Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HUC3_LEIIN

TriTrypDb:

LINF_100006500

Length:

505

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HUC3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HUC3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	177	181	PF00656	0.661
CLV_C14_Caspase3-7	496	500	PF00656	0.554
CLV_NRD_NRD_1	140	142	PF00675	0.510
CLV_NRD_NRD_1	148	150	PF00675	0.493
CLV_NRD_NRD_1	282	284	PF00675	0.507
CLV_NRD_NRD_1	72	74	PF00675	0.457
CLV_NRD_NRD_1	83	85	PF00675	0.376
CLV_NRD_NRD_1	91	93	PF00675	0.318
CLV_PCSK_KEX2_1	140	142	PF00082	0.537
CLV_PCSK_KEX2_1	282	284	PF00082	0.507
CLV_PCSK_KEX2_1	72	74	PF00082	0.457
CLV_PCSK_KEX2_1	83	85	PF00082	0.376
CLV_PCSK_KEX2_1	89	91	PF00082	0.342
CLV_PCSK_PC1ET2_1	89	91	PF00082	0.487
CLV_PCSK_SKI1_1	125	129	PF00082	0.475
CLV_PCSK_SKI1_1	469	473	PF00082	0.705
DEG_APCC_DBOX_1	52	60	PF00400	0.438
DEG_SPOP_SBC_1	229	233	PF00917	0.663
DEG_SPOP_SBC_1	402	406	PF00917	0.592
DOC_CYCLIN_RxL_1	466	476	PF00134	0.553
DOC_PP2B_LxvP_1	449	452	PF13499	0.586
DOC_PP4_FxxP_1	390	393	PF00568	0.539
DOC_USP7_MATH_1	182	186	PF00917	0.595
DOC_USP7_MATH_1	190	194	PF00917	0.533
DOC_USP7_MATH_1	204	208	PF00917	0.658
DOC_USP7_MATH_1	210	214	PF00917	0.665
DOC_USP7_MATH_1	229	233	PF00917	0.555
DOC_USP7_MATH_1	258	262	PF00917	0.439
DOC_USP7_MATH_1	358	362	PF00917	0.649
DOC_USP7_MATH_1	368	372	PF00917	0.635
DOC_USP7_MATH_1	393	397	PF00917	0.575
DOC_USP7_MATH_1	400	404	PF00917	0.549
DOC_USP7_MATH_1	419	423	PF00917	0.772
DOC_USP7_MATH_1	486	490	PF00917	0.709
DOC_USP7_MATH_1	492	496	PF00917	0.730
DOC_USP7_MATH_1	8	12	PF00917	0.570
DOC_USP7_UBL2_3	121	125	PF12436	0.483
DOC_WW_Pin1_4	194	199	PF00397	0.566
DOC_WW_Pin1_4	347	352	PF00397	0.626
DOC_WW_Pin1_4	364	369	PF00397	0.460
DOC_WW_Pin1_4	444	449	PF00397	0.791
LIG_14-3-3_CanoR_1	114	123	PF00244	0.460
LIG_14-3-3_CanoR_1	329	336	PF00244	0.603
LIG_14-3-3_CanoR_1	362	370	PF00244	0.662
LIG_14-3-3_CanoR_1	442	448	PF00244	0.595
LIG_AP2alpha_2	388	390	PF02296	0.602
LIG_BIR_III_4	499	503	PF00653	0.529
LIG_BRCT_BRCA1_1	332	336	PF00533	0.654
LIG_FHA_1	115	121	PF00498	0.459
LIG_FHA_1	158	164	PF00498	0.533
LIG_FHA_1	195	201	PF00498	0.678
LIG_FHA_1	210	216	PF00498	0.619
LIG_FHA_1	236	242	PF00498	0.674
LIG_FHA_1	244	250	PF00498	0.563
LIG_FHA_1	262	268	PF00498	0.318
LIG_FHA_1	296	302	PF00498	0.523
LIG_FHA_1	348	354	PF00498	0.712
LIG_FHA_1	45	51	PF00498	0.522
LIG_FHA_1	473	479	PF00498	0.597
LIG_FHA_2	235	241	PF00498	0.608
LIG_FHA_2	56	62	PF00498	0.511
LIG_GBD_Chelix_1	134	142	PF00786	0.459
LIG_GBD_Chelix_1	77	85	PF00786	0.423
LIG_LIR_Apic_2	388	393	PF02991	0.531
LIG_PCNA_yPIPBox_3	72	81	PF02747	0.539
LIG_RPA_C_Fungi	79	91	PF08784	0.432
LIG_SH2_STAP1	17	21	PF00017	0.522
LIG_SH2_STAT5	251	254	PF00017	0.515
LIG_SH2_STAT5	273	276	PF00017	0.518
LIG_SH3_3	195	201	PF00018	0.638
LIG_SH3_3	367	373	PF00018	0.721
LIG_SH3_3	383	389	PF00018	0.588
LIG_SH3_3	475	481	PF00018	0.778
LIG_TRAF2_1	107	110	PF00917	0.455
LIG_TRAF2_1	155	158	PF00917	0.458
LIG_TRAF2_1	58	61	PF00917	0.505
LIG_UBA3_1	81	89	PF00899	0.446
LIG_WW_1	14	17	PF00397	0.558
MOD_CDK_SPxxK_3	347	354	PF00069	0.647
MOD_CK1_1	108	114	PF00069	0.425
MOD_CK1_1	181	187	PF00069	0.536
MOD_CK1_1	206	212	PF00069	0.644
MOD_CK1_1	225	231	PF00069	0.515
MOD_CK1_1	261	267	PF00069	0.443
MOD_CK1_1	342	348	PF00069	0.565
MOD_CK1_1	403	409	PF00069	0.733
MOD_CK1_1	415	421	PF00069	0.506
MOD_CK1_1	422	428	PF00069	0.776
MOD_CK1_1	444	450	PF00069	0.706
MOD_CK1_1	462	468	PF00069	0.594
MOD_CK1_1	493	499	PF00069	0.701
MOD_CK1_1	55	61	PF00069	0.452
MOD_CK2_1	265	271	PF00069	0.617
MOD_CK2_1	451	457	PF00069	0.667
MOD_CK2_1	55	61	PF00069	0.502
MOD_GlcNHglycan	10	13	PF01048	0.644
MOD_GlcNHglycan	180	183	PF01048	0.602
MOD_GlcNHglycan	184	187	PF01048	0.650
MOD_GlcNHglycan	192	195	PF01048	0.637
MOD_GlcNHglycan	206	209	PF01048	0.676
MOD_GlcNHglycan	212	215	PF01048	0.587
MOD_GlcNHglycan	227	230	PF01048	0.575
MOD_GlcNHglycan	342	345	PF01048	0.593
MOD_GlcNHglycan	356	359	PF01048	0.637
MOD_GlcNHglycan	364	367	PF01048	0.729
MOD_GlcNHglycan	395	398	PF01048	0.693
MOD_GlcNHglycan	414	417	PF01048	0.775
MOD_GlcNHglycan	421	424	PF01048	0.471
MOD_GlcNHglycan	492	495	PF01048	0.587
MOD_GlcNHglycan	6	9	PF01048	0.669
MOD_GSK3_1	178	185	PF00069	0.548
MOD_GSK3_1	188	195	PF00069	0.656
MOD_GSK3_1	204	211	PF00069	0.781
MOD_GSK3_1	221	228	PF00069	0.531
MOD_GSK3_1	229	236	PF00069	0.591
MOD_GSK3_1	261	268	PF00069	0.482
MOD_GSK3_1	339	346	PF00069	0.567
MOD_GSK3_1	354	361	PF00069	0.639
MOD_GSK3_1	364	371	PF00069	0.679
MOD_GSK3_1	4	11	PF00069	0.564
MOD_GSK3_1	415	422	PF00069	0.739
MOD_GSK3_1	451	458	PF00069	0.696
MOD_GSK3_1	486	493	PF00069	0.689
MOD_LATS_1	220	226	PF00433	0.659
MOD_LATS_1	410	416	PF00433	0.563
MOD_N-GLC_1	114	119	PF02516	0.545
MOD_NEK2_1	113	118	PF00069	0.480
MOD_NEK2_1	331	336	PF00069	0.587
MOD_NEK2_1	340	345	PF00069	0.556
MOD_NEK2_1	443	448	PF00069	0.686
MOD_NEK2_1	45	50	PF00069	0.441
MOD_NEK2_1	472	477	PF00069	0.636
MOD_NEK2_1	52	57	PF00069	0.460
MOD_NEK2_1	85	90	PF00069	0.501
MOD_NEK2_2	258	263	PF00069	0.442
MOD_PIKK_1	105	111	PF00454	0.493
MOD_PIKK_1	114	120	PF00454	0.510
MOD_PIKK_1	188	194	PF00454	0.563
MOD_PIKK_1	295	301	PF00454	0.525
MOD_PIKK_1	462	468	PF00454	0.561
MOD_PK_1	73	79	PF00069	0.463
MOD_PKA_2	113	119	PF00069	0.459
MOD_PKA_2	221	227	PF00069	0.648
MOD_PKA_2	441	447	PF00069	0.593
MOD_PKA_2	52	58	PF00069	0.511
MOD_Plk_1	455	461	PF00069	0.810
MOD_Plk_1	473	479	PF00069	0.466
MOD_Plk_1	487	493	PF00069	0.686
MOD_Plk_4	45	51	PF00069	0.422
MOD_ProDKin_1	194	200	PF00069	0.567
MOD_ProDKin_1	347	353	PF00069	0.627
MOD_ProDKin_1	364	370	PF00069	0.463
MOD_ProDKin_1	444	450	PF00069	0.793
MOD_SUMO_for_1	127	130	PF00179	0.518
MOD_SUMO_rev_2	105	113	PF00179	0.468
TRG_DiLeu_BaLyEn_6	466	471	PF01217	0.614
TRG_ENDOCYTIC_2	67	70	PF00928	0.503
TRG_ER_diArg_1	140	142	PF00400	0.450
TRG_ER_diArg_1	282	284	PF00400	0.548
TRG_ER_diArg_1	50	53	PF00400	0.437
TRG_ER_diArg_1	82	84	PF00400	0.421
TRG_ER_diArg_1	90	92	PF00400	0.416
TRG_NLS_Bipartite_1	72	93	PF00514	0.483
TRG_NLS_MonoCore_2	88	93	PF00514	0.435
TRG_Pf-PMV_PEXEL_1	250	254	PF00026	0.457
TRG_Pf-PMV_PEXEL_1	282	287	PF00026	0.500
TRG_Pf-PMV_PEXEL_1	469	473	PF00026	0.614

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6X5	Leptomonas seymouri	55%	67%
A0A0S4JC19	Bodo saltans	27%	100%
A0A3R7MLU6	Trypanosoma rangeli	30%	100%
A0A3S7WR07	Leishmania donovani	99%	100%
A4H5Z7	Leishmania braziliensis	77%	100%
E9AN22	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QHK4	Leishmania major	91%	100%