LeishMANIAdb
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Putative nucleolar protein

Quick info Annotations Function or PPIs Localization Phosphorylation Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative nucleolar protein
Gene product:
Nucleolar protein 56 - putative
Species:
Leishmania infantum
UniProt:
A4HUC9_LEIIN
TriTrypDb:
LINF_100007300 *
Length:
473

Annotations

Annotations by Jardim et al.

Nuclear proteins, nucleolar

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 25
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 7
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 14
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005730 nucleolus 5 12
GO:0005732 sno(s)RNA-containing ribonucleoprotein complex 3 12
GO:0030684 preribosome 3 12
GO:0031428 box C/D RNP complex 4 12
GO:0032040 small-subunit processome 4 12
GO:0032991 protein-containing complex 1 12
GO:0043226 organelle 2 12
GO:0043228 non-membrane-bounded organelle 3 12
GO:0043229 intracellular organelle 3 12
GO:0043232 intracellular non-membrane-bounded organelle 4 12
GO:0110165 cellular anatomical entity 1 12
GO:1990904 ribonucleoprotein complex 2 12
GO:0005654 nucleoplasm 2 1

Phosphorylation

Promastigote: 458

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HUC9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HUC9

Function

Biological processes
Term Name Level Count
GO:0009987 cellular process 1 12
GO:0022613 ribonucleoprotein complex biogenesis 4 12
GO:0042254 ribosome biogenesis 5 12
GO:0044085 cellular component biogenesis 3 12
GO:0071840 cellular component organization or biogenesis 2 12
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 12
GO:0003723 RNA binding 4 12
GO:0005488 binding 1 12
GO:0030515 snoRNA binding 5 12
GO:0097159 organic cyclic compound binding 2 12
GO:1901363 heterocyclic compound binding 2 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 443 445 PF00675 0.436
CLV_NRD_NRD_1 447 449 PF00675 0.447
CLV_NRD_NRD_1 463 465 PF00675 0.605
CLV_PCSK_KEX2_1 279 281 PF00082 0.283
CLV_PCSK_KEX2_1 445 447 PF00082 0.444
CLV_PCSK_PC1ET2_1 279 281 PF00082 0.278
CLV_PCSK_PC1ET2_1 445 447 PF00082 0.468
CLV_PCSK_PC7_1 275 281 PF00082 0.278
CLV_PCSK_PC7_1 441 447 PF00082 0.505
CLV_PCSK_SKI1_1 257 261 PF00082 0.218
CLV_PCSK_SKI1_1 288 292 PF00082 0.250
CLV_PCSK_SKI1_1 298 302 PF00082 0.189
CLV_PCSK_SKI1_1 343 347 PF00082 0.208
CLV_PCSK_SKI1_1 386 390 PF00082 0.258
CLV_PCSK_SKI1_1 88 92 PF00082 0.444
DEG_APCC_DBOX_1 224 232 PF00400 0.370
DEG_APCC_KENBOX_2 372 376 PF00400 0.467
DEG_SCF_SKP2-CKS1_1 454 461 PF00560 0.571
DOC_CDC14_PxL_1 300 308 PF14671 0.418
DOC_MAPK_MEF2A_6 214 222 PF00069 0.417
DOC_PP1_RVXF_1 159 165 PF00149 0.419
DOC_PP1_RVXF_1 413 419 PF00149 0.418
DOC_PP1_RVXF_1 46 53 PF00149 0.442
DOC_PP2B_LxvP_1 113 116 PF13499 0.490
DOC_PP2B_LxvP_1 301 304 PF13499 0.429
DOC_PP4_FxxP_1 55 58 PF00568 0.429
DOC_USP7_MATH_1 258 262 PF00917 0.422
DOC_USP7_MATH_1 469 473 PF00917 0.661
DOC_USP7_UBL2_3 317 321 PF12436 0.418
DOC_USP7_UBL2_3 445 449 PF12436 0.486
DOC_USP7_UBL2_3 461 465 PF12436 0.703
DOC_USP7_UBL2_3 87 91 PF12436 0.426
DOC_WW_Pin1_4 328 333 PF00397 0.478
DOC_WW_Pin1_4 353 358 PF00397 0.418
DOC_WW_Pin1_4 41 46 PF00397 0.425
DOC_WW_Pin1_4 455 460 PF00397 0.678
DOC_WW_Pin1_4 54 59 PF00397 0.401
LIG_14-3-3_CanoR_1 225 229 PF00244 0.425
LIG_14-3-3_CanoR_1 280 285 PF00244 0.414
LIG_14-3-3_CanoR_1 3 9 PF00244 0.339
LIG_APCC_ABBA_1 130 135 PF00400 0.390
LIG_BIR_II_1 1 5 PF00653 0.419
LIG_BIR_III_2 398 402 PF00653 0.478
LIG_deltaCOP1_diTrp_1 196 202 PF00928 0.418
LIG_deltaCOP1_diTrp_1 268 277 PF00928 0.418
LIG_EH1_1 293 301 PF00400 0.418
LIG_eIF4E_1 215 221 PF01652 0.416
LIG_EVH1_2 400 404 PF00568 0.418
LIG_FHA_1 21 27 PF00498 0.475
LIG_FHA_1 333 339 PF00498 0.418
LIG_FHA_2 120 126 PF00498 0.477
LIG_FHA_2 20 26 PF00498 0.386
LIG_FHA_2 5 11 PF00498 0.343
LIG_GBD_Chelix_1 291 299 PF00786 0.278
LIG_GBD_Chelix_1 389 397 PF00786 0.218
LIG_LIR_Apic_2 7 12 PF02991 0.495
LIG_LIR_Gen_1 13 20 PF02991 0.478
LIG_LIR_Gen_1 268 278 PF02991 0.418
LIG_LIR_Gen_1 39 47 PF02991 0.418
LIG_LIR_Gen_1 437 443 PF02991 0.449
LIG_LIR_Nem_3 13 18 PF02991 0.429
LIG_LIR_Nem_3 268 274 PF02991 0.418
LIG_LIR_Nem_3 356 362 PF02991 0.418
LIG_LIR_Nem_3 39 43 PF02991 0.412
LIG_LIR_Nem_3 4 9 PF02991 0.286
LIG_LIR_Nem_3 437 442 PF02991 0.415
LIG_LIR_Nem_3 44 49 PF02991 0.413
LIG_LIR_Nem_3 51 55 PF02991 0.403
LIG_PCNA_yPIPBox_3 288 300 PF02747 0.418
LIG_Pex14_2 363 367 PF04695 0.418
LIG_Pex14_2 76 80 PF04695 0.328
LIG_SH2_CRK 215 219 PF00017 0.418
LIG_SH2_CRK 359 363 PF00017 0.418
LIG_SH2_CRK 439 443 PF00017 0.417
LIG_SH2_GRB2like 215 218 PF00017 0.504
LIG_SH2_NCK_1 215 219 PF00017 0.429
LIG_SH2_NCK_1 9 13 PF00017 0.442
LIG_SH2_SRC 215 218 PF00017 0.504
LIG_SH2_STAP1 215 219 PF00017 0.418
LIG_SH2_STAP1 255 259 PF00017 0.429
LIG_SH2_STAT5 294 297 PF00017 0.418
LIG_SH2_STAT5 382 385 PF00017 0.418
LIG_SH2_STAT5 6 9 PF00017 0.412
LIG_SH3_3 206 212 PF00018 0.418
LIG_SH3_3 97 103 PF00018 0.446
LIG_TRAF2_1 22 25 PF00917 0.429
LIG_TYR_ITIM 213 218 PF00017 0.429
LIG_UBA3_1 179 185 PF00899 0.305
LIG_UBA3_1 189 195 PF00899 0.386
LIG_UBA3_1 345 353 PF00899 0.418
LIG_WRC_WIRS_1 274 279 PF05994 0.478
LIG_WRC_WIRS_1 37 42 PF05994 0.419
LIG_WRC_WIRS_1 49 54 PF05994 0.415
LIG_WRC_WIRS_1 73 78 PF05994 0.395
MOD_CDK_SPK_2 353 358 PF00069 0.418
MOD_CDK_SPK_2 455 460 PF00069 0.678
MOD_CDK_SPxK_1 455 461 PF00069 0.693
MOD_CDK_SPxxK_3 41 48 PF00069 0.429
MOD_CDK_SPxxK_3 455 462 PF00069 0.687
MOD_CK1_1 331 337 PF00069 0.467
MOD_CK1_1 39 45 PF00069 0.482
MOD_CK2_1 119 125 PF00069 0.487
MOD_CK2_1 19 25 PF00069 0.374
MOD_CK2_1 4 10 PF00069 0.336
MOD_CK2_1 467 473 PF00069 0.633
MOD_CMANNOS 197 200 PF00535 0.218
MOD_GlcNHglycan 106 109 PF01048 0.377
MOD_GlcNHglycan 176 179 PF01048 0.344
MOD_GSK3_1 317 324 PF00069 0.418
MOD_GSK3_1 328 335 PF00069 0.375
MOD_N-GLC_1 119 124 PF02516 0.426
MOD_N-GLC_1 304 309 PF02516 0.218
MOD_NEK2_1 1 6 PF00069 0.403
MOD_NEK2_1 310 315 PF00069 0.490
MOD_NEK2_1 363 368 PF00069 0.418
MOD_NEK2_1 418 423 PF00069 0.430
MOD_NEK2_1 72 77 PF00069 0.367
MOD_PIKK_1 304 310 PF00454 0.478
MOD_PKA_1 460 466 PF00069 0.648
MOD_PKA_2 20 26 PF00069 0.504
MOD_PKA_2 224 230 PF00069 0.418
MOD_PKA_2 369 375 PF00069 0.495
MOD_Plk_1 119 125 PF00069 0.422
MOD_Plk_1 304 310 PF00069 0.478
MOD_Plk_4 363 369 PF00069 0.418
MOD_Plk_4 399 405 PF00069 0.483
MOD_Plk_4 4 10 PF00069 0.297
MOD_Plk_4 72 78 PF00069 0.363
MOD_ProDKin_1 328 334 PF00069 0.478
MOD_ProDKin_1 353 359 PF00069 0.418
MOD_ProDKin_1 41 47 PF00069 0.425
MOD_ProDKin_1 455 461 PF00069 0.683
MOD_ProDKin_1 54 60 PF00069 0.401
MOD_SUMO_for_1 90 93 PF00179 0.573
MOD_SUMO_rev_2 229 238 PF00179 0.478
MOD_SUMO_rev_2 97 105 PF00179 0.362
TRG_ENDOCYTIC_2 15 18 PF00928 0.435
TRG_ENDOCYTIC_2 215 218 PF00928 0.418
TRG_ENDOCYTIC_2 359 362 PF00928 0.418
TRG_ENDOCYTIC_2 439 442 PF00928 0.418
TRG_ER_diArg_1 443 446 PF00400 0.464
TRG_NES_CRM1_1 181 196 PF08389 0.418
TRG_NLS_Bipartite_1 444 465 PF00514 0.607
TRG_NLS_MonoCore_2 349 354 PF00514 0.418
TRG_NLS_MonoExtC_3 459 464 PF00514 0.575
TRG_NLS_MonoExtN_4 347 354 PF00514 0.418
TRG_NLS_MonoExtN_4 459 465 PF00514 0.575
TRG_Pf-PMV_PEXEL_1 136 140 PF00026 0.417

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PD49 Leptomonas seymouri 36% 100%
A0A0N1PE54 Leptomonas seymouri 91% 100%
A0A0S4IXK2 Bodo saltans 78% 100%
A0A0S4JJS5 Bodo saltans 37% 100%
A0A1X0NRL9 Trypanosomatidae 79% 97%
A0A1X0NUB3 Trypanosomatidae 38% 100%
A0A3Q8IDJ5 Leishmania donovani 23% 100%
A0A3R7NI91 Trypanosoma rangeli 38% 100%
A0A3R7NLD9 Trypanosoma rangeli 79% 98%
A0A3S5H6F4 Leishmania donovani 100% 100%
A0A3S5H6V9 Leishmania donovani 37% 100%
A1CL70 Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107) 43% 80%
A1D688 Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) 43% 80%
A2QE38 Aspergillus niger (strain CBS 513.88 / FGSC A1513) 41% 82%
A3LUT0 Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) 40% 92%
A4H602 Leishmania braziliensis 94% 100%
A4H8A6 Leishmania braziliensis 37% 100%
A4HWM6 Leishmania infantum 37% 100%
A4I8M9 Leishmania infantum 23% 100%
A5DHW0 Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) 39% 94%
A5E4V9 Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239) 40% 91%
A6QYH8 Ajellomyces capsulatus (strain NAm1 / WU24) 42% 74%
A6RMY5 Botryotinia fuckeliana (strain B05.10) 43% 83%
A6ZPE5 Saccharomyces cerevisiae (strain YJM789) 40% 93%
A7F2R6 Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) 43% 83%
A7TIF5 Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) 40% 92%
C9ZVG2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 79% 98%
C9ZXR1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 36% 94%
E9AN29 Leishmania mexicana (strain MHOM/GT/2001/U1103) 99% 100%
E9AQD3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 37% 100%
E9B3J1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 100%
O00567 Homo sapiens 47% 80%
O04656 Arabidopsis thaliana 37% 100%
O04658 Arabidopsis thaliana 42% 89%
O94514 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 49% 95%
P0CP26 Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) 40% 83%
P0CP27 Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) 40% 84%
Q0CQH1 Aspergillus terreus (strain NIH 2624 / FGSC A1156) 42% 82%
Q12460 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 49% 94%
Q12499 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 40% 93%
Q1E1Q5 Coccidioides immitis (strain RS) 41% 78%
Q21276 Caenorhabditis elegans 45% 97%
Q2UC04 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 42% 82%
Q3SZ63 Bos taurus 47% 79%
Q4PBF2 Ustilago maydis (strain 521 / FGSC 9021) 40% 81%
Q4Q4L0 Leishmania major 23% 100%
Q4QF42 Leishmania major 37% 100%
Q4QHJ7 Leishmania major 99% 100%
Q4R779 Macaca fascicularis 37% 89%
Q4WYK9 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 43% 80%
Q54MT2 Dictyostelium discoideum 45% 88%
Q55FI4 Dictyostelium discoideum 41% 74%
Q59S06 Candida albicans (strain SC5314 / ATCC MYA-2876) 40% 92%
Q5B8G3 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 42% 81%
Q5RA29 Pongo abelii 47% 80%
Q6BIX6 Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968) 40% 91%
Q6CG46 Yarrowia lipolytica (strain CLIB 122 / E 150) 40% 92%
Q6CKR8 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 40% 93%
Q6DFW4 Mus musculus 37% 88%
Q6FQ21 Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) 41% 92%
Q753I4 Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) 40% 92%
Q8X066 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 40% 79%
Q95K50 Macaca fascicularis 47% 80%
Q9D6Z1 Mus musculus 47% 82%
Q9MAB3 Arabidopsis thaliana 41% 89%
Q9P7S7 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 41% 93%
Q9QZ86 Rattus norvegicus 37% 89%
Q9Y2X3 Homo sapiens 37% 89%
V5AU06 Trypanosoma cruzi 79% 98%
V5BK67 Trypanosoma cruzi 38% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS