Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HUD0_LEIIN

TriTrypDb:

LINF_100007400

Length:

715

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HUD0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HUD0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	11	15	PF00656	0.570
CLV_C14_Caspase3-7	116	120	PF00656	0.568
CLV_C14_Caspase3-7	209	213	PF00656	0.674
CLV_C14_Caspase3-7	345	349	PF00656	0.458
CLV_C14_Caspase3-7	368	372	PF00656	0.441
CLV_NRD_NRD_1	12	14	PF00675	0.536
CLV_NRD_NRD_1	297	299	PF00675	0.544
CLV_NRD_NRD_1	322	324	PF00675	0.431
CLV_NRD_NRD_1	532	534	PF00675	0.362
CLV_NRD_NRD_1	550	552	PF00675	0.420
CLV_NRD_NRD_1	666	668	PF00675	0.493
CLV_PCSK_KEX2_1	12	14	PF00082	0.536
CLV_PCSK_KEX2_1	297	299	PF00082	0.544
CLV_PCSK_KEX2_1	322	324	PF00082	0.431
CLV_PCSK_KEX2_1	532	534	PF00082	0.362
CLV_PCSK_KEX2_1	550	552	PF00082	0.420
CLV_PCSK_KEX2_1	665	667	PF00082	0.480
CLV_PCSK_PC7_1	661	667	PF00082	0.463
CLV_PCSK_SKI1_1	588	592	PF00082	0.400
CLV_PCSK_SKI1_1	65	69	PF00082	0.582
DEG_APCC_DBOX_1	154	162	PF00400	0.486
DEG_Nend_Nbox_1	1	3	PF02207	0.534
DOC_ANK_TNKS_1	12	19	PF00023	0.537
DOC_CYCLIN_RxL_1	547	555	PF00134	0.409
DOC_MAPK_gen_1	155	164	PF00069	0.561
DOC_MAPK_gen_1	297	306	PF00069	0.604
DOC_MAPK_gen_1	532	539	PF00069	0.357
DOC_MAPK_MEF2A_6	300	308	PF00069	0.606
DOC_MAPK_MEF2A_6	532	539	PF00069	0.357
DOC_PP1_RVXF_1	628	634	PF00149	0.516
DOC_PP2B_LxvP_1	195	198	PF13499	0.596
DOC_PP2B_LxvP_1	498	501	PF13499	0.423
DOC_PP4_MxPP_1	711	714	PF00568	0.504
DOC_USP7_MATH_1	153	157	PF00917	0.683
DOC_USP7_MATH_1	198	202	PF00917	0.587
DOC_USP7_MATH_1	285	289	PF00917	0.563
DOC_USP7_MATH_1	290	294	PF00917	0.562
DOC_USP7_MATH_1	313	317	PF00917	0.562
DOC_USP7_MATH_1	376	380	PF00917	0.390
DOC_USP7_MATH_1	384	388	PF00917	0.408
DOC_USP7_MATH_1	423	427	PF00917	0.581
DOC_USP7_MATH_1	460	464	PF00917	0.520
DOC_USP7_MATH_1	480	484	PF00917	0.532
DOC_USP7_MATH_1	508	512	PF00917	0.650
DOC_USP7_MATH_1	540	544	PF00917	0.421
DOC_USP7_MATH_1	598	602	PF00917	0.513
DOC_USP7_MATH_1	611	615	PF00917	0.411
DOC_USP7_MATH_1	642	646	PF00917	0.484
DOC_USP7_MATH_1	73	77	PF00917	0.641
DOC_USP7_MATH_2	24	30	PF00917	0.543
DOC_USP7_MATH_2	99	105	PF00917	0.628
DOC_WW_Pin1_4	136	141	PF00397	0.567
DOC_WW_Pin1_4	196	201	PF00397	0.573
DOC_WW_Pin1_4	309	314	PF00397	0.582
DOC_WW_Pin1_4	34	39	PF00397	0.539
DOC_WW_Pin1_4	519	524	PF00397	0.450
DOC_WW_Pin1_4	566	571	PF00397	0.528
DOC_WW_Pin1_4	66	71	PF00397	0.630
DOC_WW_Pin1_4	683	688	PF00397	0.610
DOC_WW_Pin1_4	92	97	PF00397	0.613
LIG_14-3-3_CanoR_1	155	165	PF00244	0.541
LIG_14-3-3_CanoR_1	190	198	PF00244	0.610
LIG_14-3-3_CanoR_1	283	291	PF00244	0.776
LIG_14-3-3_CanoR_1	3	7	PF00244	0.710
LIG_14-3-3_CanoR_1	359	363	PF00244	0.577
LIG_14-3-3_CanoR_1	417	425	PF00244	0.505
LIG_14-3-3_CanoR_1	444	449	PF00244	0.512
LIG_14-3-3_CanoR_1	495	499	PF00244	0.505
LIG_BRCT_BRCA1_1	262	266	PF00533	0.585
LIG_CSL_BTD_1	684	687	PF09270	0.528
LIG_CtBP_PxDLS_1	363	367	PF00389	0.368
LIG_deltaCOP1_diTrp_1	42	47	PF00928	0.538
LIG_eIF4E_1	451	457	PF01652	0.694
LIG_FHA_1	2	8	PF00498	0.572
LIG_FHA_1	222	228	PF00498	0.533
LIG_FHA_1	23	29	PF00498	0.610
LIG_FHA_1	326	332	PF00498	0.455
LIG_FHA_1	394	400	PF00498	0.477
LIG_FHA_1	560	566	PF00498	0.595
LIG_FHA_1	684	690	PF00498	0.534
LIG_FHA_1	703	709	PF00498	0.317
LIG_FHA_1	82	88	PF00498	0.537
LIG_FHA_2	207	213	PF00498	0.674
LIG_FHA_2	366	372	PF00498	0.419
LIG_FHA_2	686	692	PF00498	0.464
LIG_FHA_2	9	15	PF00498	0.722
LIG_GSK3_LRP6_1	196	201	PF00069	0.578
LIG_LIR_Gen_1	124	134	PF02991	0.523
LIG_LIR_Gen_1	347	357	PF02991	0.417
LIG_LIR_Nem_3	124	129	PF02991	0.525
LIG_LIR_Nem_3	347	353	PF02991	0.391
LIG_LIR_Nem_3	698	704	PF02991	0.415
LIG_NRBOX	157	163	PF00104	0.491
LIG_SH2_CRK	301	305	PF00017	0.648
LIG_SH2_GRB2like	451	454	PF00017	0.553
LIG_SH2_NCK_1	115	119	PF00017	0.604
LIG_SH2_NCK_1	639	643	PF00017	0.471
LIG_SH2_SRC	332	335	PF00017	0.421
LIG_SH2_STAP1	471	475	PF00017	0.416
LIG_SH2_STAP1	481	485	PF00017	0.409
LIG_SH2_STAT5	188	191	PF00017	0.574
LIG_SH2_STAT5	32	35	PF00017	0.568
LIG_SH2_STAT5	332	335	PF00017	0.465
LIG_SH2_STAT5	451	454	PF00017	0.511
LIG_SH2_STAT5	529	532	PF00017	0.415
LIG_SH2_STAT5	6	9	PF00017	0.663
LIG_SH2_STAT5	60	63	PF00017	0.522
LIG_SH3_1	93	99	PF00018	0.627
LIG_SH3_3	194	200	PF00018	0.589
LIG_SH3_3	357	363	PF00018	0.473
LIG_SH3_3	42	48	PF00018	0.541
LIG_SH3_3	426	432	PF00018	0.587
LIG_SH3_3	564	570	PF00018	0.431
LIG_SH3_3	67	73	PF00018	0.534
LIG_SH3_3	93	99	PF00018	0.683
LIG_Sin3_3	496	503	PF02671	0.490
LIG_SUMO_SIM_anti_2	180	186	PF11976	0.548
LIG_SUMO_SIM_par_1	361	368	PF11976	0.431
LIG_SUMO_SIM_par_1	409	416	PF11976	0.494
LIG_SxIP_EBH_1	283	295	PF03271	0.509
LIG_TRAF2_1	617	620	PF00917	0.448
LIG_TRFH_1	6	10	PF08558	0.553
MOD_CDK_SPxxK_3	136	143	PF00069	0.563
MOD_CK1_1	156	162	PF00069	0.536
MOD_CK1_1	365	371	PF00069	0.403
MOD_CK1_1	400	406	PF00069	0.568
MOD_CK1_1	605	611	PF00069	0.458
MOD_CK1_1	76	82	PF00069	0.553
MOD_CK2_1	290	296	PF00069	0.605
MOD_CK2_1	499	505	PF00069	0.475
MOD_CMANNOS	44	47	PF00535	0.562
MOD_Cter_Amidation	548	551	PF01082	0.461
MOD_GlcNHglycan	103	106	PF01048	0.704
MOD_GlcNHglycan	121	124	PF01048	0.503
MOD_GlcNHglycan	174	177	PF01048	0.560
MOD_GlcNHglycan	179	182	PF01048	0.491
MOD_GlcNHglycan	191	194	PF01048	0.528
MOD_GlcNHglycan	292	295	PF01048	0.577
MOD_GlcNHglycan	337	340	PF01048	0.416
MOD_GlcNHglycan	382	385	PF01048	0.536
MOD_GlcNHglycan	398	402	PF01048	0.479
MOD_GlcNHglycan	446	449	PF01048	0.644
MOD_GlcNHglycan	482	485	PF01048	0.503
MOD_GlcNHglycan	501	504	PF01048	0.505
MOD_GlcNHglycan	510	513	PF01048	0.541
MOD_GlcNHglycan	570	573	PF01048	0.480
MOD_GlcNHglycan	613	616	PF01048	0.475
MOD_GlcNHglycan	644	647	PF01048	0.592
MOD_GlcNHglycan	75	79	PF01048	0.605
MOD_GSK3_1	22	29	PF00069	0.610
MOD_GSK3_1	281	288	PF00069	0.599
MOD_GSK3_1	302	309	PF00069	0.635
MOD_GSK3_1	358	365	PF00069	0.634
MOD_GSK3_1	376	383	PF00069	0.304
MOD_GSK3_1	393	400	PF00069	0.545
MOD_GSK3_1	515	522	PF00069	0.488
MOD_GSK3_1	598	605	PF00069	0.490
MOD_GSK3_1	702	709	PF00069	0.430
MOD_N-GLC_1	540	545	PF02516	0.562
MOD_NEK2_1	1	6	PF00069	0.581
MOD_NEK2_1	177	182	PF00069	0.493
MOD_NEK2_1	33	38	PF00069	0.517
MOD_NEK2_1	54	59	PF00069	0.511
MOD_NEK2_1	603	608	PF00069	0.481
MOD_NEK2_1	61	66	PF00069	0.462
MOD_OFUCOSY	595	602	PF10250	0.527
MOD_PIKK_1	384	390	PF00454	0.430
MOD_PIKK_1	540	546	PF00454	0.561
MOD_PKA_2	156	162	PF00069	0.527
MOD_PKA_2	189	195	PF00069	0.542
MOD_PKA_2	2	8	PF00069	0.612
MOD_PKA_2	358	364	PF00069	0.452
MOD_PKA_2	494	500	PF00069	0.510
MOD_PKA_2	660	666	PF00069	0.411
MOD_PKB_1	204	212	PF00069	0.584
MOD_Plk_1	325	331	PF00069	0.427
MOD_Plk_1	706	712	PF00069	0.465
MOD_Plk_4	198	204	PF00069	0.548
MOD_Plk_4	2	8	PF00069	0.684
MOD_Plk_4	233	239	PF00069	0.517
MOD_Plk_4	494	500	PF00069	0.466
MOD_Plk_4	707	713	PF00069	0.480
MOD_ProDKin_1	136	142	PF00069	0.564
MOD_ProDKin_1	196	202	PF00069	0.577
MOD_ProDKin_1	309	315	PF00069	0.583
MOD_ProDKin_1	34	40	PF00069	0.535
MOD_ProDKin_1	519	525	PF00069	0.443
MOD_ProDKin_1	566	572	PF00069	0.522
MOD_ProDKin_1	66	72	PF00069	0.637
MOD_ProDKin_1	683	689	PF00069	0.599
MOD_ProDKin_1	92	98	PF00069	0.614
MOD_SUMO_rev_2	139	145	PF00179	0.519
TRG_ENDOCYTIC_2	301	304	PF00928	0.646
TRG_ER_diArg_1	154	157	PF00400	0.557
TRG_ER_diArg_1	203	206	PF00400	0.588
TRG_ER_diArg_1	297	300	PF00400	0.550
TRG_ER_diArg_1	321	323	PF00400	0.438
TRG_ER_diArg_1	443	446	PF00400	0.497
TRG_ER_diArg_1	550	552	PF00400	0.611
TRG_ER_diArg_1	665	667	PF00400	0.581
TRG_NES_CRM1_1	258	273	PF08389	0.591
TRG_Pf-PMV_PEXEL_1	550	555	PF00026	0.428
TRG_Pf-PMV_PEXEL_1	574	578	PF00026	0.452
TRG_Pf-PMV_PEXEL_1	653	658	PF00026	0.457
TRG_Pf-PMV_PEXEL_1	669	674	PF00026	0.403

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILE3	Leptomonas seymouri	38%	100%
A0A3S7WR11	Leishmania donovani	100%	100%
A4H603	Leishmania braziliensis	71%	99%
E9AN30	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QHJ6	Leishmania major	90%	100%