F-box domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HU61_LEIIN

TriTrypDb:

LINF_090021400

Length:

661

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

A4HU61

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HU61

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	112	116	PF00656	0.696
CLV_NRD_NRD_1	195	197	PF00675	0.387
CLV_NRD_NRD_1	206	208	PF00675	0.392
CLV_NRD_NRD_1	40	42	PF00675	0.569
CLV_NRD_NRD_1	488	490	PF00675	0.612
CLV_PCSK_KEX2_1	206	208	PF00082	0.453
CLV_PCSK_KEX2_1	40	42	PF00082	0.545
CLV_PCSK_KEX2_1	488	490	PF00082	0.574
CLV_PCSK_KEX2_1	5	7	PF00082	0.470
CLV_PCSK_KEX2_1	504	506	PF00082	0.464
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.469
CLV_PCSK_PC1ET2_1	504	506	PF00082	0.512
CLV_PCSK_SKI1_1	213	217	PF00082	0.414
CLV_PCSK_SKI1_1	271	275	PF00082	0.623
CLV_PCSK_SKI1_1	348	352	PF00082	0.572
CLV_PCSK_SKI1_1	388	392	PF00082	0.470
CLV_PCSK_SKI1_1	41	45	PF00082	0.470
CLV_PCSK_SKI1_1	447	451	PF00082	0.495
CLV_PCSK_SKI1_1	505	509	PF00082	0.630
CLV_PCSK_SKI1_1	569	573	PF00082	0.273
DEG_SCF_FBW7_1	42	48	PF00400	0.722
DEG_SPOP_SBC_1	77	81	PF00917	0.680
DOC_CKS1_1	42	47	PF01111	0.701
DOC_MAPK_HePTP_8	590	602	PF00069	0.532
DOC_MAPK_MEF2A_6	593	602	PF00069	0.548
DOC_PP1_RVXF_1	239	246	PF00149	0.539
DOC_PP1_RVXF_1	316	323	PF00149	0.436
DOC_USP7_MATH_1	273	277	PF00917	0.389
DOC_USP7_MATH_1	304	308	PF00917	0.630
DOC_USP7_MATH_1	366	370	PF00917	0.444
DOC_USP7_MATH_2	363	369	PF00917	0.360
DOC_WW_Pin1_4	41	46	PF00397	0.716
LIG_14-3-3_CanoR_1	271	280	PF00244	0.379
LIG_14-3-3_CanoR_1	388	393	PF00244	0.283
LIG_14-3-3_CanoR_1	447	453	PF00244	0.375
LIG_14-3-3_CanoR_1	505	510	PF00244	0.337
LIG_14-3-3_CanoR_1	557	561	PF00244	0.375
LIG_14-3-3_CanoR_1	6	11	PF00244	0.625
LIG_14-3-3_CanoR_1	70	78	PF00244	0.713
LIG_Actin_WH2_2	556	571	PF00022	0.244
LIG_AP2alpha_2	453	455	PF02296	0.380
LIG_APCC_ABBA_1	155	160	PF00400	0.625
LIG_APCC_ABBA_1	419	424	PF00400	0.249
LIG_APCC_ABBA_1	452	457	PF00400	0.258
LIG_BIR_III_2	412	416	PF00653	0.274
LIG_BRCT_BRCA1_1	428	432	PF00533	0.280
LIG_BRCT_BRCA1_1	91	95	PF00533	0.656
LIG_Clathr_ClatBox_1	156	160	PF01394	0.647
LIG_Clathr_ClatBox_1	420	424	PF01394	0.306
LIG_deltaCOP1_diTrp_1	533	542	PF00928	0.310
LIG_EH1_1	202	210	PF00400	0.562
LIG_FHA_1	210	216	PF00498	0.673
LIG_FHA_1	281	287	PF00498	0.307
LIG_FHA_1	295	301	PF00498	0.264
LIG_FHA_1	314	320	PF00498	0.524
LIG_FHA_1	353	359	PF00498	0.371
LIG_FHA_1	414	420	PF00498	0.422
LIG_FHA_1	42	48	PF00498	0.756
LIG_FHA_1	476	482	PF00498	0.283
LIG_FHA_1	5	11	PF00498	0.656
LIG_FHA_1	603	609	PF00498	0.271
LIG_FHA_1	613	619	PF00498	0.284
LIG_FHA_1	647	653	PF00498	0.314
LIG_FHA_1	78	84	PF00498	0.775
LIG_FHA_2	110	116	PF00498	0.648
LIG_FHA_2	161	167	PF00498	0.613
LIG_FHA_2	214	220	PF00498	0.563
LIG_FHA_2	290	296	PF00498	0.459
LIG_FHA_2	389	395	PF00498	0.298
LIG_FHA_2	438	444	PF00498	0.274
LIG_FHA_2	448	454	PF00498	0.270
LIG_FHA_2	493	499	PF00498	0.433
LIG_FHA_2	63	69	PF00498	0.653
LIG_GBD_Chelix_1	290	298	PF00786	0.413
LIG_LIR_Apic_2	496	502	PF02991	0.322
LIG_LIR_Gen_1	283	293	PF02991	0.293
LIG_LIR_Gen_1	374	382	PF02991	0.262
LIG_LIR_Gen_1	416	425	PF02991	0.244
LIG_LIR_Gen_1	453	464	PF02991	0.291
LIG_LIR_Gen_1	508	514	PF02991	0.388
LIG_LIR_Gen_1	551	560	PF02991	0.384
LIG_LIR_Gen_1	649	657	PF02991	0.404
LIG_LIR_Nem_3	283	288	PF02991	0.397
LIG_LIR_Nem_3	374	378	PF02991	0.260
LIG_LIR_Nem_3	384	390	PF02991	0.268
LIG_LIR_Nem_3	450	455	PF02991	0.397
LIG_LIR_Nem_3	508	512	PF02991	0.376
LIG_LIR_Nem_3	551	556	PF02991	0.326
LIG_LIR_Nem_3	565	570	PF02991	0.281
LIG_LIR_Nem_3	649	653	PF02991	0.404
LIG_MAD2	41	49	PF02301	0.603
LIG_MYND_1	45	49	PF01753	0.668
LIG_Pex14_1	542	546	PF04695	0.316
LIG_Pex14_2	452	456	PF04695	0.240
LIG_REV1ctd_RIR_1	1	10	PF16727	0.696
LIG_SH2_CRK	180	184	PF00017	0.626
LIG_SH2_CRK	402	406	PF00017	0.377
LIG_SH2_CRK	482	486	PF00017	0.363
LIG_SH2_CRK	553	557	PF00017	0.427
LIG_SH2_CRK	570	574	PF00017	0.335
LIG_SH2_GRB2like	180	183	PF00017	0.586
LIG_SH2_NCK_1	411	415	PF00017	0.340
LIG_SH2_PTP2	546	549	PF00017	0.289
LIG_SH2_SRC	235	238	PF00017	0.542
LIG_SH2_STAP1	180	184	PF00017	0.610
LIG_SH2_STAP1	427	431	PF00017	0.336
LIG_SH2_STAP1	448	452	PF00017	0.406
LIG_SH2_STAP1	72	76	PF00017	0.728
LIG_SH2_STAT5	158	161	PF00017	0.558
LIG_SH2_STAT5	189	192	PF00017	0.649
LIG_SH2_STAT5	204	207	PF00017	0.488
LIG_SH2_STAT5	220	223	PF00017	0.577
LIG_SH2_STAT5	235	238	PF00017	0.529
LIG_SH2_STAT5	265	268	PF00017	0.349
LIG_SH2_STAT5	402	405	PF00017	0.318
LIG_SH2_STAT5	422	425	PF00017	0.169
LIG_SH2_STAT5	546	549	PF00017	0.286
LIG_SH2_STAT5	630	633	PF00017	0.357
LIG_SH2_STAT5	656	659	PF00017	0.314
LIG_SH3_3	296	302	PF00018	0.289
LIG_SH3_3	373	379	PF00018	0.352
LIG_SH3_3	39	45	PF00018	0.744
LIG_SUMO_SIM_anti_2	283	290	PF11976	0.365
LIG_SUMO_SIM_anti_2	295	300	PF11976	0.252
LIG_SUMO_SIM_par_1	286	292	PF11976	0.299
LIG_SUMO_SIM_par_1	354	359	PF11976	0.373
LIG_SUMO_SIM_par_1	388	396	PF11976	0.331
LIG_SUMO_SIM_par_1	473	478	PF11976	0.262
LIG_SUMO_SIM_par_1	6	12	PF11976	0.623
LIG_TRFH_1	375	379	PF08558	0.342
LIG_TYR_ITIM	15	20	PF00017	0.598
LIG_TYR_ITIM	568	573	PF00017	0.404
LIG_TYR_ITSM	549	556	PF00017	0.265
LIG_UBA3_1	586	593	PF00899	0.431
LIG_Vh1_VBS_1	591	609	PF01044	0.290
LIG_WRC_WIRS_1	282	287	PF05994	0.336
LIG_WRC_WIRS_1	372	377	PF05994	0.377
MOD_CK1_1	109	115	PF00069	0.522
MOD_CK1_1	276	282	PF00069	0.424
MOD_CK1_1	306	312	PF00069	0.517
MOD_CK1_1	510	516	PF00069	0.342
MOD_CK1_1	61	67	PF00069	0.645
MOD_CK1_1	9	15	PF00069	0.546
MOD_CK2_1	213	219	PF00069	0.449
MOD_CK2_1	289	295	PF00069	0.361
MOD_CK2_1	388	394	PF00069	0.439
MOD_CK2_1	62	68	PF00069	0.636
MOD_CK2_1	655	661	PF00069	0.336
MOD_DYRK1A_RPxSP_1	41	45	PF00069	0.609
MOD_GlcNHglycan	147	150	PF01048	0.497
MOD_GlcNHglycan	336	339	PF01048	0.327
MOD_GlcNHglycan	360	363	PF01048	0.511
MOD_GlcNHglycan	428	431	PF01048	0.372
MOD_GlcNHglycan	435	438	PF01048	0.360
MOD_GlcNHglycan	461	464	PF01048	0.509
MOD_GlcNHglycan	468	471	PF01048	0.533
MOD_GlcNHglycan	517	520	PF01048	0.452
MOD_GlcNHglycan	618	621	PF01048	0.316
MOD_GlcNHglycan	636	639	PF01048	0.383
MOD_GlcNHglycan	90	94	PF01048	0.592
MOD_GSK3_1	141	148	PF00069	0.578
MOD_GSK3_1	209	216	PF00069	0.592
MOD_GSK3_1	269	276	PF00069	0.469
MOD_GSK3_1	303	310	PF00069	0.572
MOD_GSK3_1	352	359	PF00069	0.487
MOD_GSK3_1	388	395	PF00069	0.369
MOD_GSK3_1	41	48	PF00069	0.635
MOD_GSK3_1	433	440	PF00069	0.354
MOD_GSK3_1	443	450	PF00069	0.359
MOD_GSK3_1	455	462	PF00069	0.459
MOD_GSK3_1	510	517	PF00069	0.334
MOD_GSK3_1	58	65	PF00069	0.487
MOD_GSK3_1	612	619	PF00069	0.394
MOD_GSK3_1	651	658	PF00069	0.390
MOD_GSK3_1	66	73	PF00069	0.582
MOD_GSK3_1	89	96	PF00069	0.582
MOD_LATS_1	87	93	PF00433	0.669
MOD_N-GLC_1	425	430	PF02516	0.382
MOD_N-GLC_1	433	438	PF02516	0.352
MOD_N-GLC_1	466	471	PF02516	0.514
MOD_NEK2_1	269	274	PF00069	0.449
MOD_NEK2_1	280	285	PF00069	0.305
MOD_NEK2_1	294	299	PF00069	0.224
MOD_NEK2_1	303	308	PF00069	0.445
MOD_NEK2_1	327	332	PF00069	0.246
MOD_NEK2_1	339	344	PF00069	0.326
MOD_NEK2_1	358	363	PF00069	0.432
MOD_NEK2_1	4	9	PF00069	0.631
MOD_NEK2_1	455	460	PF00069	0.608
MOD_NEK2_1	514	519	PF00069	0.348
MOD_NEK2_1	549	554	PF00069	0.428
MOD_NEK2_1	60	65	PF00069	0.713
MOD_NEK2_1	616	621	PF00069	0.370
MOD_NEK2_1	651	656	PF00069	0.333
MOD_NEK2_1	95	100	PF00069	0.555
MOD_PIKK_1	475	481	PF00454	0.391
MOD_PKA_2	344	350	PF00069	0.261
MOD_PKA_2	514	520	PF00069	0.411
MOD_PKA_2	521	527	PF00069	0.491
MOD_PKA_2	556	562	PF00069	0.381
MOD_PKB_1	386	394	PF00069	0.323
MOD_Plk_1	276	282	PF00069	0.418
MOD_Plk_1	294	300	PF00069	0.322
MOD_Plk_1	356	362	PF00069	0.445
MOD_Plk_1	433	439	PF00069	0.376
MOD_Plk_1	93	99	PF00069	0.607
MOD_Plk_2-3	352	358	PF00069	0.476
MOD_Plk_4	281	287	PF00069	0.345
MOD_Plk_4	289	295	PF00069	0.309
MOD_Plk_4	327	333	PF00069	0.350
MOD_Plk_4	371	377	PF00069	0.484
MOD_Plk_4	612	618	PF00069	0.376
MOD_Plk_4	626	632	PF00069	0.472
MOD_Plk_4	646	652	PF00069	0.341
MOD_ProDKin_1	41	47	PF00069	0.659
MOD_SUMO_for_1	225	228	PF00179	0.545
TRG_ENDOCYTIC_2	17	20	PF00928	0.608
TRG_ENDOCYTIC_2	180	183	PF00928	0.505
TRG_ENDOCYTIC_2	482	485	PF00928	0.334
TRG_ENDOCYTIC_2	546	549	PF00928	0.346
TRG_ENDOCYTIC_2	553	556	PF00928	0.382
TRG_ENDOCYTIC_2	570	573	PF00928	0.313
TRG_ER_diArg_1	117	120	PF00400	0.595
TRG_ER_diArg_1	190	193	PF00400	0.468
TRG_ER_diArg_1	205	207	PF00400	0.472
TRG_ER_diArg_1	40	42	PF00400	0.750
TRG_NES_CRM1_1	150	160	PF08389	0.513

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8M8	Leptomonas seymouri	64%	100%
A0A1X0NIN6	Trypanosomatidae	42%	100%
A0A3Q8I8N7	Leishmania donovani	100%	100%
A0A3R7N0K0	Trypanosoma rangeli	42%	100%
A4H5W6	Leishmania braziliensis	80%	100%
D0A9P3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AMZ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	99%
Q4QHN6	Leishmania major	92%	100%
V5BI21	Trypanosoma cruzi	40%	92%