LeishMANIAdb
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Putative folate/biopterin transporter

Quick info Annotations Function or PPIs Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative folate/biopterin transporter
Gene product:
pteridine transporter (truncated) - putative
Species:
Leishmania infantum
UniProt:
A4HUE8_LEIIN
TriTrypDb:
LINF_100009300
Length:
704

Annotations

Annotations by Jardim et al.

Transporters, folate/biopterin transporter FT1

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) yes yes: 9
Silverman et al. no yes: 0
Pissara et al. yes yes: 52
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 6
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 6
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 70
NetGPI no yes: 0, no: 70
Cellular components
Term Name Level Count
GO:0016020 membrane 2 71
GO:0110165 cellular anatomical entity 1 71
GO:0005737 cytoplasm 2 6
GO:0005886 plasma membrane 3 1

Phosphorylation

Promastigote/Amastigote: 307

Expansion

Sequence features

A4HUE8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HUE8

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 1
GO:0015877 biopterin transport 5 1
GO:0051179 localization 1 1
GO:0051234 establishment of localization 2 1
GO:0071702 organic substance transport 4 1
GO:0071705 nitrogen compound transport 4 1
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 1
GO:0015224 biopterin transmembrane transporter activity 3 1
GO:0022857 transmembrane transporter activity 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 667 671 PF00656 0.821
CLV_MEL_PAP_1 438 444 PF00089 0.301
CLV_NRD_NRD_1 271 273 PF00675 0.389
CLV_NRD_NRD_1 48 50 PF00675 0.461
CLV_PCSK_KEX2_1 133 135 PF00082 0.348
CLV_PCSK_KEX2_1 299 301 PF00082 0.432
CLV_PCSK_KEX2_1 48 50 PF00082 0.495
CLV_PCSK_KEX2_1 519 521 PF00082 0.573
CLV_PCSK_KEX2_1 697 699 PF00082 0.481
CLV_PCSK_KEX2_1 9 11 PF00082 0.467
CLV_PCSK_PC1ET2_1 133 135 PF00082 0.348
CLV_PCSK_PC1ET2_1 299 301 PF00082 0.432
CLV_PCSK_PC1ET2_1 519 521 PF00082 0.573
CLV_PCSK_PC1ET2_1 697 699 PF00082 0.498
CLV_PCSK_PC1ET2_1 9 11 PF00082 0.467
CLV_PCSK_SKI1_1 116 120 PF00082 0.405
CLV_PCSK_SKI1_1 316 320 PF00082 0.400
DEG_APCC_DBOX_1 276 284 PF00400 0.477
DOC_CDC14_PxL_1 609 617 PF14671 0.382
DOC_CKS1_1 621 626 PF01111 0.483
DOC_CYCLIN_yCln2_LP_2 626 632 PF00134 0.429
DOC_MAPK_gen_1 133 139 PF00069 0.557
DOC_MAPK_gen_1 257 267 PF00069 0.600
DOC_MAPK_gen_1 272 280 PF00069 0.592
DOC_MAPK_gen_1 519 527 PF00069 0.374
DOC_MAPK_gen_1 637 646 PF00069 0.638
DOC_MAPK_MEF2A_6 227 234 PF00069 0.380
DOC_MAPK_MEF2A_6 519 527 PF00069 0.408
DOC_PP1_RVXF_1 495 501 PF00149 0.570
DOC_PP2B_LxvP_1 626 629 PF13499 0.415
DOC_PP2B_PxIxI_1 227 233 PF00149 0.339
DOC_USP7_MATH_1 199 203 PF00917 0.373
DOC_USP7_MATH_1 302 306 PF00917 0.611
DOC_USP7_MATH_1 561 565 PF00917 0.537
DOC_USP7_MATH_1 663 667 PF00917 0.687
DOC_USP7_MATH_1 699 703 PF00917 0.795
DOC_WW_Pin1_4 298 303 PF00397 0.640
DOC_WW_Pin1_4 620 625 PF00397 0.465
LIG_14-3-3_CanoR_1 104 111 PF00244 0.542
LIG_14-3-3_CanoR_1 257 267 PF00244 0.637
LIG_14-3-3_CanoR_1 304 311 PF00244 0.651
LIG_14-3-3_CanoR_1 497 501 PF00244 0.542
LIG_14-3-3_CanoR_1 577 586 PF00244 0.550
LIG_Actin_WH2_2 50 65 PF00022 0.668
LIG_APCC_ABBA_1 50 55 PF00400 0.683
LIG_APCC_ABBAyCdc20_2 49 55 PF00400 0.554
LIG_BIR_II_1 1 5 PF00653 0.818
LIG_BIR_III_4 13 17 PF00653 0.772
LIG_Clathr_ClatBox_1 265 269 PF01394 0.498
LIG_EH1_1 499 507 PF00400 0.392
LIG_eIF4E_1 609 615 PF01652 0.282
LIG_FHA_1 117 123 PF00498 0.621
LIG_FHA_1 365 371 PF00498 0.642
LIG_FHA_1 382 388 PF00498 0.407
LIG_FHA_1 397 403 PF00498 0.310
LIG_FHA_1 481 487 PF00498 0.445
LIG_FHA_1 497 503 PF00498 0.543
LIG_FHA_1 621 627 PF00498 0.469
LIG_FHA_2 269 275 PF00498 0.622
LIG_FHA_2 598 604 PF00498 0.279
LIG_GBD_Chelix_1 478 486 PF00786 0.284
LIG_GBD_Chelix_1 501 509 PF00786 0.525
LIG_GBD_Chelix_1 539 547 PF00786 0.555
LIG_LIR_Apic_2 29 35 PF02991 0.655
LIG_LIR_Apic_2 348 354 PF02991 0.581
LIG_LIR_Apic_2 417 422 PF02991 0.467
LIG_LIR_Apic_2 453 457 PF02991 0.383
LIG_LIR_Apic_2 592 596 PF02991 0.353
LIG_LIR_Gen_1 124 131 PF02991 0.571
LIG_LIR_Gen_1 202 210 PF02991 0.555
LIG_LIR_Gen_1 466 475 PF02991 0.381
LIG_LIR_Gen_1 485 492 PF02991 0.445
LIG_LIR_Gen_1 566 576 PF02991 0.567
LIG_LIR_Gen_1 87 95 PF02991 0.590
LIG_LIR_Nem_3 124 129 PF02991 0.546
LIG_LIR_Nem_3 132 138 PF02991 0.546
LIG_LIR_Nem_3 202 208 PF02991 0.343
LIG_LIR_Nem_3 242 248 PF02991 0.395
LIG_LIR_Nem_3 371 377 PF02991 0.550
LIG_LIR_Nem_3 417 421 PF02991 0.436
LIG_LIR_Nem_3 464 468 PF02991 0.351
LIG_LIR_Nem_3 485 490 PF02991 0.393
LIG_PCNA_PIPBox_1 506 515 PF02747 0.253
LIG_Pex14_2 169 173 PF04695 0.416
LIG_Pex14_2 463 467 PF04695 0.362
LIG_Pex14_2 487 491 PF04695 0.423
LIG_PTB_Apo_2 459 466 PF02174 0.423
LIG_PTB_Apo_2 485 492 PF02174 0.491
LIG_PTB_Phospho_1 459 465 PF10480 0.457
LIG_Rb_pABgroove_1 507 515 PF01858 0.385
LIG_SH2_CRK 102 106 PF00017 0.563
LIG_SH2_CRK 136 140 PF00017 0.426
LIG_SH2_CRK 151 155 PF00017 0.378
LIG_SH2_CRK 186 190 PF00017 0.566
LIG_SH2_CRK 351 355 PF00017 0.670
LIG_SH2_CRK 379 383 PF00017 0.397
LIG_SH2_CRK 454 458 PF00017 0.379
LIG_SH2_CRK 468 472 PF00017 0.354
LIG_SH2_CRK 593 597 PF00017 0.376
LIG_SH2_CRK 609 613 PF00017 0.409
LIG_SH2_GRB2like 450 453 PF00017 0.408
LIG_SH2_GRB2like 609 612 PF00017 0.402
LIG_SH2_NCK_1 334 338 PF00017 0.488
LIG_SH2_NCK_1 468 472 PF00017 0.352
LIG_SH2_PTP2 32 35 PF00017 0.650
LIG_SH2_PTP2 524 527 PF00017 0.451
LIG_SH2_SRC 32 35 PF00017 0.656
LIG_SH2_SRC 334 337 PF00017 0.491
LIG_SH2_SRC 338 341 PF00017 0.478
LIG_SH2_STAP1 131 135 PF00017 0.552
LIG_SH2_STAP1 186 190 PF00017 0.541
LIG_SH2_STAP1 334 338 PF00017 0.483
LIG_SH2_STAP1 379 383 PF00017 0.445
LIG_SH2_STAP1 569 573 PF00017 0.390
LIG_SH2_STAP1 88 92 PF00017 0.588
LIG_SH2_STAT5 131 134 PF00017 0.553
LIG_SH2_STAT5 246 249 PF00017 0.491
LIG_SH2_STAT5 32 35 PF00017 0.645
LIG_SH2_STAT5 433 436 PF00017 0.406
LIG_SH2_STAT5 450 453 PF00017 0.338
LIG_SH2_STAT5 465 468 PF00017 0.314
LIG_SH2_STAT5 524 527 PF00017 0.353
LIG_SH2_STAT5 533 536 PF00017 0.345
LIG_SH3_1 351 357 PF00018 0.637
LIG_SH3_3 351 357 PF00018 0.647
LIG_SH3_3 439 445 PF00018 0.411
LIG_SUMO_SIM_anti_2 514 519 PF11976 0.371
LIG_SUMO_SIM_anti_2 631 636 PF11976 0.515
LIG_SUMO_SIM_par_1 480 485 PF11976 0.287
LIG_SUMO_SIM_par_1 552 557 PF11976 0.380
LIG_TRFH_1 151 155 PF08558 0.413
LIG_TYR_ITIM 149 154 PF00017 0.432
LIG_TYR_ITSM 464 471 PF00017 0.455
LIG_UBA3_1 149 157 PF00899 0.410
LIG_UBA3_1 265 273 PF00899 0.573
LIG_UBA3_1 486 493 PF00899 0.467
LIG_UBA3_1 512 519 PF00899 0.374
LIG_UBA3_1 632 637 PF00899 0.287
LIG_Vh1_VBS_1 377 395 PF01044 0.459
LIG_Vh1_VBS_1 467 485 PF01044 0.438
MOD_CDC14_SPxK_1 301 304 PF00782 0.284
MOD_CDK_SPxK_1 298 304 PF00069 0.284
MOD_CK1_1 106 112 PF00069 0.414
MOD_CK1_1 620 626 PF00069 0.297
MOD_CK1_1 666 672 PF00069 0.662
MOD_CK2_1 268 274 PF00069 0.483
MOD_Cter_Amidation 297 300 PF01082 0.521
MOD_Cter_Amidation 695 698 PF01082 0.533
MOD_GlcNHglycan 158 162 PF01048 0.411
MOD_GlcNHglycan 234 237 PF01048 0.423
MOD_GlcNHglycan 442 445 PF01048 0.485
MOD_GSK3_1 103 110 PF00069 0.458
MOD_GSK3_1 209 216 PF00069 0.371
MOD_GSK3_1 228 235 PF00069 0.493
MOD_GSK3_1 298 305 PF00069 0.472
MOD_GSK3_1 364 371 PF00069 0.532
MOD_GSK3_1 377 384 PF00069 0.426
MOD_GSK3_1 436 443 PF00069 0.300
MOD_GSK3_1 463 470 PF00069 0.430
MOD_GSK3_1 496 503 PF00069 0.416
MOD_GSK3_1 578 585 PF00069 0.425
MOD_N-GLC_1 284 289 PF02516 0.247
MOD_N-GLC_1 461 466 PF02516 0.407
MOD_NEK2_1 111 116 PF00069 0.427
MOD_NEK2_1 129 134 PF00069 0.334
MOD_NEK2_1 137 142 PF00069 0.389
MOD_NEK2_1 169 174 PF00069 0.396
MOD_NEK2_1 209 214 PF00069 0.377
MOD_NEK2_1 268 273 PF00069 0.461
MOD_NEK2_1 377 382 PF00069 0.423
MOD_NEK2_1 396 401 PF00069 0.349
MOD_NEK2_1 463 468 PF00069 0.414
MOD_NEK2_1 500 505 PF00069 0.418
MOD_NEK2_1 578 583 PF00069 0.406
MOD_NEK2_1 617 622 PF00069 0.500
MOD_NEK2_1 68 73 PF00069 0.507
MOD_NEK2_2 228 233 PF00069 0.520
MOD_PIKK_1 179 185 PF00454 0.378
MOD_PIKK_1 597 603 PF00454 0.559
MOD_PK_1 104 110 PF00069 0.503
MOD_PK_1 436 442 PF00069 0.439
MOD_PKA_2 103 109 PF00069 0.428
MOD_PKA_2 440 446 PF00069 0.511
MOD_PKA_2 496 502 PF00069 0.401
MOD_PKA_2 561 567 PF00069 0.386
MOD_PKA_2 579 585 PF00069 0.386
MOD_Plk_1 461 467 PF00069 0.424
MOD_Plk_4 199 205 PF00069 0.396
MOD_Plk_4 209 215 PF00069 0.388
MOD_Plk_4 36 42 PF00069 0.544
MOD_Plk_4 377 383 PF00069 0.407
MOD_Plk_4 414 420 PF00069 0.445
MOD_Plk_4 463 469 PF00069 0.515
MOD_Plk_4 474 480 PF00069 0.377
MOD_Plk_4 482 488 PF00069 0.258
MOD_Plk_4 496 502 PF00069 0.397
MOD_Plk_4 563 569 PF00069 0.433
MOD_Plk_4 628 634 PF00069 0.432
MOD_ProDKin_1 298 304 PF00069 0.525
MOD_ProDKin_1 620 626 PF00069 0.465
MOD_SUMO_for_1 8 11 PF00179 0.560
MOD_SUMO_rev_2 642 651 PF00179 0.459
TRG_DiLeu_BaEn_2 261 267 PF01217 0.366
TRG_DiLeu_BaLyEn_6 610 615 PF01217 0.432
TRG_DiLeu_BaLyEn_6 621 626 PF01217 0.372
TRG_ENDOCYTIC_2 102 105 PF00928 0.376
TRG_ENDOCYTIC_2 136 139 PF00928 0.404
TRG_ENDOCYTIC_2 151 154 PF00928 0.392
TRG_ENDOCYTIC_2 186 189 PF00928 0.396
TRG_ENDOCYTIC_2 379 382 PF00928 0.398
TRG_ENDOCYTIC_2 468 471 PF00928 0.407
TRG_ENDOCYTIC_2 524 527 PF00928 0.532
TRG_ENDOCYTIC_2 569 572 PF00928 0.391
TRG_ENDOCYTIC_2 609 612 PF00928 0.476
TRG_ENDOCYTIC_2 88 91 PF00928 0.403
TRG_ER_diArg_1 47 49 PF00400 0.615
TRG_Pf-PMV_PEXEL_1 257 262 PF00026 0.540

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P2U2 Leptomonas seymouri 47% 100%
A0A0N1HY49 Leptomonas seymouri 44% 100%
A0A0N1HZ06 Leptomonas seymouri 37% 100%
A0A0N1IHL1 Leptomonas seymouri 38% 99%
A0A0N1PAY4 Leptomonas seymouri 46% 80%
A0A0N1PB77 Leptomonas seymouri 35% 100%
A0A0N1PBZ2 Leptomonas seymouri 67% 100%
A0A0N1PCC1 Leptomonas seymouri 42% 100%
A0A381MBI0 Leishmania infantum 43% 100%
A0A3Q8I8X7 Leishmania donovani 42% 100%
A0A3Q8IAZ0 Leishmania donovani 91% 100%
A0A3Q8IH50 Leishmania donovani 59% 98%
A0A3Q8IVN0 Leishmania donovani 38% 100%
A0A3R7M4J1 Trypanosoma rangeli 40% 100%
A0A3S5H5P4 Leishmania donovani 43% 100%
A0A3S5H5V2 Leishmania donovani 42% 100%
A0A3S5H6F6 Leishmania donovani 95% 100%
A0A3S5H763 Leishmania donovani 51% 100%
A0A3S7WR10 Leishmania donovani 43% 94%
A0A3S7WR14 Leishmania donovani 81% 100%
A0A3S7WR15 Leishmania donovani 71% 83%
A0A3S7WR24 Leishmania donovani 99% 100%
A4H4T8 Leishmania braziliensis 44% 100%
A4H5Y4 Leishmania braziliensis 44% 100%
A4H617 Leishmania braziliensis 80% 100%
A4H618 Leishmania braziliensis 79% 100%
A4H619 Leishmania braziliensis 81% 100%
A4H620 Leishmania braziliensis 57% 100%
A4H6C3 Leishmania braziliensis 43% 100%
A4HNH7 Leishmania braziliensis 37% 98%
A4HSS2 Leishmania infantum 44% 100%
A4HUE4 Leishmania infantum 43% 100%
A4HUE5 Leishmania infantum 74% 100%
A4HUE6 Leishmania infantum 83% 100%
A4HUE7 Leishmania infantum 92% 100%
A4HUF4 Leishmania infantum 97% 100%
A4HUF5 Leishmania infantum 58% 100%
A4HYA9 Leishmania infantum 51% 100%
A4IC33 Leishmania infantum 37% 100%
C9ZIK0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 38% 100%
C9ZIK3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 38% 100%
C9ZVE8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 40% 100%
C9ZVE9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 41% 100%
C9ZVF1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 41% 100%
D0A423 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 40% 100%
E8NHQ5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
E9AG72 Leishmania infantum 42% 100%
E9AI40 Leishmania braziliensis 76% 100%
E9AJY4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 45% 100%
E9AKQ9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 42% 100%
E9AL06 Leishmania mexicana (strain MHOM/GT/2001/U1103) 43% 100%
E9AN44 Leishmania mexicana (strain MHOM/GT/2001/U1103) 43% 100%
E9AN45 Leishmania mexicana (strain MHOM/GT/2001/U1103) 74% 99%
E9AN46 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%
E9AN47 Leishmania mexicana (strain MHOM/GT/2001/U1103) 59% 100%
E9ANE5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 45% 100%
E9AS42 Leishmania mexicana (strain MHOM/GT/2001/U1103) 51% 100%
E9B741 Leishmania mexicana (strain MHOM/GT/2001/U1103) 38% 98%
Q4QDC4 Leishmania major 51% 100%
Q4QH81 Leishmania major 44% 100%
Q4QHH7 Leishmania major 57% 100%
Q4QHH8 Leishmania major 91% 100%
Q4QHH9 Leishmania major 93% 100%
Q4QHI0 Leishmania major 88% 99%
Q4QHI1 Leishmania major 85% 100%
Q4QHI2 Leishmania major 78% 100%
Q4QIU9 Leishmania major 44% 100%
Q4QJ48 Leishmania major 43% 100%
Q7KIP2 Leishmania major 37% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS