Putative folate/biopterin transporter

Quick info Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pteridine transporter (truncated) - putative

Species:

Leishmania infantum

UniProt:

A4HUE7_LEIIN

TriTrypDb:

LINF_100009400

Length:

700

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 9
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 52

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 70
NetGPI	no	yes: 0, no: 70

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	71
GO:0110165	cellular anatomical entity	1	71
GO:0005737	cytoplasm	2	6
GO:0005886	plasma membrane	3	1

Phosphorylation

Promastigote/Amastigote: 307

Expansion

Sequence features

A4HUE7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HUE7

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0015877	biopterin transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0015224	biopterin transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	665	669	PF00656	0.785
CLV_MEL_PAP_1	438	444	PF00089	0.276
CLV_NRD_NRD_1	271	273	PF00675	0.364
CLV_NRD_NRD_1	48	50	PF00675	0.435
CLV_NRD_NRD_1	685	687	PF00675	0.545
CLV_PCSK_KEX2_1	133	135	PF00082	0.323
CLV_PCSK_KEX2_1	299	301	PF00082	0.407
CLV_PCSK_KEX2_1	48	50	PF00082	0.469
CLV_PCSK_KEX2_1	519	521	PF00082	0.548
CLV_PCSK_KEX2_1	9	11	PF00082	0.456
CLV_PCSK_PC1ET2_1	133	135	PF00082	0.323
CLV_PCSK_PC1ET2_1	299	301	PF00082	0.407
CLV_PCSK_PC1ET2_1	519	521	PF00082	0.548
CLV_PCSK_PC1ET2_1	9	11	PF00082	0.456
CLV_PCSK_SKI1_1	116	120	PF00082	0.380
CLV_PCSK_SKI1_1	316	320	PF00082	0.375
CLV_PCSK_SKI1_1	686	690	PF00082	0.434
DEG_SPOP_SBC_1	663	667	PF00917	0.623
DOC_CDC14_PxL_1	609	617	PF14671	0.357
DOC_CKS1_1	621	626	PF01111	0.458
DOC_CYCLIN_yCln2_LP_2	626	632	PF00134	0.404
DOC_MAPK_gen_1	133	139	PF00069	0.532
DOC_MAPK_gen_1	257	267	PF00069	0.575
DOC_MAPK_gen_1	519	527	PF00069	0.349
DOC_MAPK_gen_1	637	646	PF00069	0.613
DOC_MAPK_MEF2A_6	227	234	PF00069	0.355
DOC_MAPK_MEF2A_6	519	527	PF00069	0.383
DOC_PP1_RVXF_1	495	501	PF00149	0.545
DOC_PP2B_LxvP_1	626	629	PF13499	0.390
DOC_PP2B_PxIxI_1	227	233	PF00149	0.314
DOC_USP7_MATH_1	107	111	PF00917	0.618
DOC_USP7_MATH_1	196	200	PF00917	0.506
DOC_USP7_MATH_1	302	306	PF00917	0.586
DOC_USP7_MATH_1	561	565	PF00917	0.512
DOC_USP7_MATH_1	663	667	PF00917	0.662
DOC_USP7_MATH_1	688	692	PF00917	0.794
DOC_WW_Pin1_4	103	108	PF00397	0.439
DOC_WW_Pin1_4	298	303	PF00397	0.615
DOC_WW_Pin1_4	441	446	PF00397	0.357
DOC_WW_Pin1_4	620	625	PF00397	0.440
LIG_14-3-3_CanoR_1	257	267	PF00244	0.612
LIG_14-3-3_CanoR_1	304	311	PF00244	0.626
LIG_14-3-3_CanoR_1	441	445	PF00244	0.438
LIG_14-3-3_CanoR_1	497	501	PF00244	0.517
LIG_14-3-3_CanoR_1	580	586	PF00244	0.502
LIG_14-3-3_CanoR_1	84	89	PF00244	0.453
LIG_APCC_ABBA_1	50	55	PF00400	0.661
LIG_APCC_ABBAyCdc20_2	49	55	PF00400	0.531
LIG_BIR_II_1	1	5	PF00653	0.816
LIG_BIR_III_4	13	17	PF00653	0.753
LIG_Clathr_ClatBox_1	265	269	PF01394	0.473
LIG_EH1_1	499	507	PF00400	0.367
LIG_eIF4E_1	609	615	PF01652	0.257
LIG_FHA_1	117	123	PF00498	0.596
LIG_FHA_1	208	214	PF00498	0.363
LIG_FHA_1	365	371	PF00498	0.617
LIG_FHA_1	382	388	PF00498	0.382
LIG_FHA_1	397	403	PF00498	0.285
LIG_FHA_1	481	487	PF00498	0.420
LIG_FHA_1	497	503	PF00498	0.518
LIG_FHA_1	621	627	PF00498	0.444
LIG_FHA_2	269	275	PF00498	0.597
LIG_FHA_2	598	604	PF00498	0.254
LIG_GBD_Chelix_1	478	486	PF00786	0.259
LIG_GBD_Chelix_1	501	509	PF00786	0.500
LIG_GBD_Chelix_1	539	547	PF00786	0.530
LIG_LIR_Apic_2	29	35	PF02991	0.630
LIG_LIR_Apic_2	348	354	PF02991	0.556
LIG_LIR_Apic_2	417	422	PF02991	0.442
LIG_LIR_Apic_2	453	457	PF02991	0.358
LIG_LIR_Apic_2	592	596	PF02991	0.328
LIG_LIR_Gen_1	124	131	PF02991	0.546
LIG_LIR_Gen_1	202	209	PF02991	0.530
LIG_LIR_Gen_1	485	492	PF02991	0.420
LIG_LIR_Gen_1	566	575	PF02991	0.542
LIG_LIR_Gen_1	87	95	PF02991	0.565
LIG_LIR_Nem_3	124	129	PF02991	0.521
LIG_LIR_Nem_3	132	138	PF02991	0.521
LIG_LIR_Nem_3	202	208	PF02991	0.318
LIG_LIR_Nem_3	242	248	PF02991	0.370
LIG_LIR_Nem_3	371	377	PF02991	0.525
LIG_LIR_Nem_3	417	421	PF02991	0.411
LIG_LIR_Nem_3	464	468	PF02991	0.326
LIG_LIR_Nem_3	485	490	PF02991	0.368
LIG_Pex14_2	169	173	PF04695	0.391
LIG_Pex14_2	463	467	PF04695	0.337
LIG_Pex14_2	487	491	PF04695	0.398
LIG_PTB_Apo_2	459	466	PF02174	0.398
LIG_PTB_Apo_2	485	492	PF02174	0.466
LIG_PTB_Phospho_1	459	465	PF10480	0.432
LIG_SH2_CRK	102	106	PF00017	0.538
LIG_SH2_CRK	136	140	PF00017	0.401
LIG_SH2_CRK	151	155	PF00017	0.353
LIG_SH2_CRK	186	190	PF00017	0.541
LIG_SH2_CRK	351	355	PF00017	0.645
LIG_SH2_CRK	379	383	PF00017	0.372
LIG_SH2_CRK	454	458	PF00017	0.354
LIG_SH2_CRK	468	472	PF00017	0.329
LIG_SH2_CRK	593	597	PF00017	0.351
LIG_SH2_CRK	609	613	PF00017	0.384
LIG_SH2_GRB2like	609	612	PF00017	0.377
LIG_SH2_NCK_1	334	338	PF00017	0.463
LIG_SH2_PTP2	32	35	PF00017	0.625
LIG_SH2_SRC	32	35	PF00017	0.631
LIG_SH2_SRC	334	337	PF00017	0.466
LIG_SH2_SRC	338	341	PF00017	0.453
LIG_SH2_STAP1	131	135	PF00017	0.527
LIG_SH2_STAP1	186	190	PF00017	0.516
LIG_SH2_STAP1	334	338	PF00017	0.458
LIG_SH2_STAP1	379	383	PF00017	0.420
LIG_SH2_STAP1	569	573	PF00017	0.365
LIG_SH2_STAP1	88	92	PF00017	0.563
LIG_SH2_STAT5	131	134	PF00017	0.528
LIG_SH2_STAT5	246	249	PF00017	0.466
LIG_SH2_STAT5	32	35	PF00017	0.620
LIG_SH2_STAT5	433	436	PF00017	0.381
LIG_SH2_STAT5	465	468	PF00017	0.289
LIG_SH2_STAT5	533	536	PF00017	0.320
LIG_SH2_STAT5	72	75	PF00017	0.551
LIG_SH3_1	351	357	PF00018	0.612
LIG_SH3_3	351	357	PF00018	0.622
LIG_SH3_3	439	445	PF00018	0.386
LIG_SUMO_SIM_anti_2	514	519	PF11976	0.346
LIG_SUMO_SIM_anti_2	623	629	PF11976	0.481
LIG_SUMO_SIM_anti_2	631	636	PF11976	0.490
LIG_SUMO_SIM_par_1	480	485	PF11976	0.262
LIG_SUMO_SIM_par_1	551	557	PF11976	0.355
LIG_TRFH_1	151	155	PF08558	0.388
LIG_TYR_ITIM	149	154	PF00017	0.407
LIG_TYR_ITSM	464	471	PF00017	0.430
LIG_UBA3_1	149	157	PF00899	0.385
LIG_UBA3_1	265	273	PF00899	0.548
LIG_UBA3_1	486	493	PF00899	0.442
LIG_UBA3_1	632	637	PF00899	0.262
LIG_Vh1_VBS_1	377	395	PF01044	0.434
LIG_Vh1_VBS_1	467	485	PF01044	0.413
MOD_CDC14_SPxK_1	301	304	PF00782	0.259
MOD_CDK_SPxK_1	298	304	PF00069	0.259
MOD_CK1_1	106	112	PF00069	0.389
MOD_CK1_1	199	205	PF00069	0.373
MOD_CK1_1	620	626	PF00069	0.272
MOD_CK1_1	666	672	PF00069	0.631
MOD_CK2_1	268	274	PF00069	0.458
MOD_Cter_Amidation	297	300	PF01082	0.496
MOD_DYRK1A_RPxSP_1	441	445	PF00069	0.442
MOD_GlcNHglycan	158	162	PF01048	0.386
MOD_GlcNHglycan	234	237	PF01048	0.398
MOD_GlcNHglycan	690	693	PF01048	0.538
MOD_GSK3_1	103	110	PF00069	0.433
MOD_GSK3_1	209	216	PF00069	0.346
MOD_GSK3_1	228	235	PF00069	0.468
MOD_GSK3_1	298	305	PF00069	0.447
MOD_GSK3_1	364	371	PF00069	0.507
MOD_GSK3_1	377	384	PF00069	0.401
MOD_GSK3_1	436	443	PF00069	0.275
MOD_GSK3_1	463	470	PF00069	0.405
MOD_GSK3_1	496	503	PF00069	0.391
MOD_GSK3_1	578	585	PF00069	0.400
MOD_GSK3_1	662	669	PF00069	0.652
MOD_N-GLC_1	461	466	PF02516	0.382
MOD_NEK2_1	111	116	PF00069	0.402
MOD_NEK2_1	129	134	PF00069	0.309
MOD_NEK2_1	137	142	PF00069	0.364
MOD_NEK2_1	209	214	PF00069	0.352
MOD_NEK2_1	268	273	PF00069	0.436
MOD_NEK2_1	377	382	PF00069	0.398
MOD_NEK2_1	396	401	PF00069	0.324
MOD_NEK2_1	436	441	PF00069	0.479
MOD_NEK2_1	450	455	PF00069	0.362
MOD_NEK2_1	463	468	PF00069	0.389
MOD_NEK2_1	500	505	PF00069	0.393
MOD_NEK2_1	578	583	PF00069	0.381
MOD_NEK2_1	617	622	PF00069	0.475
MOD_NEK2_2	228	233	PF00069	0.495
MOD_OFUCOSY	165	172	PF10250	0.238
MOD_PIKK_1	179	185	PF00454	0.353
MOD_PIKK_1	597	603	PF00454	0.534
MOD_PIKK_1	686	692	PF00454	0.525
MOD_PKA_1	686	692	PF00069	0.525
MOD_PKA_2	440	446	PF00069	0.486
MOD_PKA_2	496	502	PF00069	0.376
MOD_PKA_2	561	567	PF00069	0.361
MOD_PKA_2	579	585	PF00069	0.361
MOD_PKB_1	275	283	PF00069	0.241
MOD_Plk_1	461	467	PF00069	0.399
MOD_Plk_4	196	202	PF00069	0.372
MOD_Plk_4	209	215	PF00069	0.363
MOD_Plk_4	36	42	PF00069	0.520
MOD_Plk_4	377	383	PF00069	0.382
MOD_Plk_4	414	420	PF00069	0.420
MOD_Plk_4	463	469	PF00069	0.490
MOD_Plk_4	474	480	PF00069	0.352
MOD_Plk_4	482	488	PF00069	0.233
MOD_Plk_4	496	502	PF00069	0.372
MOD_Plk_4	563	569	PF00069	0.408
MOD_Plk_4	628	634	PF00069	0.407
MOD_ProDKin_1	103	109	PF00069	0.253
MOD_ProDKin_1	298	304	PF00069	0.500
MOD_ProDKin_1	441	447	PF00069	0.357
MOD_ProDKin_1	620	626	PF00069	0.440
MOD_SUMO_for_1	8	11	PF00179	0.554
MOD_SUMO_rev_2	642	651	PF00179	0.434
MOD_SUMO_rev_2	684	689	PF00179	0.539
TRG_DiLeu_BaEn_2	261	267	PF01217	0.341
TRG_DiLeu_BaLyEn_6	610	615	PF01217	0.407
TRG_DiLeu_BaLyEn_6	621	626	PF01217	0.347
TRG_ENDOCYTIC_2	102	105	PF00928	0.351
TRG_ENDOCYTIC_2	136	139	PF00928	0.379
TRG_ENDOCYTIC_2	151	154	PF00928	0.367
TRG_ENDOCYTIC_2	186	189	PF00928	0.371
TRG_ENDOCYTIC_2	379	382	PF00928	0.373
TRG_ENDOCYTIC_2	433	436	PF00928	0.385
TRG_ENDOCYTIC_2	468	471	PF00928	0.382
TRG_ENDOCYTIC_2	569	572	PF00928	0.366
TRG_ENDOCYTIC_2	609	612	PF00928	0.451
TRG_ENDOCYTIC_2	88	91	PF00928	0.378
TRG_ER_diArg_1	47	49	PF00400	0.587
TRG_Pf-PMV_PEXEL_1	257	262	PF00026	0.515

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2U2	Leptomonas seymouri	46%	99%
A0A0N1HY49	Leptomonas seymouri	46%	100%
A0A0N1HZ06	Leptomonas seymouri	34%	100%
A0A0N1IHL1	Leptomonas seymouri	38%	98%
A0A0N1PAY4	Leptomonas seymouri	46%	80%
A0A0N1PB77	Leptomonas seymouri	34%	100%
A0A0N1PBZ2	Leptomonas seymouri	68%	100%
A0A0N1PCC1	Leptomonas seymouri	42%	100%
A0A381MBI0	Leishmania infantum	44%	100%
A0A3Q8I8X7	Leishmania donovani	43%	100%
A0A3Q8IAZ0	Leishmania donovani	98%	100%
A0A3Q8IH50	Leishmania donovani	58%	97%
A0A3Q8IVN0	Leishmania donovani	36%	100%
A0A3R7M4J1	Trypanosoma rangeli	41%	100%
A0A3S5H5P4	Leishmania donovani	43%	100%
A0A3S5H5V2	Leishmania donovani	43%	100%
A0A3S5H6F6	Leishmania donovani	94%	100%
A0A3S5H763	Leishmania donovani	52%	100%
A0A3S7WR10	Leishmania donovani	41%	94%
A0A3S7WR14	Leishmania donovani	82%	100%
A0A3S7WR15	Leishmania donovani	71%	82%
A0A3S7WR24	Leishmania donovani	91%	99%
A4H4T8	Leishmania braziliensis	43%	100%
A4H5Y4	Leishmania braziliensis	44%	100%
A4H617	Leishmania braziliensis	82%	100%
A4H618	Leishmania braziliensis	80%	100%
A4H619	Leishmania braziliensis	81%	100%
A4H620	Leishmania braziliensis	58%	100%
A4H6C3	Leishmania braziliensis	44%	100%
A4HNH7	Leishmania braziliensis	36%	100%
A4HSS2	Leishmania infantum	43%	100%
A4HUE4	Leishmania infantum	42%	100%
A4HUE5	Leishmania infantum	74%	100%
A4HUE6	Leishmania infantum	84%	100%
A4HUE8	Leishmania infantum	92%	99%
A4HUF4	Leishmania infantum	92%	100%
A4HUF5	Leishmania infantum	58%	100%
A4HYA9	Leishmania infantum	52%	100%
A4IC33	Leishmania infantum	35%	100%
C9ZIK0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
C9ZIK3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
C9ZVE8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
C9ZVE9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
C9ZVF1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
D0A423	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E8NHQ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
E9AG72	Leishmania infantum	43%	100%
E9AI40	Leishmania braziliensis	77%	100%
E9AJY4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E9AKQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
E9AL06	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E9AN44	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E9AN45	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
E9AN46	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
E9AN47	Leishmania mexicana (strain MHOM/GT/2001/U1103)	60%	100%
E9ANE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E9AS42	Leishmania mexicana (strain MHOM/GT/2001/U1103)	52%	100%
E9B741	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
Q4QDC4	Leishmania major	52%	100%
Q4QH81	Leishmania major	44%	100%
Q4QHH7	Leishmania major	60%	100%
Q4QHH8	Leishmania major	90%	100%
Q4QHH9	Leishmania major	89%	100%
Q4QHI0	Leishmania major	95%	99%
Q4QHI1	Leishmania major	85%	100%
Q4QHI2	Leishmania major	79%	100%
Q4QIU9	Leishmania major	44%	100%
Q4QJ48	Leishmania major	42%	100%
Q7KIP2	Leishmania major	36%	100%