LeishMANIAdb
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Putative nucleoside phosphatase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative nucleoside phosphatase
Gene product:
guanosine diphosphatase - putative
Species:
Leishmania infantum
UniProt:
A4HUC4_LEIIN
TriTrypDb:
LINF_100006600
Length:
677

Annotations

Annotations by Jardim et al.

Glycosylation, nucleoside phosphatase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 4, no: 5
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0016020 membrane 2 5
GO:0110165 cellular anatomical entity 1 5

Expansion

Sequence features

A4HUC4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HUC4

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 1
GO:0006725 cellular aromatic compound metabolic process 3 1
GO:0006753 nucleoside phosphate metabolic process 4 1
GO:0006793 phosphorus metabolic process 3 1
GO:0006796 phosphate-containing compound metabolic process 4 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0009056 catabolic process 2 1
GO:0009132 nucleoside diphosphate metabolic process 5 1
GO:0009134 nucleoside diphosphate catabolic process 6 1
GO:0009987 cellular process 1 1
GO:0019439 aromatic compound catabolic process 4 1
GO:0019637 organophosphate metabolic process 3 1
GO:0034641 cellular nitrogen compound metabolic process 3 1
GO:0034655 nucleobase-containing compound catabolic process 4 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0044248 cellular catabolic process 3 1
GO:0044270 cellular nitrogen compound catabolic process 4 1
GO:0044281 small molecule metabolic process 2 1
GO:0046434 organophosphate catabolic process 4 1
GO:0046483 heterocycle metabolic process 3 1
GO:0046700 heterocycle catabolic process 4 1
GO:0055086 nucleobase-containing small molecule metabolic process 3 1
GO:0071704 organic substance metabolic process 2 1
GO:1901292 nucleoside phosphate catabolic process 5 1
GO:1901360 organic cyclic compound metabolic process 3 1
GO:1901361 organic cyclic compound catabolic process 4 1
GO:1901575 organic substance catabolic process 3 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 10
GO:0004382 GDP phosphatase activity 7 5
GO:0016462 pyrophosphatase activity 5 5
GO:0016787 hydrolase activity 2 10
GO:0016817 hydrolase activity, acting on acid anhydrides 3 5
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4 5
GO:0017110 nucleoside diphosphate phosphatase activity 6 5
GO:0000166 nucleotide binding 3 8
GO:0005488 binding 1 8
GO:0005524 ATP binding 5 8
GO:0017076 purine nucleotide binding 4 8
GO:0030554 adenyl nucleotide binding 5 8
GO:0032553 ribonucleotide binding 3 8
GO:0032555 purine ribonucleotide binding 4 8
GO:0032559 adenyl ribonucleotide binding 5 8
GO:0035639 purine ribonucleoside triphosphate binding 4 8
GO:0036094 small molecule binding 2 8
GO:0043167 ion binding 2 8
GO:0043168 anion binding 3 8
GO:0097159 organic cyclic compound binding 2 8
GO:0097367 carbohydrate derivative binding 2 8
GO:1901265 nucleoside phosphate binding 3 8
GO:1901363 heterocyclic compound binding 2 8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 246 250 PF00656 0.258
CLV_C14_Caspase3-7 298 302 PF00656 0.207
CLV_NRD_NRD_1 132 134 PF00675 0.540
CLV_NRD_NRD_1 154 156 PF00675 0.515
CLV_NRD_NRD_1 76 78 PF00675 0.486
CLV_PCSK_KEX2_1 132 134 PF00082 0.553
CLV_PCSK_KEX2_1 154 156 PF00082 0.515
CLV_PCSK_KEX2_1 472 474 PF00082 0.291
CLV_PCSK_KEX2_1 76 78 PF00082 0.504
CLV_PCSK_PC1ET2_1 132 134 PF00082 0.533
CLV_PCSK_PC1ET2_1 472 474 PF00082 0.291
CLV_PCSK_SKI1_1 410 414 PF00082 0.459
CLV_PCSK_SKI1_1 505 509 PF00082 0.466
CLV_PCSK_SKI1_1 531 535 PF00082 0.380
CLV_PCSK_SKI1_1 97 101 PF00082 0.632
DEG_APCC_DBOX_1 132 140 PF00400 0.457
DEG_APCC_DBOX_1 78 86 PF00400 0.447
DEG_SPOP_SBC_1 433 437 PF00917 0.291
DOC_CYCLIN_yCln2_LP_2 532 538 PF00134 0.315
DOC_MAPK_DCC_7 529 538 PF00069 0.315
DOC_MAPK_gen_1 529 538 PF00069 0.340
DOC_MAPK_gen_1 588 595 PF00069 0.449
DOC_MAPK_gen_1 76 85 PF00069 0.586
DOC_PP1_RVXF_1 408 415 PF00149 0.279
DOC_PP4_MxPP_1 477 480 PF00568 0.279
DOC_PP4_MxPP_1 551 554 PF00568 0.291
DOC_USP7_MATH_1 223 227 PF00917 0.312
DOC_USP7_MATH_1 30 34 PF00917 0.559
DOC_USP7_MATH_1 349 353 PF00917 0.340
DOC_USP7_MATH_1 370 374 PF00917 0.333
DOC_USP7_MATH_1 441 445 PF00917 0.254
DOC_USP7_MATH_1 460 464 PF00917 0.289
DOC_USP7_MATH_1 575 579 PF00917 0.423
DOC_USP7_MATH_1 584 588 PF00917 0.336
DOC_USP7_UBL2_3 189 193 PF12436 0.291
DOC_USP7_UBL2_3 419 423 PF12436 0.365
DOC_USP7_UBL2_3 505 509 PF12436 0.207
DOC_USP7_UBL2_3 590 594 PF12436 0.462
DOC_WW_Pin1_4 143 148 PF00397 0.402
DOC_WW_Pin1_4 437 442 PF00397 0.365
LIG_14-3-3_CanoR_1 125 130 PF00244 0.611
LIG_14-3-3_CanoR_1 154 162 PF00244 0.454
LIG_14-3-3_CanoR_1 383 389 PF00244 0.390
LIG_14-3-3_CanoR_1 391 400 PF00244 0.289
LIG_14-3-3_CanoR_1 92 100 PF00244 0.574
LIG_BIR_II_1 1 5 PF00653 0.385
LIG_BRCT_BRCA1_1 1 5 PF00533 0.361
LIG_BRCT_BRCA1_1 111 115 PF00533 0.490
LIG_BRCT_BRCA1_1 194 198 PF00533 0.264
LIG_BRCT_BRCA1_1 565 569 PF00533 0.340
LIG_deltaCOP1_diTrp_1 257 263 PF00928 0.340
LIG_FHA_1 121 127 PF00498 0.638
LIG_FHA_1 283 289 PF00498 0.264
LIG_FHA_1 295 301 PF00498 0.264
LIG_FHA_1 309 315 PF00498 0.324
LIG_FHA_1 351 357 PF00498 0.272
LIG_FHA_1 362 368 PF00498 0.285
LIG_FHA_1 407 413 PF00498 0.393
LIG_FHA_1 557 563 PF00498 0.288
LIG_FHA_2 17 23 PF00498 0.535
LIG_FHA_2 276 282 PF00498 0.380
LIG_FHA_2 598 604 PF00498 0.211
LIG_FHA_2 616 622 PF00498 0.166
LIG_LIR_Gen_1 191 200 PF02991 0.323
LIG_LIR_Gen_1 2 13 PF02991 0.417
LIG_LIR_Gen_1 257 268 PF02991 0.433
LIG_LIR_Gen_1 450 460 PF02991 0.309
LIG_LIR_Gen_1 566 575 PF02991 0.264
LIG_LIR_Gen_1 629 638 PF02991 0.320
LIG_LIR_Nem_3 145 151 PF02991 0.667
LIG_LIR_Nem_3 191 197 PF02991 0.302
LIG_LIR_Nem_3 2 8 PF02991 0.480
LIG_LIR_Nem_3 257 263 PF02991 0.423
LIG_LIR_Nem_3 399 403 PF02991 0.340
LIG_LIR_Nem_3 450 455 PF02991 0.309
LIG_LIR_Nem_3 489 494 PF02991 0.299
LIG_LIR_Nem_3 566 572 PF02991 0.264
LIG_LIR_Nem_3 631 637 PF02991 0.298
LIG_Pex14_2 5 9 PF04695 0.442
LIG_Pex14_2 565 569 PF04695 0.463
LIG_PTB_Apo_2 306 313 PF02174 0.291
LIG_SH2_CRK 194 198 PF00017 0.288
LIG_SH2_CRK 635 639 PF00017 0.389
LIG_SH2_NCK_1 194 198 PF00017 0.288
LIG_SH2_NCK_1 646 650 PF00017 0.327
LIG_SH2_SRC 396 399 PF00017 0.264
LIG_SH2_SRC 498 501 PF00017 0.359
LIG_SH2_SRC 637 640 PF00017 0.359
LIG_SH2_STAP1 194 198 PF00017 0.288
LIG_SH2_STAP1 384 388 PF00017 0.291
LIG_SH2_STAP1 630 634 PF00017 0.375
LIG_SH2_STAP1 635 639 PF00017 0.365
LIG_SH2_STAP1 663 667 PF00017 0.304
LIG_SH2_STAT5 268 271 PF00017 0.240
LIG_SH2_STAT5 338 341 PF00017 0.300
LIG_SH2_STAT5 563 566 PF00017 0.237
LIG_SH2_STAT5 637 640 PF00017 0.318
LIG_SH3_1 472 478 PF00018 0.290
LIG_SH3_3 364 370 PF00018 0.288
LIG_SH3_3 472 478 PF00018 0.385
LIG_SH3_3 512 518 PF00018 0.367
LIG_SH3_3 547 553 PF00018 0.265
LIG_SH3_3 590 596 PF00018 0.327
LIG_SUMO_SIM_anti_2 109 115 PF11976 0.481
LIG_SUMO_SIM_anti_2 229 236 PF11976 0.315
LIG_SUMO_SIM_anti_2 352 358 PF11976 0.360
LIG_SUMO_SIM_par_1 352 358 PF11976 0.356
LIG_SUMO_SIM_par_1 672 677 PF11976 0.341
LIG_SUMO_SIM_par_1 84 89 PF11976 0.583
LIG_TRAF2_1 128 131 PF00917 0.486
LIG_TRAF2_1 325 328 PF00917 0.340
LIG_UBA3_1 166 175 PF00899 0.563
LIG_UBA3_1 237 243 PF00899 0.416
LIG_UBA3_1 290 295 PF00899 0.340
LIG_UBA3_1 412 419 PF00899 0.370
LIG_WRC_WIRS_1 564 569 PF05994 0.237
LIG_WW_2 480 483 PF00397 0.225
MOD_CK1_1 109 115 PF00069 0.610
MOD_CK1_1 226 232 PF00069 0.291
MOD_CK1_1 344 350 PF00069 0.378
MOD_CK1_1 431 437 PF00069 0.435
MOD_CK1_1 95 101 PF00069 0.546
MOD_CK2_1 125 131 PF00069 0.644
MOD_CK2_1 16 22 PF00069 0.382
MOD_CK2_1 275 281 PF00069 0.380
MOD_CK2_1 597 603 PF00069 0.321
MOD_CK2_1 615 621 PF00069 0.205
MOD_GlcNHglycan 372 375 PF01048 0.371
MOD_GlcNHglycan 384 387 PF01048 0.386
MOD_GlcNHglycan 393 396 PF01048 0.435
MOD_GlcNHglycan 443 446 PF01048 0.428
MOD_GlcNHglycan 61 64 PF01048 0.534
MOD_GlcNHglycan 94 97 PF01048 0.644
MOD_GSK3_1 138 145 PF00069 0.575
MOD_GSK3_1 188 195 PF00069 0.370
MOD_GSK3_1 387 394 PF00069 0.361
MOD_GSK3_1 425 432 PF00069 0.395
MOD_GSK3_1 433 440 PF00069 0.343
MOD_GSK3_1 665 672 PF00069 0.332
MOD_N-GLC_1 120 125 PF02516 0.609
MOD_N-GLC_1 143 148 PF02516 0.408
MOD_N-GLC_1 308 313 PF02516 0.267
MOD_N-GLC_1 509 514 PF02516 0.295
MOD_N-GLC_1 556 561 PF02516 0.395
MOD_N-GLC_1 575 580 PF02516 0.145
MOD_NEK2_1 142 147 PF00069 0.545
MOD_NEK2_1 170 175 PF00069 0.574
MOD_NEK2_1 282 287 PF00069 0.279
MOD_NEK2_1 36 41 PF00069 0.451
MOD_NEK2_1 382 387 PF00069 0.267
MOD_NEK2_1 574 579 PF00069 0.354
MOD_NEK2_1 609 614 PF00069 0.327
MOD_NEK2_1 633 638 PF00069 0.287
MOD_NEK2_1 669 674 PF00069 0.286
MOD_NEK2_2 622 627 PF00069 0.391
MOD_PIKK_1 36 42 PF00454 0.605
MOD_PIKK_1 361 367 PF00454 0.264
MOD_PIKK_1 417 423 PF00454 0.327
MOD_PK_1 447 453 PF00069 0.207
MOD_PKA_1 154 160 PF00069 0.436
MOD_PKA_2 153 159 PF00069 0.494
MOD_PKA_2 170 176 PF00069 0.522
MOD_PKA_2 344 350 PF00069 0.255
MOD_PKA_2 382 388 PF00069 0.336
MOD_PKB_1 306 314 PF00069 0.315
MOD_PKB_1 90 98 PF00069 0.527
MOD_Plk_1 109 115 PF00069 0.648
MOD_Plk_1 308 314 PF00069 0.267
MOD_Plk_1 575 581 PF00069 0.340
MOD_Plk_2-3 461 467 PF00069 0.207
MOD_Plk_2-3 597 603 PF00069 0.361
MOD_Plk_4 109 115 PF00069 0.491
MOD_Plk_4 138 144 PF00069 0.557
MOD_Plk_4 192 198 PF00069 0.277
MOD_Plk_4 308 314 PF00069 0.315
MOD_Plk_4 447 453 PF00069 0.207
MOD_Plk_4 575 581 PF00069 0.433
MOD_Plk_4 633 639 PF00069 0.265
MOD_Plk_4 669 675 PF00069 0.307
MOD_ProDKin_1 143 149 PF00069 0.405
MOD_ProDKin_1 437 443 PF00069 0.365
MOD_SUMO_for_1 626 629 PF00179 0.375
MOD_SUMO_rev_2 55 62 PF00179 0.391
MOD_SUMO_rev_2 587 596 PF00179 0.327
TRG_DiLeu_BaEn_3 80 86 PF01217 0.453
TRG_DiLeu_BaEn_4 235 241 PF01217 0.291
TRG_DiLeu_BaLyEn_6 528 533 PF01217 0.340
TRG_ENDOCYTIC_2 194 197 PF00928 0.288
TRG_ENDOCYTIC_2 630 633 PF00928 0.375
TRG_ENDOCYTIC_2 635 638 PF00928 0.376
TRG_ENDOCYTIC_2 639 642 PF00928 0.377
TRG_ER_diArg_1 153 155 PF00400 0.658
TRG_ER_diArg_1 303 306 PF00400 0.324
TRG_ER_diArg_1 75 77 PF00400 0.580
TRG_NES_CRM1_1 105 119 PF08389 0.484
TRG_Pf-PMV_PEXEL_1 127 131 PF00026 0.386
TRG_Pf-PMV_PEXEL_1 243 247 PF00026 0.468
TRG_Pf-PMV_PEXEL_1 289 294 PF00026 0.380
TRG_Pf-PMV_PEXEL_1 97 101 PF00026 0.616

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I0E8 Leptomonas seymouri 46% 99%
A0A1X0NQR7 Trypanosomatidae 32% 100%
A0A3R7NV38 Trypanosoma rangeli 33% 100%
A0A3S7WR18 Leishmania donovani 99% 100%
A0JND9 Bos taurus 23% 100%
A4H5Z8 Leishmania braziliensis 70% 100%
C9ZVG6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 37% 100%
E9AN23 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 100%
P40009 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 24% 100%
P49961 Homo sapiens 25% 100%
P55772 Mus musculus 24% 100%
Q28CF8 Xenopus tropicalis 21% 100%
Q3TCT4 Mus musculus 22% 100%
Q4QHK3 Leishmania major 90% 100%
Q5MY95 Homo sapiens 24% 100%
Q5REF6 Pongo abelii 21% 100%
Q8BFW6 Mus musculus 26% 100%
Q8TGH6 Candida albicans (strain SC5314 / ATCC MYA-2876) 30% 100%
Q9HEM6 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 31% 100%
Q9NQZ7 Homo sapiens 21% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS