Amastin surface glycofamily protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Amastin surface glycoprotein - putative

Species:

Leishmania infantum

UniProt:

A4HUD3_LEIIN

TriTrypDb:

LINF_100007700

Length:

418

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 19
NetGPI	no	yes: 0, no: 19

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	16
GO:0110165	cellular anatomical entity	1	16

Expansion

Sequence features

A4HUD3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HUD3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	36	40	PF00656	0.575
CLV_NRD_NRD_1	263	265	PF00675	0.535
CLV_NRD_NRD_1	93	95	PF00675	0.510
CLV_PCSK_KEX2_1	115	117	PF00082	0.518
CLV_PCSK_PC1ET2_1	115	117	PF00082	0.501
CLV_PCSK_SKI1_1	116	120	PF00082	0.482
CLV_PCSK_SKI1_1	333	337	PF00082	0.323
DEG_APCC_DBOX_1	146	154	PF00400	0.438
DOC_AGCK_PIF_1	315	320	PF00069	0.230
DOC_CYCLIN_RxL_1	113	123	PF00134	0.238
DOC_MAPK_gen_1	264	270	PF00069	0.234
DOC_MAPK_gen_1	330	339	PF00069	0.493
DOC_MAPK_HePTP_8	327	339	PF00069	0.501
DOC_MAPK_MEF2A_6	147	154	PF00069	0.455
DOC_MAPK_MEF2A_6	330	339	PF00069	0.552
DOC_PP1_RVXF_1	383	389	PF00149	0.301
DOC_PP2B_LxvP_1	83	86	PF13499	0.262
DOC_USP7_MATH_1	236	240	PF00917	0.376
DOC_USP7_MATH_1	289	293	PF00917	0.391
DOC_USP7_UBL2_3	265	269	PF12436	0.215
DOC_WW_Pin1_4	102	107	PF00397	0.248
LIG_14-3-3_CanoR_1	216	224	PF00244	0.484
LIG_14-3-3_CanoR_1	264	269	PF00244	0.292
LIG_14-3-3_CanoR_1	358	363	PF00244	0.314
LIG_14-3-3_CanoR_1	94	99	PF00244	0.330
LIG_Actin_WH2_2	76	91	PF00022	0.261
LIG_BIR_II_1	1	5	PF00653	0.644
LIG_BRCT_BRCA1_1	311	315	PF00533	0.369
LIG_BRCT_BRCA1_1	71	75	PF00533	0.399
LIG_eIF4E_1	232	238	PF01652	0.482
LIG_FHA_1	11	17	PF00498	0.741
LIG_FHA_1	158	164	PF00498	0.335
LIG_FHA_1	203	209	PF00498	0.305
LIG_FHA_1	392	398	PF00498	0.303
LIG_FHA_1	406	412	PF00498	0.326
LIG_LIR_Apic_2	291	296	PF02991	0.271
LIG_LIR_Apic_2	372	378	PF02991	0.248
LIG_LIR_Gen_1	105	113	PF02991	0.248
LIG_LIR_Gen_1	123	132	PF02991	0.418
LIG_LIR_Gen_1	166	175	PF02991	0.377
LIG_LIR_Gen_1	203	212	PF02991	0.361
LIG_LIR_Gen_1	312	322	PF02991	0.343
LIG_LIR_Gen_1	343	352	PF02991	0.432
LIG_LIR_Gen_1	66	75	PF02991	0.289
LIG_LIR_Nem_3	105	110	PF02991	0.274
LIG_LIR_Nem_3	123	128	PF02991	0.440
LIG_LIR_Nem_3	166	171	PF02991	0.400
LIG_LIR_Nem_3	194	200	PF02991	0.343
LIG_LIR_Nem_3	271	275	PF02991	0.312
LIG_LIR_Nem_3	312	318	PF02991	0.343
LIG_LIR_Nem_3	336	342	PF02991	0.368
LIG_LIR_Nem_3	343	347	PF02991	0.356
LIG_LIR_Nem_3	66	70	PF02991	0.289
LIG_LIR_Nem_3	97	102	PF02991	0.299
LIG_Pex14_2	197	201	PF04695	0.303
LIG_Pex14_2	318	322	PF04695	0.256
LIG_SH2_CRK	293	297	PF00017	0.300
LIG_SH2_CRK	328	332	PF00017	0.429
LIG_SH2_CRK	375	379	PF00017	0.369
LIG_SH2_STAT5	413	416	PF00017	0.373
LIG_SH3_3	364	370	PF00018	0.388
LIG_SUMO_SIM_anti_2	343	349	PF11976	0.316
LIG_SUMO_SIM_par_1	130	136	PF11976	0.334
LIG_SUMO_SIM_par_1	159	164	PF11976	0.326
LIG_SUMO_SIM_par_1	245	251	PF11976	0.374
LIG_SUMO_SIM_par_1	345	351	PF11976	0.405
LIG_TRAF2_1	42	45	PF00917	0.574
LIG_TYR_ITIM	270	275	PF00017	0.257
LIG_TYR_ITIM	411	416	PF00017	0.373
LIG_UBA3_1	411	417	PF00899	0.262
LIG_WRC_WIRS_1	201	206	PF05994	0.365
LIG_WRC_WIRS_1	238	243	PF05994	0.284
LIG_WRC_WIRS_1	317	322	PF05994	0.288
LIG_WRC_WIRS_1	359	364	PF05994	0.301
MOD_CDK_SPxxK_3	102	109	PF00069	0.229
MOD_CK1_1	133	139	PF00069	0.400
MOD_CK1_1	240	246	PF00069	0.387
MOD_CK1_1	309	315	PF00069	0.393
MOD_CK1_1	32	38	PF00069	0.628
MOD_CK1_1	351	357	PF00069	0.346
MOD_CK1_1	71	77	PF00069	0.373
MOD_CK2_1	105	111	PF00069	0.311
MOD_CK2_1	220	226	PF00069	0.535
MOD_CMANNOS	96	99	PF00535	0.518
MOD_Cter_Amidation	92	95	PF01082	0.510
MOD_GlcNHglycan	234	237	PF01048	0.376
MOD_GlcNHglycan	242	245	PF01048	0.388
MOD_GlcNHglycan	350	353	PF01048	0.447
MOD_GlcNHglycan	364	367	PF01048	0.554
MOD_GlcNHglycan	401	404	PF01048	0.407
MOD_GlcNHglycan	56	61	PF01048	0.413
MOD_GSK3_1	157	164	PF00069	0.348
MOD_GSK3_1	216	223	PF00069	0.504
MOD_GSK3_1	227	234	PF00069	0.590
MOD_GSK3_1	236	243	PF00069	0.244
MOD_GSK3_1	264	271	PF00069	0.393
MOD_GSK3_1	29	36	PF00069	0.650
MOD_GSK3_1	316	323	PF00069	0.491
MOD_GSK3_1	358	365	PF00069	0.362
MOD_N-GLC_1	102	107	PF02516	0.474
MOD_N-GLC_1	29	34	PF02516	0.406
MOD_NEK2_1	1	6	PF00069	0.635
MOD_NEK2_1	218	223	PF00069	0.646
MOD_NEK2_1	227	232	PF00069	0.593
MOD_NEK2_1	237	242	PF00069	0.328
MOD_NEK2_1	268	273	PF00069	0.235
MOD_NEK2_1	316	321	PF00069	0.367
MOD_NEK2_1	33	38	PF00069	0.684
MOD_NEK2_1	348	353	PF00069	0.484
MOD_NEK2_1	399	404	PF00069	0.381
MOD_NEK2_1	69	74	PF00069	0.388
MOD_NEK2_1	79	84	PF00069	0.361
MOD_NEK2_2	296	301	PF00069	0.229
MOD_PIKK_1	33	39	PF00454	0.606
MOD_PKA_1	264	270	PF00069	0.215
MOD_PKA_1	94	100	PF00069	0.260
MOD_PKA_2	263	269	PF00069	0.421
MOD_Plk_1	29	35	PF00069	0.637
MOD_Plk_2-3	220	226	PF00069	0.521
MOD_Plk_4	133	139	PF00069	0.383
MOD_Plk_4	157	163	PF00069	0.341
MOD_Plk_4	237	243	PF00069	0.391
MOD_Plk_4	340	346	PF00069	0.386
MOD_Plk_4	71	77	PF00069	0.411
MOD_ProDKin_1	102	108	PF00069	0.248
MOD_SUMO_rev_2	260	267	PF00179	0.214
MOD_SUMO_rev_2	35	43	PF00179	0.649
TRG_ENDOCYTIC_2	272	275	PF00928	0.390
TRG_ENDOCYTIC_2	359	362	PF00928	0.295
TRG_ENDOCYTIC_2	413	416	PF00928	0.373
TRG_Pf-PMV_PEXEL_1	116	120	PF00026	0.438
TRG_Pf-PMV_PEXEL_1	41	45	PF00026	0.457

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6X2	Leptomonas seymouri	29%	82%
A0A0N1PC74	Leptomonas seymouri	25%	83%
A0A0N1PCA2	Leptomonas seymouri	55%	100%
A0A0S4IH58	Bodo saltans	21%	71%
A0A3Q8I8Q6	Leishmania donovani	27%	85%
A0A3S7WR28	Leishmania donovani	100%	100%
A0A3S7X1E1	Leishmania donovani	25%	81%
A4H605	Leishmania braziliensis	27%	100%
A4H606	Leishmania braziliensis	67%	100%
A4HGF8	Leishmania braziliensis	28%	100%
A4HUD2	Leishmania infantum	27%	100%
A4I3I9	Leishmania infantum	26%	81%
E9AN32	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9AN33	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
E9AZT1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
Q4Q8F3	Leishmania major	25%	100%
Q4QHJ3	Leishmania major	95%	100%
Q4QHJ4	Leishmania major	27%	100%