Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HUE3_LEIIN

TriTrypDb:

LINF_100008700

Length:

435

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HUE3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HUE3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	108	112	PF00656	0.693
CLV_C14_Caspase3-7	203	207	PF00656	0.664
CLV_C14_Caspase3-7	263	267	PF00656	0.646
CLV_NRD_NRD_1	252	254	PF00675	0.461
CLV_NRD_NRD_1	384	386	PF00675	0.509
CLV_PCSK_FUR_1	419	423	PF00082	0.714
CLV_PCSK_KEX2_1	252	254	PF00082	0.461
CLV_PCSK_KEX2_1	384	386	PF00082	0.509
CLV_PCSK_KEX2_1	421	423	PF00082	0.811
CLV_PCSK_PC1ET2_1	421	423	PF00082	0.811
CLV_PCSK_SKI1_1	122	126	PF00082	0.727
CLV_PCSK_SKI1_1	167	171	PF00082	0.609
CLV_PCSK_SKI1_1	22	26	PF00082	0.612
CLV_Separin_Metazoa	320	324	PF03568	0.494
DEG_APCC_DBOX_1	73	81	PF00400	0.597
DEG_SPOP_SBC_1	10	14	PF00917	0.730
DEG_SPOP_SBC_1	239	243	PF00917	0.579
DOC_MAPK_MEF2A_6	295	304	PF00069	0.600
DOC_PP2B_LxvP_1	197	200	PF13499	0.491
DOC_PP4_FxxP_1	32	35	PF00568	0.469
DOC_USP7_MATH_1	10	14	PF00917	0.614
DOC_USP7_MATH_1	239	243	PF00917	0.640
DOC_USP7_MATH_1	390	394	PF00917	0.715
DOC_WW_Pin1_4	183	188	PF00397	0.644
DOC_WW_Pin1_4	305	310	PF00397	0.569
DOC_WW_Pin1_4	394	399	PF00397	0.626
LIG_14-3-3_CanoR_1	114	118	PF00244	0.612
LIG_14-3-3_CanoR_1	147	153	PF00244	0.538
LIG_14-3-3_CanoR_1	22	32	PF00244	0.569
LIG_14-3-3_CanoR_1	252	260	PF00244	0.546
LIG_14-3-3_CanoR_1	323	333	PF00244	0.515
LIG_14-3-3_CanoR_1	369	374	PF00244	0.478
LIG_14-3-3_CanoR_1	37	46	PF00244	0.622
LIG_14-3-3_CanoR_1	384	391	PF00244	0.404
LIG_Actin_WH2_2	131	149	PF00022	0.567
LIG_Actin_WH2_2	315	332	PF00022	0.625
LIG_BIR_III_2	206	210	PF00653	0.599
LIG_CaM_IQ_9	361	377	PF13499	0.435
LIG_DLG_GKlike_1	369	377	PF00625	0.440
LIG_FHA_1	147	153	PF00498	0.557
LIG_FHA_1	155	161	PF00498	0.453
LIG_FHA_1	208	214	PF00498	0.632
LIG_FHA_1	23	29	PF00498	0.506
LIG_FHA_1	39	45	PF00498	0.715
LIG_FHA_2	201	207	PF00498	0.533
LIG_FHA_2	312	318	PF00498	0.632
LIG_GBD_Chelix_1	290	298	PF00786	0.590
LIG_LIR_Apic_2	31	35	PF02991	0.473
LIG_LIR_Gen_1	157	165	PF02991	0.412
LIG_LIR_Gen_1	219	230	PF02991	0.625
LIG_LIR_Nem_3	157	162	PF02991	0.414
LIG_LIR_Nem_3	219	225	PF02991	0.509
LIG_PROFILIN_1	403	409	PF00235	0.565
LIG_RPA_C_Fungi	379	391	PF08784	0.479
LIG_SH2_SRC	198	201	PF00017	0.499
LIG_SH2_STAP1	165	169	PF00017	0.575
LIG_SH2_STAT5	198	201	PF00017	0.563
LIG_SH2_STAT5	259	262	PF00017	0.602
LIG_SH2_STAT5	90	93	PF00017	0.441
LIG_SH3_3	178	184	PF00018	0.694
LIG_SH3_3	331	337	PF00018	0.625
LIG_SH3_3	338	344	PF00018	0.627
LIG_SH3_3	400	406	PF00018	0.742
LIG_SUMO_SIM_anti_2	317	324	PF11976	0.621
LIG_SUMO_SIM_par_1	160	166	PF11976	0.413
LIG_SUMO_SIM_par_1	357	363	PF11976	0.480
LIG_TRAF2_1	209	212	PF00917	0.672
LIG_TRAF2_1	286	289	PF00917	0.612
LIG_TRAF2_1	351	354	PF00917	0.611
MOD_CDK_SPK_2	394	399	PF00069	0.739
MOD_CK1_1	113	119	PF00069	0.486
MOD_CK1_1	154	160	PF00069	0.512
MOD_CK1_1	238	244	PF00069	0.611
MOD_CK1_1	272	278	PF00069	0.582
MOD_CK1_1	307	313	PF00069	0.696
MOD_CK1_1	335	341	PF00069	0.636
MOD_CK1_1	383	389	PF00069	0.592
MOD_CK1_1	96	102	PF00069	0.689
MOD_CK2_1	412	418	PF00069	0.706
MOD_GlcNHglycan	104	107	PF01048	0.675
MOD_GlcNHglycan	170	173	PF01048	0.662
MOD_GlcNHglycan	18	21	PF01048	0.653
MOD_GlcNHglycan	237	240	PF01048	0.754
MOD_GlcNHglycan	242	245	PF01048	0.753
MOD_GlcNHglycan	255	258	PF01048	0.409
MOD_GlcNHglycan	347	350	PF01048	0.639
MOD_GlcNHglycan	356	359	PF01048	0.566
MOD_GlcNHglycan	385	388	PF01048	0.529
MOD_GlcNHglycan	422	425	PF01048	0.746
MOD_GlcNHglycan	50	53	PF01048	0.546
MOD_GlcNHglycan	6	9	PF01048	0.676
MOD_GlcNHglycan	77	80	PF01048	0.579
MOD_GSK3_1	147	154	PF00069	0.586
MOD_GSK3_1	207	214	PF00069	0.636
MOD_GSK3_1	235	242	PF00069	0.628
MOD_GSK3_1	24	31	PF00069	0.542
MOD_GSK3_1	269	276	PF00069	0.713
MOD_GSK3_1	305	312	PF00069	0.626
MOD_GSK3_1	379	386	PF00069	0.559
MOD_GSK3_1	390	397	PF00069	0.618
MOD_GSK3_1	420	427	PF00069	0.802
MOD_GSK3_1	93	100	PF00069	0.527
MOD_N-GLC_1	147	152	PF02516	0.399
MOD_N-GLC_1	226	231	PF02516	0.569
MOD_NEK2_1	1	6	PF00069	0.581
MOD_NEK2_1	146	151	PF00069	0.537
MOD_NEK2_1	278	283	PF00069	0.609
MOD_NEK2_1	290	295	PF00069	0.431
MOD_NEK2_1	304	309	PF00069	0.552
MOD_NEK2_1	321	326	PF00069	0.553
MOD_NEK2_1	380	385	PF00069	0.652
MOD_NMyristoyl	1	7	PF02799	0.555
MOD_PIKK_1	270	276	PF00454	0.660
MOD_PIKK_1	278	284	PF00454	0.459
MOD_PIKK_1	335	341	PF00454	0.676
MOD_PK_1	147	153	PF00069	0.506
MOD_PKA_2	113	119	PF00069	0.486
MOD_PKA_2	146	152	PF00069	0.536
MOD_PKA_2	335	341	PF00069	0.578
MOD_PKA_2	383	389	PF00069	0.481
MOD_PKA_2	96	102	PF00069	0.673
MOD_PKB_1	369	377	PF00069	0.485
MOD_Plk_1	147	153	PF00069	0.395
MOD_Plk_1	211	217	PF00069	0.623
MOD_Plk_1	226	232	PF00069	0.507
MOD_Plk_4	147	153	PF00069	0.506
MOD_Plk_4	226	232	PF00069	0.574
MOD_ProDKin_1	183	189	PF00069	0.640
MOD_ProDKin_1	305	311	PF00069	0.573
MOD_ProDKin_1	394	400	PF00069	0.631
MOD_SUMO_for_1	124	127	PF00179	0.713
TRG_DiLeu_BaLyEn_6	292	297	PF01217	0.467
TRG_ER_diArg_1	251	253	PF00400	0.483
TRG_ER_diArg_1	368	371	PF00400	0.488
TRG_NES_CRM1_1	288	303	PF08389	0.534
TRG_NES_CRM1_1	354	365	PF08389	0.614
TRG_NLS_MonoExtC_3	121	127	PF00514	0.606
TRG_Pf-PMV_PEXEL_1	299	303	PF00026	0.543

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYC0	Leptomonas seymouri	36%	80%
A0A3Q8I7N0	Leishmania donovani	99%	100%
A4H616	Leishmania braziliensis	69%	100%
E9AN43	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QHI3	Leishmania major	91%	100%