Separase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Separase

Gene product:

Gryzun - putative trafficking through Golgi - putative

Species:

Leishmania infantum

UniProt:

A4HUB1_LEIIN

TriTrypDb:

LINF_100005300

Length:

937

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HUB1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HUB1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	13	17	PF00656	0.515
CLV_C14_Caspase3-7	20	24	PF00656	0.445
CLV_C14_Caspase3-7	304	308	PF00656	0.470
CLV_NRD_NRD_1	120	122	PF00675	0.353
CLV_NRD_NRD_1	206	208	PF00675	0.429
CLV_NRD_NRD_1	237	239	PF00675	0.532
CLV_NRD_NRD_1	73	75	PF00675	0.388
CLV_NRD_NRD_1	77	79	PF00675	0.562
CLV_NRD_NRD_1	883	885	PF00675	0.460
CLV_NRD_NRD_1	89	91	PF00675	0.443
CLV_PCSK_KEX2_1	73	75	PF00082	0.388
CLV_PCSK_KEX2_1	749	751	PF00082	0.398
CLV_PCSK_KEX2_1	794	796	PF00082	0.483
CLV_PCSK_KEX2_1	883	885	PF00082	0.418
CLV_PCSK_KEX2_1	89	91	PF00082	0.448
CLV_PCSK_PC1ET2_1	749	751	PF00082	0.398
CLV_PCSK_PC1ET2_1	794	796	PF00082	0.380
CLV_PCSK_PC7_1	745	751	PF00082	0.391
CLV_PCSK_PC7_1	790	796	PF00082	0.460
CLV_PCSK_SKI1_1	121	125	PF00082	0.412
CLV_PCSK_SKI1_1	269	273	PF00082	0.475
CLV_PCSK_SKI1_1	30	34	PF00082	0.449
CLV_PCSK_SKI1_1	457	461	PF00082	0.398
CLV_PCSK_SKI1_1	519	523	PF00082	0.536
CLV_PCSK_SKI1_1	528	532	PF00082	0.340
CLV_PCSK_SKI1_1	694	698	PF00082	0.493
CLV_PCSK_SKI1_1	750	754	PF00082	0.397
CLV_PCSK_SKI1_1	79	83	PF00082	0.559
CLV_PCSK_SKI1_1	805	809	PF00082	0.332
CLV_PCSK_SKI1_1	89	93	PF00082	0.405
CLV_PCSK_SKI1_1	897	901	PF00082	0.440
DEG_APCC_DBOX_1	527	535	PF00400	0.346
DEG_APCC_DBOX_1	88	96	PF00400	0.350
DEG_APCC_DBOX_1	896	904	PF00400	0.430
DEG_MDM2_SWIB_1	97	105	PF02201	0.294
DEG_Nend_UBRbox_1	1	4	PF02207	0.463
DEG_SCF_FBW7_1	840	847	PF00400	0.345
DEG_SPOP_SBC_1	285	289	PF00917	0.354
DEG_SPOP_SBC_1	682	686	PF00917	0.576
DOC_CKS1_1	841	846	PF01111	0.505
DOC_CKS1_1	899	904	PF01111	0.415
DOC_CYCLIN_yClb3_PxF_3	128	136	PF00134	0.368
DOC_CYCLIN_yCln2_LP_2	393	399	PF00134	0.460
DOC_MAPK_DCC_7	89	97	PF00069	0.341
DOC_MAPK_gen_1	238	244	PF00069	0.502
DOC_MAPK_gen_1	525	533	PF00069	0.538
DOC_MAPK_gen_1	89	97	PF00069	0.415
DOC_MAPK_MEF2A_6	347	354	PF00069	0.397
DOC_MAPK_MEF2A_6	89	97	PF00069	0.449
DOC_MAPK_NFAT4_5	347	355	PF00069	0.266
DOC_PP1_RVXF_1	582	589	PF00149	0.471
DOC_PP1_RVXF_1	803	809	PF00149	0.446
DOC_PP1_RVXF_1	96	102	PF00149	0.298
DOC_PP2B_LxvP_1	534	537	PF13499	0.407
DOC_PP2B_LxvP_1	908	911	PF13499	0.381
DOC_PP4_FxxP_1	631	634	PF00568	0.464
DOC_PP4_FxxP_1	704	707	PF00568	0.553
DOC_PP4_FxxP_1	807	810	PF00568	0.507
DOC_SPAK_OSR1_1	502	506	PF12202	0.461
DOC_SPAK_OSR1_1	912	916	PF12202	0.403
DOC_USP7_MATH_1	285	289	PF00917	0.422
DOC_USP7_MATH_1	334	338	PF00917	0.506
DOC_USP7_MATH_1	437	441	PF00917	0.301
DOC_USP7_MATH_1	511	515	PF00917	0.727
DOC_USP7_MATH_1	55	59	PF00917	0.420
DOC_USP7_MATH_1	613	617	PF00917	0.381
DOC_USP7_MATH_1	663	667	PF00917	0.407
DOC_USP7_MATH_1	678	682	PF00917	0.600
DOC_USP7_MATH_1	683	687	PF00917	0.509
DOC_USP7_MATH_1	927	931	PF00917	0.602
DOC_USP7_UBL2_3	265	269	PF12436	0.426
DOC_WW_Pin1_4	342	347	PF00397	0.511
DOC_WW_Pin1_4	392	397	PF00397	0.533
DOC_WW_Pin1_4	451	456	PF00397	0.495
DOC_WW_Pin1_4	703	708	PF00397	0.546
DOC_WW_Pin1_4	840	845	PF00397	0.468
DOC_WW_Pin1_4	898	903	PF00397	0.568
LIG_14-3-3_CanoR_1	121	127	PF00244	0.341
LIG_14-3-3_CanoR_1	207	213	PF00244	0.350
LIG_14-3-3_CanoR_1	339	348	PF00244	0.397
LIG_14-3-3_CanoR_1	416	422	PF00244	0.337
LIG_14-3-3_CanoR_1	519	527	PF00244	0.553
LIG_14-3-3_CanoR_1	745	752	PF00244	0.459
LIG_14-3-3_CanoR_1	816	824	PF00244	0.382
LIG_14-3-3_CanoR_1	883	887	PF00244	0.414
LIG_14-3-3_CanoR_1	922	932	PF00244	0.474
LIG_BIR_III_4	359	363	PF00653	0.452
LIG_BRCT_BRCA1_1	57	61	PF00533	0.418
LIG_BRCT_BRCA1_1	627	631	PF00533	0.388
LIG_BRCT_BRCA1_1	740	744	PF00533	0.412
LIG_deltaCOP1_diTrp_1	332	341	PF00928	0.401
LIG_eIF4E_1	692	698	PF01652	0.494
LIG_EVH1_2	536	540	PF00568	0.456
LIG_FHA_1	186	192	PF00498	0.483
LIG_FHA_1	207	213	PF00498	0.486
LIG_FHA_1	310	316	PF00498	0.613
LIG_FHA_1	347	353	PF00498	0.448
LIG_FHA_1	485	491	PF00498	0.399
LIG_FHA_1	516	522	PF00498	0.548
LIG_FHA_1	537	543	PF00498	0.502
LIG_FHA_1	650	656	PF00498	0.455
LIG_FHA_1	735	741	PF00498	0.441
LIG_FHA_1	823	829	PF00498	0.397
LIG_FHA_1	894	900	PF00498	0.376
LIG_FHA_1	918	924	PF00498	0.561
LIG_FHA_2	290	296	PF00498	0.413
LIG_FHA_2	724	730	PF00498	0.469
LIG_GBD_Chelix_1	189	197	PF00786	0.456
LIG_Integrin_RGD_1	734	736	PF01839	0.358
LIG_LIR_Apic_2	628	634	PF02991	0.453
LIG_LIR_Apic_2	702	707	PF02991	0.545
LIG_LIR_Apic_2	843	848	PF02991	0.383
LIG_LIR_Gen_1	161	171	PF02991	0.389
LIG_LIR_Gen_1	293	301	PF02991	0.396
LIG_LIR_Gen_1	340	348	PF02991	0.439
LIG_LIR_Gen_1	367	376	PF02991	0.534
LIG_LIR_Gen_1	395	403	PF02991	0.513
LIG_LIR_Nem_3	125	130	PF02991	0.387
LIG_LIR_Nem_3	161	167	PF02991	0.367
LIG_LIR_Nem_3	198	204	PF02991	0.331
LIG_LIR_Nem_3	261	267	PF02991	0.441
LIG_LIR_Nem_3	293	299	PF02991	0.394
LIG_LIR_Nem_3	340	344	PF02991	0.433
LIG_LIR_Nem_3	395	400	PF02991	0.443
LIG_LIR_Nem_3	4	10	PF02991	0.563
LIG_LIR_Nem_3	641	647	PF02991	0.420
LIG_LIR_Nem_3	686	692	PF02991	0.473
LIG_LIR_Nem_3	836	842	PF02991	0.447
LIG_LYPXL_yS_3	839	842	PF13949	0.512
LIG_NRBOX	28	34	PF00104	0.439
LIG_Pex14_1	144	148	PF04695	0.338
LIG_Pex14_2	142	146	PF04695	0.418
LIG_Pex14_2	799	803	PF04695	0.455
LIG_Pex14_2	97	101	PF04695	0.297
LIG_PTB_Apo_2	797	804	PF02174	0.392
LIG_REV1ctd_RIR_1	718	727	PF16727	0.513
LIG_SH2_CRK	527	531	PF00017	0.336
LIG_SH2_CRK	573	577	PF00017	0.336
LIG_SH2_CRK	644	648	PF00017	0.503
LIG_SH2_CRK	845	849	PF00017	0.421
LIG_SH2_NCK_1	606	610	PF00017	0.377
LIG_SH2_NCK_1	856	860	PF00017	0.365
LIG_SH2_SRC	164	167	PF00017	0.364
LIG_SH2_STAP1	422	426	PF00017	0.356
LIG_SH2_STAP1	692	696	PF00017	0.494
LIG_SH2_STAT5	103	106	PF00017	0.355
LIG_SH2_STAT5	204	207	PF00017	0.389
LIG_SH2_STAT5	220	223	PF00017	0.251
LIG_SH2_STAT5	296	299	PF00017	0.370
LIG_SH2_STAT5	370	373	PF00017	0.406
LIG_SH2_STAT5	402	405	PF00017	0.466
LIG_SH2_STAT5	481	484	PF00017	0.429
LIG_SH2_STAT5	719	722	PF00017	0.445
LIG_SH2_STAT5	827	830	PF00017	0.424
LIG_SH2_STAT5	898	901	PF00017	0.427
LIG_SH2_STAT5	931	934	PF00017	0.491
LIG_SH3_2	452	457	PF14604	0.531
LIG_SH3_3	125	131	PF00018	0.367
LIG_SH3_3	3	9	PF00018	0.552
LIG_SH3_3	449	455	PF00018	0.523
LIG_SH3_3	468	474	PF00018	0.493
LIG_SH3_3	530	536	PF00018	0.417
LIG_SH3_3	539	545	PF00018	0.378
LIG_SH3_3	574	580	PF00018	0.404
LIG_SH3_3	654	660	PF00018	0.317
LIG_SH3_3	818	824	PF00018	0.450
LIG_SH3_3	896	902	PF00018	0.535
LIG_SUMO_SIM_anti_2	188	194	PF11976	0.355
LIG_SUMO_SIM_anti_2	349	354	PF11976	0.361
LIG_SUMO_SIM_anti_2	763	769	PF11976	0.392
LIG_SUMO_SIM_par_1	188	194	PF11976	0.363
LIG_SUMO_SIM_par_1	417	425	PF11976	0.393
LIG_SUMO_SIM_par_1	434	440	PF11976	0.277
LIG_SUMO_SIM_par_1	736	743	PF11976	0.333
LIG_SUMO_SIM_par_1	847	852	PF11976	0.557
LIG_TRAF2_1	17	20	PF00917	0.505
LIG_TRAF2_1	364	367	PF00917	0.515
LIG_TRFH_1	127	131	PF08558	0.391
LIG_TRFH_1	898	902	PF08558	0.400
LIG_UBA3_1	116	124	PF00899	0.426
LIG_UBA3_1	314	321	PF00899	0.446
LIG_WRC_WIRS_1	130	135	PF05994	0.369
LIG_WRC_WIRS_1	767	772	PF05994	0.539
MOD_CDC14_SPxK_1	454	457	PF00782	0.545
MOD_CDK_SPK_2	342	347	PF00069	0.442
MOD_CDK_SPxK_1	451	457	PF00069	0.523
MOD_CDK_SPxK_1	898	904	PF00069	0.366
MOD_CK1_1	158	164	PF00069	0.372
MOD_CK1_1	28	34	PF00069	0.468
MOD_CK1_1	289	295	PF00069	0.410
MOD_CK1_1	337	343	PF00069	0.522
MOD_CK1_1	395	401	PF00069	0.529
MOD_CK1_1	439	445	PF00069	0.459
MOD_CK1_1	681	687	PF00069	0.533
MOD_CK2_1	14	20	PF00069	0.684
MOD_CK2_1	148	154	PF00069	0.506
MOD_CK2_1	156	162	PF00069	0.463
MOD_CK2_1	234	240	PF00069	0.509
MOD_CK2_1	285	291	PF00069	0.464
MOD_CK2_1	543	549	PF00069	0.423
MOD_CK2_1	587	593	PF00069	0.510
MOD_CK2_1	723	729	PF00069	0.454
MOD_CK2_1	774	780	PF00069	0.519
MOD_CK2_1	844	850	PF00069	0.380
MOD_CK2_1	923	929	PF00069	0.411
MOD_GlcNHglycan	110	113	PF01048	0.384
MOD_GlcNHglycan	117	120	PF01048	0.353
MOD_GlcNHglycan	223	226	PF01048	0.365
MOD_GlcNHglycan	260	263	PF01048	0.500
MOD_GlcNHglycan	268	272	PF01048	0.419
MOD_GlcNHglycan	336	339	PF01048	0.620
MOD_GlcNHglycan	341	344	PF01048	0.550
MOD_GlcNHglycan	404	409	PF01048	0.447
MOD_GlcNHglycan	413	416	PF01048	0.397
MOD_GlcNHglycan	424	427	PF01048	0.418
MOD_GlcNHglycan	439	442	PF01048	0.337
MOD_GlcNHglycan	461	464	PF01048	0.394
MOD_GlcNHglycan	477	480	PF01048	0.418
MOD_GlcNHglycan	513	516	PF01048	0.703
MOD_GlcNHglycan	522	525	PF01048	0.575
MOD_GlcNHglycan	589	592	PF01048	0.478
MOD_GlcNHglycan	627	630	PF01048	0.425
MOD_GlcNHglycan	835	838	PF01048	0.524
MOD_GlcNHglycan	925	928	PF01048	0.414
MOD_GSK3_1	10	17	PF00069	0.632
MOD_GSK3_1	21	28	PF00069	0.549
MOD_GSK3_1	234	241	PF00069	0.396
MOD_GSK3_1	263	270	PF00069	0.420
MOD_GSK3_1	285	292	PF00069	0.444
MOD_GSK3_1	321	328	PF00069	0.519
MOD_GSK3_1	342	349	PF00069	0.472
MOD_GSK3_1	37	44	PF00069	0.348
MOD_GSK3_1	417	424	PF00069	0.462
MOD_GSK3_1	511	518	PF00069	0.701
MOD_GSK3_1	645	652	PF00069	0.414
MOD_GSK3_1	678	685	PF00069	0.589
MOD_GSK3_1	703	710	PF00069	0.508
MOD_GSK3_1	719	726	PF00069	0.384
MOD_GSK3_1	734	741	PF00069	0.346
MOD_GSK3_1	840	847	PF00069	0.400
MOD_GSK3_1	878	885	PF00069	0.512
MOD_GSK3_1	923	930	PF00069	0.430
MOD_N-GLC_1	107	112	PF02516	0.413
MOD_NEK2_1	148	153	PF00069	0.437
MOD_NEK2_1	191	196	PF00069	0.452
MOD_NEK2_1	221	226	PF00069	0.325
MOD_NEK2_1	267	272	PF00069	0.381
MOD_NEK2_1	32	37	PF00069	0.594
MOD_NEK2_1	421	426	PF00069	0.393
MOD_NEK2_1	436	441	PF00069	0.325
MOD_NEK2_1	461	466	PF00069	0.405
MOD_NEK2_1	61	66	PF00069	0.423
MOD_NEK2_1	619	624	PF00069	0.332
MOD_NEK2_1	740	745	PF00069	0.402
MOD_NEK2_1	851	856	PF00069	0.520
MOD_NEK2_2	178	183	PF00069	0.559
MOD_NEK2_2	613	618	PF00069	0.382
MOD_NEK2_2	649	654	PF00069	0.445
MOD_OFUCOSY	458	465	PF10250	0.371
MOD_OFUCOSY	558	564	PF10250	0.448
MOD_PIKK_1	446	452	PF00454	0.543
MOD_PK_1	238	244	PF00069	0.477
MOD_PKA_1	238	244	PF00069	0.552
MOD_PKA_2	206	212	PF00069	0.480
MOD_PKA_2	21	27	PF00069	0.565
MOD_PKA_2	289	295	PF00069	0.463
MOD_PKA_2	346	352	PF00069	0.390
MOD_PKA_2	744	750	PF00069	0.463
MOD_PKA_2	882	888	PF00069	0.517
MOD_Plk_1	25	31	PF00069	0.416
MOD_Plk_1	267	273	PF00069	0.480
MOD_Plk_1	61	67	PF00069	0.483
MOD_Plk_1	613	619	PF00069	0.371
MOD_Plk_1	663	669	PF00069	0.425
MOD_Plk_1	692	698	PF00069	0.443
MOD_Plk_1	773	779	PF00069	0.524
MOD_Plk_1	851	857	PF00069	0.540
MOD_Plk_1	927	933	PF00069	0.452
MOD_Plk_2-3	543	549	PF00069	0.475
MOD_Plk_2-3	774	780	PF00069	0.410
MOD_Plk_2-3	870	876	PF00069	0.365
MOD_Plk_4	122	128	PF00069	0.441
MOD_Plk_4	185	191	PF00069	0.515
MOD_Plk_4	322	328	PF00069	0.525
MOD_Plk_4	37	43	PF00069	0.402
MOD_Plk_4	417	423	PF00069	0.404
MOD_Plk_4	543	549	PF00069	0.569
MOD_Plk_4	55	61	PF00069	0.354
MOD_Plk_4	663	669	PF00069	0.414
MOD_Plk_4	692	698	PF00069	0.429
MOD_Plk_4	774	780	PF00069	0.490
MOD_Plk_4	783	789	PF00069	0.424
MOD_Plk_4	822	828	PF00069	0.347
MOD_Plk_4	851	857	PF00069	0.453
MOD_Plk_4	927	933	PF00069	0.517
MOD_ProDKin_1	342	348	PF00069	0.501
MOD_ProDKin_1	392	398	PF00069	0.536
MOD_ProDKin_1	451	457	PF00069	0.495
MOD_ProDKin_1	703	709	PF00069	0.539
MOD_ProDKin_1	840	846	PF00069	0.469
MOD_ProDKin_1	898	904	PF00069	0.573
MOD_SUMO_for_1	182	185	PF00179	0.495
MOD_SUMO_rev_2	71	81	PF00179	0.532
TRG_DiLeu_BaEn_1	543	548	PF01217	0.481
TRG_DiLeu_BaEn_1	615	620	PF01217	0.400
TRG_DiLeu_BaEn_2	165	171	PF01217	0.312
TRG_DiLeu_BaEn_2	294	300	PF01217	0.339
TRG_DiLeu_BaEn_2	773	779	PF01217	0.392
TRG_DiLeu_BaEn_4	774	780	PF01217	0.433
TRG_DiLeu_BaLyEn_6	275	280	PF01217	0.445
TRG_DiLeu_LyEn_5	615	620	PF01217	0.310
TRG_ENDOCYTIC_2	103	106	PF00928	0.354
TRG_ENDOCYTIC_2	164	167	PF00928	0.391
TRG_ENDOCYTIC_2	296	299	PF00928	0.394
TRG_ENDOCYTIC_2	370	373	PF00928	0.510
TRG_ENDOCYTIC_2	527	530	PF00928	0.350
TRG_ENDOCYTIC_2	573	576	PF00928	0.429
TRG_ENDOCYTIC_2	644	647	PF00928	0.447
TRG_ENDOCYTIC_2	818	821	PF00928	0.476
TRG_ENDOCYTIC_2	839	842	PF00928	0.479
TRG_ER_diArg_1	272	275	PF00400	0.400
TRG_ER_diArg_1	72	74	PF00400	0.384
TRG_NES_CRM1_1	375	387	PF08389	0.453
TRG_Pf-PMV_PEXEL_1	278	282	PF00026	0.480
TRG_Pf-PMV_PEXEL_1	73	77	PF00026	0.396

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBA1	Leptomonas seymouri	55%	100%
A0A1X0NQK5	Trypanosomatidae	24%	86%
A0A3S7WQY9	Leishmania donovani	100%	100%
A0A422N156	Trypanosoma rangeli	24%	86%
A4H5Y6	Leishmania braziliensis	79%	100%
C9ZVH9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	87%
E9AN10	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QHL6	Leishmania major	94%	100%
V5BE46	Trypanosoma cruzi	24%	100%