Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DnaJ domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4HU66_LEIIN

TriTrypDb:

LINF_090022000

Length:

413

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HU66

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HU66

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	1
GO:0006458	'de novo' protein folding	3	1
GO:0009987	cellular process	1	1
GO:0042026	protein refolding	3	1
GO:0051084	'de novo' post-translational protein folding	4	1
GO:0051085	chaperone cofactor-dependent protein refolding	4	1
GO:0061077	chaperone-mediated protein folding	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0051082	unfolded protein binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	127	131	PF00656	0.717
CLV_NRD_NRD_1	103	105	PF00675	0.637
CLV_NRD_NRD_1	153	155	PF00675	0.470
CLV_NRD_NRD_1	260	262	PF00675	0.668
CLV_NRD_NRD_1	362	364	PF00675	0.634
CLV_NRD_NRD_1	382	384	PF00675	0.466
CLV_NRD_NRD_1	40	42	PF00675	0.509
CLV_NRD_NRD_1	5	7	PF00675	0.589
CLV_PCSK_KEX2_1	103	105	PF00082	0.637
CLV_PCSK_KEX2_1	153	155	PF00082	0.487
CLV_PCSK_KEX2_1	260	262	PF00082	0.609
CLV_PCSK_KEX2_1	270	272	PF00082	0.666
CLV_PCSK_KEX2_1	382	384	PF00082	0.612
CLV_PCSK_KEX2_1	5	7	PF00082	0.553
CLV_PCSK_KEX2_1	60	62	PF00082	0.272
CLV_PCSK_PC1ET2_1	270	272	PF00082	0.784
CLV_PCSK_PC1ET2_1	60	62	PF00082	0.289
CLV_PCSK_SKI1_1	103	107	PF00082	0.662
CLV_PCSK_SKI1_1	262	266	PF00082	0.602
DEG_SPOP_SBC_1	78	82	PF00917	0.422
DOC_CYCLIN_RxL_1	99	109	PF00134	0.536
DOC_MAPK_gen_1	41	49	PF00069	0.454
DOC_MAPK_gen_1	5	11	PF00069	0.527
DOC_USP7_MATH_1	112	116	PF00917	0.736
DOC_USP7_MATH_1	117	121	PF00917	0.773
DOC_USP7_MATH_1	15	19	PF00917	0.507
DOC_USP7_MATH_1	188	192	PF00917	0.747
DOC_USP7_MATH_1	71	75	PF00917	0.349
DOC_USP7_MATH_1	78	82	PF00917	0.349
DOC_WW_Pin1_4	283	288	PF00397	0.540
DOC_WW_Pin1_4	330	335	PF00397	0.644
LIG_14-3-3_CanoR_1	14	20	PF00244	0.523
LIG_14-3-3_CanoR_1	251	258	PF00244	0.549
LIG_14-3-3_CanoR_1	29	35	PF00244	0.424
LIG_14-3-3_CanoR_1	357	365	PF00244	0.625
LIG_14-3-3_CanoR_1	84	92	PF00244	0.404
LIG_AP2alpha_2	313	315	PF02296	0.572
LIG_APCC_ABBA_1	221	226	PF00400	0.387
LIG_BRCT_BRCA1_1	21	25	PF00533	0.518
LIG_BRCT_BRCA1_1	228	232	PF00533	0.388
LIG_FHA_2	209	215	PF00498	0.457
LIG_FHA_2	34	40	PF00498	0.414
LIG_FHA_2	52	58	PF00498	0.314
LIG_LIR_Apic_2	175	180	PF02991	0.648
LIG_LIR_Apic_2	322	328	PF02991	0.625
LIG_LIR_Gen_1	229	237	PF02991	0.380
LIG_LIR_Gen_1	293	303	PF02991	0.559
LIG_LIR_Nem_3	229	233	PF02991	0.380
LIG_LIR_Nem_3	289	295	PF02991	0.523
LIG_LIR_Nem_3	313	318	PF02991	0.689
LIG_LIR_Nem_3	333	338	PF02991	0.760
LIG_SH2_CRK	325	329	PF00017	0.740
LIG_SH2_CRK	44	48	PF00017	0.271
LIG_SH2_CRK	92	96	PF00017	0.271
LIG_SH2_NCK_1	325	329	PF00017	0.601
LIG_SH2_SRC	224	227	PF00017	0.405
LIG_SH2_SRC	329	332	PF00017	0.644
LIG_SH2_STAP1	145	149	PF00017	0.426
LIG_SH2_STAT3	126	129	PF00017	0.591
LIG_SH2_STAT5	303	306	PF00017	0.598
LIG_TRAF2_1	307	310	PF00917	0.619
LIG_WW_3	178	182	PF00397	0.670
MOD_CK1_1	115	121	PF00069	0.642
MOD_CK1_1	124	130	PF00069	0.629
MOD_CK1_1	191	197	PF00069	0.710
MOD_CK1_1	206	212	PF00069	0.588
MOD_CK1_1	366	372	PF00069	0.534
MOD_CK1_1	400	406	PF00069	0.580
MOD_CK1_1	74	80	PF00069	0.404
MOD_CK2_1	208	214	PF00069	0.580
MOD_CK2_1	283	289	PF00069	0.596
MOD_CK2_1	304	310	PF00069	0.616
MOD_Cter_Amidation	101	104	PF01082	0.474
MOD_Cter_Amidation	202	205	PF01082	0.628
MOD_GlcNHglycan	114	117	PF01048	0.594
MOD_GlcNHglycan	130	133	PF01048	0.542
MOD_GlcNHglycan	184	187	PF01048	0.751
MOD_GlcNHglycan	191	194	PF01048	0.546
MOD_GlcNHglycan	240	243	PF01048	0.535
MOD_GlcNHglycan	25	28	PF01048	0.633
MOD_GlcNHglycan	341	344	PF01048	0.561
MOD_GlcNHglycan	393	396	PF01048	0.722
MOD_GlcNHglycan	407	410	PF01048	0.735
MOD_GlcNHglycan	51	54	PF01048	0.358
MOD_GlcNHglycan	76	79	PF01048	0.363
MOD_GSK3_1	115	122	PF00069	0.650
MOD_GSK3_1	124	131	PF00069	0.604
MOD_GSK3_1	15	22	PF00069	0.546
MOD_GSK3_1	203	210	PF00069	0.539
MOD_GSK3_1	359	366	PF00069	0.708
MOD_GSK3_1	398	405	PF00069	0.518
MOD_GSK3_1	49	56	PF00069	0.335
MOD_GSK3_1	73	80	PF00069	0.358
MOD_N-GLC_1	112	117	PF02516	0.644
MOD_N-GLC_1	182	187	PF02516	0.755
MOD_N-GLC_1	359	364	PF02516	0.720
MOD_N-GLC_1	74	79	PF02516	0.360
MOD_NEK2_1	106	111	PF00069	0.715
MOD_NEK2_1	23	28	PF00069	0.587
MOD_NEK2_1	398	403	PF00069	0.502
MOD_NEK2_2	91	96	PF00069	0.349
MOD_PKA_1	204	210	PF00069	0.513
MOD_PKA_1	363	369	PF00069	0.773
MOD_PKA_2	188	194	PF00069	0.673
MOD_PKA_2	197	203	PF00069	0.677
MOD_PKA_2	250	256	PF00069	0.436
MOD_PKA_2	83	89	PF00069	0.404
MOD_PKB_1	187	195	PF00069	0.647
MOD_Plk_2-3	226	232	PF00069	0.393
MOD_Plk_2-3	305	311	PF00069	0.671
MOD_Plk_4	121	127	PF00069	0.579
MOD_ProDKin_1	283	289	PF00069	0.542
MOD_ProDKin_1	330	336	PF00069	0.648
TRG_DiLeu_BaEn_2	156	162	PF01217	0.429
TRG_ENDOCYTIC_2	137	140	PF00928	0.491
TRG_ENDOCYTIC_2	145	148	PF00928	0.395
TRG_ENDOCYTIC_2	295	298	PF00928	0.648
TRG_ENDOCYTIC_2	44	47	PF00928	0.285
TRG_ENDOCYTIC_2	62	65	PF00928	0.271
TRG_ENDOCYTIC_2	92	95	PF00928	0.319
TRG_ER_diArg_1	103	105	PF00400	0.642
TRG_ER_diArg_1	152	154	PF00400	0.466
TRG_ER_diArg_1	271	274	PF00400	0.606
TRG_ER_diArg_1	382	384	PF00400	0.619
TRG_ER_diArg_1	4	6	PF00400	0.562
TRG_ER_diArg_1	7	10	PF00400	0.560
TRG_NLS_Bipartite_1	260	274	PF00514	0.567
TRG_NLS_Bipartite_1	41	63	PF00514	0.335
TRG_NLS_MonoExtC_3	58	64	PF00514	0.314
TRG_Pf-PMV_PEXEL_1	103	107	PF00026	0.662

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I106	Leptomonas seymouri	56%	98%
A0A1X0NII8	Trypanosomatidae	39%	100%
A0A3Q8IC04	Leishmania donovani	100%	100%
A0A3R7KNF9	Trypanosoma rangeli	41%	100%
A4H5X1	Leishmania braziliensis	78%	100%
D0A9P8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AMZ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QHN1	Leishmania major	94%	100%
V5BMJ5	Trypanosoma cruzi	38%	100%