PF00069	0.766
MOD_GSK3_1	417	424	PF00069	0.541
MOD_GSK3_1	46	53	PF00069	0.778
MOD_GSK3_1	461	468	PF00069	0.652
MOD_GSK3_1	469	476	PF00069	0.694
MOD_GSK3_1	523	530	PF00069	0.606
MOD_GSK3_1	559	566	PF00069	0.574
MOD_GSK3_1	623	630	PF00069	0.655
MOD_GSK3_1	75	82	PF00069	0.847
MOD_N-GLC_1	114	119	PF02516	0.618
MOD_N-GLC_1	24	29	PF02516	0.561
MOD_NEK2_1	126	131	PF00069	0.697
MOD_NEK2_1	150	155	PF00069	0.787
MOD_NEK2_1	173	178	PF00069	0.725
MOD_NEK2_1	267	272	PF00069	0.627
MOD_NEK2_1	273	278	PF00069	0.569
MOD_NEK2_1	382	387	PF00069	0.634
MOD_NEK2_1	56	61	PF00069	0.629
MOD_NEK2_1	94	99	PF00069	0.616
MOD_PIKK_1	79	85	PF00454	0.766
MOD_PK_1	345	351	PF00069	0.805
MOD_PK_1	427	433	PF00069	0.510
MOD_PKA_1	345	351	PF00069	0.805
MOD_PKA_1	427	433	PF00069	0.452
MOD_PKA_2	118	124	PF00069	0.648
MOD_PKA_2	173	179	PF00069	0.723
MOD_PKA_2	223	229	PF00069	0.617
MOD_PKA_2	267	273	PF00069	0.701
MOD_PKA_2	345	351	PF00069	0.805
MOD_PKA_2	396	402	PF00069	0.834
MOD_PKA_2	421	427	PF00069	0.631
MOD_PKA_2	512	518	PF00069	0.729
MOD_PKA_2	527	533	PF00069	0.571
MOD_PKA_2	536	542	PF00069	0.506
MOD_PKA_2	622	628	PF00069	0.615
MOD_PKB_1	621	629	PF00069	0.542
MOD_Plk_1	24	30	PF00069	0.609
MOD_Plk_2-3	591	597	PF00069	0.545
MOD_Plk_4	121	127	PF00069	0.807
MOD_Plk_4	145	151	PF00069	0.669
MOD_Plk_4	189	195	PF00069	0.700
MOD_Plk_4	330	336	PF00069	0.704
MOD_Plk_4	345	351	PF00069	0.535
MOD_Plk_4	50	56	PF00069	0.835
MOD_Plk_4	591	597	PF00069	0.545
MOD_ProDKin_1	181	187	PF00069	0.685
MOD_ProDKin_1	215	221	PF00069	0.804
MOD_ProDKin_1	282	288	PF00069	0.804
MOD_ProDKin_1	292	298	PF00069	0.652
MOD_ProDKin_1	3	9	PF00069	0.812
MOD_ProDKin_1	320	326	PF00069	0.835
MOD_ProDKin_1	338	344	PF00069	0.796
MOD_ProDKin_1	34	40	PF00069	0.831
MOD_ProDKin_1	358	364	PF00069	0.468
MOD_ProDKin_1	47	53	PF00069	0.615
MOD_ProDKin_1	502	508	PF00069	0.699
MOD_ProDKin_1	521	527	PF00069	0.524
MOD_ProDKin_1	531	537	PF00069	0.644
MOD_ProDKin_1	563	569	PF00069	0.647
MOD_ProDKin_1	627	633	PF00069	0.631
MOD_ProDKin_1	76	82	PF00069	0.848
MOD_ProDKin_1	84	90	PF00069	0.680
MOD_SUMO_for_1	588	591	PF00179	0.711
MOD_SUMO_rev_2	249	259	PF00179	0.665
TRG_DiLeu_BaEn_1	591	596	PF01217	0.542
TRG_DiLeu_BaLyEn_6	200	205	PF01217	0.749
TRG_DiLeu_BaLyEn_6	268	273	PF01217	0.624
TRG_DiLeu_BaLyEn_6	87	92	PF01217	0.743
TRG_ENDOCYTIC_2	441	444	PF00928	0.524
TRG_ER_diArg_1	1	3	PF00400	0.645
TRG_ER_diArg_1	139	142	PF00400	0.570
TRG_ER_diArg_1	344	346	PF00400	0.625
TRG_Pf-PMV_PEXEL_1	90	95	PF00026	0.726

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8I8R8	Leishmania donovani	98%	100%
A4H622	Leishmania braziliensis	57%	100%
E9AN49	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%