Dehydrogenase-like protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dehydrogenase-like protein

Species:

Leishmania infantum

UniProt:

A4HUB6_LEIIN

TriTrypDb:

LINF_100005800

Length:

412

Annotations

LeishMANIAdb annotations

Homologous to other Eukarytotic short-chain dehydrogenases.

Annotations by Jardim et al.

Oxidoreductase, Dehydrogenase-like

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A4HUB6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HUB6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	385	387	PF00675	0.504
CLV_NRD_NRD_1	41	43	PF00675	0.280
CLV_NRD_NRD_1	62	64	PF00675	0.510
CLV_NRD_NRD_1	85	87	PF00675	0.578
CLV_PCSK_FUR_1	383	387	PF00082	0.500
CLV_PCSK_KEX2_1	211	213	PF00082	0.509
CLV_PCSK_KEX2_1	385	387	PF00082	0.504
CLV_PCSK_KEX2_1	41	43	PF00082	0.280
CLV_PCSK_KEX2_1	62	64	PF00082	0.510
CLV_PCSK_PC1ET2_1	211	213	PF00082	0.476
CLV_PCSK_SKI1_1	262	266	PF00082	0.627
CLV_PCSK_SKI1_1	287	291	PF00082	0.443
CLV_PCSK_SKI1_1	329	333	PF00082	0.598
CLV_PCSK_SKI1_1	385	389	PF00082	0.502
CLV_PCSK_SKI1_1	93	97	PF00082	0.545
DEG_Nend_Nbox_1	1	3	PF02207	0.394
DOC_CYCLIN_RxL_1	281	294	PF00134	0.265
DOC_CYCLIN_yCln2_LP_2	141	147	PF00134	0.280
DOC_CYCLIN_yCln2_LP_2	201	207	PF00134	0.316
DOC_CYCLIN_yCln2_LP_2	370	376	PF00134	0.330
DOC_MAPK_FxFP_2	336	339	PF00069	0.365
DOC_MAPK_gen_1	208	218	PF00069	0.305
DOC_MAPK_gen_1	41	49	PF00069	0.509
DOC_MAPK_gen_1	62	70	PF00069	0.311
DOC_MAPK_MEF2A_6	134	141	PF00069	0.276
DOC_MAPK_MEF2A_6	211	220	PF00069	0.276
DOC_MAPK_MEF2A_6	63	72	PF00069	0.320
DOC_PP1_RVXF_1	162	168	PF00149	0.259
DOC_PP2B_PxIxI_1	189	195	PF00149	0.268
DOC_PP4_FxxP_1	336	339	PF00568	0.323
DOC_USP7_MATH_1	102	106	PF00917	0.359
DOC_USP7_MATH_1	158	162	PF00917	0.249
DOC_USP7_MATH_1	77	81	PF00917	0.437
DOC_USP7_MATH_1	94	98	PF00917	0.229
DOC_USP7_UBL2_3	398	402	PF12436	0.373
DOC_WW_Pin1_4	186	191	PF00397	0.261
DOC_WW_Pin1_4	200	205	PF00397	0.194
DOC_WW_Pin1_4	273	278	PF00397	0.380
DOC_WW_Pin1_4	369	374	PF00397	0.291
DOC_WW_Pin1_4	78	83	PF00397	0.424
DOC_WW_Pin1_4	96	101	PF00397	0.352
LIG_14-3-3_CanoR_1	20	29	PF00244	0.303
LIG_14-3-3_CanoR_1	71	76	PF00244	0.426
LIG_14-3-3_CanoR_1	86	95	PF00244	0.351
LIG_Actin_WH2_2	121	136	PF00022	0.280
LIG_Actin_WH2_2	319	335	PF00022	0.363
LIG_Actin_WH2_2	6	22	PF00022	0.276
LIG_BRCT_BRCA1_1	218	222	PF00533	0.280
LIG_BRCT_BRCA1_1	356	360	PF00533	0.305
LIG_Clathr_ClatBox_1	250	254	PF01394	0.303
LIG_eIF4E_1	283	289	PF01652	0.255
LIG_FHA_1	187	193	PF00498	0.289
LIG_FHA_1	227	233	PF00498	0.243
LIG_FHA_1	292	298	PF00498	0.245
LIG_FHA_1	304	310	PF00498	0.268
LIG_FHA_1	398	404	PF00498	0.343
LIG_FHA_2	116	122	PF00498	0.276
LIG_FHA_2	13	19	PF00498	0.328
LIG_FHA_2	261	267	PF00498	0.357
LIG_HP1_1	113	117	PF01393	0.210
LIG_LIR_Apic_2	334	339	PF02991	0.332
LIG_LIR_Gen_1	366	375	PF02991	0.303
LIG_LIR_Nem_3	366	370	PF02991	0.354
LIG_NRBOX	284	290	PF00104	0.291
LIG_PCNA_yPIPBox_3	282	295	PF02747	0.292
LIG_PCNA_yPIPBox_3	381	390	PF02747	0.303
LIG_Pex14_2	323	327	PF04695	0.420
LIG_REV1ctd_RIR_1	56	67	PF16727	0.439
LIG_SH2_CRK	348	352	PF00017	0.297
LIG_SH2_CRK	367	371	PF00017	0.330
LIG_SH2_STAP1	214	218	PF00017	0.280
LIG_SH2_STAP1	293	297	PF00017	0.245
LIG_SH2_STAP1	361	365	PF00017	0.367
LIG_SH2_STAT5	293	296	PF00017	0.284
LIG_SH2_STAT5	348	351	PF00017	0.297
LIG_SH2_STAT5	391	394	PF00017	0.306
LIG_SH2_STAT5	53	56	PF00017	0.328
LIG_SH2_STAT5	8	11	PF00017	0.400
LIG_SH3_3	254	260	PF00018	0.320
LIG_SH3_3	271	277	PF00018	0.397
LIG_SH3_3	32	38	PF00018	0.289
LIG_SH3_4	398	405	PF00018	0.364
LIG_SUMO_SIM_anti_2	135	141	PF11976	0.284
LIG_SUMO_SIM_anti_2	263	269	PF11976	0.290
LIG_SUMO_SIM_anti_2	286	292	PF11976	0.243
LIG_SUMO_SIM_par_1	112	118	PF11976	0.235
LIG_SUMO_SIM_par_1	372	378	PF11976	0.332
LIG_TYR_ITIM	346	351	PF00017	0.354
LIG_TYR_ITIM	389	394	PF00017	0.379
MOD_CDK_SPK_2	186	191	PF00069	0.316
MOD_CK1_1	239	245	PF00069	0.328
MOD_CK1_1	369	375	PF00069	0.386
MOD_CK1_1	397	403	PF00069	0.448
MOD_CK2_1	115	121	PF00069	0.328
MOD_CK2_1	12	18	PF00069	0.328
MOD_CK2_1	77	83	PF00069	0.629
MOD_GlcNHglycan	104	107	PF01048	0.402
MOD_GlcNHglycan	238	241	PF01048	0.339
MOD_GlcNHglycan	356	359	PF01048	0.409
MOD_GlcNHglycan	65	68	PF01048	0.392
MOD_GlcNHglycan	88	91	PF01048	0.547
MOD_GSK3_1	273	280	PF00069	0.450
MOD_N-GLC_1	281	286	PF02516	0.387
MOD_NEK2_1	331	336	PF00069	0.502
MOD_NEK2_1	394	399	PF00069	0.568
MOD_NEK2_1	85	90	PF00069	0.458
MOD_PKA_1	86	92	PF00069	0.440
MOD_PKA_2	301	307	PF00069	0.429
MOD_PKA_2	85	91	PF00069	0.432
MOD_Plk_1	174	180	PF00069	0.238
MOD_Plk_1	281	287	PF00069	0.382
MOD_Plk_2-3	12	18	PF00069	0.213
MOD_Plk_4	246	252	PF00069	0.328
MOD_Plk_4	356	362	PF00069	0.307
MOD_Plk_4	366	372	PF00069	0.339
MOD_ProDKin_1	186	192	PF00069	0.306
MOD_ProDKin_1	200	206	PF00069	0.213
MOD_ProDKin_1	273	279	PF00069	0.468
MOD_ProDKin_1	369	375	PF00069	0.342
MOD_ProDKin_1	78	84	PF00069	0.525
MOD_ProDKin_1	96	102	PF00069	0.444
TRG_DiLeu_BaEn_1	366	371	PF01217	0.408
TRG_ENDOCYTIC_2	214	217	PF00928	0.333
TRG_ENDOCYTIC_2	348	351	PF00928	0.356
TRG_ENDOCYTIC_2	367	370	PF00928	0.409
TRG_ENDOCYTIC_2	391	394	PF00928	0.369
TRG_ER_diArg_1	383	386	PF00400	0.319
TRG_ER_diArg_1	62	64	PF00400	0.374
TRG_NES_CRM1_1	382	395	PF08389	0.377
TRG_Pf-PMV_PEXEL_1	122	126	PF00026	0.279

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A023I4F1	Penicillium roqueforti	25%	100%
A0A0N0P2P0	Leptomonas seymouri	66%	100%
A0A0N0P2S5	Leptomonas seymouri	29%	92%
A0A0N0P2S7	Leptomonas seymouri	26%	80%
A0A0S4IP03	Bodo saltans	27%	100%
A0A0S4IWT0	Bodo saltans	26%	88%
A0A0S4IZG2	Bodo saltans	27%	91%
A0A0S4J1I6	Bodo saltans	24%	94%
A0A0S4JBQ4	Bodo saltans	37%	100%
A0A0U5CNP2	Aspergillus calidoustus	26%	100%
A0A1J0HSL5	Pestalotiopsis fici (strain W106-1 / CGMCC3.15140)	25%	100%
A0A1X0NVT8	Trypanosomatidae	29%	83%
A0A1X0P5Q9	Trypanosomatidae	28%	90%
A0A1X0P5W3	Trypanosomatidae	27%	92%
A0A3Q8ID46	Leishmania donovani	27%	81%
A0A3Q8IM89	Leishmania donovani	25%	94%
A0A3R7K8J6	Trypanosoma rangeli	27%	94%
A0A3R7N7S2	Trypanosoma rangeli	30%	96%
A0A3S7WQY1	Leishmania donovani	100%	100%
A0A422N2B6	Trypanosoma rangeli	27%	86%
A0A7L8UXK7	Aspergillus flavipes	24%	100%
A2RVM0	Arabidopsis thaliana	28%	100%
A4H5Z1	Leishmania braziliensis	81%	100%
A4HMN7	Leishmania braziliensis	25%	100%
B2X050	Capsicum annuum	25%	100%
C8VI80	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	28%	100%
C9ZWC0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	87%
C9ZZF1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	97%
C9ZZF3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	89%
E9AF39	Leishmania major	25%	100%
E9AH89	Leishmania infantum	27%	81%
E9AHV6	Leishmania infantum	25%	94%
E9AN15	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
E9AX27	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	81%
O74959	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	100%
P59837	Bos taurus	34%	100%
Q08651	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	100%
Q0V6Q2	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	24%	100%
Q17QU7	Bos taurus	33%	100%
Q17QW3	Bos taurus	33%	100%
Q4QAE9	Leishmania major	27%	81%
Q4QHL1	Leishmania major	93%	100%
Q5F389	Gallus gallus	25%	100%
Q5SS80	Mus musculus	33%	100%
Q6RVV4	Pisum sativum	28%	100%
Q6UX07	Homo sapiens	32%	100%
Q803A8	Danio rerio	30%	100%
Q8BYK4	Mus musculus	34%	100%
Q8CEE7	Mus musculus	31%	100%
Q8N5I4	Homo sapiens	32%	100%
Q8NBN7	Homo sapiens	31%	100%
Q8VBZ0	Mus musculus	32%	100%
Q91WL8	Mus musculus	27%	100%
Q96NR8	Homo sapiens	34%	100%
Q9ERI6	Mus musculus	33%	100%
Q9HBH5	Homo sapiens	33%	100%
V5BAF4	Trypanosoma cruzi	28%	87%
V5BJC7	Trypanosoma cruzi	26%	93%
V5BNY6	Trypanosoma cruzi	32%	96%
W6QB10	Penicillium roqueforti (strain FM164)	25%	100%