LeishMANIAdb
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S-adenosylmethionine transporter

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
S-adenosylmethionine transporter
Gene product:
pteridine transporter (truncated) - putative
Species:
Leishmania infantum
UniProt:
A4HUE5_LEIIN
TriTrypDb:
LINF_100008900
Length:
691

Annotations

Annotations by Jardim et al.

Transporters, S-adenosylmethionine transporter ADOMET1

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 9
Silverman et al. no yes: 0
Pissara et al. yes yes: 52
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 6
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 6
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 70
NetGPI no yes: 0, no: 70
Cellular components
Term Name Level Count
GO:0016020 membrane 2 71
GO:0110165 cellular anatomical entity 1 71
GO:0005737 cytoplasm 2 6
GO:0005886 plasma membrane 3 1

Expansion

Sequence features

A4HUE5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HUE5

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 1
GO:0015877 biopterin transport 5 1
GO:0051179 localization 1 1
GO:0051234 establishment of localization 2 1
GO:0071702 organic substance transport 4 1
GO:0071705 nitrogen compound transport 4 1
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 1
GO:0015224 biopterin transmembrane transporter activity 3 1
GO:0022857 transmembrane transporter activity 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 339 343 PF00656 0.572
CLV_NRD_NRD_1 270 272 PF00675 0.364
CLV_NRD_NRD_1 47 49 PF00675 0.433
CLV_NRD_NRD_1 651 653 PF00675 0.306
CLV_PCSK_KEX2_1 132 134 PF00082 0.323
CLV_PCSK_KEX2_1 299 301 PF00082 0.407
CLV_PCSK_KEX2_1 47 49 PF00082 0.467
CLV_PCSK_KEX2_1 493 495 PF00082 0.237
CLV_PCSK_KEX2_1 519 521 PF00082 0.548
CLV_PCSK_KEX2_1 651 653 PF00082 0.316
CLV_PCSK_PC1ET2_1 132 134 PF00082 0.323
CLV_PCSK_PC1ET2_1 299 301 PF00082 0.407
CLV_PCSK_PC1ET2_1 493 495 PF00082 0.237
CLV_PCSK_PC1ET2_1 519 521 PF00082 0.548
CLV_PCSK_SKI1_1 115 119 PF00082 0.380
CLV_PCSK_SKI1_1 80 84 PF00082 0.397
DOC_AGCK_PIF_1 460 465 PF00069 0.218
DOC_CYCLIN_yCln2_LP_2 626 632 PF00134 0.404
DOC_MAPK_gen_1 132 138 PF00069 0.532
DOC_MAPK_gen_1 256 266 PF00069 0.575
DOC_MAPK_gen_1 493 500 PF00069 0.468
DOC_MAPK_gen_1 519 527 PF00069 0.349
DOC_MAPK_gen_1 636 645 PF00069 0.613
DOC_MAPK_MEF2A_6 226 233 PF00069 0.355
DOC_MAPK_MEF2A_6 519 527 PF00069 0.383
DOC_MAPK_RevD_3 479 494 PF00069 0.369
DOC_PP1_RVXF_1 495 501 PF00149 0.545
DOC_PP2B_LxvP_1 626 629 PF13499 0.390
DOC_PP2B_LxvP_1 632 635 PF13499 0.356
DOC_PP2B_PxIxI_1 226 232 PF00149 0.314
DOC_PP4_FxxP_1 277 280 PF00568 0.415
DOC_PP4_FxxP_1 31 34 PF00568 0.588
DOC_USP7_MATH_1 195 199 PF00917 0.506
DOC_USP7_MATH_1 302 306 PF00917 0.586
DOC_USP7_MATH_1 482 486 PF00917 0.403
DOC_USP7_MATH_1 538 542 PF00917 0.341
DOC_USP7_MATH_1 561 565 PF00917 0.512
DOC_WW_Pin1_4 298 303 PF00397 0.615
DOC_WW_Pin1_4 441 446 PF00397 0.357
DOC_WW_Pin1_4 665 670 PF00397 0.676
DOC_WW_Pin1_4 8 13 PF00397 0.720
LIG_14-3-3_CanoR_1 103 110 PF00244 0.517
LIG_14-3-3_CanoR_1 256 266 PF00244 0.612
LIG_14-3-3_CanoR_1 304 311 PF00244 0.626
LIG_14-3-3_CanoR_1 497 501 PF00244 0.517
LIG_14-3-3_CanoR_1 580 589 PF00244 0.502
LIG_Actin_WH2_2 49 64 PF00022 0.640
LIG_APCC_ABBA_1 49 54 PF00400 0.653
LIG_APCC_ABBAyCdc20_2 48 54 PF00400 0.525
LIG_BIR_II_1 1 5 PF00653 0.800
LIG_BRCT_BRCA1_1 463 467 PF00533 0.343
LIG_Clathr_ClatBox_1 264 268 PF01394 0.473
LIG_CtBP_PxDLS_1 12 16 PF00389 0.625
LIG_deltaCOP1_diTrp_1 372 377 PF00928 0.463
LIG_EVH1_1 666 670 PF00568 0.629
LIG_FHA_1 116 122 PF00498 0.596
LIG_FHA_1 382 388 PF00498 0.382
LIG_FHA_1 397 403 PF00498 0.285
LIG_FHA_1 446 452 PF00498 0.404
LIG_FHA_1 497 503 PF00498 0.518
LIG_FHA_1 511 517 PF00498 0.385
LIG_FHA_1 629 635 PF00498 0.442
LIG_FHA_1 68 74 PF00498 0.584
LIG_FHA_2 268 274 PF00498 0.597
LIG_FHA_2 598 604 PF00498 0.254
LIG_HP1_1 551 555 PF01393 0.425
LIG_LIR_Apic_2 275 280 PF02991 0.415
LIG_LIR_Apic_2 29 34 PF02991 0.633
LIG_LIR_Apic_2 348 354 PF02991 0.556
LIG_LIR_Apic_2 416 422 PF02991 0.444
LIG_LIR_Apic_2 592 596 PF02991 0.328
LIG_LIR_Gen_1 123 130 PF02991 0.546
LIG_LIR_Gen_1 182 193 PF02991 0.555
LIG_LIR_Gen_1 201 209 PF02991 0.530
LIG_LIR_Gen_1 466 475 PF02991 0.356
LIG_LIR_Gen_1 485 491 PF02991 0.420
LIG_LIR_Gen_1 503 512 PF02991 0.316
LIG_LIR_Gen_1 566 576 PF02991 0.542
LIG_LIR_Gen_1 86 94 PF02991 0.565
LIG_LIR_Nem_3 123 128 PF02991 0.521
LIG_LIR_Nem_3 131 137 PF02991 0.521
LIG_LIR_Nem_3 182 188 PF02991 0.562
LIG_LIR_Nem_3 201 207 PF02991 0.318
LIG_LIR_Nem_3 241 247 PF02991 0.370
LIG_LIR_Nem_3 371 377 PF02991 0.525
LIG_LIR_Nem_3 41 46 PF02991 0.620
LIG_LIR_Nem_3 416 421 PF02991 0.407
LIG_LIR_Nem_3 457 463 PF02991 0.321
LIG_LIR_Nem_3 464 468 PF02991 0.326
LIG_LIR_Nem_3 485 490 PF02991 0.368
LIG_LIR_Nem_3 503 508 PF02991 0.353
LIG_NRBOX 611 617 PF00104 0.252
LIG_PDZ_Class_3 686 691 PF00595 0.661
LIG_Pex14_2 168 172 PF04695 0.391
LIG_Pex14_2 463 467 PF04695 0.337
LIG_Pex14_2 487 491 PF04695 0.398
LIG_PTB_Apo_2 459 466 PF02174 0.398
LIG_PTB_Phospho_1 459 465 PF10480 0.432
LIG_SH2_CRK 101 105 PF00017 0.538
LIG_SH2_CRK 135 139 PF00017 0.401
LIG_SH2_CRK 150 154 PF00017 0.353
LIG_SH2_CRK 185 189 PF00017 0.541
LIG_SH2_CRK 351 355 PF00017 0.645
LIG_SH2_CRK 379 383 PF00017 0.372
LIG_SH2_CRK 468 472 PF00017 0.329
LIG_SH2_CRK 593 597 PF00017 0.351
LIG_SH2_GRB2like 439 442 PF00017 0.431
LIG_SH2_GRB2like 450 453 PF00017 0.383
LIG_SH2_NCK_1 468 472 PF00017 0.327
LIG_SH2_PTP2 439 442 PF00017 0.376
LIG_SH2_PTP2 524 527 PF00017 0.426
LIG_SH2_SRC 439 442 PF00017 0.507
LIG_SH2_SRC 450 453 PF00017 0.371
LIG_SH2_STAP1 130 134 PF00017 0.527
LIG_SH2_STAP1 185 189 PF00017 0.516
LIG_SH2_STAP1 379 383 PF00017 0.420
LIG_SH2_STAP1 569 573 PF00017 0.365
LIG_SH2_STAP1 87 91 PF00017 0.563
LIG_SH2_STAT3 433 436 PF00017 0.234
LIG_SH2_STAT5 130 133 PF00017 0.528
LIG_SH2_STAT5 245 248 PF00017 0.466
LIG_SH2_STAT5 433 436 PF00017 0.381
LIG_SH2_STAT5 439 442 PF00017 0.373
LIG_SH2_STAT5 450 453 PF00017 0.313
LIG_SH2_STAT5 524 527 PF00017 0.328
LIG_SH2_STAT5 533 536 PF00017 0.320
LIG_SH3_1 351 357 PF00018 0.612
LIG_SH3_3 321 327 PF00018 0.455
LIG_SH3_3 351 357 PF00018 0.622
LIG_SH3_3 618 624 PF00018 0.366
LIG_SH3_3 664 670 PF00018 0.760
LIG_SUMO_SIM_anti_2 513 519 PF11976 0.345
LIG_SUMO_SIM_par_1 551 557 PF11976 0.355
LIG_TRAF2_1 11 14 PF00917 0.767
LIG_TRFH_1 150 154 PF08558 0.388
LIG_TYR_ITIM 148 153 PF00017 0.407
LIG_UBA3_1 148 156 PF00899 0.385
LIG_UBA3_1 264 272 PF00899 0.548
LIG_Vh1_VBS_1 377 395 PF01044 0.434
LIG_WRC_WIRS_1 446 451 PF05994 0.361
LIG_WRC_WIRS_1 502 507 PF05994 0.332
MOD_CDC14_SPxK_1 301 304 PF00782 0.259
MOD_CDK_SPxK_1 298 304 PF00069 0.259
MOD_CK1_1 198 204 PF00069 0.373
MOD_CK1_1 492 498 PF00069 0.378
MOD_CK1_1 668 674 PF00069 0.689
MOD_CK2_1 267 273 PF00069 0.458
MOD_CK2_1 668 674 PF00069 0.763
MOD_CK2_1 8 14 PF00069 0.709
MOD_Cter_Amidation 297 300 PF01082 0.496
MOD_GlcNHglycan 13 18 PF01048 0.653
MOD_GlcNHglycan 157 161 PF01048 0.386
MOD_GlcNHglycan 233 236 PF01048 0.398
MOD_GlcNHglycan 484 487 PF01048 0.372
MOD_GlcNHglycan 582 585 PF01048 0.418
MOD_GlcNHglycan 671 674 PF01048 0.788
MOD_GSK3_1 102 109 PF00069 0.433
MOD_GSK3_1 227 234 PF00069 0.468
MOD_GSK3_1 298 305 PF00069 0.447
MOD_GSK3_1 377 384 PF00069 0.401
MOD_GSK3_1 441 448 PF00069 0.266
MOD_GSK3_1 463 470 PF00069 0.405
MOD_GSK3_1 492 499 PF00069 0.390
MOD_GSK3_1 574 581 PF00069 0.402
MOD_GSK3_1 665 672 PF00069 0.734
MOD_N-GLC_1 461 466 PF02516 0.382
MOD_N-GLC_2 620 622 PF02516 0.514
MOD_NEK2_1 110 115 PF00069 0.402
MOD_NEK2_1 128 133 PF00069 0.309
MOD_NEK2_1 136 141 PF00069 0.364
MOD_NEK2_1 168 173 PF00069 0.371
MOD_NEK2_1 267 272 PF00069 0.436
MOD_NEK2_1 377 382 PF00069 0.398
MOD_NEK2_1 396 401 PF00069 0.324
MOD_NEK2_1 408 413 PF00069 0.344
MOD_NEK2_1 463 468 PF00069 0.389
MOD_NEK2_1 500 505 PF00069 0.393
MOD_NEK2_1 578 583 PF00069 0.381
MOD_NEK2_1 67 72 PF00069 0.478
MOD_NEK2_2 227 232 PF00069 0.495
MOD_NEK2_2 445 450 PF00069 0.363
MOD_PKA_2 102 108 PF00069 0.403
MOD_PKA_2 496 502 PF00069 0.376
MOD_PKA_2 561 567 PF00069 0.361
MOD_PKA_2 579 585 PF00069 0.361
MOD_PKA_2 676 682 PF00069 0.853
MOD_Plk_1 461 467 PF00069 0.399
MOD_Plk_4 195 201 PF00069 0.372
MOD_Plk_4 212 218 PF00069 0.358
MOD_Plk_4 377 383 PF00069 0.382
MOD_Plk_4 414 420 PF00069 0.420
MOD_Plk_4 445 451 PF00069 0.365
MOD_Plk_4 463 469 PF00069 0.490
MOD_Plk_4 563 569 PF00069 0.408
MOD_Plk_4 628 634 PF00069 0.407
MOD_ProDKin_1 298 304 PF00069 0.500
MOD_ProDKin_1 441 447 PF00069 0.357
MOD_ProDKin_1 665 671 PF00069 0.588
MOD_ProDKin_1 8 14 PF00069 0.647
MOD_SUMO_for_1 26 29 PF00179 0.454
MOD_SUMO_rev_2 641 650 PF00179 0.434
TRG_DiLeu_BaEn_2 260 266 PF01217 0.341
TRG_ENDOCYTIC_2 101 104 PF00928 0.351
TRG_ENDOCYTIC_2 135 138 PF00928 0.379
TRG_ENDOCYTIC_2 150 153 PF00928 0.367
TRG_ENDOCYTIC_2 185 188 PF00928 0.371
TRG_ENDOCYTIC_2 379 382 PF00928 0.373
TRG_ENDOCYTIC_2 439 442 PF00928 0.386
TRG_ENDOCYTIC_2 468 471 PF00928 0.382
TRG_ENDOCYTIC_2 524 527 PF00928 0.507
TRG_ENDOCYTIC_2 549 552 PF00928 0.330
TRG_ENDOCYTIC_2 569 572 PF00928 0.366
TRG_ENDOCYTIC_2 87 90 PF00928 0.378
TRG_ER_diArg_1 46 48 PF00400 0.584
TRG_ER_diArg_1 650 652 PF00400 0.326
TRG_Pf-PMV_PEXEL_1 256 261 PF00026 0.515
TRG_Pf-PMV_PEXEL_1 328 332 PF00026 0.495
TRG_Pf-PMV_PEXEL_1 80 85 PF00026 0.231

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P2U2 Leptomonas seymouri 45% 98%
A0A0N1HY49 Leptomonas seymouri 46% 100%
A0A0N1HZ06 Leptomonas seymouri 37% 100%
A0A0N1IHL1 Leptomonas seymouri 40% 97%
A0A0N1PAY4 Leptomonas seymouri 45% 79%
A0A0N1PB77 Leptomonas seymouri 37% 100%
A0A0N1PBZ2 Leptomonas seymouri 65% 100%
A0A0N1PCC1 Leptomonas seymouri 42% 100%
A0A381MBI0 Leishmania infantum 42% 100%
A0A3Q8I8X7 Leishmania donovani 43% 100%
A0A3Q8IAZ0 Leishmania donovani 74% 99%
A0A3Q8IH50 Leishmania donovani 58% 96%
A0A3Q8IVN0 Leishmania donovani 38% 100%
A0A3R7M4J1 Trypanosoma rangeli 40% 100%
A0A3S5H5P4 Leishmania donovani 44% 100%
A0A3S5H5V2 Leishmania donovani 44% 100%
A0A3S5H6F6 Leishmania donovani 75% 99%
A0A3S5H763 Leishmania donovani 53% 100%
A0A3S7WR10 Leishmania donovani 42% 93%
A0A3S7WR14 Leishmania donovani 74% 100%
A0A3S7WR15 Leishmania donovani 99% 81%
A0A3S7WR24 Leishmania donovani 74% 98%
A4H4T8 Leishmania braziliensis 41% 94%
A4H5Y4 Leishmania braziliensis 44% 100%
A4H617 Leishmania braziliensis 70% 100%
A4H618 Leishmania braziliensis 68% 100%
A4H619 Leishmania braziliensis 70% 100%
A4H620 Leishmania braziliensis 62% 100%
A4H6C3 Leishmania braziliensis 42% 98%
A4HNH7 Leishmania braziliensis 35% 93%
A4HSS2 Leishmania infantum 43% 100%
A4HUE4 Leishmania infantum 42% 100%
A4HUE6 Leishmania infantum 74% 100%
A4HUE7 Leishmania infantum 74% 99%
A4HUE8 Leishmania infantum 74% 98%
A4HUF4 Leishmania infantum 75% 99%
A4HUF5 Leishmania infantum 58% 100%
A4HYA9 Leishmania infantum 53% 100%
A4IC33 Leishmania infantum 37% 100%
C9ZIK0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 39% 100%
C9ZIK3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 39% 100%
C9ZVE8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 38% 100%
C9ZVE9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 38% 100%
C9ZVF1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 38% 100%
D0A423 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 41% 100%
E8NHQ5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 72% 100%
E9AG72 Leishmania infantum 43% 100%
E9AI40 Leishmania braziliensis 77% 98%
E9AJY4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 46% 100%
E9AKQ9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 42% 100%
E9AL06 Leishmania mexicana (strain MHOM/GT/2001/U1103) 40% 94%
E9AN44 Leishmania mexicana (strain MHOM/GT/2001/U1103) 42% 100%
E9AN45 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
E9AN46 Leishmania mexicana (strain MHOM/GT/2001/U1103) 72% 100%
E9AN47 Leishmania mexicana (strain MHOM/GT/2001/U1103) 58% 100%
E9ANE5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 44% 100%
E9AS42 Leishmania mexicana (strain MHOM/GT/2001/U1103) 51% 100%
E9B741 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 96%
Q4QDC4 Leishmania major 51% 100%
Q4QH81 Leishmania major 42% 95%
Q4QHH7 Leishmania major 57% 98%
Q4QHH8 Leishmania major 71% 100%
Q4QHH9 Leishmania major 71% 100%
Q4QHI0 Leishmania major 71% 100%
Q4QHI1 Leishmania major 72% 99%
Q4QHI2 Leishmania major 87% 99%
Q4QIU9 Leishmania major 42% 100%
Q4QJ48 Leishmania major 41% 100%
Q7KIP2 Leishmania major 36% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS