Putative folate/biopterin transporter

Quick info Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pteridine transporter (truncated) - putative

Species:

Leishmania infantum

UniProt:

A4HUE6_LEIIN

TriTrypDb:

LINF_100009000

Length:

686

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 9
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 52

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 70
NetGPI	no	yes: 0, no: 70

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	71
GO:0110165	cellular anatomical entity	1	71
GO:0005737	cytoplasm	2	6
GO:0005886	plasma membrane	3	1

Phosphorylation

Promastigote/Amastigote: 309

Expansion

Sequence features

A4HUE6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HUE6

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0015877	biopterin transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0015224	biopterin transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	273	275	PF00675	0.364
CLV_NRD_NRD_1	50	52	PF00675	0.437
CLV_PCSK_KEX2_1	135	137	PF00082	0.323
CLV_PCSK_KEX2_1	301	303	PF00082	0.407
CLV_PCSK_KEX2_1	50	52	PF00082	0.471
CLV_PCSK_KEX2_1	521	523	PF00082	0.548
CLV_PCSK_KEX2_1	525	527	PF00082	0.548
CLV_PCSK_PC1ET2_1	135	137	PF00082	0.323
CLV_PCSK_PC1ET2_1	301	303	PF00082	0.407
CLV_PCSK_PC1ET2_1	521	523	PF00082	0.548
CLV_PCSK_PC1ET2_1	525	527	PF00082	0.548
CLV_PCSK_SKI1_1	118	122	PF00082	0.380
CLV_PCSK_SKI1_1	318	322	PF00082	0.375
DOC_CDC14_PxL_1	608	616	PF14671	0.357
DOC_CKS1_1	620	625	PF01111	0.458
DOC_CYCLIN_yCln2_LP_2	625	631	PF00134	0.404
DOC_MAPK_gen_1	135	141	PF00069	0.532
DOC_MAPK_gen_1	259	269	PF00069	0.575
DOC_MAPK_gen_1	521	529	PF00069	0.349
DOC_MAPK_MEF2A_6	229	236	PF00069	0.355
DOC_PP2B_LxvP_1	625	628	PF13499	0.390
DOC_PP2B_PxIxI_1	229	235	PF00149	0.314
DOC_USP7_MATH_1	109	113	PF00917	0.618
DOC_USP7_MATH_1	198	202	PF00917	0.506
DOC_USP7_MATH_1	20	24	PF00917	0.698
DOC_USP7_MATH_1	304	308	PF00917	0.586
DOC_USP7_MATH_1	563	567	PF00917	0.512
DOC_USP7_MATH_1	664	668	PF00917	0.599
DOC_USP7_MATH_1	673	677	PF00917	0.776
DOC_USP7_UBL2_3	521	525	PF12436	0.209
DOC_WW_Pin1_4	105	110	PF00397	0.439
DOC_WW_Pin1_4	300	305	PF00397	0.615
DOC_WW_Pin1_4	443	448	PF00397	0.357
DOC_WW_Pin1_4	619	624	PF00397	0.440
LIG_14-3-3_CanoR_1	259	269	PF00244	0.612
LIG_14-3-3_CanoR_1	306	313	PF00244	0.626
LIG_14-3-3_CanoR_1	443	447	PF00244	0.438
LIG_14-3-3_CanoR_1	96	102	PF00244	0.482
LIG_APCC_ABBA_1	52	57	PF00400	0.660
LIG_APCC_ABBAyCdc20_2	51	57	PF00400	0.531
LIG_Clathr_ClatBox_1	267	271	PF01394	0.473
LIG_deltaCOP1_diTrp_1	594	600	PF00928	0.269
LIG_EH1_1	501	509	PF00400	0.367
LIG_eIF4E_1	608	614	PF01652	0.257
LIG_FHA_1	119	125	PF00498	0.596
LIG_FHA_1	367	373	PF00498	0.617
LIG_FHA_1	384	390	PF00498	0.382
LIG_FHA_1	399	405	PF00498	0.285
LIG_FHA_1	443	449	PF00498	0.411
LIG_FHA_1	499	505	PF00498	0.518
LIG_FHA_1	620	626	PF00498	0.444
LIG_FHA_1	70	76	PF00498	0.586
LIG_FHA_2	271	277	PF00498	0.597
LIG_GBD_Chelix_1	503	511	PF00786	0.500
LIG_GBD_Chelix_1	541	549	PF00786	0.530
LIG_HP1_1	553	557	PF01393	0.425
LIG_LIR_Apic_2	350	356	PF02991	0.556
LIG_LIR_Apic_2	418	424	PF02991	0.444
LIG_LIR_Apic_2	594	598	PF02991	0.328
LIG_LIR_Apic_2	630	634	PF02991	0.364
LIG_LIR_Gen_1	126	133	PF02991	0.546
LIG_LIR_Gen_1	185	196	PF02991	0.555
LIG_LIR_Gen_1	204	212	PF02991	0.530
LIG_LIR_Gen_1	468	477	PF02991	0.356
LIG_LIR_Gen_1	487	494	PF02991	0.420
LIG_LIR_Gen_1	568	578	PF02991	0.542
LIG_LIR_Gen_1	89	97	PF02991	0.565
LIG_LIR_Nem_3	126	131	PF02991	0.521
LIG_LIR_Nem_3	134	140	PF02991	0.521
LIG_LIR_Nem_3	185	191	PF02991	0.562
LIG_LIR_Nem_3	204	210	PF02991	0.318
LIG_LIR_Nem_3	244	250	PF02991	0.370
LIG_LIR_Nem_3	373	379	PF02991	0.525
LIG_LIR_Nem_3	418	423	PF02991	0.407
LIG_LIR_Nem_3	44	49	PF02991	0.623
LIG_LIR_Nem_3	446	452	PF02991	0.449
LIG_LIR_Nem_3	461	465	PF02991	0.330
LIG_LIR_Nem_3	466	470	PF02991	0.326
LIG_LIR_Nem_3	487	492	PF02991	0.368
LIG_LIR_Nem_3	594	600	PF02991	0.318
LIG_PCNA_PIPBox_1	508	517	PF02747	0.228
LIG_Pex14_2	171	175	PF04695	0.391
LIG_Pex14_2	465	469	PF04695	0.337
LIG_Pex14_2	489	493	PF04695	0.398
LIG_PTB_Apo_2	461	468	PF02174	0.398
LIG_PTB_Apo_2	487	494	PF02174	0.466
LIG_PTB_Phospho_1	461	467	PF10480	0.432
LIG_Rb_pABgroove_1	509	517	PF01858	0.360
LIG_SH2_CRK	104	108	PF00017	0.538
LIG_SH2_CRK	138	142	PF00017	0.401
LIG_SH2_CRK	153	157	PF00017	0.353
LIG_SH2_CRK	188	192	PF00017	0.541
LIG_SH2_CRK	353	357	PF00017	0.645
LIG_SH2_CRK	381	385	PF00017	0.372
LIG_SH2_CRK	470	474	PF00017	0.329
LIG_SH2_CRK	608	612	PF00017	0.384
LIG_SH2_GRB2like	452	455	PF00017	0.383
LIG_SH2_GRB2like	608	611	PF00017	0.377
LIG_SH2_NCK_1	336	340	PF00017	0.463
LIG_SH2_NCK_1	470	474	PF00017	0.327
LIG_SH2_PTP2	34	37	PF00017	0.625
LIG_SH2_SRC	336	339	PF00017	0.466
LIG_SH2_SRC	34	37	PF00017	0.631
LIG_SH2_SRC	340	343	PF00017	0.453
LIG_SH2_SRC	452	455	PF00017	0.371
LIG_SH2_STAP1	133	137	PF00017	0.527
LIG_SH2_STAP1	188	192	PF00017	0.516
LIG_SH2_STAP1	336	340	PF00017	0.458
LIG_SH2_STAP1	381	385	PF00017	0.420
LIG_SH2_STAP1	449	453	PF00017	0.361
LIG_SH2_STAP1	571	575	PF00017	0.365
LIG_SH2_STAP1	90	94	PF00017	0.563
LIG_SH2_STAT5	133	136	PF00017	0.528
LIG_SH2_STAT5	248	251	PF00017	0.466
LIG_SH2_STAT5	34	37	PF00017	0.620
LIG_SH2_STAT5	435	438	PF00017	0.381
LIG_SH2_STAT5	441	444	PF00017	0.373
LIG_SH2_STAT5	452	455	PF00017	0.313
LIG_SH2_STAT5	467	470	PF00017	0.289
LIG_SH2_STAT5	535	538	PF00017	0.320
LIG_SH2_STAT5	631	634	PF00017	0.538
LIG_SH2_STAT5	74	77	PF00017	0.551
LIG_SH3_1	353	359	PF00018	0.612
LIG_SH3_3	353	359	PF00018	0.622
LIG_SH3_3	617	623	PF00018	0.366
LIG_SUMO_SIM_anti_2	622	628	PF11976	0.481
LIG_SUMO_SIM_par_1	554	559	PF11976	0.355
LIG_SUMO_SIM_par_1	66	73	PF11976	0.431
LIG_TRFH_1	153	157	PF08558	0.388
LIG_TYR_ITIM	151	156	PF00017	0.407
LIG_TYR_ITSM	466	473	PF00017	0.430
LIG_UBA3_1	151	159	PF00899	0.385
LIG_UBA3_1	267	275	PF00899	0.548
LIG_UBA3_1	488	495	PF00899	0.442
LIG_UBA3_1	514	521	PF00899	0.349
LIG_Vh1_VBS_1	379	397	PF01044	0.434
LIG_Vh1_VBS_1	469	487	PF01044	0.413
MOD_CDC14_SPxK_1	303	306	PF00782	0.259
MOD_CDK_SPxK_1	300	306	PF00069	0.259
MOD_CK1_1	108	114	PF00069	0.389
MOD_CK1_1	201	207	PF00069	0.373
MOD_CK1_1	27	33	PF00069	0.528
MOD_CK1_1	619	625	PF00069	0.272
MOD_CK2_1	270	276	PF00069	0.458
MOD_CK2_1	664	670	PF00069	0.614
MOD_Cter_Amidation	299	302	PF01082	0.496
MOD_DYRK1A_RPxSP_1	443	447	PF00069	0.442
MOD_GlcNHglycan	160	164	PF01048	0.386
MOD_GlcNHglycan	22	25	PF01048	0.645
MOD_GlcNHglycan	236	239	PF01048	0.398
MOD_GlcNHglycan	670	674	PF01048	0.663
MOD_GlcNHglycan	675	678	PF01048	0.678
MOD_GSK3_1	105	112	PF00069	0.433
MOD_GSK3_1	20	27	PF00069	0.565
MOD_GSK3_1	230	237	PF00069	0.468
MOD_GSK3_1	300	307	PF00069	0.447
MOD_GSK3_1	366	373	PF00069	0.507
MOD_GSK3_1	379	386	PF00069	0.401
MOD_GSK3_1	465	472	PF00069	0.405
MOD_GSK3_1	498	505	PF00069	0.391
MOD_GSK3_1	580	587	PF00069	0.400
MOD_GSK3_1	615	622	PF00069	0.411
MOD_GSK3_1	665	672	PF00069	0.623
MOD_GSK3_1	7	14	PF00069	0.622
MOD_N-GLC_1	463	468	PF02516	0.382
MOD_N-GLC_2	456	458	PF02516	0.226
MOD_NEK2_1	1	6	PF00069	0.701
MOD_NEK2_1	113	118	PF00069	0.402
MOD_NEK2_1	131	136	PF00069	0.309
MOD_NEK2_1	139	144	PF00069	0.364
MOD_NEK2_1	171	176	PF00069	0.371
MOD_NEK2_1	270	275	PF00069	0.436
MOD_NEK2_1	379	384	PF00069	0.398
MOD_NEK2_1	398	403	PF00069	0.324
MOD_NEK2_1	465	470	PF00069	0.389
MOD_NEK2_1	502	507	PF00069	0.393
MOD_NEK2_1	580	585	PF00069	0.381
MOD_NEK2_1	615	620	PF00069	0.480
MOD_NEK2_1	70	75	PF00069	0.480
MOD_NEK2_2	230	235	PF00069	0.495
MOD_PIKK_1	1	7	PF00454	0.598
MOD_PIKK_1	24	30	PF00454	0.747
MOD_PKA_2	442	448	PF00069	0.486
MOD_PKA_2	563	569	PF00069	0.361
MOD_PKB_1	277	285	PF00069	0.241
MOD_Plk_1	463	469	PF00069	0.399
MOD_Plk_1	665	671	PF00069	0.413
MOD_Plk_4	198	204	PF00069	0.372
MOD_Plk_4	215	221	PF00069	0.358
MOD_Plk_4	379	385	PF00069	0.382
MOD_Plk_4	416	422	PF00069	0.420
MOD_Plk_4	465	471	PF00069	0.490
MOD_Plk_4	484	490	PF00069	0.233
MOD_Plk_4	498	504	PF00069	0.372
MOD_Plk_4	565	571	PF00069	0.408
MOD_Plk_4	627	633	PF00069	0.407
MOD_Plk_4	70	76	PF00069	0.322
MOD_ProDKin_1	105	111	PF00069	0.253
MOD_ProDKin_1	300	306	PF00069	0.500
MOD_ProDKin_1	443	449	PF00069	0.357
MOD_ProDKin_1	619	625	PF00069	0.440
MOD_SUMO_rev_2	640	649	PF00179	0.434
TRG_DiLeu_BaEn_2	263	269	PF01217	0.341
TRG_DiLeu_BaLyEn_6	609	614	PF01217	0.407
TRG_DiLeu_BaLyEn_6	620	625	PF01217	0.347
TRG_ENDOCYTIC_2	104	107	PF00928	0.351
TRG_ENDOCYTIC_2	138	141	PF00928	0.379
TRG_ENDOCYTIC_2	153	156	PF00928	0.367
TRG_ENDOCYTIC_2	188	191	PF00928	0.371
TRG_ENDOCYTIC_2	381	384	PF00928	0.373
TRG_ENDOCYTIC_2	435	438	PF00928	0.385
TRG_ENDOCYTIC_2	462	465	PF00928	0.385
TRG_ENDOCYTIC_2	470	473	PF00928	0.382
TRG_ENDOCYTIC_2	571	574	PF00928	0.366
TRG_ENDOCYTIC_2	608	611	PF00928	0.451
TRG_ENDOCYTIC_2	90	93	PF00928	0.378
TRG_ER_diArg_1	49	51	PF00400	0.591
TRG_Pf-PMV_PEXEL_1	259	264	PF00026	0.515
TRG_Pf-PMV_PEXEL_1	637	641	PF00026	0.307

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2U2	Leptomonas seymouri	48%	97%
A0A0N1HY49	Leptomonas seymouri	46%	100%
A0A0N1HZ06	Leptomonas seymouri	35%	100%
A0A0N1IHL1	Leptomonas seymouri	40%	96%
A0A0N1PAY4	Leptomonas seymouri	46%	78%
A0A0N1PB77	Leptomonas seymouri	35%	100%
A0A0N1PBZ2	Leptomonas seymouri	67%	100%
A0A0N1PCC1	Leptomonas seymouri	43%	100%
A0A381MBI0	Leishmania infantum	45%	100%
A0A3Q8I8X7	Leishmania donovani	45%	100%
A0A3Q8IAZ0	Leishmania donovani	85%	98%
A0A3Q8IH50	Leishmania donovani	60%	95%
A0A3Q8IVN0	Leishmania donovani	37%	100%
A0A3R7M4J1	Trypanosoma rangeli	41%	100%
A0A3S5H5P4	Leishmania donovani	45%	100%
A0A3S5H5V2	Leishmania donovani	43%	100%
A0A3S5H6F6	Leishmania donovani	84%	98%
A0A3S5H763	Leishmania donovani	55%	100%
A0A3S7WR10	Leishmania donovani	43%	92%
A0A3S7WR14	Leishmania donovani	100%	100%
A0A3S7WR15	Leishmania donovani	72%	81%
A0A3S7WR24	Leishmania donovani	83%	97%
A4H4T8	Leishmania braziliensis	41%	99%
A4H5Y4	Leishmania braziliensis	45%	100%
A4H617	Leishmania braziliensis	74%	100%
A4H618	Leishmania braziliensis	72%	100%
A4H619	Leishmania braziliensis	74%	100%
A4H620	Leishmania braziliensis	59%	100%
A4H6C3	Leishmania braziliensis	46%	100%
A4HNH7	Leishmania braziliensis	36%	97%
A4HSS2	Leishmania infantum	45%	100%
A4HUE4	Leishmania infantum	45%	100%
A4HUE5	Leishmania infantum	74%	100%
A4HUE7	Leishmania infantum	84%	98%
A4HUE8	Leishmania infantum	83%	97%
A4HUF4	Leishmania infantum	82%	98%
A4HUF5	Leishmania infantum	60%	100%
A4HYA9	Leishmania infantum	55%	100%
A4IC33	Leishmania infantum	36%	100%
C9ZIK0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
C9ZIK3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
C9ZVE8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
C9ZVE9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
C9ZVF1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
D0A423	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E8NHQ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
E9AG72	Leishmania infantum	43%	100%
E9AI40	Leishmania braziliensis	74%	100%
E9AJY4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	100%
E9AKQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E9AL06	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E9AN44	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E9AN45	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
E9AN46	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
E9AN47	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	100%
E9ANE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	100%
E9AS42	Leishmania mexicana (strain MHOM/GT/2001/U1103)	55%	100%
E9B741	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	95%
Q4QDC4	Leishmania major	55%	100%
Q4QH81	Leishmania major	46%	100%
Q4QHH7	Leishmania major	59%	100%
Q4QHH8	Leishmania major	79%	100%
Q4QHH9	Leishmania major	79%	100%
Q4QHI0	Leishmania major	83%	100%
Q4QHI1	Leishmania major	93%	100%
Q4QHI2	Leishmania major	82%	100%
Q4QIU9	Leishmania major	42%	100%
Q4QJ48	Leishmania major	44%	100%
Q7KIP2	Leishmania major	36%	100%