Conserved domain protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Bacterial trigger factor protein (TF) C-terminus - putative

Species:

Leishmania infantum

UniProt:

A4HU64_LEIIN

TriTrypDb:

LINF_090021700

Length:

139

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HU64

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HU64

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	111	113	PF00675	0.575
CLV_NRD_NRD_1	124	126	PF00675	0.483
CLV_PCSK_KEX2_1	111	113	PF00082	0.535
CLV_PCSK_KEX2_1	124	126	PF00082	0.525
CLV_PCSK_SKI1_1	118	122	PF00082	0.593
CLV_PCSK_SKI1_1	61	65	PF00082	0.621
DOC_USP7_MATH_1	98	102	PF00917	0.674
DOC_USP7_UBL2_3	39	43	PF12436	0.529
LIG_FHA_2	62	68	PF00498	0.545
LIG_FHA_2	80	86	PF00498	0.557
LIG_Integrin_RGD_1	129	131	PF01839	0.678
LIG_LIR_Gen_1	14	24	PF02991	0.625
LIG_LIR_Gen_1	69	76	PF02991	0.640
LIG_LIR_Nem_3	14	19	PF02991	0.572
LIG_LIR_Nem_3	69	75	PF02991	0.569
LIG_PDZ_Class_3	134	139	PF00595	0.562
LIG_SH2_NCK_1	16	20	PF00017	0.612
LIG_SH2_NCK_1	31	35	PF00017	0.368
LIG_SH2_STAP1	5	9	PF00017	0.530
LIG_SH2_STAP1	72	76	PF00017	0.629
LIG_TRAF2_1	64	67	PF00917	0.542
LIG_TRAF2_1	82	85	PF00917	0.556
MOD_CK1_1	101	107	PF00069	0.695
MOD_CK2_1	61	67	PF00069	0.550
MOD_CK2_1	79	85	PF00069	0.522
MOD_N-GLC_1	79	84	PF02516	0.544
MOD_NEK2_1	120	125	PF00069	0.615
MOD_NEK2_1	86	91	PF00069	0.624
MOD_PIKK_1	54	60	PF00454	0.566
MOD_PKA_1	54	60	PF00069	0.643
MOD_PKA_1	61	67	PF00069	0.530
MOD_Plk_1	79	85	PF00069	0.656
MOD_Plk_4	86	92	PF00069	0.622
MOD_SUMO_rev_2	113	123	PF00179	0.635
MOD_SUMO_rev_2	57	63	PF00179	0.538
MOD_SUMO_rev_2	84	89	PF00179	0.579
TRG_ENDOCYTIC_2	16	19	PF00928	0.574
TRG_ENDOCYTIC_2	72	75	PF00928	0.638
TRG_Pf-PMV_PEXEL_1	118	122	PF00026	0.598
TRG_Pf-PMV_PEXEL_1	13	17	PF00026	0.492

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMF6	Leptomonas seymouri	64%	100%
A0A0S4JCJ1	Bodo saltans	34%	87%
A0A1X0NHX4	Trypanosomatidae	39%	100%
A0A3R7KW49	Trypanosoma rangeli	42%	100%
A0A3S7WQW5	Leishmania donovani	100%	100%
A4H5W9	Leishmania braziliensis	88%	100%
D0A9P5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AMZ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4QHN3	Leishmania major	97%	100%