Putative folate/biopterin transporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pteridine transporter (truncated) - putative

Species:

Leishmania infantum

UniProt:

A4HUE4_LEIIN

TriTrypDb:

LINF_100008800

Length:

745

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 9
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 52

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 67
NetGPI	no	yes: 0, no: 67

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	68
GO:0110165	cellular anatomical entity	1	68
GO:0005737	cytoplasm	2	6
GO:0005886	plasma membrane	3	1

Expansion

Sequence features

A4HUE4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HUE4

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0015877	biopterin transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0015224	biopterin transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	13	17	PF00656	0.604
CLV_C14_Caspase3-7	285	289	PF00656	0.458
CLV_C14_Caspase3-7	379	383	PF00656	0.405
CLV_C14_Caspase3-7	48	52	PF00656	0.659
CLV_NRD_NRD_1	115	117	PF00675	0.189
CLV_NRD_NRD_1	213	215	PF00675	0.225
CLV_NRD_NRD_1	741	743	PF00675	0.370
CLV_PCSK_KEX2_1	115	117	PF00082	0.262
CLV_PCSK_KEX2_1	155	157	PF00082	0.297
CLV_PCSK_KEX2_1	213	215	PF00082	0.254
CLV_PCSK_KEX2_1	741	743	PF00082	0.370
CLV_PCSK_PC1ET2_1	155	157	PF00082	0.297
CLV_PCSK_SKI1_1	287	291	PF00082	0.283
CLV_PCSK_SKI1_1	341	345	PF00082	0.293
CLV_PCSK_SKI1_1	413	417	PF00082	0.276
CLV_Separin_Metazoa	693	697	PF03568	0.541
DEG_APCC_DBOX_1	690	698	PF00400	0.542
DOC_ANK_TNKS_1	46	53	PF00023	0.543
DOC_CYCLIN_yCln2_LP_2	656	662	PF00134	0.390
DOC_MAPK_gen_1	155	161	PF00069	0.518
DOC_MAPK_gen_1	672	681	PF00069	0.581
DOC_MAPK_MEF2A_6	249	256	PF00069	0.344
DOC_MAPK_MEF2A_6	301	309	PF00069	0.391
DOC_MAPK_MEF2A_6	691	699	PF00069	0.554
DOC_PP2B_LxvP_1	391	394	PF13499	0.391
DOC_PP2B_LxvP_1	478	481	PF13499	0.354
DOC_PP2B_LxvP_1	661	664	PF13499	0.365
DOC_PP2B_LxvP_1	668	671	PF13499	0.338
DOC_PP4_FxxP_1	457	460	PF00568	0.330
DOC_USP7_MATH_1	178	182	PF00917	0.259
DOC_USP7_MATH_1	221	225	PF00917	0.321
DOC_USP7_MATH_1	31	35	PF00917	0.643
DOC_USP7_MATH_1	370	374	PF00917	0.476
DOC_USP7_MATH_1	378	382	PF00917	0.512
DOC_USP7_MATH_1	483	487	PF00917	0.306
DOC_USP7_MATH_1	490	494	PF00917	0.283
DOC_USP7_MATH_1	546	550	PF00917	0.327
DOC_USP7_MATH_1	599	603	PF00917	0.488
DOC_USP7_MATH_1	608	612	PF00917	0.340
DOC_USP7_MATH_1	623	627	PF00917	0.370
DOC_USP7_MATH_1	725	729	PF00917	0.756
DOC_USP7_UBL2_3	295	299	PF12436	0.575
DOC_WW_Pin1_4	301	306	PF00397	0.536
DOC_WW_Pin1_4	323	328	PF00397	0.566
LIG_14-3-3_CanoR_1	367	375	PF00244	0.393
LIG_14-3-3_CanoR_1	696	704	PF00244	0.674
LIG_14-3-3_CanoR_1	726	730	PF00244	0.803
LIG_14-3-3_CanoR_1	85	91	PF00244	0.506
LIG_BIR_II_1	1	5	PF00653	0.741
LIG_BRCT_BRCA1_1	394	398	PF00533	0.457
LIG_BRCT_BRCA1_1	501	505	PF00533	0.304
LIG_CaM_NSCaTE_8	412	419	PF13499	0.391
LIG_EH1_1	578	586	PF00400	0.348
LIG_FHA_1	230	236	PF00498	0.365
LIG_FHA_1	334	340	PF00498	0.393
LIG_FHA_1	403	409	PF00498	0.585
LIG_FHA_1	420	426	PF00498	0.336
LIG_FHA_1	535	541	PF00498	0.502
LIG_FHA_1	635	641	PF00498	0.412
LIG_FHA_1	651	657	PF00498	0.466
LIG_FHA_2	384	390	PF00498	0.557
LIG_FHA_2	434	440	PF00498	0.212
LIG_FHA_2	46	52	PF00498	0.636
LIG_FHA_2	704	710	PF00498	0.672
LIG_LIR_Gen_1	122	130	PF02991	0.488
LIG_LIR_Gen_1	145	153	PF02991	0.531
LIG_LIR_Gen_1	170	180	PF02991	0.308
LIG_LIR_Gen_1	205	216	PF02991	0.515
LIG_LIR_Gen_1	224	235	PF02991	0.456
LIG_LIR_Gen_1	342	351	PF02991	0.450
LIG_LIR_Gen_1	436	446	PF02991	0.282
LIG_LIR_Gen_1	474	484	PF02991	0.341
LIG_LIR_Gen_1	526	536	PF02991	0.351
LIG_LIR_Gen_1	549	556	PF02991	0.341
LIG_LIR_Gen_1	604	613	PF02991	0.523
LIG_LIR_Gen_1	643	652	PF02991	0.281
LIG_LIR_Gen_1	666	675	PF02991	0.266
LIG_LIR_Nem_3	122	127	PF02991	0.470
LIG_LIR_Nem_3	147	153	PF02991	0.498
LIG_LIR_Nem_3	154	160	PF02991	0.497
LIG_LIR_Nem_3	170	176	PF02991	0.335
LIG_LIR_Nem_3	205	211	PF02991	0.527
LIG_LIR_Nem_3	224	230	PF02991	0.366
LIG_LIR_Nem_3	342	346	PF02991	0.389
LIG_LIR_Nem_3	395	401	PF02991	0.537
LIG_LIR_Nem_3	439	445	PF02991	0.274
LIG_LIR_Nem_3	474	480	PF02991	0.320
LIG_LIR_Nem_3	502	506	PF02991	0.304
LIG_LIR_Nem_3	549	554	PF02991	0.348
LIG_LIR_Nem_3	557	562	PF02991	0.293
LIG_LIR_Nem_3	643	647	PF02991	0.276
LIG_LIR_Nem_3	666	670	PF02991	0.266
LIG_NRBOX	471	477	PF00104	0.225
LIG_PCNA_yPIPBox_3	737	745	PF02747	0.569
LIG_Pex14_1	227	231	PF04695	0.361
LIG_Pex14_1	438	442	PF04695	0.273
LIG_Pex14_2	268	272	PF04695	0.289
LIG_Pex14_2	501	505	PF04695	0.297
LIG_Pex14_2	525	529	PF04695	0.379
LIG_SH2_CRK	124	128	PF00017	0.499
LIG_SH2_CRK	158	162	PF00017	0.363
LIG_SH2_CRK	173	177	PF00017	0.357
LIG_SH2_CRK	208	212	PF00017	0.527
LIG_SH2_CRK	417	421	PF00017	0.347
LIG_SH2_CRK	442	446	PF00017	0.335
LIG_SH2_CRK	506	510	PF00017	0.311
LIG_SH2_CRK	562	566	PF00017	0.191
LIG_SH2_GRB2like	471	474	PF00017	0.361
LIG_SH2_NCK_1	506	510	PF00017	0.310
LIG_SH2_SRC	471	474	PF00017	0.508
LIG_SH2_STAP1	153	157	PF00017	0.502
LIG_SH2_STAP1	208	212	PF00017	0.491
LIG_SH2_STAP1	417	421	PF00017	0.374
LIG_SH2_STAT5	153	156	PF00017	0.504
LIG_SH2_STAT5	471	474	PF00017	0.350
LIG_SH2_STAT5	477	480	PF00017	0.355
LIG_SH2_STAT5	488	491	PF00017	0.306
LIG_SH2_STAT5	503	506	PF00017	0.277
LIG_SH2_STAT5	571	574	PF00017	0.291
LIG_SH2_STAT5	94	97	PF00017	0.517
LIG_SH3_3	174	180	PF00018	0.282
LIG_SH3_3	25	31	PF00018	0.651
LIG_SH3_3	493	499	PF00018	0.290
LIG_SUMO_SIM_anti_2	198	205	PF11976	0.401
LIG_SUMO_SIM_anti_2	424	430	PF11976	0.246
LIG_SUMO_SIM_anti_2	541	546	PF11976	0.299
LIG_SUMO_SIM_par_1	347	355	PF11976	0.402
LIG_SUMO_SIM_par_1	552	557	PF11976	0.421
LIG_TRAF2_1	377	380	PF00917	0.425
LIG_TRAF2_2	730	735	PF00917	0.593
LIG_TRFH_1	173	177	PF08558	0.341
LIG_TRFH_1	457	461	PF08558	0.191
LIG_TRFH_1	667	671	PF08558	0.301
LIG_TYR_ITIM	171	176	PF00017	0.396
LIG_TYR_ITIM	415	420	PF00017	0.261
LIG_TYR_ITIM	440	445	PF00017	0.354
LIG_TYR_ITIM	475	480	PF00017	0.354
LIG_TYR_ITIM	504	509	PF00017	0.318
LIG_UBA3_1	524	531	PF00899	0.398
LIG_WRC_WIRS_1	484	489	PF05994	0.322
MOD_CK1_1	229	235	PF00069	0.380
MOD_CK1_1	23	29	PF00069	0.602
MOD_CK1_1	424	430	PF00069	0.356
MOD_CK1_1	45	51	PF00069	0.478
MOD_CK1_1	530	536	PF00069	0.379
MOD_CK1_1	583	589	PF00069	0.424
MOD_CK1_1	611	617	PF00069	0.306
MOD_CK2_1	383	389	PF00069	0.280
MOD_CK2_1	433	439	PF00069	0.205
MOD_GlcNHglycan	181	184	PF01048	0.337
MOD_GlcNHglycan	246	249	PF01048	0.393
MOD_GlcNHglycan	25	28	PF01048	0.659
MOD_GlcNHglycan	256	259	PF01048	0.396
MOD_GlcNHglycan	33	36	PF01048	0.650
MOD_GlcNHglycan	368	371	PF01048	0.469
MOD_GlcNHglycan	509	512	PF01048	0.413
MOD_GlcNHglycan	6	9	PF01048	0.725
MOD_GlcNHglycan	610	613	PF01048	0.368
MOD_GSK3_1	191	198	PF00069	0.269
MOD_GSK3_1	297	304	PF00069	0.434
MOD_GSK3_1	366	373	PF00069	0.295
MOD_GSK3_1	415	422	PF00069	0.372
MOD_GSK3_1	429	436	PF00069	0.315
MOD_GSK3_1	441	448	PF00069	0.263
MOD_GSK3_1	507	514	PF00069	0.343
MOD_GSK3_1	523	530	PF00069	0.366
MOD_GSK3_1	534	541	PF00069	0.372
MOD_GSK3_1	580	587	PF00069	0.227
MOD_GSK3_1	588	595	PF00069	0.215
MOD_GSK3_1	619	626	PF00069	0.390
MOD_N-GLC_1	323	328	PF02516	0.197
MOD_N-GLC_2	580	582	PF02516	0.195
MOD_NEK2_1	119	124	PF00069	0.318
MOD_NEK2_1	144	149	PF00069	0.346
MOD_NEK2_1	151	156	PF00069	0.341
MOD_NEK2_1	159	164	PF00069	0.354
MOD_NEK2_1	191	196	PF00069	0.358
MOD_NEK2_1	235	240	PF00069	0.335
MOD_NEK2_1	244	249	PF00069	0.373
MOD_NEK2_1	339	344	PF00069	0.365
MOD_NEK2_1	351	356	PF00069	0.293
MOD_NEK2_1	4	9	PF00069	0.676
MOD_NEK2_1	416	421	PF00069	0.377
MOD_NEK2_1	441	446	PF00069	0.336
MOD_NEK2_1	505	510	PF00069	0.352
MOD_NEK2_1	538	543	PF00069	0.374
MOD_NEK2_1	584	589	PF00069	0.418
MOD_NEK2_1	616	621	PF00069	0.362
MOD_NEK2_1	628	633	PF00069	0.377
MOD_NEK2_1	650	655	PF00069	0.444
MOD_NEK2_1	86	91	PF00069	0.441
MOD_NEK2_2	133	138	PF00069	0.195
MOD_NEK2_2	483	488	PF00069	0.317
MOD_NEK2_2	546	551	PF00069	0.348
MOD_PIKK_1	39	45	PF00454	0.671
MOD_PKA_2	366	372	PF00069	0.396
MOD_PKA_2	599	605	PF00069	0.335
MOD_PKA_2	702	708	PF00069	0.650
MOD_PKA_2	725	731	PF00069	0.629
MOD_Plk_1	119	125	PF00069	0.298
MOD_Plk_1	383	389	PF00069	0.253
MOD_Plk_1	490	496	PF00069	0.427
MOD_Plk_4	226	232	PF00069	0.348
MOD_Plk_4	235	241	PF00069	0.336
MOD_Plk_4	416	422	PF00069	0.342
MOD_Plk_4	424	430	PF00069	0.331
MOD_Plk_4	471	477	PF00069	0.352
MOD_Plk_4	483	489	PF00069	0.319
MOD_Plk_4	540	546	PF00069	0.311
MOD_Plk_4	58	64	PF00069	0.493
MOD_Plk_4	580	586	PF00069	0.328
MOD_Plk_4	588	594	PF00069	0.326
MOD_Plk_4	601	607	PF00069	0.373
MOD_Plk_4	623	629	PF00069	0.319
MOD_Plk_4	663	669	PF00069	0.361
MOD_ProDKin_1	301	307	PF00069	0.397
MOD_ProDKin_1	323	329	PF00069	0.440
MOD_SUMO_rev_2	285	292	PF00179	0.236
MOD_SUMO_rev_2	304	312	PF00179	0.433
MOD_SUMO_rev_2	34	40	PF00179	0.692
TRG_DiLeu_BaLyEn_6	656	661	PF01217	0.329
TRG_DiLeu_BaLyEn_6	82	87	PF01217	0.236
TRG_ENDOCYTIC_2	124	127	PF00928	0.333
TRG_ENDOCYTIC_2	158	161	PF00928	0.359
TRG_ENDOCYTIC_2	173	176	PF00928	0.335
TRG_ENDOCYTIC_2	208	211	PF00928	0.349
TRG_ENDOCYTIC_2	417	420	PF00928	0.349
TRG_ENDOCYTIC_2	442	445	PF00928	0.337
TRG_ENDOCYTIC_2	477	480	PF00928	0.373
TRG_ENDOCYTIC_2	506	509	PF00928	0.359
TRG_ENDOCYTIC_2	562	565	PF00928	0.473
TRG_ENDOCYTIC_2	607	610	PF00928	0.355
TRG_ER_diArg_1	114	116	PF00400	0.234
TRG_ER_diArg_1	212	214	PF00400	0.265
TRG_ER_diArg_1	671	674	PF00400	0.326
TRG_ER_diArg_1	740	742	PF00400	0.445
TRG_NES_CRM1_1	479	491	PF08389	0.329

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2U2	Leptomonas seymouri	58%	100%
A0A0N1HY49	Leptomonas seymouri	48%	100%
A0A0N1HZ06	Leptomonas seymouri	41%	100%
A0A0N1IHL1	Leptomonas seymouri	42%	100%
A0A0N1PAY4	Leptomonas seymouri	39%	85%
A0A0N1PB77	Leptomonas seymouri	40%	100%
A0A0N1PBZ2	Leptomonas seymouri	44%	100%
A0A0N1PCC1	Leptomonas seymouri	40%	100%
A0A381MBI0	Leishmania infantum	40%	100%
A0A3Q8I8X7	Leishmania donovani	40%	100%
A0A3Q8IAZ0	Leishmania donovani	43%	100%
A0A3Q8IH50	Leishmania donovani	50%	100%
A0A3Q8IVN0	Leishmania donovani	40%	100%
A0A3R7M4J1	Trypanosoma rangeli	42%	100%
A0A3S5H5P4	Leishmania donovani	46%	100%
A0A3S5H5V2	Leishmania donovani	45%	100%
A0A3S5H6F6	Leishmania donovani	42%	100%
A0A3S5H763	Leishmania donovani	48%	100%
A0A3S7WR10	Leishmania donovani	100%	100%
A0A3S7WR14	Leishmania donovani	45%	100%
A0A3S7WR15	Leishmania donovani	42%	88%
A0A3S7WR24	Leishmania donovani	43%	100%
A4H4T8	Leishmania braziliensis	45%	96%
A4H5Y4	Leishmania braziliensis	41%	100%
A4H617	Leishmania braziliensis	44%	100%
A4H618	Leishmania braziliensis	44%	100%
A4H619	Leishmania braziliensis	43%	100%
A4H620	Leishmania braziliensis	50%	100%
A4H6C3	Leishmania braziliensis	41%	100%
A4HNH7	Leishmania braziliensis	39%	98%
A4HSS2	Leishmania infantum	45%	100%
A4HUE5	Leishmania infantum	42%	100%
A4HUE6	Leishmania infantum	45%	100%
A4HUE7	Leishmania infantum	42%	100%
A4HUE8	Leishmania infantum	43%	100%
A4HUF4	Leishmania infantum	42%	100%
A4HUF5	Leishmania infantum	49%	100%
A4HYA9	Leishmania infantum	48%	100%
A4IC33	Leishmania infantum	40%	100%
C9ZIK0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
C9ZIK3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
D0A423	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E8NHQ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E9AG72	Leishmania infantum	45%	100%
E9AI40	Leishmania braziliensis	44%	100%
E9AJY4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	98%
E9AKQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	100%
E9AL06	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E9AN44	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
E9AN45	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	99%
E9AN46	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	99%
E9AN47	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	100%
E9ANE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E9AS42	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	100%
E9B741	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	92%
Q4QDC4	Leishmania major	48%	100%
Q4QH81	Leishmania major	41%	100%
Q4QHH7	Leishmania major	49%	100%
Q4QHH8	Leishmania major	42%	100%
Q4QHH9	Leishmania major	41%	100%
Q4QHI0	Leishmania major	43%	100%
Q4QHI1	Leishmania major	43%	96%
Q4QHI2	Leishmania major	43%	100%
Q4QIU9	Leishmania major	44%	97%
Q4QJ48	Leishmania major	45%	100%
Q7KIP2	Leishmania major	40%	93%