Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HU60_LEIIN

TriTrypDb:

LINF_090021300

Length:

580

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HU60

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HU60

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	110	112	PF00675	0.523
CLV_NRD_NRD_1	28	30	PF00675	0.601
CLV_NRD_NRD_1	382	384	PF00675	0.566
CLV_PCSK_KEX2_1	110	112	PF00082	0.446
CLV_PCSK_KEX2_1	28	30	PF00082	0.603
CLV_PCSK_KEX2_1	382	384	PF00082	0.509
CLV_PCSK_KEX2_1	94	96	PF00082	0.601
CLV_PCSK_PC1ET2_1	94	96	PF00082	0.661
CLV_PCSK_SKI1_1	323	327	PF00082	0.562
CLV_PCSK_SKI1_1	352	356	PF00082	0.475
CLV_PCSK_SKI1_1	429	433	PF00082	0.612
CLV_PCSK_SKI1_1	463	467	PF00082	0.468
CLV_PCSK_SKI1_1	545	549	PF00082	0.513
DEG_APCC_DBOX_1	322	330	PF00400	0.551
DEG_APCC_DBOX_1	34	42	PF00400	0.507
DEG_APCC_DBOX_1	351	359	PF00400	0.497
DEG_Nend_Nbox_1	1	3	PF02207	0.513
DEG_SCF_FBW7_1	519	526	PF00400	0.584
DOC_CYCLIN_RxL_1	423	435	PF00134	0.593
DOC_CYCLIN_RxL_1	460	469	PF00134	0.535
DOC_CYCLIN_yCln2_LP_2	257	260	PF00134	0.553
DOC_MAPK_HePTP_8	349	361	PF00069	0.499
DOC_MAPK_MEF2A_6	276	283	PF00069	0.446
DOC_MAPK_MEF2A_6	352	361	PF00069	0.500
DOC_MAPK_MEF2A_6	408	415	PF00069	0.528
DOC_MAPK_NFAT4_5	352	360	PF00069	0.541
DOC_PP1_RVXF_1	427	433	PF00149	0.520
DOC_PP2B_LxvP_1	257	260	PF13499	0.610
DOC_PP2B_LxvP_1	303	306	PF13499	0.575
DOC_PP4_FxxP_1	325	328	PF00568	0.589
DOC_USP7_MATH_1	168	172	PF00917	0.714
DOC_USP7_MATH_1	285	289	PF00917	0.756
DOC_USP7_MATH_1	364	368	PF00917	0.559
DOC_USP7_MATH_1	45	49	PF00917	0.743
DOC_USP7_MATH_1	50	54	PF00917	0.731
DOC_USP7_MATH_1	61	65	PF00917	0.603
DOC_WW_Pin1_4	101	106	PF00397	0.648
DOC_WW_Pin1_4	275	280	PF00397	0.641
DOC_WW_Pin1_4	281	286	PF00397	0.690
DOC_WW_Pin1_4	432	437	PF00397	0.592
DOC_WW_Pin1_4	519	524	PF00397	0.591
LIG_14-3-3_CanoR_1	210	219	PF00244	0.591
LIG_14-3-3_CanoR_1	28	32	PF00244	0.589
LIG_14-3-3_CanoR_1	356	362	PF00244	0.475
LIG_14-3-3_CanoR_1	382	391	PF00244	0.515
LIG_14-3-3_CanoR_1	408	414	PF00244	0.420
LIG_14-3-3_CanoR_1	568	573	PF00244	0.492
LIG_14-3-3_CanoR_1	74	80	PF00244	0.547
LIG_APCC_ABBA_1	547	552	PF00400	0.395
LIG_BRCT_BRCA1_1	321	325	PF00533	0.603
LIG_BRCT_BRCA1_1	411	415	PF00533	0.527
LIG_BRCT_BRCA1_1	65	69	PF00533	0.578
LIG_CaM_NSCaTE_8	453	460	PF13499	0.544
LIG_Clathr_ClatBox_1	395	399	PF01394	0.393
LIG_Clathr_ClatBox_1	465	469	PF01394	0.406
LIG_CtBP_PxDLS_1	232	236	PF00389	0.520
LIG_EH1_1	424	432	PF00400	0.580
LIG_FHA_1	139	145	PF00498	0.652
LIG_FHA_1	190	196	PF00498	0.440
LIG_FHA_1	262	268	PF00498	0.579
LIG_FHA_2	329	335	PF00498	0.516
LIG_FHA_2	508	514	PF00498	0.539
LIG_GBD_Chelix_1	266	274	PF00786	0.536
LIG_LIR_Apic_2	322	328	PF02991	0.601
LIG_LIR_Apic_2	392	397	PF02991	0.492
LIG_LIR_Gen_1	116	124	PF02991	0.547
LIG_LIR_Gen_1	194	205	PF02991	0.511
LIG_LIR_Gen_1	491	496	PF02991	0.579
LIG_LIR_Nem_3	116	120	PF02991	0.505
LIG_LIR_Nem_3	194	200	PF02991	0.503
LIG_LIR_Nem_3	307	313	PF02991	0.490
LIG_LIR_Nem_3	450	456	PF02991	0.481
LIG_LIR_Nem_3	459	465	PF02991	0.342
LIG_LIR_Nem_3	573	579	PF02991	0.492
LIG_LIR_Nem_3	81	85	PF02991	0.483
LIG_NRBOX	246	252	PF00104	0.499
LIG_PCNA_yPIPBox_3	241	251	PF02747	0.604
LIG_SH2_CRK	462	466	PF00017	0.424
LIG_SH2_NCK_1	341	345	PF00017	0.593
LIG_SH2_SRC	85	88	PF00017	0.623
LIG_SH2_STAP1	391	395	PF00017	0.469
LIG_SH2_STAP1	458	462	PF00017	0.548
LIG_SH2_STAP1	492	496	PF00017	0.573
LIG_SH2_STAT3	363	366	PF00017	0.561
LIG_SH2_STAT3	458	461	PF00017	0.542
LIG_SH2_STAT5	311	314	PF00017	0.468
LIG_SH2_STAT5	550	553	PF00017	0.420
LIG_SH2_STAT5	85	88	PF00017	0.623
LIG_SH3_1	276	282	PF00018	0.624
LIG_SH3_3	219	225	PF00018	0.551
LIG_SH3_3	227	233	PF00018	0.541
LIG_SH3_3	276	282	PF00018	0.666
LIG_SH3_5	306	310	PF00018	0.491
LIG_SUMO_SIM_anti_2	504	510	PF11976	0.578
LIG_SUMO_SIM_par_1	463	469	PF11976	0.456
LIG_TYR_ITIM	308	313	PF00017	0.535
LIG_UBA3_1	395	400	PF00899	0.462
LIG_UBA3_1	464	470	PF00899	0.505
LIG_UBA3_1	507	515	PF00899	0.541
MOD_CDK_SPK_2	281	286	PF00069	0.635
MOD_CDK_SPxK_1	519	525	PF00069	0.591
MOD_CK1_1	138	144	PF00069	0.620
MOD_CK1_1	181	187	PF00069	0.683
MOD_CK1_1	234	240	PF00069	0.683
MOD_CK1_1	319	325	PF00069	0.526
MOD_CK1_1	373	379	PF00069	0.656
MOD_CK1_1	435	441	PF00069	0.706
MOD_CK1_1	483	489	PF00069	0.580
MOD_CK1_1	53	59	PF00069	0.711
MOD_CK1_1	75	81	PF00069	0.616
MOD_CK2_1	144	150	PF00069	0.587
MOD_CK2_1	281	287	PF00069	0.677
MOD_CK2_1	328	334	PF00069	0.455
MOD_CK2_1	507	513	PF00069	0.532
MOD_CK2_1	75	81	PF00069	0.555
MOD_GlcNHglycan	165	168	PF01048	0.741
MOD_GlcNHglycan	170	173	PF01048	0.692
MOD_GlcNHglycan	180	183	PF01048	0.584
MOD_GlcNHglycan	186	189	PF01048	0.446
MOD_GlcNHglycan	197	200	PF01048	0.405
MOD_GlcNHglycan	2	5	PF01048	0.445
MOD_GlcNHglycan	212	215	PF01048	0.617
MOD_GlcNHglycan	247	250	PF01048	0.494
MOD_GlcNHglycan	287	291	PF01048	0.736
MOD_GlcNHglycan	298	301	PF01048	0.509
MOD_GlcNHglycan	342	345	PF01048	0.516
MOD_GlcNHglycan	366	369	PF01048	0.559
MOD_GlcNHglycan	372	375	PF01048	0.563
MOD_GlcNHglycan	437	440	PF01048	0.702
MOD_GlcNHglycan	452	456	PF01048	0.468
MOD_GlcNHglycan	458	461	PF01048	0.467
MOD_GlcNHglycan	47	50	PF01048	0.721
MOD_GlcNHglycan	485	488	PF01048	0.589
MOD_GlcNHglycan	52	55	PF01048	0.708
MOD_GlcNHglycan	541	545	PF01048	0.635
MOD_GlcNHglycan	56	59	PF01048	0.688
MOD_GlcNHglycan	65	68	PF01048	0.466
MOD_GSK3_1	10	17	PF00069	0.557
MOD_GSK3_1	134	141	PF00069	0.613
MOD_GSK3_1	180	187	PF00069	0.663
MOD_GSK3_1	191	198	PF00069	0.554
MOD_GSK3_1	281	288	PF00069	0.675
MOD_GSK3_1	315	322	PF00069	0.609
MOD_GSK3_1	369	376	PF00069	0.697
MOD_GSK3_1	431	438	PF00069	0.571
MOD_GSK3_1	447	454	PF00069	0.500
MOD_GSK3_1	479	486	PF00069	0.599
MOD_GSK3_1	50	57	PF00069	0.704
MOD_GSK3_1	503	510	PF00069	0.458
MOD_GSK3_1	519	526	PF00069	0.430
MOD_GSK3_1	61	68	PF00069	0.594
MOD_N-GLC_1	403	408	PF02516	0.480
MOD_N-GLC_1	479	484	PF02516	0.616
MOD_NEK2_1	10	15	PF00069	0.477
MOD_NEK2_1	119	124	PF00069	0.541
MOD_NEK2_1	144	149	PF00069	0.646
MOD_NEK2_1	18	23	PF00069	0.398
MOD_NEK2_1	191	196	PF00069	0.489
MOD_NEK2_1	2	7	PF00069	0.603
MOD_NEK2_1	357	362	PF00069	0.498
MOD_NEK2_1	370	375	PF00069	0.529
MOD_NEK2_1	398	403	PF00069	0.486
MOD_NEK2_1	411	416	PF00069	0.373
MOD_NEK2_1	431	436	PF00069	0.602
MOD_NEK2_1	507	512	PF00069	0.476
MOD_NEK2_1	540	545	PF00069	0.664
MOD_NEK2_1	69	74	PF00069	0.583
MOD_PIKK_1	18	24	PF00454	0.497
MOD_PK_1	568	574	PF00069	0.489
MOD_PKA_2	184	190	PF00069	0.601
MOD_PKA_2	27	33	PF00069	0.610
MOD_Plk_1	398	404	PF00069	0.532
MOD_Plk_2-3	81	87	PF00069	0.595
MOD_Plk_4	119	125	PF00069	0.577
MOD_Plk_4	191	197	PF00069	0.514
MOD_Plk_4	218	224	PF00069	0.579
MOD_Plk_4	231	237	PF00069	0.704
MOD_Plk_4	357	363	PF00069	0.477
MOD_Plk_4	503	509	PF00069	0.525
MOD_ProDKin_1	101	107	PF00069	0.639
MOD_ProDKin_1	275	281	PF00069	0.654
MOD_ProDKin_1	432	438	PF00069	0.600
MOD_ProDKin_1	519	525	PF00069	0.591
TRG_DiLeu_BaEn_1	513	518	PF01217	0.475
TRG_DiLeu_BaLyEn_6	426	431	PF01217	0.545
TRG_DiLeu_BaLyEn_6	460	465	PF01217	0.489
TRG_ENDOCYTIC_2	310	313	PF00928	0.562
TRG_ENDOCYTIC_2	462	465	PF00928	0.422
TRG_ENDOCYTIC_2	492	495	PF00928	0.475
TRG_ER_diArg_1	110	113	PF00400	0.538
TRG_ER_diArg_1	382	385	PF00400	0.570
TRG_Pf-PMV_PEXEL_1	417	421	PF00026	0.530

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2L4	Leptomonas seymouri	55%	96%
A0A3Q8I8N5	Leishmania donovani	99%	100%
A0A3R7NSE1	Trypanosoma rangeli	30%	100%
A4H5W5	Leishmania braziliensis	81%	100%
D0A9P2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AMZ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QHN7	Leishmania major	93%	100%
V5BMK0	Trypanosoma cruzi	29%	100%