LeishMANIAdb
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Alpha-1,2-Mannosidase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Alpha-1,2-Mannosidase
Gene product:
Protein of unknown function (DUF2946), putative
Species:
Leishmania infantum
UniProt:
A4HU62_LEIIN
TriTrypDb:
Length:
536

Annotations

Annotations by Jardim et al.

Metal Binding, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0016020 membrane 2 7
GO:0110165 cellular anatomical entity 1 7

Expansion

Sequence features

A4HU62
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HU62

Function

Biological processes
Term Name Level Count
GO:0005975 carbohydrate metabolic process 3 7
GO:0008152 metabolic process 1 7
GO:0044238 primary metabolic process 2 7
GO:0071704 organic substance metabolic process 2 7
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 7
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 4 7
GO:0004559 alpha-mannosidase activity 6 7
GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity 8 7
GO:0005488 binding 1 7
GO:0005509 calcium ion binding 5 7
GO:0015923 mannosidase activity 5 7
GO:0015924 mannosyl-oligosaccharide mannosidase activity 7 7
GO:0016787 hydrolase activity 2 7
GO:0016798 hydrolase activity, acting on glycosyl bonds 3 7
GO:0043167 ion binding 2 7
GO:0043169 cation binding 3 7
GO:0046872 metal ion binding 4 7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 10 12 PF00675 0.456
CLV_NRD_NRD_1 286 288 PF00675 0.705
CLV_NRD_NRD_1 393 395 PF00675 0.600
CLV_NRD_NRD_1 468 470 PF00675 0.720
CLV_NRD_NRD_1 480 482 PF00675 0.547
CLV_NRD_NRD_1 508 510 PF00675 0.620
CLV_PCSK_KEX2_1 286 288 PF00082 0.616
CLV_PCSK_KEX2_1 480 482 PF00082 0.603
CLV_PCSK_KEX2_1 508 510 PF00082 0.620
CLV_PCSK_KEX2_1 9 11 PF00082 0.464
CLV_PCSK_SKI1_1 135 139 PF00082 0.645
CLV_PCSK_SKI1_1 161 165 PF00082 0.570
CLV_PCSK_SKI1_1 184 188 PF00082 0.718
CLV_PCSK_SKI1_1 275 279 PF00082 0.546
CLV_PCSK_SKI1_1 312 316 PF00082 0.660
CLV_PCSK_SKI1_1 62 66 PF00082 0.688
DEG_APCC_DBOX_1 183 191 PF00400 0.519
DEG_Nend_UBRbox_3 1 3 PF02207 0.648
DOC_CKS1_1 191 196 PF01111 0.420
DOC_CKS1_1 3 8 PF01111 0.549
DOC_CKS1_1 336 341 PF01111 0.423
DOC_CKS1_1 530 535 PF01111 0.514
DOC_MAPK_gen_1 394 402 PF00069 0.458
DOC_MAPK_gen_1 480 491 PF00069 0.333
DOC_MAPK_MEF2A_6 275 282 PF00069 0.350
DOC_MAPK_MEF2A_6 484 493 PF00069 0.348
DOC_MAPK_NFAT4_5 275 283 PF00069 0.375
DOC_PP1_RVXF_1 19 26 PF00149 0.618
DOC_PP4_FxxP_1 241 244 PF00568 0.473
DOC_PP4_FxxP_1 3 6 PF00568 0.560
DOC_USP7_MATH_1 163 167 PF00917 0.343
DOC_USP7_MATH_1 197 201 PF00917 0.493
DOC_USP7_MATH_1 237 241 PF00917 0.488
DOC_USP7_MATH_1 261 265 PF00917 0.506
DOC_USP7_MATH_1 300 304 PF00917 0.463
DOC_USP7_MATH_1 361 365 PF00917 0.460
DOC_USP7_MATH_1 54 58 PF00917 0.572
DOC_USP7_MATH_1 64 68 PF00917 0.483
DOC_WW_Pin1_4 128 133 PF00397 0.508
DOC_WW_Pin1_4 190 195 PF00397 0.441
DOC_WW_Pin1_4 2 7 PF00397 0.554
DOC_WW_Pin1_4 335 340 PF00397 0.430
DOC_WW_Pin1_4 474 479 PF00397 0.481
DOC_WW_Pin1_4 517 522 PF00397 0.389
DOC_WW_Pin1_4 529 534 PF00397 0.479
LIG_14-3-3_CanoR_1 235 244 PF00244 0.547
LIG_14-3-3_CanoR_1 312 321 PF00244 0.459
LIG_14-3-3_CanoR_1 367 374 PF00244 0.425
LIG_14-3-3_CanoR_1 394 402 PF00244 0.442
LIG_14-3-3_CanoR_1 424 428 PF00244 0.442
LIG_APCC_ABBA_1 103 108 PF00400 0.320
LIG_APCC_ABBA_1 385 390 PF00400 0.422
LIG_BRCT_BRCA1_1 237 241 PF00533 0.436
LIG_CSL_BTD_1 241 244 PF09270 0.473
LIG_deltaCOP1_diTrp_1 70 78 PF00928 0.514
LIG_EH1_1 493 501 PF00400 0.465
LIG_FHA_1 105 111 PF00498 0.426
LIG_FHA_1 222 228 PF00498 0.461
LIG_FHA_1 309 315 PF00498 0.431
LIG_FHA_1 486 492 PF00498 0.440
LIG_FHA_1 513 519 PF00498 0.373
LIG_FHA_1 521 527 PF00498 0.386
LIG_FHA_1 63 69 PF00498 0.535
LIG_FHA_1 95 101 PF00498 0.410
LIG_FHA_2 131 137 PF00498 0.402
LIG_FHA_2 413 419 PF00498 0.565
LIG_FHA_2 442 448 PF00498 0.461
LIG_GBD_Chelix_1 31 39 PF00786 0.320
LIG_LIR_Apic_2 238 244 PF02991 0.481
LIG_LIR_Gen_1 20 30 PF02991 0.522
LIG_LIR_Gen_1 203 211 PF02991 0.434
LIG_LIR_Gen_1 264 274 PF02991 0.420
LIG_LIR_Gen_1 425 435 PF02991 0.483
LIG_LIR_Gen_1 488 496 PF02991 0.366
LIG_LIR_Nem_3 20 25 PF02991 0.520
LIG_LIR_Nem_3 203 207 PF02991 0.384
LIG_LIR_Nem_3 210 215 PF02991 0.359
LIG_LIR_Nem_3 264 270 PF02991 0.406
LIG_LIR_Nem_3 382 388 PF02991 0.397
LIG_LIR_Nem_3 425 430 PF02991 0.428
LIG_LIR_Nem_3 436 442 PF02991 0.287
LIG_LIR_Nem_3 488 493 PF02991 0.335
LIG_PCNA_PIPBox_1 302 311 PF02747 0.426
LIG_SH2_CRK 267 271 PF00017 0.414
LIG_SH2_NCK_1 388 392 PF00017 0.430
LIG_SH2_NCK_1 411 415 PF00017 0.613
LIG_SH2_PTP2 33 36 PF00017 0.512
LIG_SH2_SRC 388 391 PF00017 0.382
LIG_SH2_STAP1 267 271 PF00017 0.372
LIG_SH2_STAP1 297 301 PF00017 0.385
LIG_SH2_STAP1 310 314 PF00017 0.430
LIG_SH2_STAT5 22 25 PF00017 0.375
LIG_SH2_STAT5 310 313 PF00017 0.435
LIG_SH2_STAT5 33 36 PF00017 0.411
LIG_SH2_STAT5 401 404 PF00017 0.451
LIG_SH2_STAT5 411 414 PF00017 0.538
LIG_SH2_STAT5 427 430 PF00017 0.419
LIG_SH2_STAT5 95 98 PF00017 0.399
LIG_SH3_1 188 194 PF00018 0.413
LIG_SH3_3 188 194 PF00018 0.472
LIG_SH3_3 333 339 PF00018 0.443
LIG_SH3_3 357 363 PF00018 0.515
LIG_SH3_3 524 530 PF00018 0.438
LIG_SH3_3 69 75 PF00018 0.508
LIG_SH3_3 76 82 PF00018 0.509
LIG_SH3_CIN85_PxpxPR_1 335 340 PF14604 0.502
LIG_Sin3_3 330 337 PF02671 0.543
LIG_SUMO_SIM_anti_2 119 124 PF11976 0.373
LIG_SUMO_SIM_anti_2 454 459 PF11976 0.382
LIG_SUMO_SIM_par_1 119 124 PF11976 0.356
LIG_SUMO_SIM_par_1 33 38 PF11976 0.430
LIG_TYR_ITIM 31 36 PF00017 0.409
LIG_WRC_WIRS_1 435 440 PF05994 0.439
MOD_CDK_SPK_2 335 340 PF00069 0.528
MOD_CDK_SPxK_1 474 480 PF00069 0.596
MOD_CDK_SPxxK_3 128 135 PF00069 0.585
MOD_CDK_SPxxK_3 2 9 PF00069 0.420
MOD_CDK_SPxxK_3 474 481 PF00069 0.500
MOD_CK1_1 200 206 PF00069 0.562
MOD_CK1_1 213 219 PF00069 0.580
MOD_CK1_1 221 227 PF00069 0.676
MOD_CK1_1 422 428 PF00069 0.548
MOD_CK1_1 43 49 PF00069 0.464
MOD_CK1_1 504 510 PF00069 0.573
MOD_CK1_1 520 526 PF00069 0.480
MOD_CK2_1 130 136 PF00069 0.424
MOD_CK2_1 325 331 PF00069 0.644
MOD_CK2_1 434 440 PF00069 0.439
MOD_CK2_1 54 60 PF00069 0.688
MOD_CK2_1 64 70 PF00069 0.609
MOD_Cter_Amidation 284 287 PF01082 0.468
MOD_Cter_Amidation 392 395 PF01082 0.579
MOD_GlcNHglycan 165 168 PF01048 0.551
MOD_GlcNHglycan 199 202 PF01048 0.610
MOD_GlcNHglycan 204 207 PF01048 0.524
MOD_GlcNHglycan 263 266 PF01048 0.587
MOD_GlcNHglycan 364 367 PF01048 0.506
MOD_GlcNHglycan 397 400 PF01048 0.606
MOD_GlcNHglycan 404 407 PF01048 0.565
MOD_GlcNHglycan 417 422 PF01048 0.452
MOD_GlcNHglycan 474 477 PF01048 0.649
MOD_GlcNHglycan 56 59 PF01048 0.658
MOD_GSK3_1 121 128 PF00069 0.436
MOD_GSK3_1 143 150 PF00069 0.635
MOD_GSK3_1 196 203 PF00069 0.665
MOD_GSK3_1 221 228 PF00069 0.706
MOD_GSK3_1 308 315 PF00069 0.526
MOD_GSK3_1 321 328 PF00069 0.519
MOD_GSK3_1 362 369 PF00069 0.563
MOD_GSK3_1 412 419 PF00069 0.699
MOD_GSK3_1 468 475 PF00069 0.679
MOD_GSK3_1 513 520 PF00069 0.453
MOD_GSK3_1 94 101 PF00069 0.588
MOD_N-GLC_1 235 240 PF02516 0.429
MOD_N-GLC_1 321 326 PF02516 0.509
MOD_N-GLC_2 2 4 PF02516 0.623
MOD_NEK2_1 254 259 PF00069 0.713
MOD_NEK2_1 308 313 PF00069 0.522
MOD_NEK2_1 321 326 PF00069 0.509
MOD_NEK2_1 35 40 PF00069 0.411
MOD_NEK2_1 380 385 PF00069 0.430
MOD_NEK2_1 423 428 PF00069 0.650
MOD_NEK2_1 434 439 PF00069 0.371
MOD_NEK2_1 441 446 PF00069 0.308
MOD_NEK2_1 513 518 PF00069 0.407
MOD_NEK2_2 230 235 PF00069 0.551
MOD_PKA_1 286 292 PF00069 0.550
MOD_PKA_2 286 292 PF00069 0.550
MOD_PKA_2 361 367 PF00069 0.678
MOD_PKA_2 412 418 PF00069 0.651
MOD_PKA_2 423 429 PF00069 0.523
MOD_PKA_2 468 474 PF00069 0.685
MOD_PKA_2 501 507 PF00069 0.581
MOD_PKB_1 11 19 PF00069 0.661
MOD_Plk_1 321 327 PF00069 0.510
MOD_Plk_4 237 243 PF00069 0.587
MOD_Plk_4 300 306 PF00069 0.483
MOD_Plk_4 35 41 PF00069 0.471
MOD_Plk_4 434 440 PF00069 0.439
MOD_Plk_4 514 520 PF00069 0.493
MOD_ProDKin_1 128 134 PF00069 0.631
MOD_ProDKin_1 190 196 PF00069 0.543
MOD_ProDKin_1 2 8 PF00069 0.420
MOD_ProDKin_1 335 341 PF00069 0.521
MOD_ProDKin_1 474 480 PF00069 0.596
MOD_ProDKin_1 517 523 PF00069 0.474
MOD_ProDKin_1 529 535 PF00069 0.610
MOD_SUMO_rev_2 57 64 PF00179 0.563
TRG_DiLeu_BaEn_2 181 187 PF01217 0.510
TRG_DiLeu_BaLyEn_6 14 19 PF01217 0.435
TRG_DiLeu_BaLyEn_6 272 277 PF01217 0.433
TRG_ENDOCYTIC_2 22 25 PF00928 0.375
TRG_ENDOCYTIC_2 267 270 PF00928 0.515
TRG_ENDOCYTIC_2 33 36 PF00928 0.411
TRG_ENDOCYTIC_2 427 430 PF00928 0.615
TRG_ER_diArg_1 479 481 PF00400 0.493
TRG_ER_diArg_1 508 510 PF00400 0.518
TRG_ER_diArg_1 9 11 PF00400 0.577
TRG_NES_CRM1_1 447 461 PF08389 0.492
TRG_NLS_MonoExtN_4 391 398 PF00514 0.581
TRG_Pf-PMV_PEXEL_1 275 279 PF00026 0.464
TRG_Pf-PMV_PEXEL_1 291 295 PF00026 0.332
TRG_Pf-PMV_PEXEL_1 481 485 PF00026 0.548

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P8A3 Leptomonas seymouri 51% 97%
A0A3Q8I8J9 Leishmania donovani 99% 81%
A4H5W7 Leishmania braziliensis 75% 100%
E9AMZ2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
Q4QHN5 Leishmania major 92% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS