LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Phosphorylation Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4HUD1_LEIIN
TriTrypDb:
LINF_100007500
Length:
278

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 6, no: 0
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0016020 membrane 2 5
GO:0110165 cellular anatomical entity 1 5

Phosphorylation

Promastigote/Amastigote: 275

Expansion

Sequence features

A4HUD1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HUD1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 44 48 PF00656 0.478
CLV_NRD_NRD_1 230 232 PF00675 0.559
CLV_NRD_NRD_1 234 236 PF00675 0.573
CLV_PCSK_KEX2_1 230 232 PF00082 0.554
CLV_PCSK_KEX2_1 234 236 PF00082 0.573
CLV_PCSK_PC7_1 230 236 PF00082 0.538
CLV_PCSK_SKI1_1 120 124 PF00082 0.662
CLV_PCSK_SKI1_1 5 9 PF00082 0.684
DEG_SCF_FBW7_1 62 69 PF00400 0.482
DOC_CKS1_1 123 128 PF01111 0.467
DOC_PP4_FxxP_1 123 126 PF00568 0.480
DOC_USP7_MATH_1 161 165 PF00917 0.426
DOC_USP7_MATH_1 214 218 PF00917 0.684
DOC_USP7_MATH_1 39 43 PF00917 0.405
DOC_WW_Pin1_4 122 127 PF00397 0.457
DOC_WW_Pin1_4 164 169 PF00397 0.485
DOC_WW_Pin1_4 212 217 PF00397 0.701
DOC_WW_Pin1_4 62 67 PF00397 0.462
LIG_14-3-3_CanoR_1 131 135 PF00244 0.475
LIG_14-3-3_CanoR_1 144 148 PF00244 0.381
LIG_14-3-3_CanoR_1 183 190 PF00244 0.567
LIG_14-3-3_CanoR_1 5 14 PF00244 0.526
LIG_14-3-3_CanoR_1 57 63 PF00244 0.406
LIG_FHA_1 107 113 PF00498 0.507
LIG_FHA_1 15 21 PF00498 0.672
LIG_FHA_1 185 191 PF00498 0.455
LIG_FHA_1 200 206 PF00498 0.436
LIG_FHA_1 57 63 PF00498 0.406
LIG_FHA_2 218 224 PF00498 0.712
LIG_LIR_Apic_2 121 126 PF02991 0.468
LIG_LIR_Gen_1 220 226 PF02991 0.725
LIG_LIR_Nem_3 146 151 PF02991 0.422
LIG_LIR_Nem_3 90 96 PF02991 0.408
LIG_PTAP_UEV_1 167 172 PF05743 0.585
LIG_PTB_Apo_2 246 253 PF02174 0.753
LIG_PTB_Phospho_1 246 252 PF10480 0.753
LIG_SH2_CRK 97 101 PF00017 0.379
LIG_SH2_NCK_1 45 49 PF00017 0.430
LIG_SH2_STAP1 222 226 PF00017 0.683
LIG_SH2_STAP1 45 49 PF00017 0.447
LIG_SH2_STAP1 97 101 PF00017 0.392
LIG_SH3_2 126 131 PF14604 0.481
LIG_SH3_3 123 129 PF00018 0.464
LIG_SH3_3 165 171 PF00018 0.574
LIG_SH3_3 33 39 PF00018 0.472
LIG_SUMO_SIM_anti_2 17 24 PF11976 0.551
LIG_SUMO_SIM_par_1 17 24 PF11976 0.686
MOD_CDK_SPxxK_3 212 219 PF00069 0.704
MOD_CK1_1 150 156 PF00069 0.451
MOD_CK1_1 164 170 PF00069 0.338
MOD_CK1_1 217 223 PF00069 0.694
MOD_CK1_1 80 86 PF00069 0.478
MOD_CK2_1 217 223 PF00069 0.706
MOD_CK2_1 263 269 PF00069 0.694
MOD_GlcNHglycan 168 171 PF01048 0.684
MOD_GlcNHglycan 23 26 PF01048 0.725
MOD_GlcNHglycan 81 85 PF01048 0.558
MOD_GSK3_1 143 150 PF00069 0.446
MOD_GSK3_1 162 169 PF00069 0.471
MOD_GSK3_1 184 191 PF00069 0.498
MOD_GSK3_1 214 221 PF00069 0.665
MOD_GSK3_1 259 266 PF00069 0.683
MOD_GSK3_1 39 46 PF00069 0.399
MOD_GSK3_1 58 65 PF00069 0.358
MOD_GSK3_1 76 83 PF00069 0.293
MOD_N-GLC_1 107 112 PF02516 0.624
MOD_N-GLC_1 156 161 PF02516 0.731
MOD_N-GLC_1 5 10 PF02516 0.590
MOD_N-GLC_1 62 67 PF02516 0.682
MOD_N-GLC_2 249 251 PF02516 0.553
MOD_NEK2_1 104 109 PF00069 0.418
MOD_NEK2_1 184 189 PF00069 0.491
MOD_NEK2_1 20 25 PF00069 0.617
MOD_NEK2_2 143 148 PF00069 0.470
MOD_OFUCOSY 155 160 PF10250 0.647
MOD_PIKK_1 162 168 PF00454 0.465
MOD_PKA_2 130 136 PF00069 0.471
MOD_PKA_2 143 149 PF00069 0.382
MOD_PKA_2 56 62 PF00069 0.399
MOD_Plk_1 5 11 PF00069 0.539
MOD_Plk_4 130 136 PF00069 0.474
MOD_Plk_4 14 20 PF00069 0.568
MOD_Plk_4 143 149 PF00069 0.372
MOD_ProDKin_1 122 128 PF00069 0.460
MOD_ProDKin_1 164 170 PF00069 0.485
MOD_ProDKin_1 212 218 PF00069 0.701
MOD_ProDKin_1 62 68 PF00069 0.464
MOD_SUMO_rev_2 150 156 PF00179 0.355
MOD_SUMO_rev_2 257 266 PF00179 0.672
TRG_ENDOCYTIC_2 222 225 PF00928 0.784
TRG_ENDOCYTIC_2 97 100 PF00928 0.397
TRG_ER_diArg_1 233 235 PF00400 0.779
TRG_NLS_MonoExtC_3 230 235 PF00514 0.732
TRG_NLS_MonoExtN_4 230 235 PF00514 0.732

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HYT1 Leptomonas seymouri 54% 87%
A0A3S7WR08 Leishmania donovani 100% 100%
A4H604 Leishmania braziliensis 68% 100%
E9AN31 Leishmania mexicana (strain MHOM/GT/2001/U1103) 81% 100%
Q4QHJ5 Leishmania major 92% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS