Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HUB5_LEIIN

TriTrypDb:

LINF_100005700

Length:

343

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HUB5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HUB5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	312	316	PF00656	0.584
CLV_NRD_NRD_1	137	139	PF00675	0.629
CLV_NRD_NRD_1	142	144	PF00675	0.521
CLV_NRD_NRD_1	219	221	PF00675	0.516
CLV_PCSK_KEX2_1	137	139	PF00082	0.629
CLV_PCSK_KEX2_1	142	144	PF00082	0.521
CLV_PCSK_KEX2_1	219	221	PF00082	0.516
CLV_PCSK_PC7_1	138	144	PF00082	0.504
CLV_PCSK_SKI1_1	241	245	PF00082	0.574
CLV_PCSK_SKI1_1	63	67	PF00082	0.489
DEG_APCC_DBOX_1	60	68	PF00400	0.603
DEG_Nend_Nbox_1	1	3	PF02207	0.654
DEG_SPOP_SBC_1	328	332	PF00917	0.454
DOC_CYCLIN_yClb5_NLxxxL_5	187	196	PF00134	0.518
DOC_CYCLIN_yCln2_LP_2	192	198	PF00134	0.472
DOC_MAPK_gen_1	219	229	PF00069	0.605
DOC_MAPK_gen_1	61	69	PF00069	0.597
DOC_USP7_MATH_1	71	75	PF00917	0.510
DOC_WW_Pin1_4	36	41	PF00397	0.681
LIG_14-3-3_CanoR_1	118	124	PF00244	0.591
LIG_14-3-3_CanoR_1	142	150	PF00244	0.465
LIG_14-3-3_CanoR_1	171	175	PF00244	0.522
LIG_14-3-3_CanoR_1	220	229	PF00244	0.604
LIG_14-3-3_CanoR_1	241	247	PF00244	0.565
LIG_14-3-3_CanoR_1	282	286	PF00244	0.562
LIG_14-3-3_CanoR_1	327	337	PF00244	0.465
LIG_14-3-3_CanoR_1	63	68	PF00244	0.493
LIG_14-3-3_CanoR_1	72	79	PF00244	0.523
LIG_BRCT_BRCA1_1	74	78	PF00533	0.613
LIG_Clathr_ClatBox_1	64	68	PF01394	0.486
LIG_FHA_1	15	21	PF00498	0.644
LIG_FHA_1	177	183	PF00498	0.516
LIG_FHA_1	203	209	PF00498	0.448
LIG_FHA_1	64	70	PF00498	0.434
LIG_FHA_2	158	164	PF00498	0.541
LIG_FHA_2	243	249	PF00498	0.564
LIG_FHA_2	310	316	PF00498	0.594
LIG_LIR_Apic_2	19	25	PF02991	0.499
LIG_LIR_Gen_1	269	279	PF02991	0.481
LIG_LIR_Gen_1	292	303	PF02991	0.577
LIG_LIR_Gen_1	75	82	PF02991	0.506
LIG_LIR_Nem_3	269	275	PF02991	0.482
LIG_LIR_Nem_3	292	298	PF02991	0.563
LIG_LIR_Nem_3	75	81	PF02991	0.508
LIG_LIR_Nem_3	9	15	PF02991	0.578
LIG_PDZ_Class_1	338	343	PF00595	0.487
LIG_RPA_C_Fungi	215	227	PF08784	0.493
LIG_SH2_CRK	12	16	PF00017	0.575
LIG_SH2_CRK	22	26	PF00017	0.484
LIG_SH2_NCK_1	172	176	PF00017	0.461
LIG_SH2_STAP1	135	139	PF00017	0.524
LIG_SH2_STAP1	250	254	PF00017	0.557
LIG_SH2_STAP1	338	342	PF00017	0.467
LIG_SH2_STAT5	124	127	PF00017	0.500
LIG_SH2_STAT5	250	253	PF00017	0.459
LIG_SH2_STAT5	272	275	PF00017	0.471
LIG_SH2_STAT5	97	100	PF00017	0.596
LIG_SH3_3	257	263	PF00018	0.602
LIG_SUMO_SIM_par_1	197	205	PF11976	0.444
LIG_SUMO_SIM_par_1	87	92	PF11976	0.499
LIG_WRC_WIRS_1	243	248	PF05994	0.557
LIG_WRC_WIRS_1	50	55	PF05994	0.649
MOD_CK1_1	145	151	PF00069	0.458
MOD_CK1_1	173	179	PF00069	0.600
MOD_CK1_1	183	189	PF00069	0.441
MOD_CK1_1	202	208	PF00069	0.562
MOD_CK1_1	289	295	PF00069	0.552
MOD_CK1_1	309	315	PF00069	0.276
MOD_CK1_1	331	337	PF00069	0.466
MOD_CK1_1	36	42	PF00069	0.607
MOD_CK1_1	74	80	PF00069	0.601
MOD_CK2_1	242	248	PF00069	0.560
MOD_CK2_1	96	102	PF00069	0.588
MOD_GlcNHglycan	107	110	PF01048	0.417
MOD_GlcNHglycan	113	116	PF01048	0.472
MOD_GlcNHglycan	144	147	PF01048	0.417
MOD_GlcNHglycan	188	191	PF01048	0.507
MOD_GlcNHglycan	259	263	PF01048	0.596
MOD_GlcNHglycan	268	271	PF01048	0.502
MOD_GlcNHglycan	308	311	PF01048	0.511
MOD_GlcNHglycan	320	323	PF01048	0.574
MOD_GlcNHglycan	333	336	PF01048	0.451
MOD_GlcNHglycan	68	72	PF01048	0.538
MOD_GSK3_1	105	112	PF00069	0.439
MOD_GSK3_1	145	152	PF00069	0.436
MOD_GSK3_1	176	183	PF00069	0.513
MOD_GSK3_1	274	281	PF00069	0.531
MOD_GSK3_1	29	36	PF00069	0.564
MOD_GSK3_1	298	305	PF00069	0.530
MOD_GSK3_1	327	334	PF00069	0.464
MOD_GSK3_1	63	70	PF00069	0.494
MOD_GSK3_1	96	103	PF00069	0.504
MOD_LATS_1	140	146	PF00433	0.486
MOD_NEK2_1	149	154	PF00069	0.555
MOD_NEK2_1	298	303	PF00069	0.592
MOD_NEK2_1	67	72	PF00069	0.508
MOD_NEK2_1	8	13	PF00069	0.570
MOD_NEK2_1	81	86	PF00069	0.546
MOD_NEK2_2	119	124	PF00069	0.479
MOD_PK_1	72	78	PF00069	0.623
MOD_PKA_1	142	148	PF00069	0.470
MOD_PKA_2	117	123	PF00069	0.594
MOD_PKA_2	142	148	PF00069	0.502
MOD_PKA_2	170	176	PF00069	0.492
MOD_PKA_2	221	227	PF00069	0.604
MOD_PKA_2	281	287	PF00069	0.563
MOD_PKA_2	29	35	PF00069	0.490
MOD_PKA_2	71	77	PF00069	0.633
MOD_PKB_1	61	69	PF00069	0.495
MOD_Plk_1	183	189	PF00069	0.607
MOD_Plk_1	202	208	PF00069	0.562
MOD_Plk_1	248	254	PF00069	0.571
MOD_Plk_4	119	125	PF00069	0.483
MOD_Plk_4	145	151	PF00069	0.458
MOD_Plk_4	183	189	PF00069	0.607
MOD_Plk_4	268	274	PF00069	0.494
MOD_Plk_4	281	287	PF00069	0.461
MOD_Plk_4	309	315	PF00069	0.526
MOD_ProDKin_1	36	42	PF00069	0.669
MOD_SUMO_for_1	275	278	PF00179	0.493
TRG_DiLeu_BaEn_1	203	208	PF01217	0.519
TRG_DiLeu_BaLyEn_6	60	65	PF01217	0.507
TRG_ENDOCYTIC_2	12	15	PF00928	0.581
TRG_ENDOCYTIC_2	272	275	PF00928	0.471
TRG_ER_diArg_1	141	143	PF00400	0.535
TRG_ER_diArg_1	219	222	PF00400	0.629
TRG_ER_diArg_1	61	64	PF00400	0.507
TRG_Pf-PMV_PEXEL_1	63	68	PF00026	0.493

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ49	Leptomonas seymouri	47%	100%
A0A3S7WQY3	Leishmania donovani	99%	100%
A4H5Z0	Leishmania braziliensis	83%	100%
E9AN14	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4QHL2	Leishmania major	93%	100%