This cluster contains a high variety of cytochrome b5 homologs. Although all membrane-anchored, some use the N-terminal [type-III] while others the C-terminal TM helix [type-IV]. The heme domain is assumed to be cytoplasmic.. Localization: ER (by homology) / Mitochondrial outer membrane (by homology)
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Cuervo et al. | no | yes: 0 |
| Hassani et al. | no | yes: 0 |
| Forrest at al. (metacyclic) | no | yes: 0 |
| Forrest at al. (procyclic) | no | yes: 0 |
| Silverman et al. | no | yes: 0 |
| Pissara et al. | no | yes: 25 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pires et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Silverman et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Jamdhade et al. | no | yes: 16 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| DeepLoc | ||
| SignalP6 | no | yes: 0, no: 12 |
| NetGPI | no | yes: 0, no: 12 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0005635 | nuclear envelope | 4 | 1 |
| GO:0005783 | endoplasmic reticulum | 5 | 1 |
| GO:0016020 | membrane | 2 | 9 |
| GO:0020016 | ciliary pocket | 2 | 1 |
| GO:0031967 | organelle envelope | 3 | 1 |
| GO:0031975 | envelope | 2 | 1 |
| GO:0043226 | organelle | 2 | 1 |
| GO:0043227 | membrane-bounded organelle | 3 | 1 |
| GO:0043229 | intracellular organelle | 3 | 1 |
| GO:0043231 | intracellular membrane-bounded organelle | 4 | 1 |
| GO:0110165 | cellular anatomical entity | 1 | 9 |
Related structures:
AlphaFold database: A4HU72
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0005488 | binding | 1 | 3 |
| GO:0020037 | heme binding | 4 | 3 |
| GO:0046906 | tetrapyrrole binding | 3 | 3 |
| GO:0097159 | organic cyclic compound binding | 2 | 3 |
| GO:1901363 | heterocyclic compound binding | 2 | 3 |
| GO:0043167 | ion binding | 2 | 2 |
| GO:0043169 | cation binding | 3 | 2 |
| GO:0046872 | metal ion binding | 4 | 2 |
| Leishmania | From | To | Domain/Motif | Score |
|---|---|---|---|---|
| CLV_C14_Caspase3-7 | 58 | 62 | PF00656 | 0.386 |
| CLV_PCSK_SKI1_1 | 127 | 131 | PF00082 | 0.675 |
| CLV_PCSK_SKI1_1 | 42 | 46 | PF00082 | 0.252 |
| DEG_SPOP_SBC_1 | 96 | 100 | PF00917 | 0.328 |
| DOC_MAPK_gen_1 | 13 | 21 | PF00069 | 0.386 |
| DOC_USP7_MATH_1 | 106 | 110 | PF00917 | 0.412 |
| DOC_USP7_MATH_1 | 96 | 100 | PF00917 | 0.362 |
| DOC_USP7_UBL2_3 | 66 | 70 | PF12436 | 0.408 |
| LIG_14-3-3_CanoR_1 | 42 | 48 | PF00244 | 0.473 |
| LIG_BIR_II_1 | 1 | 5 | PF00653 | 0.543 |
| LIG_BRCT_BRCA1_1 | 52 | 56 | PF00533 | 0.473 |
| LIG_FHA_2 | 117 | 123 | PF00498 | 0.342 |
| LIG_LIR_Nem_3 | 17 | 23 | PF02991 | 0.379 |
| LIG_LIR_Nem_3 | 3 | 9 | PF02991 | 0.542 |
| LIG_LIR_Nem_3 | 53 | 59 | PF02991 | 0.445 |
| LIG_SH2_STAT5 | 10 | 13 | PF00017 | 0.592 |
| LIG_SH3_3 | 35 | 41 | PF00018 | 0.386 |
| LIG_TRAF2_1 | 119 | 122 | PF00917 | 0.337 |
| LIG_WRC_WIRS_1 | 30 | 35 | PF05994 | 0.386 |
| MOD_CK1_1 | 109 | 115 | PF00069 | 0.293 |
| MOD_CK1_1 | 98 | 104 | PF00069 | 0.269 |
| MOD_CK2_1 | 116 | 122 | PF00069 | 0.339 |
| MOD_CK2_1 | 29 | 35 | PF00069 | 0.502 |
| MOD_CK2_1 | 61 | 67 | PF00069 | 0.509 |
| MOD_GlcNHglycan | 104 | 107 | PF01048 | 0.309 |
| MOD_GlcNHglycan | 108 | 111 | PF01048 | 0.343 |
| MOD_GlcNHglycan | 63 | 66 | PF01048 | 0.257 |
| MOD_GSK3_1 | 116 | 123 | PF00069 | 0.290 |
| MOD_GSK3_1 | 55 | 62 | PF00069 | 0.383 |
| MOD_GSK3_1 | 96 | 103 | PF00069 | 0.273 |
| MOD_N-GLC_1 | 28 | 33 | PF02516 | 0.186 |
| MOD_NEK2_1 | 102 | 107 | PF00069 | 0.185 |
| MOD_NEK2_1 | 84 | 89 | PF00069 | 0.544 |
| MOD_Plk_1 | 120 | 126 | PF00069 | 0.350 |
| MOD_Plk_1 | 28 | 34 | PF00069 | 0.386 |
| MOD_Plk_4 | 120 | 126 | PF00069 | 0.527 |
| MOD_SUMO_for_1 | 129 | 132 | PF00179 | 0.360 |
| Protein | Taxonomy | Sequence identity | Coverage |
|---|---|---|---|
| A0A0N1I073 | Leptomonas seymouri | 58% | 100% |
| A0A0S4JCD1 | Bodo saltans | 41% | 100% |
| A0A1X0NIP9 | Trypanosomatidae | 42% | 100% |
| A0A3S5ISF2 | Trypanosoma rangeli | 42% | 100% |
| A0A3S7WQX9 | Leishmania donovani | 99% | 100% |
| A0A3S7WQZ7 | Leishmania donovani | 37% | 100% |
| A4H5X6 | Leishmania braziliensis | 38% | 100% |
| A4HU71 | Leishmania infantum | 40% | 100% |
| D0A9Q4 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 42% | 100% |
| E9AN01 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 42% | 100% |
| Q4QHM6 | Leishmania major | 44% | 100% |
| Q9P5L0 | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) | 32% | 100% |