LeishMANIAdb
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MMS19 nucleotide excision repair protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
MMS19 nucleotide excision repair protein
Gene product:
Dos2-interacting transcription regulator of RNA-Pol-II - putative
Species:
Leishmania infantum
UniProt:
A4HUB2_LEIIN
TriTrypDb:
LINF_100005400
Length:
919

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 8
GO:0032991 protein-containing complex 1 8
GO:0043226 organelle 2 8
GO:0043227 membrane-bounded organelle 3 8
GO:0043229 intracellular organelle 3 8
GO:0043231 intracellular membrane-bounded organelle 4 8
GO:0097361 CIA complex 3 8
GO:0110165 cellular anatomical entity 1 8
GO:0140535 intracellular protein-containing complex 2 8

Expansion

Sequence features

A4HUB2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HUB2

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 8
GO:0006259 DNA metabolic process 4 8
GO:0006281 DNA repair 5 8
GO:0006725 cellular aromatic compound metabolic process 3 8
GO:0006790 sulfur compound metabolic process 3 8
GO:0006807 nitrogen compound metabolic process 2 8
GO:0006950 response to stress 2 8
GO:0006974 DNA damage response 4 8
GO:0008152 metabolic process 1 8
GO:0009987 cellular process 1 8
GO:0016043 cellular component organization 3 8
GO:0016226 iron-sulfur cluster assembly 4 8
GO:0019538 protein metabolic process 3 8
GO:0022607 cellular component assembly 4 8
GO:0031163 metallo-sulfur cluster assembly 5 8
GO:0033554 cellular response to stress 3 8
GO:0034641 cellular nitrogen compound metabolic process 3 8
GO:0043170 macromolecule metabolic process 3 8
GO:0044237 cellular metabolic process 2 8
GO:0044238 primary metabolic process 2 8
GO:0044260 obsolete cellular macromolecule metabolic process 3 8
GO:0046483 heterocycle metabolic process 3 8
GO:0050896 response to stimulus 1 8
GO:0051604 protein maturation 4 8
GO:0051716 cellular response to stimulus 2 8
GO:0071704 organic substance metabolic process 2 8
GO:0071840 cellular component organization or biogenesis 2 8
GO:0090304 nucleic acid metabolic process 4 8
GO:0097428 protein maturation by iron-sulfur cluster transfer 5 8
GO:1901360 organic cyclic compound metabolic process 3 8
GO:1901564 organonitrogen compound metabolic process 3 8
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 125 129 PF00656 0.356
CLV_C14_Caspase3-7 372 376 PF00656 0.577
CLV_C14_Caspase3-7 450 454 PF00656 0.560
CLV_C14_Caspase3-7 691 695 PF00656 0.695
CLV_C14_Caspase3-7 801 805 PF00656 0.705
CLV_MEL_PAP_1 279 285 PF00089 0.629
CLV_MEL_PAP_1 668 674 PF00089 0.428
CLV_NRD_NRD_1 645 647 PF00675 0.412
CLV_NRD_NRD_1 795 797 PF00675 0.457
CLV_NRD_NRD_1 902 904 PF00675 0.424
CLV_NRD_NRD_1 95 97 PF00675 0.519
CLV_PCSK_KEX2_1 192 194 PF00082 0.524
CLV_PCSK_KEX2_1 645 647 PF00082 0.412
CLV_PCSK_KEX2_1 894 896 PF00082 0.406
CLV_PCSK_KEX2_1 901 903 PF00082 0.419
CLV_PCSK_PC1ET2_1 192 194 PF00082 0.556
CLV_PCSK_PC1ET2_1 894 896 PF00082 0.406
CLV_PCSK_PC1ET2_1 901 903 PF00082 0.419
CLV_PCSK_PC7_1 188 194 PF00082 0.524
CLV_PCSK_SKI1_1 152 156 PF00082 0.607
CLV_PCSK_SKI1_1 271 275 PF00082 0.622
CLV_PCSK_SKI1_1 34 38 PF00082 0.556
CLV_PCSK_SKI1_1 796 800 PF00082 0.463
CLV_PCSK_SKI1_1 811 815 PF00082 0.271
CLV_PCSK_SKI1_1 829 833 PF00082 0.267
CLV_PCSK_SKI1_1 865 869 PF00082 0.455
DEG_APCC_DBOX_1 615 623 PF00400 0.630
DEG_APCC_DBOX_1 745 753 PF00400 0.553
DEG_APCC_DBOX_1 810 818 PF00400 0.579
DEG_APCC_DBOX_1 864 872 PF00400 0.606
DEG_Nend_UBRbox_1 1 4 PF02207 0.463
DEG_SCF_FBW7_2 77 84 PF00400 0.324
DOC_CDC14_PxL_1 733 741 PF14671 0.647
DOC_CKS1_1 5 10 PF01111 0.503
DOC_CKS1_1 78 83 PF01111 0.351
DOC_CYCLIN_RxL_1 241 252 PF00134 0.310
DOC_CYCLIN_RxL_1 268 278 PF00134 0.441
DOC_CYCLIN_RxL_1 807 818 PF00134 0.588
DOC_CYCLIN_RxL_1 852 862 PF00134 0.641
DOC_MAPK_gen_1 192 199 PF00069 0.349
DOC_MAPK_gen_1 671 681 PF00069 0.566
DOC_MAPK_gen_1 884 892 PF00069 0.605
DOC_MAPK_JIP1_4 746 752 PF00069 0.607
DOC_MAPK_MEF2A_6 192 199 PF00069 0.354
DOC_MAPK_MEF2A_6 220 228 PF00069 0.332
DOC_MAPK_MEF2A_6 30 37 PF00069 0.407
DOC_MAPK_MEF2A_6 674 683 PF00069 0.618
DOC_MAPK_MEF2A_6 746 754 PF00069 0.571
DOC_MAPK_MEF2A_6 884 892 PF00069 0.526
DOC_MAPK_NFAT4_5 192 200 PF00069 0.356
DOC_MAPK_NFAT4_5 30 38 PF00069 0.351
DOC_PP1_RVXF_1 32 38 PF00149 0.407
DOC_PP1_RVXF_1 809 816 PF00149 0.569
DOC_PP1_RVXF_1 827 834 PF00149 0.627
DOC_PP2B_LxvP_1 203 206 PF13499 0.407
DOC_PP4_FxxP_1 174 177 PF00568 0.317
DOC_USP7_MATH_1 147 151 PF00917 0.407
DOC_USP7_MATH_1 215 219 PF00917 0.392
DOC_USP7_MATH_1 315 319 PF00917 0.372
DOC_USP7_MATH_1 365 369 PF00917 0.621
DOC_USP7_MATH_1 446 450 PF00917 0.647
DOC_USP7_MATH_1 464 468 PF00917 0.446
DOC_USP7_MATH_1 511 515 PF00917 0.587
DOC_USP7_MATH_1 53 57 PF00917 0.314
DOC_USP7_MATH_1 611 615 PF00917 0.596
DOC_USP7_MATH_1 767 771 PF00917 0.595
DOC_USP7_MATH_1 92 96 PF00917 0.400
DOC_USP7_MATH_2 703 709 PF00917 0.596
DOC_WW_Pin1_4 211 216 PF00397 0.317
DOC_WW_Pin1_4 391 396 PF00397 0.638
DOC_WW_Pin1_4 4 9 PF00397 0.513
DOC_WW_Pin1_4 572 577 PF00397 0.538
DOC_WW_Pin1_4 77 82 PF00397 0.351
LIG_14-3-3_CanoR_1 16 22 PF00244 0.300
LIG_14-3-3_CanoR_1 853 858 PF00244 0.568
LIG_14-3-3_CanoR_1 905 910 PF00244 0.596
LIG_AP2alpha_1 522 526 PF02296 0.624
LIG_APCC_ABBA_1 197 202 PF00400 0.407
LIG_APCC_ABBA_1 519 524 PF00400 0.648
LIG_APCC_ABBAyCdc20_2 829 835 PF00400 0.650
LIG_BIR_III_2 375 379 PF00653 0.600
LIG_BRCT_BRCA1_1 103 107 PF00533 0.407
LIG_BRCT_BRCA1_1 166 170 PF00533 0.317
LIG_BRCT_BRCA1_1 339 343 PF00533 0.501
LIG_BRCT_BRCA1_1 574 578 PF00533 0.516
LIG_BRCT_BRCA1_1 829 833 PF00533 0.608
LIG_Clathr_ClatBox_1 137 141 PF01394 0.337
LIG_Clathr_ClatBox_1 814 818 PF01394 0.571
LIG_CSL_BTD_1 441 444 PF09270 0.610
LIG_eIF4E_1 234 240 PF01652 0.351
LIG_FHA_1 109 115 PF00498 0.356
LIG_FHA_1 137 143 PF00498 0.337
LIG_FHA_1 268 274 PF00498 0.450
LIG_FHA_1 320 326 PF00498 0.433
LIG_FHA_1 392 398 PF00498 0.623
LIG_FHA_1 461 467 PF00498 0.661
LIG_FHA_1 49 55 PF00498 0.349
LIG_FHA_1 564 570 PF00498 0.632
LIG_FHA_1 651 657 PF00498 0.594
LIG_FHA_1 663 669 PF00498 0.675
LIG_FHA_1 81 87 PF00498 0.407
LIG_FHA_2 120 126 PF00498 0.226
LIG_FHA_2 155 161 PF00498 0.380
LIG_FHA_2 181 187 PF00498 0.317
LIG_FHA_2 227 233 PF00498 0.349
LIG_FHA_2 289 295 PF00498 0.438
LIG_FHA_2 379 385 PF00498 0.622
LIG_FHA_2 386 392 PF00498 0.603
LIG_FHA_2 413 419 PF00498 0.606
LIG_FHA_2 445 451 PF00498 0.499
LIG_FHA_2 527 533 PF00498 0.619
LIG_FHA_2 635 641 PF00498 0.622
LIG_GBD_Chelix_1 338 346 PF00786 0.424
LIG_IRF3_LxIS_1 57 62 PF10401 0.348
LIG_LIR_Gen_1 153 163 PF02991 0.342
LIG_LIR_Gen_1 340 350 PF02991 0.509
LIG_LIR_Gen_1 418 428 PF02991 0.582
LIG_LIR_Gen_1 476 485 PF02991 0.648
LIG_LIR_Gen_1 709 718 PF02991 0.667
LIG_LIR_Gen_1 731 740 PF02991 0.589
LIG_LIR_Gen_1 83 93 PF02991 0.379
LIG_LIR_Nem_3 153 158 PF02991 0.329
LIG_LIR_Nem_3 160 166 PF02991 0.303
LIG_LIR_Nem_3 167 173 PF02991 0.289
LIG_LIR_Nem_3 229 234 PF02991 0.356
LIG_LIR_Nem_3 297 302 PF02991 0.377
LIG_LIR_Nem_3 340 346 PF02991 0.492
LIG_LIR_Nem_3 476 480 PF02991 0.651
LIG_LIR_Nem_3 709 715 PF02991 0.621
LIG_LIR_Nem_3 71 77 PF02991 0.318
LIG_LIR_Nem_3 731 736 PF02991 0.583
LIG_LIR_Nem_3 80 85 PF02991 0.316
LIG_LIR_Nem_3 914 918 PF02991 0.598
LIG_MLH1_MIPbox_1 166 170 PF16413 0.317
LIG_NRBOX 119 125 PF00104 0.317
LIG_NRBOX 223 229 PF00104 0.407
LIG_NRBOX 488 494 PF00104 0.603
LIG_NRBOX 514 520 PF00104 0.640
LIG_NRBOX 748 754 PF00104 0.601
LIG_NRBOX 787 793 PF00104 0.650
LIG_PCNA_yPIPBox_3 778 792 PF02747 0.632
LIG_Pex14_2 170 174 PF04695 0.317
LIG_Pex14_2 522 526 PF04695 0.652
LIG_PTAP_UEV_1 495 500 PF05743 0.617
LIG_PTB_Apo_2 655 662 PF02174 0.606
LIG_REV1ctd_RIR_1 37 47 PF16727 0.317
LIG_SH2_NCK_1 477 481 PF00017 0.649
LIG_SH2_PTP2 85 88 PF00017 0.351
LIG_SH2_STAT3 234 237 PF00017 0.407
LIG_SH2_STAT5 162 165 PF00017 0.351
LIG_SH2_STAT5 169 172 PF00017 0.356
LIG_SH2_STAT5 341 344 PF00017 0.376
LIG_SH2_STAT5 63 66 PF00017 0.254
LIG_SH2_STAT5 735 738 PF00017 0.587
LIG_SH2_STAT5 85 88 PF00017 0.351
LIG_SH3_3 438 444 PF00018 0.603
LIG_SH3_3 493 499 PF00018 0.650
LIG_SH3_3 75 81 PF00018 0.356
LIG_SUMO_SIM_anti_2 122 128 PF11976 0.307
LIG_SUMO_SIM_anti_2 134 139 PF11976 0.371
LIG_SUMO_SIM_anti_2 221 229 PF11976 0.358
LIG_SUMO_SIM_anti_2 55 62 PF11976 0.310
LIG_SUMO_SIM_anti_2 887 893 PF11976 0.589
LIG_SUMO_SIM_par_1 122 128 PF11976 0.344
LIG_SUMO_SIM_par_1 134 139 PF11976 0.356
LIG_SUMO_SIM_par_1 887 893 PF11976 0.598
LIG_TRAF2_1 45 48 PF00917 0.400
LIG_TRAF2_1 728 731 PF00917 0.653
LIG_TRAF2_1 875 878 PF00917 0.637
LIG_TYR_ITSM 81 88 PF00017 0.351
LIG_UBA3_1 102 110 PF00899 0.345
LIG_UBA3_1 791 797 PF00899 0.591
LIG_UBA3_1 888 894 PF00899 0.541
LIG_WRC_WIRS_1 102 107 PF05994 0.356
LIG_WRC_WIRS_1 137 142 PF05994 0.337
LIG_WRC_WIRS_1 257 262 PF05994 0.428
LIG_WRC_WIRS_1 707 712 PF05994 0.665
MOD_CDK_SPxK_1 4 10 PF00069 0.509
MOD_CK1_1 165 171 PF00069 0.317
MOD_CK1_1 210 216 PF00069 0.314
MOD_CK1_1 265 271 PF00069 0.425
MOD_CK1_1 288 294 PF00069 0.415
MOD_CK1_1 587 593 PF00069 0.653
MOD_CK1_1 614 620 PF00069 0.622
MOD_CK1_1 756 762 PF00069 0.668
MOD_CK2_1 119 125 PF00069 0.307
MOD_CK2_1 128 134 PF00069 0.326
MOD_CK2_1 147 153 PF00069 0.317
MOD_CK2_1 215 221 PF00069 0.355
MOD_CK2_1 288 294 PF00069 0.410
MOD_CK2_1 378 384 PF00069 0.631
MOD_CK2_1 385 391 PF00069 0.602
MOD_CK2_1 444 450 PF00069 0.507
MOD_CK2_1 526 532 PF00069 0.619
MOD_CK2_1 756 762 PF00069 0.706
MOD_CK2_1 872 878 PF00069 0.607
MOD_GlcNHglycan 287 290 PF01048 0.635
MOD_GlcNHglycan 310 313 PF01048 0.583
MOD_GlcNHglycan 317 320 PF01048 0.581
MOD_GlcNHglycan 367 370 PF01048 0.373
MOD_GlcNHglycan 435 438 PF01048 0.430
MOD_GlcNHglycan 465 469 PF01048 0.383
MOD_GlcNHglycan 496 499 PF01048 0.417
MOD_GlcNHglycan 589 592 PF01048 0.419
MOD_GlcNHglycan 613 616 PF01048 0.285
MOD_GlcNHglycan 719 722 PF01048 0.447
MOD_GlcNHglycan 769 772 PF01048 0.433
MOD_GlcNHglycan 800 803 PF01048 0.460
MOD_GSK3_1 101 108 PF00069 0.356
MOD_GSK3_1 182 189 PF00069 0.270
MOD_GSK3_1 207 214 PF00069 0.408
MOD_GSK3_1 226 233 PF00069 0.200
MOD_GSK3_1 281 288 PF00069 0.378
MOD_GSK3_1 315 322 PF00069 0.382
MOD_GSK3_1 337 344 PF00069 0.455
MOD_GSK3_1 386 393 PF00069 0.652
MOD_GSK3_1 460 467 PF00069 0.606
MOD_GSK3_1 48 55 PF00069 0.340
MOD_GSK3_1 842 849 PF00069 0.539
MOD_N-GLC_1 265 270 PF02516 0.618
MOD_N-GLC_1 587 592 PF02516 0.464
MOD_N-GLC_1 833 838 PF02516 0.452
MOD_N-GLC_1 872 877 PF02516 0.402
MOD_N-GLC_2 333 335 PF02516 0.410
MOD_NEK2_1 17 22 PF00069 0.319
MOD_NEK2_1 207 212 PF00069 0.346
MOD_NEK2_1 328 333 PF00069 0.413
MOD_NEK2_1 337 342 PF00069 0.445
MOD_NEK2_1 433 438 PF00069 0.586
MOD_NEK2_1 49 54 PF00069 0.394
MOD_NEK2_1 510 515 PF00069 0.547
MOD_NEK2_1 526 531 PF00069 0.584
MOD_NEK2_1 584 589 PF00069 0.591
MOD_NEK2_1 59 64 PF00069 0.275
MOD_NEK2_1 706 711 PF00069 0.608
MOD_NEK2_1 738 743 PF00069 0.619
MOD_NEK2_1 798 803 PF00069 0.588
MOD_NEK2_1 827 832 PF00069 0.602
MOD_NEK2_1 833 838 PF00069 0.604
MOD_NEK2_1 859 864 PF00069 0.572
MOD_NEK2_1 890 895 PF00069 0.612
MOD_NEK2_2 215 220 PF00069 0.368
MOD_NEK2_2 848 853 PF00069 0.658
MOD_OFUCOSY 272 277 PF10250 0.563
MOD_PIKK_1 172 178 PF00454 0.301
MOD_PIKK_1 233 239 PF00454 0.407
MOD_PIKK_1 288 294 PF00454 0.447
MOD_PIKK_1 402 408 PF00454 0.613
MOD_PIKK_1 662 668 PF00454 0.675
MOD_PIKK_1 738 744 PF00454 0.625
MOD_PIKK_1 872 878 PF00454 0.693
MOD_PK_1 905 911 PF00069 0.520
MOD_PKA_1 796 802 PF00069 0.676
MOD_PKA_2 148 154 PF00069 0.339
MOD_PKA_2 262 268 PF00069 0.425
MOD_PKA_2 281 287 PF00069 0.435
MOD_PKA_2 386 392 PF00069 0.691
MOD_PKA_2 563 569 PF00069 0.617
MOD_PKA_2 670 676 PF00069 0.656
MOD_PKA_2 745 751 PF00069 0.580
MOD_PKB_1 903 911 PF00069 0.678
MOD_Plk_1 108 114 PF00069 0.356
MOD_Plk_1 265 271 PF00069 0.417
MOD_Plk_1 412 418 PF00069 0.694
MOD_Plk_1 833 839 PF00069 0.607
MOD_Plk_1 846 852 PF00069 0.624
MOD_Plk_2-3 128 134 PF00069 0.317
MOD_Plk_2-3 777 783 PF00069 0.597
MOD_Plk_4 101 107 PF00069 0.342
MOD_Plk_4 119 125 PF00069 0.231
MOD_Plk_4 154 160 PF00069 0.344
MOD_Plk_4 165 171 PF00069 0.297
MOD_Plk_4 319 325 PF00069 0.342
MOD_Plk_4 337 343 PF00069 0.376
MOD_Plk_4 602 608 PF00069 0.595
MOD_Plk_4 706 712 PF00069 0.623
MOD_Plk_4 745 751 PF00069 0.662
MOD_ProDKin_1 211 217 PF00069 0.317
MOD_ProDKin_1 391 397 PF00069 0.632
MOD_ProDKin_1 4 10 PF00069 0.509
MOD_ProDKin_1 572 578 PF00069 0.532
MOD_ProDKin_1 77 83 PF00069 0.351
MOD_SUMO_for_1 250 253 PF00179 0.356
MOD_SUMO_rev_2 875 880 PF00179 0.637
TRG_DiLeu_BaEn_1 580 585 PF01217 0.631
TRG_DiLeu_BaEn_3 72 78 PF01217 0.337
TRG_DiLeu_BaEn_4 877 883 PF01217 0.621
TRG_DiLeu_BaLyEn_6 13 18 PF01217 0.331
TRG_DiLeu_BaLyEn_6 31 36 PF01217 0.403
TRG_DiLeu_BaLyEn_6 469 474 PF01217 0.586
TRG_DiLeu_BaLyEn_6 488 493 PF01217 0.596
TRG_ENDOCYTIC_2 169 172 PF00928 0.317
TRG_ENDOCYTIC_2 200 203 PF00928 0.407
TRG_ENDOCYTIC_2 320 323 PF00928 0.319
TRG_ENDOCYTIC_2 477 480 PF00928 0.649
TRG_ENDOCYTIC_2 712 715 PF00928 0.624
TRG_ENDOCYTIC_2 735 738 PF00928 0.585
TRG_ENDOCYTIC_2 85 88 PF00928 0.395
TRG_ER_diArg_1 644 646 PF00400 0.620
TRG_ER_diArg_1 852 855 PF00400 0.625
TRG_ER_diArg_1 902 905 PF00400 0.660
TRG_NLS_MonoExtC_3 900 905 PF00514 0.659
TRG_Pf-PMV_PEXEL_1 472 476 PF00026 0.397
TRG_Pf-PMV_PEXEL_1 555 559 PF00026 0.449
TRG_Pf-PMV_PEXEL_1 895 899 PF00026 0.395

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IGU9 Leptomonas seymouri 53% 95%
A0A1X0NRK4 Trypanosomatidae 26% 97%
A0A3S7WQY6 Leishmania donovani 99% 100%
A4H5Y7 Leishmania braziliensis 79% 100%
E9AN11 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%
Q4QHL5 Leishmania major 91% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS