HJURP_C domain-containing protein

Quick info Localization Phosphorylation Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HUC2_LEIIN

TriTrypDb:

LINF_100006400

Length:

369

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0010494	cytoplasmic stress granule	5	1
GO:0035770	ribonucleoprotein granule	3	1
GO:0036464	cytoplasmic ribonucleoprotein granule	4	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0099080	supramolecular complex	2	1
GO:0110165	cellular anatomical entity	1	1

Phosphorylation

Promastigote/Amastigote: 85

Expansion

Sequence features

A4HUC2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HUC2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DEG_SCF_FBW7_1	260	265	PF00400	0.525
DEG_SPOP_SBC_1	268	272	PF00917	0.642
DOC_CDC14_PxL_1	181	189	PF14671	0.617
DOC_CKS1_1	166	171	PF01111	0.681
DOC_CKS1_1	263	268	PF01111	0.537
DOC_PP2B_LxvP_1	152	155	PF13499	0.638
DOC_USP7_MATH_1	23	27	PF00917	0.653
DOC_USP7_MATH_1	267	271	PF00917	0.640
DOC_USP7_MATH_1	286	290	PF00917	0.483
DOC_USP7_MATH_1	309	313	PF00917	0.634
DOC_USP7_MATH_1	82	86	PF00917	0.626
DOC_WW_Pin1_4	165	170	PF00397	0.587
DOC_WW_Pin1_4	172	177	PF00397	0.550
DOC_WW_Pin1_4	187	192	PF00397	0.605
DOC_WW_Pin1_4	207	212	PF00397	0.425
DOC_WW_Pin1_4	222	227	PF00397	0.581
DOC_WW_Pin1_4	258	263	PF00397	0.520
DOC_WW_Pin1_4	269	274	PF00397	0.563
DOC_WW_Pin1_4	326	331	PF00397	0.586
DOC_WW_Pin1_4	345	350	PF00397	0.452
LIG_14-3-3_CanoR_1	280	284	PF00244	0.646
LIG_14-3-3_CanoR_1	310	318	PF00244	0.664
LIG_14-3-3_CterR_2	364	369	PF00244	0.561
LIG_BIR_II_1	1	5	PF00653	0.655
LIG_BRCT_BRCA1_1	20	24	PF00533	0.690
LIG_BRCT_BRCA1_1	50	54	PF00533	0.611
LIG_EVH1_1	152	156	PF00568	0.633
LIG_EVH1_2	196	200	PF00568	0.507
LIG_FHA_1	14	20	PF00498	0.586
LIG_FHA_1	240	246	PF00498	0.520
LIG_FHA_1	313	319	PF00498	0.556
LIG_FHA_1	346	352	PF00498	0.677
LIG_FHA_2	30	36	PF00498	0.657
LIG_LIR_Apic_2	261	267	PF02991	0.525
LIG_LIR_Gen_1	51	60	PF02991	0.651
LIG_LIR_Nem_3	51	57	PF02991	0.584
LIG_NRBOX	72	78	PF00104	0.500
LIG_PCNA_yPIPBox_3	70	81	PF02747	0.568
LIG_PROFILIN_1	153	159	PF00235	0.619
LIG_PTB_Apo_2	9	16	PF02174	0.554
LIG_PTB_Phospho_1	9	15	PF10480	0.554
LIG_SH2_CRK	119	123	PF00017	0.639
LIG_SH2_CRK	166	170	PF00017	0.623
LIG_SH2_CRK	181	185	PF00017	0.574
LIG_SH2_CRK	264	268	PF00017	0.540
LIG_SH2_CRK	281	285	PF00017	0.552
LIG_SH2_GRB2like	177	180	PF00017	0.616
LIG_SH2_NCK_1	123	127	PF00017	0.641
LIG_SH2_NCK_1	146	150	PF00017	0.686
LIG_SH2_NCK_1	166	170	PF00017	0.657
LIG_SH2_NCK_1	264	268	PF00017	0.574
LIG_SH2_NCK_1	281	285	PF00017	0.586
LIG_SH2_PTP2	231	234	PF00017	0.613
LIG_SH2_SRC	231	234	PF00017	0.554
LIG_SH2_STAP1	146	150	PF00017	0.663
LIG_SH2_STAP1	177	181	PF00017	0.653
LIG_SH2_STAP1	338	342	PF00017	0.592
LIG_SH2_STAP1	40	44	PF00017	0.522
LIG_SH2_STAT5	123	126	PF00017	0.637
LIG_SH2_STAT5	15	18	PF00017	0.583
LIG_SH2_STAT5	231	234	PF00017	0.613
LIG_SH2_STAT5	264	267	PF00017	0.527
LIG_SH2_STAT5	331	334	PF00017	0.606
LIG_SH3_3	112	118	PF00018	0.603
LIG_SH3_3	150	156	PF00018	0.589
LIG_SH3_3	157	163	PF00018	0.558
LIG_SH3_3	170	176	PF00018	0.537
LIG_SH3_3	192	198	PF00018	0.729
LIG_SH3_3	230	236	PF00018	0.524
LIG_SH3_3	257	263	PF00018	0.518
LIG_SH3_3	271	277	PF00018	0.565
LIG_SH3_3	319	325	PF00018	0.622
LIG_SH3_3	360	366	PF00018	0.691
LIG_SH3_5	36	40	PF00018	0.520
LIG_SUMO_SIM_anti_2	88	96	PF11976	0.550
LIG_TRAF2_1	220	223	PF00917	0.639
LIG_TRAF2_1	238	241	PF00917	0.605
LIG_TRAF2_1	59	62	PF00917	0.641
LIG_TRFH_1	252	256	PF08558	0.459
LIG_TRFH_1	281	285	PF08558	0.586
LIG_UBA3_1	253	259	PF00899	0.517
LIG_WW_1	163	166	PF00397	0.596
LIG_WW_1	355	358	PF00397	0.550
MOD_CDK_SPxxK_3	187	194	PF00069	0.631
MOD_CDK_SPxxK_3	273	280	PF00069	0.639
MOD_CK1_1	145	151	PF00069	0.655
MOD_CK1_1	167	173	PF00069	0.711
MOD_CK1_1	218	224	PF00069	0.699
MOD_CK1_1	258	264	PF00069	0.580
MOD_CK1_1	312	318	PF00069	0.652
MOD_CK1_1	350	356	PF00069	0.659
MOD_CK2_1	14	20	PF00069	0.769
MOD_CK2_1	196	202	PF00069	0.543
MOD_CK2_1	310	316	PF00069	0.673
MOD_GlcNHglycan	147	150	PF01048	0.696
MOD_GlcNHglycan	16	19	PF01048	0.647
MOD_GlcNHglycan	181	184	PF01048	0.636
MOD_GlcNHglycan	20	23	PF01048	0.655
MOD_GlcNHglycan	332	335	PF01048	0.558
MOD_GlcNHglycan	41	45	PF01048	0.539
MOD_GSK3_1	14	21	PF00069	0.680
MOD_GSK3_1	144	151	PF00069	0.649
MOD_GSK3_1	203	210	PF00069	0.507
MOD_GSK3_1	218	225	PF00069	0.539
MOD_GSK3_1	258	265	PF00069	0.521
MOD_GSK3_1	269	276	PF00069	0.558
MOD_GSK3_1	286	293	PF00069	0.588
MOD_GSK3_1	326	333	PF00069	0.593
MOD_GSK3_1	341	348	PF00069	0.581
MOD_N-GLC_1	142	147	PF02516	0.657
MOD_NEK2_1	13	18	PF00069	0.522
MOD_NEK2_1	215	220	PF00069	0.712
MOD_NEK2_1	245	250	PF00069	0.520
MOD_NEK2_1	299	304	PF00069	0.575
MOD_NEK2_1	332	337	PF00069	0.655
MOD_NEK2_2	49	54	PF00069	0.611
MOD_PIKK_1	218	224	PF00454	0.645
MOD_PK_1	310	316	PF00069	0.579
MOD_PKA_2	245	251	PF00069	0.539
MOD_PKA_2	279	285	PF00069	0.645
MOD_PKA_2	309	315	PF00069	0.652
MOD_Plk_1	142	148	PF00069	0.661
MOD_Plk_2-3	96	102	PF00069	0.631
MOD_Plk_4	210	216	PF00069	0.639
MOD_Plk_4	239	245	PF00069	0.565
MOD_Plk_4	300	306	PF00069	0.668
MOD_Plk_4	49	55	PF00069	0.624
MOD_ProDKin_1	165	171	PF00069	0.587
MOD_ProDKin_1	172	178	PF00069	0.548
MOD_ProDKin_1	187	193	PF00069	0.576
MOD_ProDKin_1	207	213	PF00069	0.427
MOD_ProDKin_1	222	228	PF00069	0.580
MOD_ProDKin_1	258	264	PF00069	0.521
MOD_ProDKin_1	269	275	PF00069	0.561
MOD_ProDKin_1	326	332	PF00069	0.586
MOD_ProDKin_1	345	351	PF00069	0.454
TRG_DiLeu_BaLyEn_6	72	77	PF01217	0.599
TRG_ENDOCYTIC_2	123	126	PF00928	0.646
TRG_ENDOCYTIC_2	181	184	PF00928	0.634
TRG_ENDOCYTIC_2	320	323	PF00928	0.579
TRG_Pf-PMV_PEXEL_1	75	79	PF00026	0.492

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCX5	Leptomonas seymouri	58%	100%
A0A3Q8IAY2	Leishmania donovani	99%	99%
A4H5Z6	Leishmania braziliensis	80%	100%
C9ZVG8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AN21	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QHK5	Leishmania major	95%	100%
V5BE36	Trypanosoma cruzi	36%	100%