LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4HUC6_LEIIN
TriTrypDb:
LINF_100006900
Length:
668

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HUC6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HUC6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 207 209 PF00675 0.681
CLV_NRD_NRD_1 278 280 PF00675 0.667
CLV_PCSK_KEX2_1 207 209 PF00082 0.594
CLV_PCSK_SKI1_1 193 197 PF00082 0.658
CLV_PCSK_SKI1_1 211 215 PF00082 0.516
CLV_PCSK_SKI1_1 402 406 PF00082 0.768
CLV_PCSK_SKI1_1 432 436 PF00082 0.810
CLV_PCSK_SKI1_1 636 640 PF00082 0.471
CLV_PCSK_SKI1_1 96 100 PF00082 0.635
DEG_APCC_DBOX_1 154 162 PF00400 0.842
DEG_APCC_DBOX_1 284 292 PF00400 0.727
DEG_APCC_DBOX_1 635 643 PF00400 0.471
DEG_Kelch_actinfilin_1 112 116 PF01344 0.541
DEG_SPOP_SBC_1 132 136 PF00917 0.814
DEG_SPOP_SBC_1 551 555 PF00917 0.664
DOC_ANK_TNKS_1 479 486 PF00023 0.627
DOC_CYCLIN_yClb5_NLxxxL_5 5 14 PF00134 0.645
DOC_CYCLIN_yCln2_LP_2 295 298 PF00134 0.706
DOC_MAPK_DCC_7 600 609 PF00069 0.355
DOC_MAPK_MEF2A_6 617 624 PF00069 0.433
DOC_PP2B_LxvP_1 295 298 PF13499 0.604
DOC_USP7_MATH_1 126 130 PF00917 0.729
DOC_USP7_MATH_1 133 137 PF00917 0.700
DOC_USP7_MATH_1 165 169 PF00917 0.856
DOC_USP7_MATH_1 260 264 PF00917 0.616
DOC_USP7_MATH_1 343 347 PF00917 0.723
DOC_USP7_MATH_1 386 390 PF00917 0.841
DOC_USP7_MATH_1 393 397 PF00917 0.720
DOC_USP7_MATH_1 430 434 PF00917 0.667
DOC_USP7_MATH_1 48 52 PF00917 0.705
DOC_USP7_MATH_1 498 502 PF00917 0.743
DOC_USP7_MATH_1 512 516 PF00917 0.665
DOC_USP7_MATH_1 55 59 PF00917 0.662
DOC_USP7_MATH_1 552 556 PF00917 0.795
DOC_USP7_MATH_1 628 632 PF00917 0.452
DOC_USP7_MATH_1 81 85 PF00917 0.790
DOC_USP7_UBL2_3 33 37 PF12436 0.681
DOC_WW_Pin1_4 136 141 PF00397 0.736
DOC_WW_Pin1_4 161 166 PF00397 0.846
DOC_WW_Pin1_4 167 172 PF00397 0.736
DOC_WW_Pin1_4 173 178 PF00397 0.629
DOC_WW_Pin1_4 181 186 PF00397 0.561
DOC_WW_Pin1_4 261 266 PF00397 0.642
DOC_WW_Pin1_4 318 323 PF00397 0.688
DOC_WW_Pin1_4 348 353 PF00397 0.802
DOC_WW_Pin1_4 356 361 PF00397 0.746
DOC_WW_Pin1_4 367 372 PF00397 0.540
DOC_WW_Pin1_4 447 452 PF00397 0.706
DOC_WW_Pin1_4 558 563 PF00397 0.686
DOC_WW_Pin1_4 602 607 PF00397 0.452
DOC_WW_Pin1_4 644 649 PF00397 0.316
DOC_WW_Pin1_4 72 77 PF00397 0.828
DOC_WW_Pin1_4 86 91 PF00397 0.580
LIG_14-3-3_CanoR_1 402 407 PF00244 0.734
LIG_14-3-3_CanoR_1 544 548 PF00244 0.676
LIG_14-3-3_CanoR_1 643 651 PF00244 0.452
LIG_14-3-3_CanoR_1 70 76 PF00244 0.759
LIG_BIR_II_1 1 5 PF00653 0.674
LIG_BIR_III_4 482 486 PF00653 0.670
LIG_BIR_III_4 566 570 PF00653 0.521
LIG_BIR_III_4 63 67 PF00653 0.753
LIG_BRCT_BRCA1_1 43 47 PF00533 0.658
LIG_deltaCOP1_diTrp_1 93 98 PF00928 0.721
LIG_Dynein_DLC8_1 641 647 PF01221 0.316
LIG_EH1_1 655 663 PF00400 0.507
LIG_EVH1_1 158 162 PF00568 0.835
LIG_FHA_1 173 179 PF00498 0.729
LIG_FHA_1 373 379 PF00498 0.720
LIG_FHA_1 648 654 PF00498 0.339
LIG_FHA_2 459 465 PF00498 0.784
LIG_FHA_2 655 661 PF00498 0.511
LIG_GBD_Chelix_1 288 296 PF00786 0.745
LIG_Integrin_RGD_1 364 366 PF01839 0.754
LIG_Integrin_RGD_1 617 619 PF01839 0.433
LIG_LIR_Apic_2 341 345 PF02991 0.723
LIG_LIR_Gen_1 545 556 PF02991 0.717
LIG_LIR_Gen_1 660 668 PF02991 0.401
LIG_LIR_Nem_3 545 551 PF02991 0.714
LIG_LIR_Nem_3 660 666 PF02991 0.428
LIG_MYND_1 159 163 PF01753 0.835
LIG_MYND_1 322 326 PF01753 0.623
LIG_PCNA_yPIPBox_3 228 242 PF02747 0.666
LIG_Pex14_1 94 98 PF04695 0.716
LIG_PROFILIN_1 451 457 PF00235 0.604
LIG_SH2_CRK 342 346 PF00017 0.727
LIG_SH2_CRK 548 552 PF00017 0.716
LIG_SH2_NCK_1 342 346 PF00017 0.727
LIG_SH2_STAP1 17 21 PF00017 0.644
LIG_SH2_STAT5 247 250 PF00017 0.544
LIG_SH3_3 156 162 PF00018 0.829
LIG_SH3_3 296 302 PF00018 0.734
LIG_SH3_3 375 381 PF00018 0.778
LIG_SH3_3 445 451 PF00018 0.753
LIG_SH3_3 465 471 PF00018 0.743
LIG_SH3_3 484 490 PF00018 0.525
LIG_SH3_3 556 562 PF00018 0.660
LIG_SH3_3 579 585 PF00018 0.523
LIG_SUMO_SIM_anti_2 194 200 PF11976 0.624
LIG_SUMO_SIM_par_1 647 652 PF11976 0.347
LIG_TRAF2_1 657 660 PF00917 0.554
LIG_TRAF2_2 352 357 PF00917 0.766
LIG_WRC_WIRS_1 95 100 PF05994 0.709
LIG_WW_2 159 162 PF00397 0.832
LIG_WW_2 468 471 PF00397 0.765
MOD_CDK_SPK_2 161 166 PF00069 0.729
MOD_CDK_SPK_2 558 563 PF00069 0.628
MOD_CDK_SPxxK_3 181 188 PF00069 0.763
MOD_CDK_SPxxK_3 72 79 PF00069 0.623
MOD_CK1_1 134 140 PF00069 0.832
MOD_CK1_1 164 170 PF00069 0.656
MOD_CK1_1 263 269 PF00069 0.585
MOD_CK1_1 320 326 PF00069 0.748
MOD_CK1_1 335 341 PF00069 0.631
MOD_CK1_1 400 406 PF00069 0.734
MOD_CK1_1 433 439 PF00069 0.810
MOD_CK1_1 458 464 PF00069 0.649
MOD_CK1_1 521 527 PF00069 0.766
MOD_CK1_1 550 556 PF00069 0.789
MOD_CK1_1 558 564 PF00069 0.700
MOD_CK1_1 58 64 PF00069 0.688
MOD_CK1_1 75 81 PF00069 0.609
MOD_CK1_1 84 90 PF00069 0.736
MOD_CK2_1 16 22 PF00069 0.721
MOD_CK2_1 256 262 PF00069 0.567
MOD_CK2_1 458 464 PF00069 0.785
MOD_CK2_1 498 504 PF00069 0.817
MOD_CK2_1 558 564 PF00069 0.747
MOD_CK2_1 654 660 PF00069 0.506
MOD_Cter_Amidation 205 208 PF01082 0.592
MOD_GlcNHglycan 1 4 PF01048 0.787
MOD_GlcNHglycan 11 14 PF01048 0.539
MOD_GlcNHglycan 128 131 PF01048 0.783
MOD_GlcNHglycan 136 139 PF01048 0.619
MOD_GlcNHglycan 199 202 PF01048 0.638
MOD_GlcNHglycan 258 261 PF01048 0.585
MOD_GlcNHglycan 303 306 PF01048 0.764
MOD_GlcNHglycan 332 335 PF01048 0.800
MOD_GlcNHglycan 337 340 PF01048 0.494
MOD_GlcNHglycan 346 349 PF01048 0.686
MOD_GlcNHglycan 388 391 PF01048 0.756
MOD_GlcNHglycan 395 398 PF01048 0.734
MOD_GlcNHglycan 399 402 PF01048 0.679
MOD_GlcNHglycan 411 415 PF01048 0.567
MOD_GlcNHglycan 441 444 PF01048 0.772
MOD_GlcNHglycan 60 63 PF01048 0.690
MOD_GSK3_1 132 139 PF00069 0.751
MOD_GSK3_1 161 168 PF00069 0.788
MOD_GSK3_1 193 200 PF00069 0.656
MOD_GSK3_1 248 255 PF00069 0.558
MOD_GSK3_1 256 263 PF00069 0.619
MOD_GSK3_1 314 321 PF00069 0.719
MOD_GSK3_1 344 351 PF00069 0.799
MOD_GSK3_1 367 374 PF00069 0.633
MOD_GSK3_1 393 400 PF00069 0.762
MOD_GSK3_1 432 439 PF00069 0.637
MOD_GSK3_1 455 462 PF00069 0.807
MOD_GSK3_1 507 514 PF00069 0.799
MOD_GSK3_1 521 528 PF00069 0.609
MOD_GSK3_1 529 536 PF00069 0.653
MOD_GSK3_1 543 550 PF00069 0.674
MOD_GSK3_1 551 558 PF00069 0.708
MOD_GSK3_1 66 73 PF00069 0.765
MOD_GSK3_1 77 84 PF00069 0.687
MOD_N-GLC_1 126 131 PF02516 0.694
MOD_N-GLC_1 462 467 PF02516 0.737
MOD_N-GLC_1 533 538 PF02516 0.643
MOD_N-GLC_2 540 542 PF02516 0.715
MOD_NEK2_1 197 202 PF00069 0.628
MOD_NEK2_1 248 253 PF00069 0.554
MOD_NEK2_1 332 337 PF00069 0.729
MOD_NEK2_1 372 377 PF00069 0.639
MOD_NEK2_1 518 523 PF00069 0.707
MOD_NEK2_1 543 548 PF00069 0.709
MOD_NEK2_2 512 517 PF00069 0.622
MOD_PIKK_1 642 648 PF00454 0.530
MOD_PK_1 600 606 PF00069 0.530
MOD_PKA_2 165 171 PF00069 0.856
MOD_PKA_2 238 244 PF00069 0.623
MOD_PKA_2 317 323 PF00069 0.650
MOD_PKA_2 436 442 PF00069 0.825
MOD_PKA_2 507 513 PF00069 0.843
MOD_PKA_2 543 549 PF00069 0.678
MOD_PKA_2 642 648 PF00069 0.483
MOD_PKA_2 654 660 PF00069 0.471
MOD_Plk_1 143 149 PF00069 0.754
MOD_Plk_1 193 199 PF00069 0.626
MOD_Plk_4 193 199 PF00069 0.661
MOD_Plk_4 455 461 PF00069 0.633
MOD_Plk_4 543 549 PF00069 0.721
MOD_ProDKin_1 136 142 PF00069 0.738
MOD_ProDKin_1 161 167 PF00069 0.849
MOD_ProDKin_1 173 179 PF00069 0.629
MOD_ProDKin_1 181 187 PF00069 0.639
MOD_ProDKin_1 261 267 PF00069 0.637
MOD_ProDKin_1 318 324 PF00069 0.687
MOD_ProDKin_1 348 354 PF00069 0.803
MOD_ProDKin_1 356 362 PF00069 0.746
MOD_ProDKin_1 367 373 PF00069 0.542
MOD_ProDKin_1 447 453 PF00069 0.699
MOD_ProDKin_1 558 564 PF00069 0.688
MOD_ProDKin_1 602 608 PF00069 0.452
MOD_ProDKin_1 644 650 PF00069 0.316
MOD_ProDKin_1 72 78 PF00069 0.830
MOD_ProDKin_1 86 92 PF00069 0.564
MOD_SUMO_rev_2 273 281 PF00179 0.611
MOD_SUMO_rev_2 28 34 PF00179 0.679
TRG_DiLeu_BaLyEn_6 327 332 PF01217 0.719
TRG_ENDOCYTIC_2 548 551 PF00928 0.714
TRG_ER_diArg_1 207 210 PF00400 0.534
TRG_ER_diArg_1 242 245 PF00400 0.686
TRG_ER_diArg_1 284 287 PF00400 0.727
TRG_ER_diArg_1 478 481 PF00400 0.723
TRG_Pf-PMV_PEXEL_1 229 233 PF00026 0.690
TRG_Pf-PMV_PEXEL_1 41 45 PF00026 0.698

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3S7WQZ0 Leishmania donovani 99% 100%
A4H600 Leishmania braziliensis 59% 98%
E9AN26 Leishmania mexicana (strain MHOM/GT/2001/U1103) 82% 99%
Q4QHK0 Leishmania major 89% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS