Putative DEAD/DEAH box helicase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DEAD/DEAH box helicase - putative

Species:

Leishmania infantum

UniProt:

A4HUC1_LEIIN

TriTrypDb:

LINF_100006300

Length:

780

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 18

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 30

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 35
NetGPI	no	yes: 0, no: 35

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	3
GO:0043226	organelle	2	7
GO:0043228	non-membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	7
GO:0043232	intracellular non-membrane-bounded organelle	4	3
GO:0110165	cellular anatomical entity	1	7
GO:0005634	nucleus	5	5
GO:0005737	cytoplasm	2	2
GO:0005739	mitochondrion	5	2
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0043227	membrane-bounded organelle	3	6
GO:0043231	intracellular membrane-bounded organelle	4	6
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0032991	protein-containing complex	1	4
GO:1990904	ribonucleoprotein complex	2	4
GO:0005654	nucleoplasm	2	1

Expansion

Sequence features

A4HUC1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HUC1

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	6
GO:0006364	rRNA processing	8	5
GO:0006396	RNA processing	6	5
GO:0006725	cellular aromatic compound metabolic process	3	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0008152	metabolic process	1	6
GO:0009987	cellular process	1	7
GO:0016070	RNA metabolic process	5	6
GO:0016072	rRNA metabolic process	7	5
GO:0030490	maturation of SSU-rRNA	9	5
GO:0034470	ncRNA processing	7	5
GO:0034641	cellular nitrogen compound metabolic process	3	6
GO:0034660	ncRNA metabolic process	6	5
GO:0043170	macromolecule metabolic process	3	6
GO:0044237	cellular metabolic process	2	6
GO:0044238	primary metabolic process	2	6
GO:0046483	heterocycle metabolic process	3	6
GO:0071704	organic substance metabolic process	2	6
GO:0090304	nucleic acid metabolic process	4	6
GO:1901360	organic cyclic compound metabolic process	3	6
GO:0009451	RNA modification	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0016556	mRNA modification	6	1
GO:0043412	macromolecule modification	4	1
GO:0000027	ribosomal large subunit assembly	7	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0022618	ribonucleoprotein complex assembly	6	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071826	ribonucleoprotein complex subunit organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:1902775	mitochondrial large ribosomal subunit assembly	8	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	36
GO:0003676	nucleic acid binding	3	36
GO:0003824	catalytic activity	1	36
GO:0004386	helicase activity	2	36
GO:0005488	binding	1	36
GO:0005524	ATP binding	5	36
GO:0017076	purine nucleotide binding	4	36
GO:0030554	adenyl nucleotide binding	5	36
GO:0032553	ribonucleotide binding	3	36
GO:0032555	purine ribonucleotide binding	4	36
GO:0032559	adenyl ribonucleotide binding	5	36
GO:0035639	purine ribonucleoside triphosphate binding	4	36
GO:0036094	small molecule binding	2	36
GO:0043167	ion binding	2	36
GO:0043168	anion binding	3	36
GO:0097159	organic cyclic compound binding	2	36
GO:0097367	carbohydrate derivative binding	2	36
GO:0140640	catalytic activity, acting on a nucleic acid	2	36
GO:0140657	ATP-dependent activity	1	36
GO:1901265	nucleoside phosphate binding	3	36
GO:1901363	heterocyclic compound binding	2	36
GO:0003724	RNA helicase activity	3	17
GO:0003743	translation initiation factor activity	4	9
GO:0008135	translation factor activity, RNA binding	3	9
GO:0008186	ATP-dependent activity, acting on RNA	2	17
GO:0016787	hydrolase activity	2	27
GO:0045182	translation regulator activity	1	9
GO:0090079	translation regulator activity, nucleic acid binding	2	9
GO:0140098	catalytic activity, acting on RNA	3	17
GO:0003723	RNA binding	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	158	162	PF00656	0.520
CLV_C14_Caspase3-7	243	247	PF00656	0.488
CLV_C14_Caspase3-7	65	69	PF00656	0.525
CLV_C14_Caspase3-7	727	731	PF00656	0.348
CLV_NRD_NRD_1	187	189	PF00675	0.488
CLV_NRD_NRD_1	258	260	PF00675	0.434
CLV_NRD_NRD_1	29	31	PF00675	0.594
CLV_NRD_NRD_1	446	448	PF00675	0.231
CLV_NRD_NRD_1	533	535	PF00675	0.371
CLV_NRD_NRD_1	602	604	PF00675	0.207
CLV_NRD_NRD_1	625	627	PF00675	0.201
CLV_NRD_NRD_1	719	721	PF00675	0.337
CLV_NRD_NRD_1	757	759	PF00675	0.540
CLV_PCSK_FUR_1	755	759	PF00082	0.522
CLV_PCSK_KEX2_1	187	189	PF00082	0.486
CLV_PCSK_KEX2_1	258	260	PF00082	0.442
CLV_PCSK_KEX2_1	29	31	PF00082	0.594
CLV_PCSK_KEX2_1	363	365	PF00082	0.198
CLV_PCSK_KEX2_1	446	448	PF00082	0.209
CLV_PCSK_KEX2_1	584	586	PF00082	0.221
CLV_PCSK_KEX2_1	602	604	PF00082	0.333
CLV_PCSK_KEX2_1	627	629	PF00082	0.221
CLV_PCSK_KEX2_1	651	653	PF00082	0.202
CLV_PCSK_KEX2_1	757	759	PF00082	0.528
CLV_PCSK_PC1ET2_1	363	365	PF00082	0.198
CLV_PCSK_PC1ET2_1	584	586	PF00082	0.221
CLV_PCSK_PC1ET2_1	627	629	PF00082	0.221
CLV_PCSK_PC1ET2_1	651	653	PF00082	0.202
CLV_PCSK_PC7_1	25	31	PF00082	0.491
CLV_PCSK_PC7_1	442	448	PF00082	0.196
CLV_PCSK_PC7_1	753	759	PF00082	0.484
CLV_PCSK_SKI1_1	30	34	PF00082	0.487
CLV_PCSK_SKI1_1	364	368	PF00082	0.204
CLV_PCSK_SKI1_1	496	500	PF00082	0.262
CLV_PCSK_SKI1_1	557	561	PF00082	0.382
DEG_APCC_DBOX_1	29	37	PF00400	0.482
DEG_APCC_DBOX_1	495	503	PF00400	0.419
DEG_APCC_DBOX_1	556	564	PF00400	0.337
DEG_Nend_UBRbox_1	1	4	PF02207	0.406
DEG_SCF_FBW7_1	693	698	PF00400	0.325
DEG_SPOP_SBC_1	385	389	PF00917	0.403
DOC_ANK_TNKS_1	186	193	PF00023	0.494
DOC_CKS1_1	455	460	PF01111	0.476
DOC_CKS1_1	692	697	PF01111	0.316
DOC_CYCLIN_yCln2_LP_2	13	19	PF00134	0.449
DOC_MAPK_gen_1	327	334	PF00069	0.388
DOC_MAPK_gen_1	446	455	PF00069	0.440
DOC_MAPK_gen_1	534	542	PF00069	0.299
DOC_MAPK_gen_1	584	590	PF00069	0.446
DOC_MAPK_HePTP_8	532	544	PF00069	0.292
DOC_MAPK_MEF2A_6	535	544	PF00069	0.357
DOC_PP1_RVXF_1	216	223	PF00149	0.520
DOC_PP2B_LxvP_1	609	612	PF13499	0.401
DOC_PP4_FxxP_1	692	695	PF00568	0.393
DOC_USP7_MATH_1	135	139	PF00917	0.548
DOC_USP7_MATH_1	336	340	PF00917	0.428
DOC_USP7_MATH_1	38	42	PF00917	0.471
DOC_USP7_MATH_1	386	390	PF00917	0.438
DOC_USP7_MATH_1	429	433	PF00917	0.398
DOC_USP7_MATH_1	489	493	PF00917	0.382
DOC_USP7_MATH_1	53	57	PF00917	0.543
DOC_USP7_MATH_1	562	566	PF00917	0.300
DOC_USP7_MATH_1	67	71	PF00917	0.489
DOC_USP7_MATH_1	728	732	PF00917	0.388
DOC_USP7_UBL2_3	363	367	PF12436	0.394
DOC_WW_Pin1_4	12	17	PF00397	0.428
DOC_WW_Pin1_4	138	143	PF00397	0.543
DOC_WW_Pin1_4	209	214	PF00397	0.508
DOC_WW_Pin1_4	454	459	PF00397	0.485
DOC_WW_Pin1_4	535	540	PF00397	0.314
DOC_WW_Pin1_4	691	696	PF00397	0.321
LIG_14-3-3_CanoR_1	406	410	PF00244	0.411
LIG_14-3-3_CanoR_1	493	502	PF00244	0.385
LIG_14-3-3_CanoR_1	685	695	PF00244	0.375
LIG_Actin_WH2_2	395	413	PF00022	0.398
LIG_APCC_ABBA_1	82	87	PF00400	0.492
LIG_BRCT_BRCA1_1	688	692	PF00533	0.361
LIG_CtBP_PxDLS_1	379	383	PF00389	0.389
LIG_eIF4E_1	108	114	PF01652	0.441
LIG_FHA_1	128	134	PF00498	0.547
LIG_FHA_1	268	274	PF00498	0.370
LIG_FHA_1	46	52	PF00498	0.509
LIG_FHA_1	460	466	PF00498	0.428
LIG_FHA_1	539	545	PF00498	0.507
LIG_FHA_1	648	654	PF00498	0.435
LIG_FHA_1	70	76	PF00498	0.468
LIG_FHA_2	521	527	PF00498	0.326
LIG_FHA_2	545	551	PF00498	0.392
LIG_FHA_2	595	601	PF00498	0.412
LIG_FHA_2	692	698	PF00498	0.379
LIG_Integrin_isoDGR_2	494	496	PF01839	0.198
LIG_LIR_Apic_2	68	74	PF02991	0.492
LIG_LIR_Apic_2	689	695	PF02991	0.385
LIG_LIR_Apic_2	732	738	PF02991	0.450
LIG_LIR_Gen_1	342	353	PF02991	0.402
LIG_LIR_Nem_3	342	348	PF02991	0.404
LIG_LIR_Nem_3	80	85	PF02991	0.530
LIG_PCNA_yPIPBox_3	355	369	PF02747	0.398
LIG_PCNA_yPIPBox_3	709	723	PF02747	0.337
LIG_Rb_LxCxE_1	243	262	PF01857	0.458
LIG_Rb_LxCxE_1	519	538	PF01857	0.293
LIG_Rb_pABgroove_1	571	579	PF01858	0.289
LIG_RPA_C_Fungi	182	194	PF08784	0.476
LIG_SH2_CRK	345	349	PF00017	0.249
LIG_SH2_CRK	416	420	PF00017	0.212
LIG_SH2_CRK	536	540	PF00017	0.314
LIG_SH2_CRK	664	668	PF00017	0.315
LIG_SH2_NCK_1	664	668	PF00017	0.259
LIG_SH2_STAT5	591	594	PF00017	0.308
LIG_SH2_STAT5	71	74	PF00017	0.467
LIG_SH3_3	194	200	PF00018	0.519
LIG_SH3_3	374	380	PF00018	0.204
LIG_SH3_3	391	397	PF00018	0.294
LIG_SH3_3	452	458	PF00018	0.433
LIG_Sin3_3	344	351	PF02671	0.202
LIG_SUMO_SIM_anti_2	541	547	PF11976	0.299
LIG_SUMO_SIM_par_1	398	404	PF11976	0.266
LIG_SUMO_SIM_par_1	476	481	PF11976	0.258
LIG_SUMO_SIM_par_1	538	543	PF11976	0.354
LIG_SUMO_SIM_par_1	641	647	PF11976	0.194
LIG_SUMO_SIM_par_1	72	78	PF11976	0.476
LIG_TRAF2_1	154	157	PF00917	0.493
LIG_TRAF2_1	240	243	PF00917	0.497
LIG_TRAF2_1	358	361	PF00917	0.240
LIG_TRAF2_1	547	550	PF00917	0.391
LIG_TRAF2_1	597	600	PF00917	0.217
LIG_TYR_ITIM	343	348	PF00017	0.202
MOD_CDK_SPxK_1	454	460	PF00069	0.312
MOD_CDK_SPxxK_3	209	216	PF00069	0.507
MOD_CK1_1	138	144	PF00069	0.583
MOD_CK1_1	309	315	PF00069	0.349
MOD_CK1_1	339	345	PF00069	0.331
MOD_CK1_1	387	393	PF00069	0.235
MOD_CK1_1	41	47	PF00069	0.483
MOD_CK1_1	417	423	PF00069	0.207
MOD_CK1_1	528	534	PF00069	0.337
MOD_CK1_1	538	544	PF00069	0.305
MOD_CK1_1	56	62	PF00069	0.551
MOD_CK1_1	610	616	PF00069	0.226
MOD_CK1_1	69	75	PF00069	0.478
MOD_CK1_1	731	737	PF00069	0.459
MOD_CK1_1	78	84	PF00069	0.482
MOD_CK2_1	237	243	PF00069	0.532
MOD_CK2_1	520	526	PF00069	0.343
MOD_CK2_1	544	550	PF00069	0.371
MOD_CK2_1	594	600	PF00069	0.226
MOD_Cter_Amidation	755	758	PF01082	0.472
MOD_GlcNHglycan	101	104	PF01048	0.495
MOD_GlcNHglycan	137	140	PF01048	0.706
MOD_GlcNHglycan	165	168	PF01048	0.527
MOD_GlcNHglycan	308	311	PF01048	0.346
MOD_GlcNHglycan	318	321	PF01048	0.343
MOD_GlcNHglycan	337	341	PF01048	0.316
MOD_GlcNHglycan	374	377	PF01048	0.214
MOD_GlcNHglycan	389	392	PF01048	0.231
MOD_GlcNHglycan	39	43	PF01048	0.515
MOD_GlcNHglycan	419	422	PF01048	0.207
MOD_GlcNHglycan	56	59	PF01048	0.541
MOD_GlcNHglycan	609	612	PF01048	0.242
MOD_GlcNHglycan	620	623	PF01048	0.300
MOD_GlcNHglycan	681	685	PF01048	0.458
MOD_GlcNHglycan	76	80	PF01048	0.496
MOD_GlcNHglycan	767	770	PF01048	0.499
MOD_GSK3_1	205	212	PF00069	0.504
MOD_GSK3_1	261	268	PF00069	0.491
MOD_GSK3_1	312	319	PF00069	0.371
MOD_GSK3_1	380	387	PF00069	0.215
MOD_GSK3_1	401	408	PF00069	0.249
MOD_GSK3_1	41	48	PF00069	0.552
MOD_GSK3_1	516	523	PF00069	0.354
MOD_GSK3_1	540	547	PF00069	0.320
MOD_GSK3_1	607	614	PF00069	0.237
MOD_GSK3_1	618	625	PF00069	0.273
MOD_GSK3_1	62	69	PF00069	0.670
MOD_GSK3_1	643	650	PF00069	0.268
MOD_GSK3_1	691	698	PF00069	0.375
MOD_GSK3_1	765	772	PF00069	0.481
MOD_N-GLC_1	225	230	PF02516	0.510
MOD_NEK2_1	183	188	PF00069	0.480
MOD_NEK2_1	225	230	PF00069	0.549
MOD_NEK2_1	265	270	PF00069	0.440
MOD_NEK2_1	306	311	PF00069	0.358
MOD_NEK2_1	316	321	PF00069	0.299
MOD_NEK2_1	32	37	PF00069	0.497
MOD_NEK2_1	415	420	PF00069	0.214
MOD_NEK2_1	540	545	PF00069	0.328
MOD_NEK2_1	747	752	PF00069	0.509
MOD_NEK2_1	75	80	PF00069	0.487
MOD_PIKK_1	24	30	PF00454	0.492
MOD_PIKK_1	675	681	PF00454	0.207
MOD_PKA_2	234	240	PF00069	0.540
MOD_PKA_2	24	30	PF00069	0.507
MOD_PKA_2	312	318	PF00069	0.350
MOD_PKA_2	405	411	PF00069	0.214
MOD_PKA_2	459	465	PF00069	0.245
MOD_PKA_2	594	600	PF00069	0.243
MOD_PKA_2	675	681	PF00069	0.252
MOD_Plk_1	38	44	PF00069	0.466
MOD_Plk_1	67	73	PF00069	0.487
MOD_Plk_1	731	737	PF00069	0.468
MOD_Plk_1	86	92	PF00069	0.489
MOD_Plk_4	312	318	PF00069	0.364
MOD_Plk_4	32	38	PF00069	0.511
MOD_Plk_4	405	411	PF00069	0.228
MOD_Plk_4	528	534	PF00069	0.405
MOD_Plk_4	540	546	PF00069	0.279
MOD_Plk_4	578	584	PF00069	0.219
MOD_Plk_4	611	617	PF00069	0.246
MOD_Plk_4	688	694	PF00069	0.402
MOD_Plk_4	731	737	PF00069	0.461
MOD_ProDKin_1	12	18	PF00069	0.435
MOD_ProDKin_1	138	144	PF00069	0.543
MOD_ProDKin_1	209	215	PF00069	0.508
MOD_ProDKin_1	454	460	PF00069	0.329
MOD_ProDKin_1	535	541	PF00069	0.310
MOD_ProDKin_1	691	697	PF00069	0.318
MOD_SUMO_rev_2	360	365	PF00179	0.226
MOD_SUMO_rev_2	772	779	PF00179	0.473
TRG_DiLeu_BaEn_1	422	427	PF01217	0.217
TRG_DiLeu_BaEn_4	360	366	PF01217	0.194
TRG_ENDOCYTIC_2	345	348	PF00928	0.204
TRG_ENDOCYTIC_2	416	419	PF00928	0.212
TRG_ENDOCYTIC_2	430	433	PF00928	0.223
TRG_ER_diArg_1	1	4	PF00400	0.407
TRG_ER_diArg_1	258	260	PF00400	0.434
TRG_ER_diArg_1	326	329	PF00400	0.193
TRG_ER_diArg_1	445	447	PF00400	0.224
TRG_ER_diArg_1	601	603	PF00400	0.207
TRG_ER_diArg_1	752	755	PF00400	0.567
TRG_NES_CRM1_1	665	675	PF08389	0.215
TRG_NLS_MonoExtC_3	446	452	PF00514	0.204
TRG_NLS_MonoExtN_4	446	451	PF00514	0.204
TRG_Pf-PMV_PEXEL_1	758	762	PF00026	0.485

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5R1	Leptomonas seymouri	58%	98%
A0A3Q8ID91	Leishmania donovani	28%	100%
A0A3Q8IF94	Leishmania donovani	23%	100%
A0A3Q8IQY6	Leishmania donovani	25%	100%
A0A3S5H5X3	Leishmania donovani	23%	100%
A0A3S7WR01	Leishmania donovani	99%	100%
A0A3S7X579	Leishmania donovani	26%	100%
A0A3S7X9W0	Leishmania donovani	27%	100%
A1CHL3	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	23%	98%
A4H4Y0	Leishmania braziliensis	25%	100%
A4H5Z5	Leishmania braziliensis	69%	98%
A4HGR1	Leishmania braziliensis	28%	100%
A4HK20	Leishmania braziliensis	23%	100%
A4HK38	Leishmania braziliensis	25%	100%
A4HP82	Leishmania braziliensis	25%	100%
A4HTF8	Leishmania infantum	26%	100%
A4HZF8	Leishmania infantum	21%	100%
A4I3T6	Leishmania infantum	28%	100%
A4I7K4	Leishmania infantum	23%	100%
A4I7M5	Leishmania infantum	26%	100%
A4IBU1	Leishmania infantum	27%	100%
A4IDI7	Leishmania infantum	25%	100%
A5DF03	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	22%	100%
E9AM86	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9AN20	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
E9ASZ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9AT30	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
E9B028	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9B2G1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	100%
E9B2I0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9B6T1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
P0CQ88	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	23%	100%
P0CQ89	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	23%	100%
Q4Q1G8	Leishmania major	23%	100%
Q4Q1K8	Leishmania major	24%	100%
Q4Q5M6	Leishmania major	26%	100%
Q4Q5P5	Leishmania major	22%	100%
Q4Q858	Leishmania major	28%	100%
Q4QHK6	Leishmania major	91%	100%
Q4QIG1	Leishmania major	26%	100%
Q4QIQ9	Leishmania major	24%	100%