Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PSP1 C-terminal conserved region containing protein - putative

Species:

Leishmania infantum

UniProt:

A4HUB9_LEIIN

TriTrypDb:

LINF_100006100

Length:

362

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4HUB9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HUB9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	290	292	PF00675	0.289
CLV_NRD_NRD_1	339	341	PF00675	0.597
CLV_NRD_NRD_1	358	360	PF00675	0.680
CLV_NRD_NRD_1	88	90	PF00675	0.669
CLV_PCSK_FUR_1	337	341	PF00082	0.569
CLV_PCSK_KEX2_1	20	22	PF00082	0.569
CLV_PCSK_KEX2_1	336	338	PF00082	0.563
CLV_PCSK_KEX2_1	339	341	PF00082	0.591
CLV_PCSK_KEX2_1	357	359	PF00082	0.573
CLV_PCSK_KEX2_1	88	90	PF00082	0.669
CLV_PCSK_PC1ET2_1	20	22	PF00082	0.592
CLV_PCSK_PC1ET2_1	336	338	PF00082	0.623
CLV_PCSK_PC1ET2_1	357	359	PF00082	0.591
CLV_PCSK_PC7_1	353	359	PF00082	0.654
CLV_PCSK_SKI1_1	133	137	PF00082	0.487
CLV_PCSK_SKI1_1	236	240	PF00082	0.575
CLV_PCSK_SKI1_1	292	296	PF00082	0.400
CLV_PCSK_SKI1_1	89	93	PF00082	0.666
DEG_Nend_UBRbox_3	1	3	PF02207	0.506
DEG_SCF_FBW7_1	69	75	PF00400	0.521
DOC_CKS1_1	69	74	PF01111	0.636
DOC_CYCLIN_RxL_1	86	95	PF00134	0.665
DOC_CYCLIN_yCln2_LP_2	276	282	PF00134	0.345
DOC_CYCLIN_yCln2_LP_2	42	48	PF00134	0.586
DOC_MAPK_gen_1	133	141	PF00069	0.548
DOC_MAPK_gen_1	240	250	PF00069	0.361
DOC_MAPK_MEF2A_6	150	159	PF00069	0.512
DOC_MAPK_MEF2A_6	182	191	PF00069	0.513
DOC_PP2B_LxvP_1	276	279	PF13499	0.402
DOC_PP4_FxxP_1	166	169	PF00568	0.354
DOC_USP7_MATH_1	13	17	PF00917	0.708
DOC_USP7_MATH_1	24	28	PF00917	0.565
DOC_USP7_MATH_1	32	36	PF00917	0.603
DOC_USP7_MATH_1	79	83	PF00917	0.662
DOC_USP7_UBL2_3	134	138	PF12436	0.572
DOC_USP7_UBL2_3	236	240	PF12436	0.421
DOC_WW_Pin1_4	100	105	PF00397	0.647
DOC_WW_Pin1_4	215	220	PF00397	0.734
DOC_WW_Pin1_4	227	232	PF00397	0.760
DOC_WW_Pin1_4	41	46	PF00397	0.674
DOC_WW_Pin1_4	48	53	PF00397	0.676
DOC_WW_Pin1_4	68	73	PF00397	0.412
DOC_WW_Pin1_4	92	97	PF00397	0.624
LIG_14-3-3_CanoR_1	125	131	PF00244	0.569
LIG_14-3-3_CanoR_1	160	168	PF00244	0.492
LIG_14-3-3_CanoR_1	243	250	PF00244	0.453
LIG_14-3-3_CanoR_1	291	297	PF00244	0.317
LIG_APCC_ABBAyCdc20_2	88	94	PF00400	0.667
LIG_BRCT_BRCA1_1	34	38	PF00533	0.527
LIG_Clathr_ClatBox_1	174	178	PF01394	0.535
LIG_FHA_1	154	160	PF00498	0.509
LIG_FHA_1	163	169	PF00498	0.500
LIG_FHA_1	179	185	PF00498	0.503
LIG_FHA_1	308	314	PF00498	0.411
LIG_FHA_1	69	75	PF00498	0.557
LIG_FHA_2	218	224	PF00498	0.806
LIG_IBAR_NPY_1	23	25	PF08397	0.510
LIG_LIR_Apic_2	163	169	PF02991	0.368
LIG_LIR_Gen_1	170	177	PF02991	0.562
LIG_LIR_Gen_1	300	309	PF02991	0.363
LIG_LIR_Gen_1	35	46	PF02991	0.553
LIG_LIR_Gen_1	63	74	PF02991	0.622
LIG_LIR_Nem_3	197	202	PF02991	0.576
LIG_LIR_Nem_3	300	306	PF02991	0.350
LIG_LIR_Nem_3	63	69	PF02991	0.555
LIG_Pex14_2	60	64	PF04695	0.493
LIG_SH2_CRK	66	70	PF00017	0.529
LIG_SH2_GRB2like	66	69	PF00017	0.704
LIG_SH2_NCK_1	66	70	PF00017	0.501
LIG_SH2_STAP1	172	176	PF00017	0.554
LIG_SH2_STAP1	25	29	PF00017	0.629
LIG_SH2_STAP1	298	302	PF00017	0.402
LIG_SH2_STAT3	73	76	PF00017	0.530
LIG_SH2_STAT5	140	143	PF00017	0.437
LIG_SH2_STAT5	266	269	PF00017	0.402
LIG_SH2_STAT5	298	301	PF00017	0.282
LIG_SH2_STAT5	303	306	PF00017	0.257
LIG_SH2_STAT5	73	76	PF00017	0.626
LIG_SH3_3	116	122	PF00018	0.640
LIG_SH3_3	125	131	PF00018	0.550
LIG_SH3_3	143	149	PF00018	0.483
LIG_SH3_3	182	188	PF00018	0.423
LIG_SH3_3	26	32	PF00018	0.657
LIG_SH3_3	66	72	PF00018	0.636
LIG_SH3_3	84	90	PF00018	0.622
LIG_SH3_4	236	243	PF00018	0.387
LIG_SUMO_SIM_par_1	187	192	PF11976	0.574
LIG_SUMO_SIM_par_1	277	283	PF11976	0.415
LIG_TRAF2_1	176	179	PF00917	0.592
LIG_TRAF2_1	220	223	PF00917	0.766
MOD_CK1_1	105	111	PF00069	0.615
MOD_CK1_1	126	132	PF00069	0.650
MOD_CK1_1	16	22	PF00069	0.626
MOD_CK1_1	162	168	PF00069	0.518
MOD_CK1_1	218	224	PF00069	0.689
MOD_CK1_1	44	50	PF00069	0.710
MOD_CK1_1	67	73	PF00069	0.605
MOD_CK1_1	77	83	PF00069	0.617
MOD_CK2_1	217	223	PF00069	0.761
MOD_CK2_1	243	249	PF00069	0.408
MOD_Cter_Amidation	337	340	PF01082	0.689
MOD_Cter_Amidation	344	347	PF01082	0.643
MOD_GlcNHglycan	11	14	PF01048	0.667
MOD_GlcNHglycan	202	205	PF01048	0.445
MOD_GlcNHglycan	245	248	PF01048	0.399
MOD_GlcNHglycan	46	49	PF01048	0.590
MOD_GSK3_1	102	109	PF00069	0.671
MOD_GSK3_1	211	218	PF00069	0.681
MOD_GSK3_1	274	281	PF00069	0.488
MOD_GSK3_1	292	299	PF00069	0.336
MOD_GSK3_1	37	44	PF00069	0.687
MOD_GSK3_1	5	12	PF00069	0.686
MOD_GSK3_1	60	67	PF00069	0.593
MOD_GSK3_1	68	75	PF00069	0.520
MOD_N-GLC_1	67	72	PF02516	0.695
MOD_NEK2_1	124	129	PF00069	0.666
MOD_NEK2_1	14	19	PF00069	0.520
MOD_NEK2_1	64	69	PF00069	0.569
MOD_NEK2_1	74	79	PF00069	0.661
MOD_PIKK_1	72	78	PF00454	0.591
MOD_PKA_1	292	298	PF00069	0.371
MOD_PKA_2	124	130	PF00069	0.574
MOD_PKA_2	159	165	PF00069	0.478
MOD_PKA_2	296	302	PF00069	0.439
MOD_PKA_2	327	333	PF00069	0.570
MOD_Plk_1	153	159	PF00069	0.476
MOD_Plk_1	162	168	PF00069	0.441
MOD_Plk_1	307	313	PF00069	0.402
MOD_Plk_1	32	38	PF00069	0.603
MOD_Plk_4	162	168	PF00069	0.482
MOD_Plk_4	170	176	PF00069	0.544
MOD_Plk_4	37	43	PF00069	0.650
MOD_Plk_4	60	66	PF00069	0.578
MOD_ProDKin_1	100	106	PF00069	0.648
MOD_ProDKin_1	215	221	PF00069	0.736
MOD_ProDKin_1	227	233	PF00069	0.756
MOD_ProDKin_1	41	47	PF00069	0.672
MOD_ProDKin_1	48	54	PF00069	0.671
MOD_ProDKin_1	68	74	PF00069	0.410
MOD_ProDKin_1	92	98	PF00069	0.625
MOD_SUMO_for_1	206	209	PF00179	0.609
TRG_DiLeu_BaLyEn_6	234	239	PF01217	0.442
TRG_ENDOCYTIC_2	172	175	PF00928	0.541
TRG_ENDOCYTIC_2	303	306	PF00928	0.286
TRG_ENDOCYTIC_2	66	69	PF00928	0.646
TRG_ER_diArg_1	337	340	PF00400	0.567
TRG_ER_diArg_1	87	89	PF00400	0.669
TRG_Pf-PMV_PEXEL_1	89	94	PF00026	0.670

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYT9	Leptomonas seymouri	61%	95%
A0A0S4JEW1	Bodo saltans	29%	100%
A0A1X0NQL8	Trypanosomatidae	30%	91%
A0A3Q8IC14	Leishmania donovani	100%	100%
A0A3Q8IJZ1	Leishmania donovani	25%	100%
A0A3Q8ILM8	Leishmania donovani	31%	100%
A0A3R7KIC4	Trypanosoma rangeli	31%	92%
A4IC69	Leishmania infantum	25%	100%
E9AI38	Leishmania braziliensis	83%	100%
E9AN18	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
E9AUD9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
Q4Q051	Leishmania major	32%	100%
Q4QHK8	Leishmania major	95%	100%
V5DA19	Trypanosoma cruzi	38%	92%