MORN repeat family protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

MORN repeat - putative

Species:

Leishmania infantum

UniProt:

A4HUC7_LEIIN

TriTrypDb:

LINF_100007000

Length:

221

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	2
GO:0097542	ciliary tip	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A4HUC7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HUC7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	217	221	PF00656	0.457
CLV_NRD_NRD_1	36	38	PF00675	0.413
CLV_PCSK_KEX2_1	36	38	PF00082	0.413
CLV_PCSK_SKI1_1	6	10	PF00082	0.681
DOC_ANK_TNKS_1	161	168	PF00023	0.414
DOC_ANK_TNKS_1	36	43	PF00023	0.474
DOC_CDC14_PxL_1	190	198	PF14671	0.529
DOC_MAPK_gen_1	4	16	PF00069	0.533
DOC_USP7_MATH_1	202	206	PF00917	0.670
DOC_USP7_MATH_1	54	58	PF00917	0.727
DOC_USP7_MATH_1	85	89	PF00917	0.647
DOC_USP7_UBL2_3	5	9	PF12436	0.562
DOC_WW_Pin1_4	200	205	PF00397	0.677
DOC_WW_Pin1_4	49	54	PF00397	0.644
DOC_WW_Pin1_4	61	66	PF00397	0.748
LIG_14-3-3_CanoR_1	58	65	PF00244	0.611
LIG_14-3-3_CanoR_1	97	103	PF00244	0.429
LIG_BIR_III_2	201	205	PF00653	0.517
LIG_BIR_III_4	45	49	PF00653	0.589
LIG_FHA_2	215	221	PF00498	0.458
LIG_LIR_Gen_1	166	176	PF02991	0.344
LIG_LIR_Nem_3	166	172	PF02991	0.344
LIG_LYPXL_S_1	192	196	PF13949	0.627
LIG_LYPXL_yS_3	193	196	PF13949	0.640
LIG_Pex14_1	177	181	PF04695	0.417
LIG_SH2_CRK	100	104	PF00017	0.402
LIG_SH2_CRK	38	42	PF00017	0.522
LIG_SH2_GRB2like	181	184	PF00017	0.467
LIG_SH2_NCK_1	100	104	PF00017	0.414
LIG_SH2_NCK_1	169	173	PF00017	0.299
LIG_SH2_NCK_1	38	42	PF00017	0.622
LIG_SH2_SRC	38	41	PF00017	0.453
LIG_SH2_STAT3	154	157	PF00017	0.300
LIG_SH2_STAT5	100	103	PF00017	0.414
LIG_SH2_STAT5	154	157	PF00017	0.324
LIG_SH2_STAT5	169	172	PF00017	0.284
LIG_SH2_STAT5	22	25	PF00017	0.452
LIG_SH3_3	201	207	PF00018	0.557
LIG_SH3_3	7	13	PF00018	0.645
MOD_CDC14_SPxK_1	52	55	PF00782	0.521
MOD_CDC14_SPxK_1	64	67	PF00782	0.644
MOD_CDK_SPxK_1	49	55	PF00069	0.525
MOD_CDK_SPxK_1	61	67	PF00069	0.634
MOD_CK1_1	203	209	PF00069	0.488
MOD_CK1_1	59	65	PF00069	0.734
MOD_GlcNHglycan	118	121	PF01048	0.322
MOD_GlcNHglycan	126	129	PF01048	0.434
MOD_GlcNHglycan	140	143	PF01048	0.417
MOD_GlcNHglycan	214	217	PF01048	0.605
MOD_GlcNHglycan	74	77	PF01048	0.787
MOD_GSK3_1	138	145	PF00069	0.374
MOD_GSK3_1	208	215	PF00069	0.532
MOD_GSK3_1	54	61	PF00069	0.758
MOD_GSK3_1	68	75	PF00069	0.788
MOD_N-GLC_1	182	187	PF02516	0.465
MOD_N-GLC_1	212	217	PF02516	0.466
MOD_NEK2_1	116	121	PF00069	0.423
MOD_NEK2_1	124	129	PF00069	0.553
MOD_NEK2_1	209	214	PF00069	0.473
MOD_PIKK_1	68	74	PF00454	0.484
MOD_PKA_2	59	65	PF00069	0.570
MOD_PKB_1	58	66	PF00069	0.554
MOD_Plk_4	18	24	PF00069	0.443
MOD_ProDKin_1	200	206	PF00069	0.677
MOD_ProDKin_1	49	55	PF00069	0.642
MOD_ProDKin_1	61	67	PF00069	0.750
MOD_SUMO_for_1	8	11	PF00179	0.590
TRG_DiLeu_BaEn_2	10	16	PF01217	0.457
TRG_ENDOCYTIC_2	169	172	PF00928	0.334
TRG_ENDOCYTIC_2	193	196	PF00928	0.612
TRG_ER_diArg_1	35	37	PF00400	0.422

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I749	Leptomonas seymouri	61%	86%
A0A1X0NQ66	Trypanosomatidae	42%	100%
A0A3Q8IQ71	Leishmania donovani	35%	100%
A0A3R7KKB6	Trypanosoma rangeli	47%	100%
A0A3S5H6F3	Leishmania donovani	98%	100%
A4I327	Leishmania infantum	34%	100%
C9ZJK1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
C9ZVG4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9ACU8	Leishmania major	34%	94%
E9AI39	Leishmania braziliensis	76%	97%
E9AN27	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
E9AZD7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	94%
Q4QHJ9	Leishmania major	94%	100%
V5BCY8	Trypanosoma cruzi	35%	100%