Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HU78_LEIIN

TriTrypDb:

LINF_090023200

Length:

181

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A4HU78

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HU78

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	122	124	PF00675	0.427
CLV_NRD_NRD_1	87	89	PF00675	0.395
CLV_PCSK_KEX2_1	86	88	PF00082	0.400
CLV_PCSK_SKI1_1	68	72	PF00082	0.393
CLV_PCSK_SKI1_1	87	91	PF00082	0.368
CLV_PCSK_SKI1_1	95	99	PF00082	0.390
DOC_MAPK_gen_1	126	135	PF00069	0.535
DOC_MAPK_MEF2A_6	128	137	PF00069	0.466
DOC_MAPK_RevD_3	109	124	PF00069	0.574
DOC_PP4_FxxP_1	122	125	PF00568	0.589
DOC_USP7_MATH_1	12	16	PF00917	0.764
DOC_USP7_MATH_1	157	161	PF00917	0.419
DOC_WW_Pin1_4	19	24	PF00397	0.727
DOC_WW_Pin1_4	39	44	PF00397	0.512
LIG_14-3-3_CanoR_1	95	103	PF00244	0.585
LIG_BRCT_BRCA1_1	133	137	PF00533	0.317
LIG_FHA_1	43	49	PF00498	0.607
LIG_LIR_Gen_1	117	125	PF02991	0.582
LIG_LIR_LC3C_4	31	34	PF02991	0.610
LIG_LIR_Nem_3	117	122	PF02991	0.570
LIG_LYPXL_L_2	61	70	PF13949	0.611
LIG_NRP_CendR_1	180	181	PF00754	0.680
LIG_Pex14_2	137	141	PF04695	0.347
LIG_SH2_SRC	19	22	PF00017	0.677
LIG_SH2_STAT3	158	161	PF00017	0.361
LIG_SH2_STAT5	73	76	PF00017	0.562
LIG_SH3_2	55	60	PF14604	0.554
LIG_SH3_3	143	149	PF00018	0.403
LIG_SH3_3	37	43	PF00018	0.674
LIG_SH3_3	52	58	PF00018	0.693
LIG_SUMO_SIM_anti_2	44	50	PF11976	0.609
MOD_CK1_1	42	48	PF00069	0.640
MOD_CK2_1	19	25	PF00069	0.643
MOD_CK2_1	3	9	PF00069	0.671
MOD_GlcNHglycan	116	119	PF01048	0.395
MOD_GlcNHglycan	34	37	PF01048	0.434
MOD_GSK3_1	19	26	PF00069	0.703
MOD_GSK3_1	3	10	PF00069	0.749
MOD_NEK2_1	1	6	PF00069	0.685
MOD_NEK2_1	32	37	PF00069	0.634
MOD_NMyristoyl	1	7	PF02799	0.702
MOD_PIKK_1	157	163	PF00454	0.327
MOD_ProDKin_1	19	25	PF00069	0.724
MOD_ProDKin_1	39	45	PF00069	0.510
MOD_SUMO_rev_2	64	70	PF00179	0.630
TRG_DiLeu_BaEn_1	44	49	PF01217	0.606
TRG_ER_diArg_1	125	128	PF00400	0.594
TRG_ER_diArg_1	86	88	PF00400	0.692
TRG_NLS_MonoCore_2	122	127	PF00514	0.605
TRG_Pf-PMV_PEXEL_1	88	92	PF00026	0.463

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JHE9	Bodo saltans	61%	100%
A0A1X0NID1	Trypanosomatidae	63%	96%
A0A3R7KNE8	Trypanosoma rangeli	61%	96%
A0A3S5H6F1	Leishmania donovani	99%	100%
A4H5Y2	Leishmania braziliensis	82%	100%
D0A9R0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	68%	73%
E9AN08	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QHM0	Leishmania major	91%	100%