EF-hand domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HU76_LEIIN

TriTrypDb:

LINF_090023000

Length:

161

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HU76

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HU76

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016310	phosphorylation	5	2
GO:0044237	cellular metabolic process	2	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	4
GO:0005509	calcium ion binding	5	4
GO:0043167	ion binding	2	4
GO:0043169	cation binding	3	4
GO:0046872	metal ion binding	4	4
GO:0003824	catalytic activity	1	2
GO:0016301	kinase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	96	98	PF00675	0.551
CLV_PCSK_KEX2_1	96	98	PF00082	0.543
CLV_PCSK_SKI1_1	152	156	PF00082	0.396
CLV_Separin_Metazoa	110	114	PF03568	0.322
DEG_Nend_UBRbox_3	1	3	PF02207	0.580
DOC_USP7_MATH_1	52	56	PF00917	0.431
DOC_USP7_UBL2_3	21	25	PF12436	0.395
LIG_14-3-3_CanoR_1	119	125	PF00244	0.626
LIG_BRCT_BRCA1_1	38	42	PF00533	0.328
LIG_CtBP_PxDLS_1	13	17	PF00389	0.408
LIG_FHA_1	22	28	PF00498	0.405
LIG_LIR_Apic_2	103	108	PF02991	0.451
LIG_LIR_Apic_2	47	52	PF02991	0.520
LIG_LIR_Nem_3	39	45	PF02991	0.511
LIG_NRBOX	150	156	PF00104	0.489
LIG_SH2_CRK	49	53	PF00017	0.411
LIG_SH2_NCK_1	49	53	PF00017	0.411
LIG_SH2_STAP1	23	27	PF00017	0.370
LIG_SH2_STAP1	38	42	PF00017	0.328
LIG_SH2_STAT5	23	26	PF00017	0.426
LIG_SUMO_SIM_anti_2	133	141	PF11976	0.400
LIG_SUMO_SIM_anti_2	89	95	PF11976	0.360
LIG_SUMO_SIM_par_1	147	153	PF11976	0.419
MOD_CK1_1	68	74	PF00069	0.622
MOD_CK1_1	76	82	PF00069	0.738
MOD_CK2_1	120	126	PF00069	0.548
MOD_GlcNHglycan	130	133	PF01048	0.583
MOD_GlcNHglycan	140	143	PF01048	0.582
MOD_GlcNHglycan	38	41	PF01048	0.329
MOD_GlcNHglycan	46	49	PF01048	0.378
MOD_GlcNHglycan	5	8	PF01048	0.530
MOD_GlcNHglycan	70	73	PF01048	0.682
MOD_GSK3_1	61	68	PF00069	0.685
MOD_N-GLC_1	120	125	PF02516	0.563
MOD_N-GLC_1	61	66	PF02516	0.686
MOD_PIKK_1	61	67	PF00454	0.698
MOD_PIKK_1	84	90	PF00454	0.638
MOD_Plk_1	120	126	PF00069	0.482
MOD_Plk_4	15	21	PF00069	0.433
MOD_SUMO_rev_2	123	129	PF00179	0.607
MOD_SUMO_rev_2	76	85	PF00179	0.495
TRG_DiLeu_BaEn_1	110	115	PF01217	0.519
TRG_DiLeu_BaEn_1	150	155	PF01217	0.487
TRG_DiLeu_LyEn_5	110	115	PF01217	0.319
TRG_ER_diArg_1	95	97	PF00400	0.539
TRG_NES_CRM1_1	147	157	PF08389	0.362
TRG_Pf-PMV_PEXEL_1	113	117	PF00026	0.319
TRG_Pf-PMV_PEXEL_1	152	157	PF00026	0.388

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2R7	Leptomonas seymouri	62%	99%
A0A0S4JCS1	Bodo saltans	42%	93%
A0A1X0NI72	Trypanosomatidae	43%	96%
A0A3R7KW38	Trypanosoma rangeli	44%	93%
A0A3S7WQX2	Leishmania donovani	99%	100%
A4H5Y0	Leishmania braziliensis	79%	100%
D0A9Q8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	82%
E9AN06	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QHM2	Leishmania major	90%	100%
V5DED0	Trypanosoma cruzi	42%	98%